Frontiers in Pharmacology | Ethnopharmacology

Original Research

Published on 25 Nov 2025

Identification of active metabolites from Gentiana scabra Bunge ethanol-water extract for chicken metatarsal fracture repair

in Ethnopharmacology

Yi Jiang Liu
Yue Min Wang
Bin Jiang
Hou Qiang Luo
Su Zhen Liu
Shuai Luo

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1706754

848 views
1 citation

Original Research

Published on 25 Nov 2025

Allocryptopine, tetrahydropalmatine, and tetrahydroberberine N-oxide alkaloids alleviate cellular stress by modulating calcium homeostasis and the MAPK and akt/GSK-3β/tau signaling pathways

in Ethnopharmacology

Serap Nigdelioglu Dolanbay
Belma Aslim

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1589390

1,145 views

Original Research

Published on 25 Nov 2025

Selaginella extracts extend lifespan and mitigate oxidative stress in Caenorhabditis elegans

in Ethnopharmacology

Xueqing Chen
Bingjian Yan
Yingmei Wu
Wenjing Quan
Yu Liu
Yaning Huang
Yinjie Shao
Yuan Wang
Qi Zhou
Yifei Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1658991

1,266 views

Original Research

Published on 25 Nov 2025

Sporoderm-removed ganoderma lucidum spore powder (S-GLSP) alleviates neuroinflammation injury by regulating microglial polarization through inhibition of NLRP3 inflammasome activation

in Ethnopharmacology

Wenli Li
Wei Huang
Peng Zhou
Yongchuan Yao
Biao Cai
Shu Ye

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1690192

1,250 views

Review

Published on 24 Nov 2025

The therapeutic effect of curcumin in metabolic dysfunction-associated steatotic liver disease: a systematic review and meta-analysis of animal studies

in Ethnopharmacology

Xiao Li
Yiting Wang
Maocheng Xiong
Chunfang Xie
Dianxing Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1714245

1,939 views
1 citation

Original Research

Published on 24 Nov 2025

Cepharanthine may inhibit the proliferation of prostate cells by blocking the EGFR/PI3K/AKT signaling pathway: comprehensive network analysis, molecular docking, and experimental evaluation

in Ethnopharmacology

Yin Huang
Jingxing Bai
Biao Ran
Jinze Li
Bo Chen
Zeyu Chen
Jie Chen
Yan Wang
Jin Li
Qiang Dong

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1654757

1,513 views

Correction

Published on 24 Nov 2025

Correction: Wild Cordyceps sinensis exhibits far lower arsenic accumulation and hepatorenal toxicity in mice compared to equivalent dose of inorganic arsenic

in Ethnopharmacology

Liang Gao
Hongxia Yang
Jinmei Ma
Hongtao Bi
Yuancan Xiao
Cen Li
Lixin Wei

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1730109

580 views

Systematic Review

Published on 24 Nov 2025

The impact of climate change on medicinal plants and natural products: A scoping review

in Ethnopharmacology

Marce Inggritha Takubessi
Banaz Jalil
Michael Heinrich

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1697581

3,600 views
1 citation

Review

Published on 24 Nov 2025

Traditional uses, nutritional properties, phytochemical metabolites, pharmacological properties, and potential applications of Lilium spp.: a systematic review

in Ethnopharmacology

Yi Wang
Huan Chen
Pucheng Feng
Deyun Wang
Xiaoquan Du

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1713957

2,194 views

Review

Published on 24 Nov 2025

The pathogenesis of diabetic kidney disease and the therapeutic potential of bioactive substances

in Ethnopharmacology

Yan Chen
He Li
Qiuju Dai
Zhen Tan
Huihui Wu
Zhiyi Xu
Guangwei Wang
Yang Fang
Jie Luo
Chenghao Yu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1669424

1,700 views

Original Research

Published on 24 Nov 2025

Cannabis-based extract for managing pain in dogs with osteoarthritis: efficacy and safety assessment

in Ethnopharmacology

Neide Maria Griebeler
Ricardo Penayo Cremonese
Yasmin Rafaela Fakih Correa
Priscila Romero Mazzini Pereira
Amanda Furjan Rial
Emanuela Leite
Maria Victoria Luz Gonçalves
Luiz Renato Marques das Almas
Nedice Borges Cardoso
Fernando Cezar-dos-Santos

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1539704

1,893 views

Correction

Published on 21 Nov 2025

Correction: Harmine derivative B-9-3 inhibits non-small cell lung cancer via the VEGFA/PI3K/AKT pathway

in Ethnopharmacology

Yuche Wu
Bing Wang
Xuwen Mao
Wei Chen
Haji Akber Aisa

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1701287

534 views

Systematic Review

Published on 21 Nov 2025

Efficacy comparison of four different Chinese herbal mediciness in intervening acute respiratory distress syndrome: a bayesian network meta-analysis

in Ethnopharmacology

Xinhui Wu
Sisi Feng
Xuemei Dai
Zhihao Liu
Yi Luo
Fei Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1671930

