Frontiers in Pharmacology | Experimental Pharmacology and Drug Discovery

Original Research

Published on 19 Mar 2025

Transdermal administration of herbal essential oil alleviates high-fat diet-induced obesity by regulating metabolism and gut microbiota

in Experimental Pharmacology and Drug Discovery

Zu-Wen Ye
Qi-Yue Yang
Dong-Hua Yang
Qiao-Hong Lin
Xiao-Xia Liu
Feng-Qin Li
Fang-Fang Yan
Ping Luo
Si Qin
Fang Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1565030

1,611 views

Systematic Review

Published on 19 Mar 2025

Prognostic and clinicopathological roles of circular RNA expression in chemoresistance in head and neck squamous cell carcinoma: a systematic review

in Experimental Pharmacology and Drug Discovery

Sayan Kumar Das
Sameer Khasbage
Ashim Mishra
Babban Jee

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1502107

1,565 views

Review

Published on 19 Mar 2025

The potential of ARL4C and its-mediated genes in atherosclerosis and agent development

in Experimental Pharmacology and Drug Discovery

Dan Liu
Jie Wang
Shuangshuang Zhang
Hongfei Jiang
Yudong Wu
Chao Wang
Wujun Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1513340

1,652 views

Original Research

Published on 19 Mar 2025

Ethanol extract of Portulaca oleracea L. mitigates atherosclerosis through modulation of cholesterol efflux and uptake pathways

in Experimental Pharmacology and Drug Discovery

Bin Chen
Shanshan Sun
Jialei Fu
Ling Ge
Wei Nie
Peina Zhou
Peng Cao
Qian Zhou

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1550812

2,054 views
1 citation

Original Research

Published on 19 Mar 2025

Unraveling human transferrin-tryptamine interactions: a computational and biophysical approach to Alzheimer’s disease therapeutics

in Experimental Pharmacology and Drug Discovery

Mohammed Alrouji
Mohammed S. Alshammari
Taghreed A. Majrashi
Azna Zuberi
Moyad Shahwan
Akhtar Atiya
Anas Shamsi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1540736

902 views

Editorial

Published on 19 Mar 2025

Editorial: Targeting cellular signalling pathways for disease therapy: the potential of cellular reprogramming and protein kinase inhibitors

in Experimental Pharmacology and Drug Discovery

Vanessa Marensi
Pedro Fontes Oliveira
Ariane Zamoner

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1580686

747 views

Editorial

Published on 19 Mar 2025

Editorial: Old drugs: confronting recent advancements and challenges

in Experimental Pharmacology and Drug Discovery

Anna Wiktorowska-Owczarek
Diego Iacono
Magdalena Jasińska-Stroschein

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1565890

953 views

Editorial

Published on 18 Mar 2025

Editorial: Education and training in pharmaceutical medicine, medicines development and regulation for scientists worldwide

in Experimental Pharmacology and Drug Discovery

Bernd Rosenkranz
Tomoya Tachi
Rolf Bass

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1544678

735 views

Original Research

Published on 17 Mar 2025

FDA-approved drug repurposing screen identifies inhibitors of SARS-CoV-2 pseudovirus entry

in Experimental Pharmacology and Drug Discovery

Manisha Singh
Shruthi Shanmukha
Raghda E. Eldesouki
Maged M. Harraz

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1537912

1,617 views

Original Research

Published on 17 Mar 2025

Resveratrol prevents gallstones in mice fed on a high fat diet via regulating PPAR-γ and SR-BI

in Experimental Pharmacology and Drug Discovery

Menglu Zhao
Boya Xie
Yuxuan Li
Haiqing Dong
Sijia Jiang
Tiantian Zhu
Xiaolong Wu
Chengchen Xu
Jian Zhang
Shiyi Sun

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1543865

1,913 views

Original Research

Published on 12 Mar 2025

Exosomes enriched with miR-124-3p show therapeutic potential in a new microfluidic triculture model that recapitulates neuron–glia crosstalk in Alzheimer’s disease

in Experimental Pharmacology and Drug Discovery

Artemizia Évora
Gonçalo Garcia
Ana Rubi
Eleonora De Vitis
Ana Teresa Matos
Ana Rita Vaz
Francesca Gervaso
Giuseppe Gigli
Alessandro Polini
Dora Brites

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1474012

3,306 views
1 citation

Original Research

Published on 12 Mar 2025

The role of TRAF2 in pan-cancer revealed by integrating informatics and experimental validation

in Experimental Pharmacology and Drug Discovery

Xizheng Wang
Jianfeng Yuan
Chenchen Zhang
Lingyu Kong
Enzhen Wu
Jianxin Guo
Zhongbing Wu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1563435

1,735 views

Review

Published on 12 Mar 2025

Advances in the study of death receptor 5

in Experimental Pharmacology and Drug Discovery

Xuan Qiao
Shuang Guo
Zhiyun Meng
Hui Gan
Zhuona Wu
Yunbo Sun
Shuchen Liu
Guifang Dou
Ruolan Gu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1549808

1,170 views

Original Research

Published on 11 Mar 2025

Predicting protein–protein interactions in microbes associated with cardiovascular diseases using deep denoising autoencoders and evolutionary information

in Experimental Pharmacology and Drug Discovery

Senyu Zhou
Jian Luo
Mei Tang
Chaojun Li
Yang Li
Wenhua He

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1565860

714 views

Original Research

Published on 10 Mar 2025

Prediction of adverse drug reactions based on pharmacogenomics combination features: a preliminary study

in Experimental Pharmacology and Drug Discovery

Mingxiu He
Yiyang Shi
Fangfang Han
Yongming Cai

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1448106

1,369 views

Original Research

Published on 10 Mar 2025

Antimicrobial photodynamic therapy with 5-aminolevulinic acid plus antibiotics: a promising treatment for tibial osteomyelitis caused by drug-resistant bacteria

in Experimental Pharmacology and Drug Discovery

Ju Zuo
Feiyan Kong
Xiyu Wang
Tianyu Wang
Jianxi Zhao
Zhanjuan Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1566744

938 views