Frontiers in Pharmacology | Ethnopharmacology

Review

Published on 07 Nov 2025

The therapeutic potential of icariin in the intervention of bone and joint diseases through multiple pathways: a narrative review

in Ethnopharmacology

Jiayi Luo
Lijiao Wu
Yunying Xu
Jingqi Zhang
Xinyi Zhao
Xiangjin Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1606912

2,770 views

Original Research

Published on 07 Nov 2025

A randomized controlled trial of Shengji ointment combined with bromelain in promoting healing of tendon-exposed diabetic foot wounds: integrated 16S rDNA sequencing and metabolomics analysis

in Ethnopharmacology

Xu Sun
Jielin Song
Junchao Sun
Zhaohui Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1666278

1,614 views
1 citation

Original Research

Published on 07 Nov 2025

Antiproliferative effects of Trigonostemon xyphophyllorides on renal cell carcinoma via the PI3K/AKT pathway

in Ethnopharmacology

Andong Wang
Yuru Yang
Tingting Chen
Jinyan He
Bai Ling
Xiaotian Cheng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1594461

959 views

Original Research

Published on 07 Nov 2025

Green synthesis of silver nanoparticles using Saudi Xanthium strumarium extract: anticancer potential against breast and lung cancer cells

in Ethnopharmacology

Hanan Aati
Jawaher Al-Qahtani
Areej Al-Taweel
Nida N. Farshori
Raha Orfali
Shagufta Perveen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1653711

1,494 views
1 citation

Review

Published on 07 Nov 2025

Mechanistic insights into traditional Chinese medicine for viral pneumonia treatment: signaling pathway perspectives

in Ethnopharmacology

Shihao Zheng
Tianyu Xue
Size Li
Wenying Qi
Xiaobin Zao
Peng Zhang
Fan-E Cheng
Yongan Ye
Peipei Dong

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1577580

1,424 views
1 citation

Review

Published on 07 Nov 2025

From molecules to medicine: a systematic review of Gastrodia elata’s bioactive metabolites and therapeutic potential

in Ethnopharmacology

Xiantai Zhou
Minna Han
Shiyu Yan
Mengyuan Wang
Shengzhou Zu
Shenghui Zhong

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1641443

2,508 views

Editorial

Published on 07 Nov 2025

Editorial: Applications of medicinal plants and their metabolites in fibrotic disease: novel strategies, mechanisms, and their impact on clinical practice

in Ethnopharmacology

Houfu Qian
Xiang Tao
Li Yuan
Xin Wang
Bing Yu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1711009

971 views

Review

Published on 07 Nov 2025

The therapeutic potential of Astragalus membranaceus in atopic dermatitis: from traditional applications and modern pharmacological research to regulation of the Gut-Skin Axis

in Ethnopharmacology

Chengshuang Lu
Yuping Zeng
Guo Wang
Buqing Lou
Yifan Wang
Wancheng Liu
Zhiming Yan
Haoyang Fu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1685708

2,183 views

Clinical Trial

Published on 06 Nov 2025

Prophylactic effect of the traditional Chinese medicine formula danxiong granules (TDX105) on hand–foot skin reaction associated with the antitumor targeted drug regorafenib: a randomized, double-blind, placebo-controlled trial

in Ethnopharmacology

Shuang Yu
Xinrui Hu
Yaqin Tan
Caixia Wang
Zhenyu Shao
Ying Xiao
Hailong Liu
Jing Lv
Sheng Li
Xuan Jiang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1641477

1,609 views

Editorial

Published on 06 Nov 2025

Editorial: Bioactive metabolites in traditional medicine: dual pathways to metabolic health

in Ethnopharmacology

Wenlong Sun

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1729667

669 views

General Commentary

Published on 06 Nov 2025

Commentary: Iridoids derived from Valeriana jatamansi jones alleviates neuroinflammation and blood spinal cord barrier permeability after spinal cord injury by activating the Nrf2/HO-1 signaling pathway

in Ethnopharmacology

Kai Zhang
Lei Wu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1699044

756 views

Review

Published on 06 Nov 2025

Potential of herbal formulas and bioactive metabolites in treating atherosclerosis: targeted modulation of macrophage polarization

in Ethnopharmacology

Shixin Liu
Jinpeng Jing
Yunsha Zhang
Junchao Sun
Chaojun Zhu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1631274

2,262 views

Original Research

Published on 06 Nov 2025

Prediction and quality evaluation of quality markers of Gentiana scabra Bunge. in treatment of liver injury

in Ethnopharmacology

Jiayi Liu
Xuelin Yu
Jiayi Luo
Dan Wang
Haibo Yin

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1679981

934 views

Review

Published on 06 Nov 2025

The therapeutic potential of phytochemicals in morphine tolerance: targeting microglia-mediated neuroinflammation

in Ethnopharmacology

Ruizhen Shi
Tingting Jin
Weilong Xu
Yongxin Liang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1669257

