Frontiers in Pharmacology | Experimental Pharmacology and Drug Discovery

Original Research

Published on 09 Dec 2024

Comprehensive analysis of IRF8-related genes and immune characteristics in lupus nephritis

in Experimental Pharmacology and Drug Discovery

Zhibin Yu
Chenghui Zheng
Yilun Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1468323

619 views

Original Research

Published on 09 Dec 2024

Synergistic combinations of Angelica sinensis for myocardial infarction treatment: network pharmacology and quadratic optimization approach

in Experimental Pharmacology and Drug Discovery

Wen-Di Wang
Xin-Yi Fan
Xiao-Qi Wei
Wang-Jing Chai
Fang-He Li
Kuo Gao
Bin Liu
Shu-Zhen Guo

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1466208

845 views

Correction

Published on 06 Dec 2024

Corrigendum: FOXO1-mediated autophagy regulation by miR-223 in sepsis-induced immunosuppression

in Experimental Pharmacology and Drug Discovery

Guoan Xiang
Qi Li
Di Lian
Chengcheng Su
Xin Li
Shoulong Deng
Lixin Xie

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1533534

612 views

Review

Published on 05 Dec 2024

The role of CYP-sEH derived lipid mediators in regulating mitochondrial biology and cellular senescence: implications for the aging heart

in Experimental Pharmacology and Drug Discovery

Ala Yousef
Liye Fang
Mobina Heidari
Joshua Kranrod
John M. Seubert

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1486717

1,169 views

Original Research

Published on 03 Dec 2024

Diphenyl diselenide protects against diabetic kidney disease through modulating gut microbiota dysbiosis in streptozotocin-induced diabetic rats

in Experimental Pharmacology and Drug Discovery

Xing Wang
Dongmei Long
Xingcan Peng
Jiaxuan Li
Maoting Zhou
Yu Wang
Xianghong Hu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1506398

967 views
1 citation

Original Research

Published on 03 Dec 2024

Combining Acmella oleracea and Boswellia serrata extracts: a novel pharmacological approach in inflammatory vestibulodynia

in Experimental Pharmacology and Drug Discovery

Antimo Fusco
Michela Perrone
Federica Ricciardi
Andrea Maria Morace
Roozbe Bonsale
Milena Melake Teweldemedhin
Emanuele Di Martino
Rebecca Limongelli
Alfonso Papa
Sabatino Maione

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1508107

844 views

Original Research

Published on 03 Dec 2024

Clinical predictors of treatment response to gabapentin in women with unexplained chronic pelvic pain

in Experimental Pharmacology and Drug Discovery

Lydia Coxon
Maryam Amer
Jane Daniels
Ann M. Doust
Scott C. Mackenzie
Andrew W. Horne
Katy Vincent

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1460206

558 views

Original Research

Published on 03 Dec 2024

Coptisine enhances the sensitivity of chemoresistant breast cancer cells by inhibiting the function and expression of ABC transporters

in Experimental Pharmacology and Drug Discovery

Safaa Yehia Eid

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1472458

565 views
1 citation

Original Research

Published on 03 Dec 2024

In vitro hair growth-promoting effects of araliadiol via the p38/PPAR-γ signaling pathway in human hair follicle stem cells and dermal papilla cells

in Experimental Pharmacology and Drug Discovery

Seokmuk Park
Han Woong Park
Dae Bang Seo
Dae Sung Yoo
Seunghee Bae

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1482898

1,215 views

Correction

Published on 02 Dec 2024

Corrigendum: Estrogens modulate somatostatin receptors expression and synergize with the somatostatin analog pasireotide in prostate cells

in Experimental Pharmacology and Drug Discovery

Valentina Rossi
Erika Di Zazzo
Giovanni Galasso
Caterina De Rosa
Ciro Abbondanza
Antonio A. Sinisi
Lucia Altucci
Antimo Migliaccio
Gabriella Castoria

