Frontiers in Pharmacology | Experimental Pharmacology and Drug Discovery

Original Research

Published on 01 Oct 2025

Scutellarin attenuates hypoxia-induced retinal neovascularization through bidirectional modulation of the VEGF/Ang/Tie2 pathway

in Experimental Pharmacology and Drug Discovery

Shan Ding
Wei Wang
Chunmeng Liu
Wenfeng Zhang
Jie Wang
Fuwen Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1631316

740 views

Original Research

Published on 01 Oct 2025

Unraveling the influence of α-mangostin on MDA-MB-231 cell line via WNT/β-catenin signaling pathway: in silico and in vitro approaches

in Experimental Pharmacology and Drug Discovery

Riezki Amalia
Citra Dewi
Adryan Fristiohady
Taufik Muhammad Fakih
Muchtaridi Muchtaridi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1600281

326 views

Original Research

Accepted on 30 Sep 2025

A thermo-sensitive peptide hydrogel loaded with paclitaxel and antimony nanosheets for synergistic photothermal-chemotherapeutic treatment of breast cancer

in Experimental Pharmacology and Drug Discovery

Bo Yan
Ling Gu
Hajra Zafar
Aiping Shi
Huanming Ge
Yu Jin
Nan Wang
Miao Wang
Binbin Liu
Wu Yiqun

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1681276

106 views

Original Research

Accepted on 29 Sep 2025

Network pharmacology and molecular docking analyses of the Wuwei Mingmu formula indicate that IL-10 and IL-6 are critical targets for treating experimental autoimmune uveitis in rats

in Experimental Pharmacology and Drug Discovery

Xing Liang
Junkun Zhang
Fang Yuan
Li Liang
Jie Li
Yajian Duan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1614561

287 views

Mini Review

Published on 29 Sep 2025

Phytochemical nanoencapsulation and microfluidics drive gene and tumor microenvironment modulation

in Experimental Pharmacology and Drug Discovery

Ana Belen Peñaherrera-Pazmiño
Mishell Criollo
Rebeca Gonzalez-Pastor

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1694752

828 views

Original Research

Accepted on 26 Sep 2025

20(S)-protopanaxadiol prolongs lifespan and enhances stress resistance in Caenorhabditis elegans via the insulin/IGF-1 signaling pathway

in Experimental Pharmacology and Drug Discovery

Zhuo Song
Xiuci Yan
Xiaohao Xu
Tingting Lou
Yu Wang
Limei Ren
Fangbing Liu
Shuai Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1657436

681 views

Methods

Published on 26 Sep 2025

Enhancing therapeutic antibody profiling: orthogonal strategies for stability and quality assessment

in Experimental Pharmacology and Drug Discovery

Nicole G. Metzendorf
Inga Petersen
Greta Hultqvist

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1667210

902 views

Original Research

Published on 26 Sep 2025

Pharmacokinetics and safety of a fixed-dose combination of pregabalin and thioctic acid in healthy volunteers: a randomized, open-label, phase 1 crossover study

in Experimental Pharmacology and Drug Discovery

Edith Zárate
Cecilia Bravo-Lamicq
Diego Antonio Ocampo-Gutiérrez de Velasco
Oscar Arias-Carrión

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1692519

1,018 views

Original Research

Published on 26 Sep 2025

Neurotherapeutics across blood–brain barrier: screening of BBB-permeable and CNS-active molecules for neurodegenerative disease

in Experimental Pharmacology and Drug Discovery

D. Mohan Kumar
Priti Talwar

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1616144

913 views

Mini Review

Accepted on 25 Sep 2025

The Computationally Guided Design of Selective Targeters of Multiple Proteins (STaMPs) as a New Opportunity for Small Molecule Drug Discovery

in Experimental Pharmacology and Drug Discovery

Thomas M Kaiser

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1691119

316 views

Original Research

Accepted on 25 Sep 2025

HuangLian-4 Alleviates Myocardial Ischemia-Reperfusion Injury by Activating the Pro-Survival STAT3 Signaling Pathway

in Experimental Pharmacology and Drug Discovery

Chelimuge Gong
Dalintai Wang
Qingshan Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1683575

210 views

Original Research

Published on 25 Sep 2025

Biosynthesized zinc oxide nanoparticles from Cycas revoluta seed extract demonstrate significant wound healing, antimicrobial, antioxidant, and cytotoxic potential

in Experimental Pharmacology and Drug Discovery

Hajar Hassan AlWadai
Shifhali Morabad
Uday M. Muddapur
Abdulrahman Manaa Alamri
Bader Aldoah
Adel Moalwi
Nasser A. N. Alzerwi
Saeed Ali Alsareii
Mater H. Mahnashi
Ibrahim Ahmed Shaikh

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1605717

815 views

Original Research

Accepted on 24 Sep 2025

Topical prevention from High Energy Visible light-induced pigmentation by 2-Mercaptonicotinoyl glycine, but not by Ascorbic Acid antioxidant: 2 randomized controlled trials

in Experimental Pharmacology and Drug Discovery

Virginie Piffaut
Romain De Dormael
Jean-Philippe Belaidi
Laudine Bertrand
Thierry Passeron
Françoise Bernerd
Claire Marionnet

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1651068

358 views

Systematic Review

Published on 24 Sep 2025

Exploring the potential of computer simulation models in drug testing and biomedical research: a systematic review

in Experimental Pharmacology and Drug Discovery

Rahul Mittal
Alan Ho
Harini Adivikolanu
Muskaan Sawhney
Joana R. N. Lemos
Mannat Mittal
Khemraj Hirani

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1644907

691 views

Original Research

Published on 24 Sep 2025

Insecticidal activity of the linear pseudoscorpion venom peptide Ammogarypin revealed by functional profiling

in Experimental Pharmacology and Drug Discovery

Maurice Pierry
Ludwig Dersch
Jonas Krämer
Lennart Schulte
Kornelia Hardes
Tobias Kessel
Jens Grotmann
Maximilian Seip
Andreas Vilcinskas
Tim Lüddecke

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1661173

743 views

Original Research

Published on 24 Sep 2025

Multi-pathway mechanisms of Liujunzi decoction in promoting glioma apoptosis and reversing drug resistance: network pharmacology and experimental validation

in Experimental Pharmacology and Drug Discovery

Jinxiang Huang
Shengnan Lin
Lei Lin
Luning Xu
Dezhi Kang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1682550

561 views