1,222 views

Original Research

Published on 05 Nov 2025

Effects of plant extracts on patients with heart failure: a network meta-analysis of randomized controlled trials

in Ethnopharmacology

Jieyin Deng
Ye Huang
Dehui Fu
Yi Deng
Ke Yu
Cong Lan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1648811

1,978 views

Review

Published on 05 Nov 2025

Mylabris: a review of its biological characteristics, chemical composition, pharmacological, toxicology, pharmacokinetics, and marketed drugs

in Ethnopharmacology

Qingqing Cai
Jing Yan
Xinghong Li
Lihua He
Shan Xie
Yaxin Yang
Hongwei Wu
Fangbo Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1652857

1,730 views

Review

Published on 05 Nov 2025

Recent advances in Bletilla striata polysaccharide research: extraction methodologies, structural elucidation, pharmacological mechanisms, structure–activity relationships, and therapeutic delivery applications

in Ethnopharmacology

Bo Wang
Chaomeng Wu
Yingjuan Ma
Xiaofen Liu
Lijun Tao
Xuebing Zhou
Limin Jia

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1688676

2,271 views

Systematic Review

Published on 04 Nov 2025

Comparative efficacy of commercial Chinese polyherbal preparation for coronary microvascular dysfunction: a systematic review and network meta-analysis of randomized controlled trials

in Ethnopharmacology

Wujiao Wang
Jun Zhang
Xinyue Wang
Yuxuan Li
Yudou Li
Fenglan Pu
Zhifei Yang
Jie Wan
Haiyan Zhu
Tianli Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1642864

2,064 views

Original Research

Published on 03 Nov 2025

Multi-omics analysis elucidates the therapeutic mechanisms of the Quzhi formula in metabolic dysfunction-associated steatohepatitis targeting gut microbiota, lipid metabolism, and the role of its metabolite fraxin

in Ethnopharmacology

Jiao-Xiang Wu
Yue-Lan Wu
Mei-Fang Li
Nian Liu
Ying Liu
Yan-Ping Huang
Yuan Gan
Xiao-Yu Wang
Hai-Sheng Chai
Jin Xu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1694242

1,468 views

Review

Published on 03 Nov 2025

Integrated toxicology of Aconitum carmichaelii Debx.: bridging traditional toxicity-efficacy understanding and modern toxicology

in Ethnopharmacology

Xin-Yu Li
Li Zhou
Zhen-Hong Jiang
Yong Liang
Ya-Guo Fan
Zhao-Hui Ding
Hao Chen
Wen-Jun Liu
Xiang Zhou
Huan-Hua Xu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1667059

2,394 views
1 citation

Original Research

Published on 03 Nov 2025

Crosstalk between MSC-extracellular vesicles and Olea europaea leaf extract in encapsulated liposomal hydrogel: attenuation of neuroinflammation and brain neurotransmitter and memory impairment associated with obesity-induced high-fat diet

in Ethnopharmacology

Doaa Ibrahim
Ioan Pet
Hoda S. Sherkawy
Haitham Eldoumani
Ola M. Fathy
Aya Elgamal
Heba S. A. Gharib
Asmaa A. Muhammed
Aya Sh. Metwally
Mirela Ahmadi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1621092

1,717 views

Original Research

Published on 03 Nov 2025

The potential value of the use of berberine in depression: a systematic review and meta-analysis of preclinical studies

in Ethnopharmacology

Bifang Yao
Zhengxiang Long
Xiaojiao Lin
Guangqiang Chen
Xiaoyu Li
Ziqi Ye
Jiahong Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1664784

1,933 views
1 citation

Original Research

Published on 31 Oct 2025

Total alkaloids from Coptis chinensis Franch ameliorate hyperlipidemia and hepatic steatosis via dual pathway modulation of AMPK/SREBP-1c and PPARα/LXRα in mice

in Ethnopharmacology

Xiangyang Li
Xiaomin Zhang
Nina Wei
Haibo Peng
Xianli Niu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1662325

1,476 views

Systematic Review

Published on 31 Oct 2025

Efficacy and safety of traditional Chinese medicine (TCM) combined with immune checkpoint inhibitors (ICIs) for the treatment of cancer: a systematic review and meta-analysis

in Ethnopharmacology

Yani Ke
Yuyan Pan
Xueru Huang
Xing Bai
Xiaojuan Liu
Mingsi Zhang
Yunhai Wei
Tao Jiang
Guangji Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1661503

2,556 views
2 citations