Frontiers in Pharmacology | Experimental Pharmacology and Drug Discovery

Systematic Review

Published on 01 Jul 2025

Efficacy and safety of stem cells in the treatment of glaucoma: systematic review and meta-analysis based on animal experiments

in Experimental Pharmacology and Drug Discovery

Danning Wu
Yanjing Liu
Xia Zhang
Ruixuan Zhang
Shaopeng Wang
Hui Lu
Tao Yue

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1587440

196 views

Original Research

Published on 01 Jul 2025

Formulation of zein nanoparticles for augmenting the anti-inflammatory activity of dexketoprofen

in Experimental Pharmacology and Drug Discovery

Mahmoud A. El Hassab
Mona H. Ibrahim
Sherif S. Abdel Mageed
Abdulla M. A. Mahmoud
Zainab Sabry Othman Ahmed
Shaimaa Mosallam
Manar Adel Abdelbari
Eman F. Khaleel
Maram A. El Hasab
Asmaa Elsayyad

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1560585

Systematic Review

Accepted on 30 Jun 2025

Drug Tapering in Animal Research: A Scoping Review

in Experimental Pharmacology and Drug Discovery

Yatong Zhang
Mengrui Chen
Tongtong Jiang
Qianfang Fu
Rong Ma
Lianghui Nie
Yuqiong You
Shuqi Gao
Ping Rong

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1544784

Original Research

Accepted on 30 Jun 2025

Fucoxanthin Inhibits the Proliferation of MOLM13 Cells by Targeting AKT to Disrupt Glucose Metabolism

in Experimental Pharmacology and Drug Discovery

Tingting Niu
Ying Chen
Mengmeng Sun
Cong Shi
Duobing Zou
Wei Wu
Yuzhan Chen
Juanjuan Chen
Haimin Chen
Guifang Ouyang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1601281

Original Research

Accepted on 30 Jun 2025

Machine Learning-Enhanced Discovery of tsRNA-mRNA Regulatory Networks: Identifying Novel Diagnostic Biomarkers and Therapeutic Targets in Breast Cancer

in Experimental Pharmacology and Drug Discovery

Zhongling Ma
Rui Wang
Ming Yuan
Bo Wang
Li Li
Tianfu Zhao
Xinhan Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1640192

Original Research

Accepted on 30 Jun 2025

Co-Delivery of Anti-inflammatory and Antioxidant Agents via Polymersomes for Osteoarthritis Therapy

in Experimental Pharmacology and Drug Discovery

Mengjie Rui
Li Wang
Ke Mi
Yinfeng Li
Naying Fang
Yingying Ge
Qiuqi Feng
Yaqi Luo
Chunlai Feng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1635761

Systematic Review

Accepted on 30 Jun 2025

Efficacy and safety of berberine on the components of metabolic syndrome: a systematic review and meta-analysis of randomized placebo-controlled trials

in Experimental Pharmacology and Drug Discovery

Dangzhen Liu
Haiyan Zhao
Yiwen Zhang
Jingqing Hu
Hong Xu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1572197

Original Research

Published on 30 Jun 2025

Myricetin protects against doxorubicin-induced acute kidney injury in rats by mitigating oxidative damage and apoptotic response

in Experimental Pharmacology and Drug Discovery

Muhammed Talha Karadogan
Betul Cicek
Kagan Tolga Cinisli
Ali Sefa Mendil
Mustafa Ozkaraca
Furkan Yilmaz
Halis Suleyman

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1601628

202 views

Original Research

Published on 30 Jun 2025

Identifying potential drugs for treating Cardiovascular-kidney metabolic syndrome via reverse network pharmacology

in Experimental Pharmacology and Drug Discovery

Si’ao Wen
Ao’ni Fu
Fen Liu
Yayu You
Linkai Li
Wen Xiao
Haoran Zhong
Xiuqin Hong
Xin Zhong
Yongjun Hu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1627236

171 views

Original Research

Accepted on 27 Jun 2025

A diaryl urea derivative, SMCl inhibits cell proliferation through the RAS/RAF/MEK/ERK pathway in hepatocellular carcinoma

in Experimental Pharmacology and Drug Discovery

Yue Fu
Weiyue Fang
Xiaohui Zhu
Fuqiang Qiu
Juncai Lai
Yangjin Xu
Bin Chen
Yang Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1605515

Review

Accepted on 27 Jun 2025

Application of Artificial Intelligence Large Language Models in Drug Target Discovery

in Experimental Pharmacology and Drug Discovery

Xinyu Liu
Jia Zhang
Xiaoran Wang
Maoda Teng
GuoYing Wang
Xiaoming Zhou

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1597351

Original Research

Published on 27 Jun 2025

Design, synthesis and antiproliferative activity of novel colchicine derivatives: selective inhibition of melanoma cell proliferation

in Experimental Pharmacology and Drug Discovery

Puneet Kumar
Tusharika Kotra
Waseem I. Lone
Yassir Arfath
Harshita Tiwari
Ashutosh Kumar Shukla
Zabeer Ahmed
Sheikh Rayees
Jasha Momo H. Anal

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1528235

476 views

Original Research

Published on 27 Jun 2025

Uncovering the molecular targets of phytocannabinoids: mechanistic insights from inverse molecular docking fingerprint approaches

in Experimental Pharmacology and Drug Discovery

Vid Ravnik
Marko Jukič
Veronika Furlan
Uroš Maver
Jan Rožanc
Urban Bren

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1611461

489 views

Original Research

Published on 27 Jun 2025

Design and screening of novel 1,2,4-Triazole-3-thione derivatives as DCN1 inhibitors for anticardiac fibrosis based on 3D-QSAR modeling and molecular dynamics

in Experimental Pharmacology and Drug Discovery

Wengong Bian
Yaxin Guo

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1590711

312 views

Original Research

Accepted on 26 Jun 2025

Deferoxamine prevents dexamethasone-induced muscle atrophy by reducing MuRF1 and atrogin-1

in Experimental Pharmacology and Drug Discovery

Jae-Yeop Jeong
Youngho Son
Youngha Kim
Nami Lee
Yujin Kim
Yu Jung Heo
Sung-E Choi
Jaemyung Choi
Seung Jin Han
Ja Young Jeon

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1582216

Mini Review

Accepted on 26 Jun 2025

Non-Hematopoietic Roles of Erythropoietin in Inflammation and Metabolic Disorders

in Experimental Pharmacology and Drug Discovery

Satoru Sugimoto
Takeshi Goda

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1613849