Frontiers in Pharmacology | Experimental Pharmacology and Drug Discovery

Systematic Review

Accepted on 15 Aug 2025

Exploring the Potential of Computer Simulation Models in Drug Testing and Biomedical Research: A Systematic Review

in Experimental Pharmacology and Drug Discovery

Rahul Mittal
Alan Ho
Harini Adivikolanu
Muskaan Sawhney
Joana R N Lemos
Mannat Mittal
Khemraj Hirani

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1644907

122 views

Editorial

Published on 15 Aug 2025

Editorial: Advances in pharmacotherapy for alcohol use disorder: from mechanisms to clinical interventions

in Experimental Pharmacology and Drug Discovery

Regina A. Mangieri
Sunil Sirohi
Ezequiel Marron Fernandez de Velasco
Seungwoo Kang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1671114

257 views

Original Research

Published on 14 Aug 2025

Exploring murE protein inhibitors of Tropheryma whipplei through pharmacoinformatic approaches incorporating solubility-enhancing formulation insights

in Experimental Pharmacology and Drug Discovery

Zarrin Basharat
Calvin R. Wei
Madiha Islam
Ibrar Ahmed
Hanan A. Ogaly
Fatimah A. M. Al-Zahrani
Yasir Waheed
Seil Kim

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1630038

429 views

Original Research

Published on 14 Aug 2025

Targeting adipocyte differentiation with CRT0066101: activation of AMPK signaling in 3T3-L1 cells

in Experimental Pharmacology and Drug Discovery

Jinque Luo
Ling Wang
Li Zhang
Wenyu Tang
Meijing Deng
Yuxin Shi
Kun Xu
Qingjun Wu
Jieyang Zhao
Jinghuan Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1645587

339 views

Original Research

Accepted on 13 Aug 2025

Analyzing antibacterial potential of Bellamya Bengalensis derived peptide-silver nanoparticle conjugates over surgical implant surfaces

in Experimental Pharmacology and Drug Discovery

SHAFQAT QAMER
Muhammad Shamim
Mahmoud H El-Bidawy
Soha Abdallah Moursi
MOHD SALEEM
Muhammad Aslam Siddiqui
Abrar Ali
Prof Dr Muhammad Shahid Iqbal

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1658027

119 views

Mini Review

Published on 13 Aug 2025

Intravitreal drug injection for glaucoma: mechanisms, clinical efficacy, and future horizons

in Experimental Pharmacology and Drug Discovery

Bin Lin
Peng Shi
Dong-Kan Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1660401

438 views

Systematic Review

Published on 13 Aug 2025

Drug tapering in animal research: current practices and challenges

in Experimental Pharmacology and Drug Discovery

Yatong Zhang
Mengrui Chen
Tongtong Jiang
Qianfang Fu
Rong Ma
Lianghui Nie
Yuqiong You
Shuqi Gao
Ping Rong

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1544784

508 views

Original Research

Published on 13 Aug 2025

Cepharanthine hydrochloride inhibits prostate cancer progression by modulating gut microbiota and metabolites

in Experimental Pharmacology and Drug Discovery

Hui Li
Xing Luo
Peng He
Zongming Dong
Yongming Jia
Bishao Sun
Ji Zheng
Jingzhen Zhu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1627656

333 views

Review

Published on 12 Aug 2025

Progress in the application of epimedium and its major bioactive components in the treatment of orthopedic diseases

in Experimental Pharmacology and Drug Discovery

Dan Tong
Long Chen
Zeyi Jiang
Xuxia Ye
Mengjie Ma
Angzhi Ye
Jian Xu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1628602

324 views

Editorial

Published on 12 Aug 2025

Editorial: Approaches to improve the performance of virtual screening: scoring functions, structural filtration, prediction of physicochemical properties/pharmacological activity

in Experimental Pharmacology and Drug Discovery

Hélcio Silva Dos Santos
Alexander Veselovsky
Dmitry Nilov

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1658699

331 views

General Commentary

Accepted on 11 Aug 2025

Commentary ： Blood metabolites as mediators in erectile dysfunction: insights from a multi-center proteomics and genetic study

in Experimental Pharmacology and Drug Discovery

Zhihao Huang
Hongxing Gu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1650398

Original Research

Published on 11 Aug 2025

The Eucommia ulmoides - Achyranthes bidentata pair and their active monomers exert synergistic therapeutic potential for osteoarthritis through the PI3K-AKT pathway

in Experimental Pharmacology and Drug Discovery

Chun Chen
Lei Lv
Yueying Huang
Fangyuan Xie
Mingzhu Gao
Sailiang Zeng
Zijun Wang
Xue Jiang
Yangyang Zhan
Leilei Bao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1571884

515 views

Original Research

Accepted on 08 Aug 2025

Pinostilbene Inhibits Lung Epithelial-Mesenchymal Transition and Delays Pulmonary Fibrosis by Modulating the PI3K/Akt Pathway

in Experimental Pharmacology and Drug Discovery

Xin Yu
Xiao Li
Xuefang Kou
Yuhe Zhou
Mengzhen Xu
Kaihui Lu
Kai Gong
Jiang Zhu
Tianying Sun
Hua Sun

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1614546

518 views

Editorial

Published on 08 Aug 2025

Editorial: The pharmacological effects and mechanisms of drugs against human diseases by modulating redox homeostasis - volume II

in Experimental Pharmacology and Drug Discovery

Xiaofang Zhang
Ming Xu
Zhihao Liu
Luchen Shan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1665486

273 views

Mini Review

Accepted on 07 Aug 2025

COPZ1: an example of non-oncogene addiction in human tumors

in Experimental Pharmacology and Drug Discovery

Tiziana Di Marco
Debora Vergaro
Angela Greco

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1636326

144 views

Original Research

Accepted on 07 Aug 2025

Bibliometric analysis and initial animal efficacy evaluation of top ten scoring drugs to enhance oral rehydration therapy in early post-burn shock

in Experimental Pharmacology and Drug Discovery

Xiang-yu Liu
Yu-shou Wu
Yirui Qu
Hui Zhou
Tian Liu
Xiao-wei Su
Fang-chao Hu
Jin-guang Zheng
Shao-fang Han
Yunfei Chi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1614159

183 views