Frontiers in Pharmacology | Experimental Pharmacology and Drug Discovery

Original Research

Published on 28 Apr 2025

Irisin attenuates cardiac injury and improves prognosis in rats with hemorrhagic shock by maintaining mitochondrial homeostasis via the AMPK/Drp1 pathway

in Experimental Pharmacology and Drug Discovery

Zheng Zhang
Yufang Zhang
Xiaofang Zou
Jiake Li
Yunfei Chi
Hailiang Bai
Bin Wei
Huiting Yun
Quanxi Zhang
Weihua Cao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1560608

1,658 views

Original Research

Published on 28 Apr 2025

DTGHAT: multi-molecule heterogeneous graph transformer based on multi-molecule graph for drug-target identification

in Experimental Pharmacology and Drug Discovery

Xinchen Jiang
Lu Wen
Wenshui Li
Deng Que
Lu Ming

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1596216

759 views

Original Research

Published on 28 Apr 2025

Adverse drug events associated with insulin glargine: a real-world pharmacovigilance study based on the FAERS database

in Experimental Pharmacology and Drug Discovery

Tongtong Wang
Gefei He
Wan Xiong
Juanjuan Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1563238

1,966 views

Review

Published on 28 Apr 2025

Quercetin as a therapeutic agent for acute pancreatitis: a comprehensive review of antioxidant, anti-inflammatory, and immunomodulatory mechanisms

in Experimental Pharmacology and Drug Discovery

Zeyi Jiang
Gamar Lhamo
Mengjie Ma
Xuxia Ye
Jin Chen
Yibo He
Jian Xu
Liquan Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1587314

1,310 views
1 citation

Original Research

Published on 28 Apr 2025

The effects of ondansetron on diabetes and high-fat diet-induced liver disease: a critical role for protein tyrosine phosphatase 1B

in Experimental Pharmacology and Drug Discovery

Fawad Naeem
Maryam Aqeel
Muhammad Ammar Zahid
Mustafeez Mujtaba Babar
Fawad Ali Shah
Abdelali Agouni
Sohaib Zafar Malik

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1565628

1,371 views

Original Research

Published on 28 Apr 2025

Apigenin promotes melanogenesis and melanosome transport through the c-KIT/Raf-1/MAPK/CREB pathway in HEMCs

in Experimental Pharmacology and Drug Discovery

Jinpeng Lv
Duo Meng
Huansha Zhang
Wenhui Xu
Xiaohong An
Chuanwei Yin
Kun Zou
Rongyin Gao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1572878

1,843 views

Original Research

Published on 25 Apr 2025

Brain-derived uroguanylin as a regulator of postprandial brown adipose tissue activation: a potential therapeutic approach for metabolic disorders

in Experimental Pharmacology and Drug Discovery

Nikola Habek
Martina Ratko
Dora Sedmak
Ivan Banovac
Vladiana Crljen
Milan Kordić
Marina Radmilović
Siniša Škokić
Martina Tkalčić
Anton Mažuranić

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1569163

1,300 views

Original Research

Published on 25 Apr 2025

Assessment of potential drug-drug interactions in patients with hereditary angioedema from the ITACA cohort: simulations from a real-life dataset considering danazol versus berotralstat

in Experimental Pharmacology and Drug Discovery

Andrea Zanichelli
Dario Cattaneo
Antonio Gidaro
Riccardo Senter
Francesco Arcoleo
Pietro Accardo
Donatella Bignardi
Paolo Borrelli
Caterina Colangelo
Tiziana De Pasquale

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1550133

1,740 views

Original Research

Published on 25 Apr 2025

Prognostic significance and multivariate modeling of COL4A family genes and HMGA2 in glioma

in Experimental Pharmacology and Drug Discovery

Aijun Lu
Jiankun Zang
Na Tan
Liping Wei
Ying Liang
Zefeng Tan
Anding Xu
Dan Lu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1591932

1,002 views

Original Research

Published on 24 Apr 2025

Synergistic effects of retinol and retinyl palmitate in alleviating UVB-induced DNA damage and promoting the homologous recombination repair in keratinocytes

in Experimental Pharmacology and Drug Discovery

Jiangming Zhong
Ling Liang
Nan Zhao
Jing Wang
Peng Shu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1562244

1,675 views

Original Research

Published on 24 Apr 2025

Combinatorial biosynthesis of novel gentamicin derivatives with nonsense mutation readthrough activity and low cytotoxicity

in Experimental Pharmacology and Drug Discovery

Lihua Yang
Hang Zhai
Tingting Tian
Botong Liu
Xianpu Ni
Huanzhang Xia

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1575840

1,052 views

Original Research

Published on 24 Apr 2025

Druggable proteins of Alistipes reveal promising antimicrobial targets against chronic intestinal inflammation

in Experimental Pharmacology and Drug Discovery

Saman Sohail
Ayesha Wisal
Sobia Rana
Rao Muhammad Abid Khan
Asad Ullah
Farooq-Ahmad Khan
Muhammad Irfan
Muhammad Imran
Paulo V. S. D. Carvalho
Renato Rozental

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1555062

1,387 views

Original Research

Published on 24 Apr 2025

Integrating ensemble machine learning and multi-omics approaches to identify Dp44mT as a novel anti-Candida albicans agent targeting cellular iron homeostasis

in Experimental Pharmacology and Drug Discovery

Xiaowei Chai
Yuanying Jiang
Hui Lu
Xin Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1574990

1,601 views

Review

Published on 24 Apr 2025

TRPV1-target drugs for the treatment of orofacial pain

in Experimental Pharmacology and Drug Discovery

Ana Cláudia Macedo Andrade
Natalia Molina Esquivel
Florencia Goldschmied Rossel
Bruna Benso

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1568109

1,556 views

Original Research

Published on 23 Apr 2025

PDP1 related ferroptosis risk signature indicates distinct immune microenvironment and prognosis of breast cancer patients

in Experimental Pharmacology and Drug Discovery

Yufeng Wang
Huifen Dang
Gongjian Zhu
Yingxia Tian

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1551325

1,608 views

Original Research

Published on 23 Apr 2025

Comprehensive characterisation of the active ingredients of Smilax glabra Roxb based on chemical fingerprinting, metabolic fingerprinting and pharmacodynamic fingerprinting

in Experimental Pharmacology and Drug Discovery

Wenqing Shi
Mengqi Jia
Xiao Li
Xin Zhao
Chenxi Wang
Guorong Fan
Yuefen Lou

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1519054

1,290 views