Frontiers in Pharmacology | Experimental Pharmacology and Drug Discovery

Original Research

Published on 16 Apr 2025

Repurposing major metabolites of lamiaceae family as potential inhibitors of α-synuclein aggregation to alleviate neurodegenerative diseases: an in silico approach

in Experimental Pharmacology and Drug Discovery

Soham Bhattacharya
Neha Gupta
Adrish Dutta
Pijush Kanti Khanra
Ritesh Dutta
Jana Žiarovská
Nikolay T. Tzvetkov
Lucie Severová
Lenka Kopecká
Luigi Milella

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1519145

102 views

Original Research

Published on 16 Apr 2025

The development of a high-throughput acoustic droplet ejection mass-spectrometry assay and a solid-supported membrane (SSM)-based electrophysiological assay to study the pharmacological inhibition of SLC1-A3, -A2 and -A1 in a drug discovery program

in Experimental Pharmacology and Drug Discovery

Yasmin Zuschlag
Antje Pommereau
Jennifer Warkentin
Thomas Licher
Felix Bärenz

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1544682

Review

Published on 16 Apr 2025

Hepatorenal protective effects of essential oils against chemical overexposure induced oxidative damage

in Experimental Pharmacology and Drug Discovery

Faming Jiang
Xiaoyan Huang
Xingying Chen
Yuanhua Xian

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1580805

Perspective

Published on 15 Apr 2025

Metabolic anomalies in vitiligo: a new frontier for drug repurposing strategies

in Experimental Pharmacology and Drug Discovery

Alessia Paganelli
Federica Papaccio
Mauro Picardo
Barbara Bellei

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1546836

313 views

Original Research

Published on 15 Apr 2025

YX-112, a novel celastrol-derived PROTAC, inhibits the development of triple-negative breast cancer by targeting the degradation of multiple proteins

in Experimental Pharmacology and Drug Discovery

Yongxue Gu
Mengmeng Yang
Wenbin Wang
Lihua Li
Ying Ma
Wenshan Liu
Qiang Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1571135

165 views

Review

Accepted on 14 Apr 2025

Role and Mechanism of Integrin α5β1 in Bone Formation and Disease

in Experimental Pharmacology and Drug Discovery

Xiaoying Li
Hu Guangxuan
Jinshi Guo
Bo Chang
Tingting Yao
Xuejie Yi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1494062

Original Research

Accepted on 14 Apr 2025

Stress Signaling and Programmed Cell Death in Breast

in Experimental Pharmacology and Drug Discovery

jian xu
xue li
一多贾

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1467504

Original Research

Accepted on 14 Apr 2025

DTGHAT: Multi-molecule heterogeneous graph Transformer based on multi-molecule graph for drug-target identification

in Experimental Pharmacology and Drug Discovery

Xinchen Jiang
Lu Wen
Wenshui Li
Que Deng
Ming Lu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1596216

Original Research

Published on 14 Apr 2025

Integrating traditional omics and machine learning approaches to identify microbial biomarkers and therapeutic targets in pediatric inflammatory bowel disease

in Experimental Pharmacology and Drug Discovery

Lanlan Li
XuZai Deng
Shuge Wang
Tao Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1545392

279 views

Original Research

Accepted on 11 Apr 2025

Canagliflozin alleviates progestin resistance by suppressing RARβ/CRABP2 signaling in THRB knockout endometrial cancer cells

in Experimental Pharmacology and Drug Discovery

Ye Yang
Jieyun Zhou
Qiaoying Lv
Qicheng Ni
Baichun Hu
Yulong Wang
Shuning Qu
Guoting Li
Wenjie Yang
Ruihua Zhong

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1573032

101 views

Original Research

Accepted on 11 Apr 2025

Synergistic Effects of Retinol and Retinyl Palmitate in Alleviating UVB-Induced DNA Damage and Promoting the Homologous Recombination Repair in Keratinocytes

in Experimental Pharmacology and Drug Discovery

Jiangming Zhong
Ling Liang
Nan Zhao
Jing Wang
Peng Shu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1562244

133 views

Original Research

Accepted on 11 Apr 2025

Prognostic Significance and Multivariate Modeling of COL4A Family Genes and HMGA2 in Glioma

in Experimental Pharmacology and Drug Discovery

Aijun Lu
Jiankun Zang
Na Tan
Liping Wei
Ying Liang
Zefeng Tan
Anding Xu
Dan Lu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1591932

Original Research

Accepted on 11 Apr 2025

Integrating ensemble machine learning and multi-omics approaches to identify Dp44mT as a novel anti-Candida albicans agent targeting cellular iron homeostasis

in Experimental Pharmacology and Drug Discovery

Xiaowei Chai
Yuanying Jiang
Hui Lu
Xin Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1574990

135 views

Original Research

Published on 11 Apr 2025

Coordinated regulation of IGF1R by HIF1α and HIF2α enhances chemoresistance in glioblastoma

in Experimental Pharmacology and Drug Discovery

Bin Liao
Pan Wang
Sheng Gong
Lu Zhao
Jie Liu
Nan Wu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1575332

297 views

Original Research

Accepted on 10 Apr 2025

Assessment of potential drug-drug interactions in patients with hereditary angioedema from the ITACA cohort: simulations from a real-life dataset considering Danazol versus Berotralstat

in Experimental Pharmacology and Drug Discovery

Mauro Cancian
Andrea Zanichelli
Dario Cattaneo
Antonio Gidaro
Riccardo Senter
Francesco Arcoleo
Pietro Andrea Accardo
Donatella Bignardi
Paolo Borrelli
Caterina Colangelo

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1550133

181 views

Review

Published on 09 Apr 2025

Regulation of pyroptosis by natural products in ulcerative colitis: mechanisms and therapeutic potential

in Experimental Pharmacology and Drug Discovery

Xiaobei Lu
Yapeng Sun
Zhaoyi Zhang
Zhigang Sun
Shaohui Wang
Erping Xu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1573684

209 views