Frontiers in Pharmacology | Experimental Pharmacology and Drug Discovery

Original Research

Published on 25 Nov 2024

Preparation and characterization of Pistacia atlantica oleo-gum-resin-loaded electrospun nanofibers and evaluating its wound healing activity in two rat models of skin scar and burn wound

in Experimental Pharmacology and Drug Discovery

Ghobad Mohammadi
Mosayyeb Safari
Masoud Karimi
Amin Iranpanah
Mohammad Hosein Farzaei
Sajad Fakhri
Javier Echeverría

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1474981

885 views

Original Research

Published on 21 Nov 2024

Evaluation of the inhibitory mechanism of Pennisetum glaucum (pearl millet) bioactive compounds for rheumatoid arthritis: an in vitro and computational approach

in Experimental Pharmacology and Drug Discovery

Maria Sharif
Peter John
Attya Bhatti
Rehan Zafar Paracha
Abid Majeed

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1488790

1,262 views

Original Research

Published on 20 Nov 2024

Exploring somatic mutations in BRAF, KRAS, and NRAS as therapeutic targets in Saudi colorectal cancer patients through massive parallel sequencing and variant classification

in Experimental Pharmacology and Drug Discovery

Thamer Abdulhamid Aljuhani
Noor Ahmad Shaik
Rahaf Talal Alqawas
Rana Y. Bokhary
Mahmood Al-Mutadares
Hadiah Bassam Al Mahdi
Nuha Al-Rayes
Ashraf AbdulRahman El-Harouni
Ramu Elango
Babajan Banaganapalli

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1498295

976 views

Systematic Review

Published on 18 Nov 2024

Efficacy and safety of Epimedium total flavonoids for primary osteoporosis: a systematic review and meta-analysis

in Experimental Pharmacology and Drug Discovery

Jinkun Li
Xudong Huang
Yifeng Yuan
Haixin Zhang
Hang Zhou
Wei Xiong
Yuyi Li
Zechen Zhang
Fengqing Qie
Yingdelong Mao

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1505926

997 views

Original Research

Published on 18 Nov 2024

Integrated chemical analysis, metabolic profiling, network pharmacology, molecular docking and toxicity prediction to reveal the active ingredients and their safety of raw and prepared rhubarbs in the treatment of gastric ulcers

in Experimental Pharmacology and Drug Discovery

Chenxi Wang
Xin Zhao
Jingjing Jiang
Mengqi Jia
Wenqing Shi
Zhenghua Wu
Shiyu Feng
Guorong Fan
Yuefen Lou

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1481091

1,034 views

Original Research

Published on 15 Nov 2024

Discovery of novel and highly potent dual-targeting PKMYT1/HDAC2 inhibitors for hepatocellular carcinoma through structure-based virtual screening and biological evaluation

in Experimental Pharmacology and Drug Discovery

Yang Yang
Yuting Wang
Jing Chen
Miao-Miao Niu
Yongbin Wang
Xing Jin

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1491497

986 views

Original Research

Published on 14 Nov 2024

Repurposed drugs as histone deacetylase 8 inhibitors: Implications in cancer and neuropathological conditions

in Experimental Pharmacology and Drug Discovery

Mohammed Alrouji
Kumar Venkatesan
Mohammed S. Alshammari
Fahad A. Alhumaydhi
Sheeba Shafi
Sharaf E. Sharaf
Moyad Shahwan
Anas Shamsi

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1488585

882 views

Original Research

Published on 13 Nov 2024

Glucocorticoids influence on rat hematological parameters and catalase activity

in Experimental Pharmacology and Drug Discovery

Safija Herenda
Ivana Carev
Denis Haskovic
Sabina Prevljak
Sara Causevic
Edhem Haskovic

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1367350

487 views

Review

Published on 13 Nov 2024

In-depth analysis of lupeol: delving into the diverse pharmacological profile

in Experimental Pharmacology and Drug Discovery

Aminah Dalimunthe
Mega Carensia Gunawan
Zahirah Dhiya Utari
Muhammad Riza Dinata
Princella Halim
Nathasya Estherina S. Pakpahan
Alex Insandus Sitohang
M. Andriansyah Sukarno
Yuandani
Yahdiana Harahap

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1461478

2,410 views
1 citation

Original Research

Published on 13 Nov 2024

Integration of metabolomics and transcriptomics to reveal anti-immunosuppression mechanism of Lycium barbarum polysaccharide

in Experimental Pharmacology and Drug Discovery

Jiandong Wang
Xue Zhang
Yi Wu
Qianfei Wei
Lingshan Yan
Youli Yu
Yanan Guo
Zhengqin Yu
Pan Wang
Xiaonan Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1486739

