Frontiers in Pharmacology | Experimental Pharmacology and Drug Discovery

Original Research

Published on 07 Apr 2025

Pharmacophore-based virtual screening and in silico investigations of small molecule library for discovery of human hepatic ketohexokinase inhibitors for the treatment of fructose metabolic disorders

in Experimental Pharmacology and Drug Discovery

Tilal Elsaman
Magdi Awadalla Mohamed
Abozer Y. Elderdery
Abdullah Alsrhani
Badr Alzahrani
Heba Bassiony Ghanem
Jeremy Mills
Musaed Rayzah
Nasser A. N. Alzerwi
Afnan Al-sultan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1531512

1,842 views

Original Research

Published on 07 Apr 2025

Ocular pharmacokinetics of intravitreal conbercept in a rabbit model following retinal scatter laser photocoagulation

in Experimental Pharmacology and Drug Discovery

Lanlan Chen
Hua Liu
Qingrong Zhang
Houbin Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1534048

636 views

Review

Published on 03 Apr 2025

Protein structure prediction via deep learning: an in-depth review

in Experimental Pharmacology and Drug Discovery

Yajie Meng
Zhuang Zhang
Chang Zhou
Xianfang Tang
Xinrong Hu
Geng Tian
Jialiang Yang
Yuhua Yao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1498662

3,080 views

Original Research

Published on 03 Apr 2025

Transdermal delivery of traditional Chinese medicine patch vs. NSAIDs patch for alleviating inflammation and relieving pain for early-stage knee osteoarthritis: a retrospective case control study

in Experimental Pharmacology and Drug Discovery

Shoufeng Wang
Jingtao Guan
Wanran Gong
Bingbo Bao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1549883

1,141 views

Original Research

Published on 02 Apr 2025

Chromium and formoterol therapy for obesity-induced asthma in rats

in Experimental Pharmacology and Drug Discovery

Rania T. Ibrahim
Yasser M. Moustafa
Maha Abdullah Alwaili
Amjad N. Alrebdi
Afaf Alharthi
Noha R. Noufal
Dina M. Khodeer

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1537022

1,376 views

Original Research

Published on 02 Apr 2025

Attenuation of cisplatin-induced acute kidney injury by sanguinarine: modulation of oxidative stress, inflammation, and cellular damage

in Experimental Pharmacology and Drug Discovery

Nur Elena Zaaba
Suhail Al-Salam
Sumaya Beegam
Ozaz Elzaki
Fatima Aldhaheri
Anas Nemmar
Badreldin H. Ali
Abderrahim Nemmar

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1567888

1,443 views

Original Research

Published on 01 Apr 2025

GraphTransNet: predicting epilepsy-related genes using a graph-augmented protein language model

in Experimental Pharmacology and Drug Discovery

Junfeng Xie
Wei Li
Hairu You
Dafang Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1584625

917 views

Editorial

Published on 01 Apr 2025

Editorial: Reviews in experimental pharmacology and drug discovery 2023: pharmacological management of non-communicable diseases

in Experimental Pharmacology and Drug Discovery

Ali Sharif
Virginia Flores-Morales
Hanan Farouk Aly

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1435638

622 views

Original Research

Published on 31 Mar 2025

Machine learning-based transcriptmics analysis reveals BMX, GRB10, and GADD45A as crucial biomarkers and therapeutic targets in sepsis

in Experimental Pharmacology and Drug Discovery

Yanwei Cheng
Haoran Peng
Qiao Chen
Lijun Xu
Lijie Qin

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1576467

1,752 views

Mini Review

Published on 28 Mar 2025

Overcoming immunotherapy resistance in glioblastoma: challenges and emerging strategies

in Experimental Pharmacology and Drug Discovery

Maowu Fu
Bing Xue
Xiuming Miao
Zong Gao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1584688

2,255 views

Original Research

Published on 27 Mar 2025

Gastrodin attenuates rheumatoid arthritis by targeting KAT8 to inhibit the lactylation of H3K9

in Experimental Pharmacology and Drug Discovery

Yufang Dai
Shunshun Wang
Jiayi Luo
Huiming Yu
Qianqian Du
Shuwan Hou
Minfu Liu
Shan Jiang
Huajiao Xu
Siyi Ye

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1559744

3,016 views
1 citation

Original Research

Published on 27 Mar 2025

Agonist efficacy at the β2AR is driven by the faster association rate of the Gs protein

in Experimental Pharmacology and Drug Discovery

Clare R. Harwood
David A. Sykes
Theo Redfern-Nichols
Owen Underwood
Colin Nicholson
Armin N. Khoshgrudi
Eline J. Koers
Graham Ladds
Stephen J. Briddon
Dmitry B. Veprintsev

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1367991

3,458 views

Original Research

Published on 27 Mar 2025

Celastrol reduces cisplatin-induced nephrotoxicity by downregulating SNORD3A level in kidney organoids derived from human iPSCs

in Experimental Pharmacology and Drug Discovery

Chongayng Shen
Qizheng Wang
Xun Ye
Yi Zhou
Huayang Xing
Chengjie Pan
Heying Li
Chunjie Wu
Mingliang You

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1464525

1,534 views

Original Research

Published on 27 Mar 2025

A multifaceted microenvironment nanoregulator for targeted ovarian cancer therapy

in Experimental Pharmacology and Drug Discovery

Yizheng Zu
Min Li
Ruyue Li
Shaohan Ma
Yu’e Yang
Shun Zhang
Yuan Ma
Tiantian Wu
Chunfang Ha

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1584463

1,156 views

Original Research

Published on 27 Mar 2025

Radiosensitization effect of iridium (III) complex on lung cancer cells via mitochondria apoptosis pathway

in Experimental Pharmacology and Drug Discovery

Yuru Pang
Qiqi Meng
Yangchen Cui
Shiyi Liu
Huihui Jiang
Chenlan Xu
Yan An
Yang Jiao
Qi Zhang
Jihua Nie

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1562228

1,226 views

Review

Published on 26 Mar 2025

The landscape of research on ferroptosis under hypoxic conditions: a bibliometric analysis

in Experimental Pharmacology and Drug Discovery

Di Yu
Yibo Hu
Meijuan Ma
Wenjia Li
Xiaohui Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1519000

1,100 views