1,293 views

Review

Published on 21 Nov 2025

Scorpion (Buthus martensii Karsch) in Chinese medicine: a review of traditional uses, chemical constituents, pharmacology, and toxicology

in Ethnopharmacology

Meng-Han Liu
Juan-Juan Zhu
Qi Lu
Zhen-Ni Qu
Qiao Zhou
Lei Zhang
Yan-Peng Dai
Dian-Hua Shi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1702650

1,859 views

Original Research

Published on 21 Nov 2025

Anti-inflammatory and analgesic effects of Kaihoujian throat spray, and therapeutic mechanism in acute pharyngitis: involvement of the NF-κB/COX-2 pathway and formula deconstruction strategy

in Ethnopharmacology

Hui Shi
Jinhe Zhang
Liyan Zhang
Xiu Dong
Chang Liu
Xiongwei Liu
Ying Zhou
Tingting Feng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1687046

1,370 views

Original Research

Published on 21 Nov 2025

Integrated effects of Kampo treatment on gastrointestinal symptoms and stress in patients with functional dyspepsia: a preliminary prospective observational study

in Ethnopharmacology

Lian Liang
Hongyang Li
Hirokazu Doi
Yaxuan Jiang
Satoshi Tashiro
Jiying Sun
Akihiro Kawahara
Shiro Oka
Masanori Ito
Keiko Ogawa-Ochiai

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1685656

1,278 views

Original Research

Published on 21 Nov 2025

Anti-ulcer activity of green synthesized selenium nanoparticles using Nigella sativa L. seed extract in rats

in Ethnopharmacology

Awatef Elwej
Fawziah Al-Otaibi
Khadija Boukholda
Fahad Alminderej
Faez Alotaibi
Amani Kaabi
Nada M. Ali
Hamadi Fetoui
Kaiss Aouadi
Adel Kadri

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1638593

1,712 views
1 citation

Review

Published on 21 Nov 2025

Curcumin mediates oxidative stress to play an anti-fibrotic role, focusing on liver, renal, myocardial and pulmonary fibrosis

in Ethnopharmacology

Shishuang Yu
Jufang Pu
Ke Liu
Cuifang He
Feifei Yang
Ke Chen
Xiuli Yang
Yi Zhu
Jun Jiang
Maocai Luo

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1636538

2,194 views

Review

Published on 21 Nov 2025

A critical review of natural products driven correction of bile acid dysregulation: a therapeutic strategy for nonalcoholic fatty liver disease

in Ethnopharmacology

Qing Peng
Liyuan Hao
Shenghao Li
Fei Yu
Na Li
Xiaoyu Hu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1640873

2,779 views
1 citation

Original Research

Published on 21 Nov 2025

Epimedium brevicornu Maxim. extract activates natural killer cells against hepatocellular carcinoma via the cGAS-STING pathway

in Ethnopharmacology

Lu Liu
Xiaoyan Zhan
Xianling Wang
Jincai Wen
Caiping He
Xiaoyan Chen
Yuanyuan Guo
Xueting Wang
Liu Li
Haibo Cheng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1681650

1,588 views

Systematic Review

Published on 21 Nov 2025

Preclinical evidence and mechanistic insights of ligustilide in ischemic stroke: a systematic review and meta-analysis

in Ethnopharmacology

Hengtong An
Shuhan Guo
Wei Wang
Tiangang Zheng
Xiaofei Jin
Xiaohong Zhou
Weijuan Gao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1666207

1,109 views
1 citation

Original Research

Published on 20 Nov 2025

Evaluation of long-term safety profile of an EU-GMP certified Cannabis sativa L. strain in a naturally aging preclinical model

in Ethnopharmacology

Gabriela-Dumitrita Stanciu
Ivona Costachescu
Daniela-Carmen Ababei
Andrei Szilagyi
Raluca-Maria Gogu
Vlad-Constantin Craciun
Andrei-Daniel Timofte
Irina-Draga Caruntu
Cristina-Elena Dobre
Bogdan-Ionel Tamba

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1716366

1,122 views

Original Research

Published on 20 Nov 2025

Full-spectrum cannabis extracts for women with chronic pain syndromes: a real-life retrospective report of multi-symptomatic benefits after treatment with individually tailored dosage schemes

in Ethnopharmacology

Patrícia Montagner Soares Silva
Wesley Medeiros
Clarissa Nogueira Borges
Joaquim P. Brasil-Neto
Wilson Lessa Jr.
Ricardo Ferreira de Oliveira e Silva
Fabio V. Caixeta
Renato Malcher-Lopes

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1538518

3,282 views

Systematic Review

Published on 20 Nov 2025

Cardioprotective Chinese herbs and antiretroviral drug metabolism: a systematic review of in vitro evidence

in Ethnopharmacology

Wan-Jung Cheng
Anthony Jaworowski
Janine M. Trevillyan
Anna C. Hearps
Charlie C. Xue
Anthony L. Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1627058

1,300 views