732 views

Review

Published on 13 Nov 2024

β-blockers and statins: exploring the potential off-label applications in breast, colorectal, prostate, and lung cancers

in Experimental Pharmacology and Drug Discovery

Pedro Gabriel Senger Braga
Janaína da Silva Vieira
Aline Rachel Bezerra Gurgel
Patricia Chakur Brum

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1423502

1,180 views

Original Research

Published on 13 Nov 2024

Herbal formula xuling-jiangu improves bone metabolic balance in rats with ovariectomy-induced osteoporosis via the gut-bone axis

in Experimental Pharmacology and Drug Discovery

Juan Chen
Szetuen Ng
Pengchao Xu
Sainan Chen
Shengqiang Li
Xuan Chen
Lihua Xie
Jirong Ge

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1505231

897 views

Original Research

Published on 12 Nov 2024

Preparation and anti-colon cancer effect of a novel curcumin analogue (CA8): in vivo and in vitro evaluation

in Experimental Pharmacology and Drug Discovery

Jie Wen
Lingmao Zhao
Zhuohan Li
Chao Pi
Xianhu Feng
Peng Shi
Hongru Yang
Ligang Chen
Xiaodong Wang
Furong Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1464626

712 views

Original Research

Published on 12 Nov 2024

Development of bombesin-tubulysin conjugates using multicomponent chemistry to functionalize both the payload and the homing peptide

in Experimental Pharmacology and Drug Discovery

Dayma Llanes
Robert Rennert
Paul Jänicke
Ibrahim Morgan
Leslie Reguera
Daniel G. Rivera
Manuel G. Ricardo
Ludger A. Wessjohann

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1408091

765 views

Original Research

Published on 11 Nov 2024

Enhanced anticancer effect of thymidylate synthase dimer disrupters by promoting intracellular accumulation

in Experimental Pharmacology and Drug Discovery

Gaetano Marverti
Maria Gaetana Moschella
Alice Belardo
Michele Lamesta
Giada Mercanile
Lorenzo Tagliazucchi
Daniele Aiello
Alberto Venturelli
Davide Illuminati
Remo Guerrini

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1477318

765 views

Original Research

Published on 11 Nov 2024

Nanotechnological prospective for enhancing the antibacterial activity of mupirocin and cinnamon essential oil: a combination therapy

in Experimental Pharmacology and Drug Discovery

Bandar Aldhubiab
Rashed M. Almuqbil
Tamer M. Shehata
Wafaa E. Soliman
Heba S. Elsewedy

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1468374

634 views

Navigation group

Articles

Preparation and characterization of Pistacia atlantica oleo-gum-resin-loaded electrospun nanofibers and evaluating its wound healing activity in two rat models of skin scar and burn wound

Evaluation of the inhibitory mechanism of Pennisetum glaucum (pearl millet) bioactive compounds for rheumatoid arthritis: an in vitro and computational approach

Exploring somatic mutations in BRAF, KRAS, and NRAS as therapeutic targets in Saudi colorectal cancer patients through massive parallel sequencing and variant classification

Efficacy and safety of Epimedium total flavonoids for primary osteoporosis: a systematic review and meta-analysis

Integrated chemical analysis, metabolic profiling, network pharmacology, molecular docking and toxicity prediction to reveal the active ingredients and their safety of raw and prepared rhubarbs in the treatment of gastric ulcers

Discovery of novel and highly potent dual-targeting PKMYT1/HDAC2 inhibitors for hepatocellular carcinoma through structure-based virtual screening and biological evaluation

Repurposed drugs as histone deacetylase 8 inhibitors: Implications in cancer and neuropathological conditions

Glucocorticoids influence on rat hematological parameters and catalase activity

In-depth analysis of lupeol: delving into the diverse pharmacological profile

Integration of metabolomics and transcriptomics to reveal anti-immunosuppression mechanism of Lycium barbarum polysaccharide

β-blockers and statins: exploring the potential off-label applications in breast, colorectal, prostate, and lung cancers

Herbal formula xuling-jiangu improves bone metabolic balance in rats with ovariectomy-induced osteoporosis via the gut-bone axis

Preparation and anti-colon cancer effect of a novel curcumin analogue (CA8): in vivo and in vitro evaluation

Development of bombesin-tubulysin conjugates using multicomponent chemistry to functionalize both the payload and the homing peptide

Enhanced anticancer effect of thymidylate synthase dimer disrupters by promoting intracellular accumulation

Nanotechnological prospective for enhancing the antibacterial activity of mupirocin and cinnamon essential oil: a combination therapy