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1515349

317 views

Review

Published on 29 Nov 2024

The role of artificial intelligence in drug screening, drug design, and clinical trials

in Experimental Pharmacology and Drug Discovery

Yuyuan Wu
Lijing Ma
Xinyi Li
Jingpeng Yang
Xinyu Rao
Yiru Hu
Jingyi Xi
Lin Tao
Jianjun Wang
Lailing Du

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1459954

2,488 views
2 citations

Original Research

Published on 29 Nov 2024

Discovery of novel PARP1/NRP1 dual-targeting inhibitors with strong antitumor potency

in Experimental Pharmacology and Drug Discovery

Juanjuan Liu
Yifei Geng
Su Jiang
Lixia Guan
Junyi Gao
Miao-Miao Niu
Jindong Li

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1454957

721 views

Editorial

Published on 29 Nov 2024

Editorial: What does experimental pharmacology and drug discovery look like in 2035?

in Experimental Pharmacology and Drug Discovery

Maria Serena Fabbrini
Riccardo Vago

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1504817

1,118 views

Original Research

Published on 28 Nov 2024

Investigation of the effects of Periplaneta americana (L.) extract on ischemic stroke based on combined multi-omics of gut microbiota

in Experimental Pharmacology and Drug Discovery

Xin Yang
Canhui Hong
Tangfei Guan
ChengGui Zhang
Peiyun Xiao
Yongshou Yang
Huai Xiao
Zhengchun He

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1429960

926 views

Original Research

Published on 26 Nov 2024

Cytotoxicity of natural and synthetic cannabinoids and their synergistic antiproliferative effects with cisplatin in human ovarian cancer cells

in Experimental Pharmacology and Drug Discovery

Ying Chen
Huifang Li
Jia Liu
Jie Ni
Qicheng Deng
Haotian He
Panpan Wu
Yinsheng Wan
Navindra P. Seeram
Chang Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1496131

987 views

Original Research

Published on 25 Nov 2024

Dexmedetomidine regulates the anti-oxidation and autophagy of adipose-derived stromal cells under H2O2-induced oxidative stress through Nrf2/p62 pathway and improves the retention rate of autologous fat transplantation

in Experimental Pharmacology and Drug Discovery

Zihao Li
Qing Wei
Yijun Li
Fangfang Yang
Chen Ke
Tian Li
Liqun Li
Zhongming Cai

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1453938

719 views

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Articles

Comprehensive analysis of IRF8-related genes and immune characteristics in lupus nephritis

Synergistic combinations of Angelica sinensis for myocardial infarction treatment: network pharmacology and quadratic optimization approach

Corrigendum: FOXO1-mediated autophagy regulation by miR-223 in sepsis-induced immunosuppression

The role of CYP-sEH derived lipid mediators in regulating mitochondrial biology and cellular senescence: implications for the aging heart

Diphenyl diselenide protects against diabetic kidney disease through modulating gut microbiota dysbiosis in streptozotocin-induced diabetic rats

Combining Acmella oleracea and Boswellia serrata extracts: a novel pharmacological approach in inflammatory vestibulodynia

Clinical predictors of treatment response to gabapentin in women with unexplained chronic pelvic pain

Coptisine enhances the sensitivity of chemoresistant breast cancer cells by inhibiting the function and expression of ABC transporters

In vitro hair growth-promoting effects of araliadiol via the p38/PPAR-γ signaling pathway in human hair follicle stem cells and dermal papilla cells

Corrigendum: Estrogens modulate somatostatin receptors expression and synergize with the somatostatin analog pasireotide in prostate cells

The role of artificial intelligence in drug screening, drug design, and clinical trials

Discovery of novel PARP1/NRP1 dual-targeting inhibitors with strong antitumor potency

Editorial: What does experimental pharmacology and drug discovery look like in 2035?

Investigation of the effects of Periplaneta americana (L.) extract on ischemic stroke based on combined multi-omics of gut microbiota

Cytotoxicity of natural and synthetic cannabinoids and their synergistic antiproliferative effects with cisplatin in human ovarian cancer cells

Dexmedetomidine regulates the anti-oxidation and autophagy of adipose-derived stromal cells under H2O2-induced oxidative stress through Nrf2/p62 pathway and improves the retention rate of autologous fat transplantation