Frontiers in Pharmacology | Experimental Pharmacology and Drug Discovery

Original Research

Published on 22 Oct 2024

Exploring the antioxidant and protective effects of Marsdenia thyrsiflora Hook.f. leaf extract against carbon tetrachloride-induced hepatic damage in rat models

in Experimental Pharmacology and Drug Discovery

Sushmita Saha
Abdulrahman Alshammari
Norah A. Albekairi
Tasniya Nahiyan Zulfiquar
Md Salman Shakil
Kakoli Rani Mondal
Milton Kumar Kundu
Milon Mondal
Mohammad S. Mubarak

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1463922

800 views

Original Research

Published on 22 Oct 2024

Sodium danshensu modulates skeletal muscle fiber type formation and metabolism by inhibiting pyruvate kinase M1

in Experimental Pharmacology and Drug Discovery

Yunxia Zhang
Xiaoxiao Wu
Ruoqi Li
Mengru Sui
Guoyin Li
Shuhua Fan
Mingsheng Yang
Qiuping Liu
Xiaomeng Liu
Changjing Wu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1467620

1,012 views

Original Research

Published on 22 Oct 2024

Exploring the effects of moxibustion on cognitive function in rats with multiple cerebral infarctions from the perspective of glial vascular unit repairing

in Experimental Pharmacology and Drug Discovery

Jingji Wang
Kunrui Du
Chang Liu
Xiaoyu Chen
Wenming Ban
Guoqi Zhu
Jun Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1428907

1,518 views
2 citations

Original Research

Published on 22 Oct 2024

PACAP38 synergizes with irradiation to suppress the proliferation of multiple cancer cells via regulating SOX6/Wnt/β-catenin signaling

in Experimental Pharmacology and Drug Discovery

Ran Wu
Chun-Xiang Cao
Lu Cao
Jun Su
Ke-Man Liao
Huan Li
Qian Zhu
Shu-Yan Li
Min Li
Jia-Yi Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1492453

1,249 views

Original Research

Published on 21 Oct 2024

Design, synthesis, and biological evaluation of 2,4-dimorpholinopyrimidine-5-carbonitrile derivatives as orally bioavailable PI3K inhibitors

in Experimental Pharmacology and Drug Discovery

Daowei Huang
Jixia Yang
Qingwei Zhang
Xiaolei Zhou
Yanbo Wang
Zhenhua Shang
Jianqi Li
Baoyin Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1467028

675 views
1 citation

Correction

Published on 16 Oct 2024

Corrigendum: Combination of rapamycin and MK-2206 induced cell death via autophagy and necroptosis in MYCN-amplified neuroblastoma cell lines

in Experimental Pharmacology and Drug Discovery

Yudi Dong
Wei Gong
Zhongyan Hua
Bo Chen
Guifeng Zhao
Zhihui Liu
Carol J. Thiele
Zhijie Li

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1425039

509 views

Original Research

Published on 16 Oct 2024

Apoptotic and proliferative processes in the small intestine of rats with type 2 diabetes mellitus after metformin and propionic acid treatment

in Experimental Pharmacology and Drug Discovery

Larysa Natrus
Olha Lisakovska
Anton Smirnov
Yuliia Osadchuk
Yuliia Klys

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1477793

785 views

Editorial

Published on 16 Oct 2024

Editorial: Modulation of immune function: drug discovery and translational application

in Experimental Pharmacology and Drug Discovery

Ruirong Tan
Junning Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1495815

401 views

Original Research

Published on 16 Oct 2024

Family Malvaceae: a potential source of secondary metabolites with chemopreventive and anticancer activities supported with in silico pharmacokinetic and pharmacodynamic profiles

in Experimental Pharmacology and Drug Discovery

Salma Sameh
Ahmed M. Elissawy
Eman Al-Sayed
Rola M. Labib
Hsueh-Wei Chang
Szu-Yin Yu
Fang-Rong Chang
Shyh-Chyun Yang
Abdel Nasser B. Singab

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1465055

3,226 views

Correction

Published on 16 Oct 2024

Corrigendum: An orally available small molecule that targets soluble TNF to deliver anti-TNF biologic-like efficacy in rheumatoid arthritis

in Experimental Pharmacology and Drug Discovery

Alexander Vugler
James O’connell
Mai Anh Nguyen
Dietmar Weitz
Thomas Leeuw
Elizabeth Hickford
Alexander Verbitsky
Xiaoyou Ying
Markus Rehberg
Bruce Carrington

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1479557

827 views

Original Research

Published on 15 Oct 2024

The single-strand DNA-binding protein SSB1 is involved in the expression of salivary gland radiation injury repair

in Experimental Pharmacology and Drug Discovery

Xian Wang
Yuetong Wang
Xianglin Zeng
Haoyu Lu
Dongqin Mo
Yuetao Li
Zhiqing Liu
Yude Huang
Kun Yu
Daiyou Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1471996

641 views

Correction

Accepted on 14 Oct 2024

Corrigendum: Novel chemical scaffolds to inhibit the neutral amino acid transporter B0AT1 (SLC6A19), a potential target to treat metabolic diseases.

in Experimental Pharmacology and Drug Discovery

Aditya Yadav
Nishank Shah
Praveen Tiwari
Kiran Javed
Qi Cheng
Indrapal Singh Aidhen
Stefan Broer

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1485054

Original Research

Published on 14 Oct 2024

Mitochondrial proteins as therapeutic targets in diabetic ketoacidosis: evidence from Mendelian randomization analysis

in Experimental Pharmacology and Drug Discovery

Ruiqiang Xie
Hongyan Xie
Hong Gao
Chunguang Xie
Haipo Yuan
Zhijun Feng

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1448505

1,760 views
1 citation

Original Research

Published on 11 Oct 2024

Tirzepatide, GIP(1-42) and GIP(1-30) display unique signaling profiles at two common GIP receptor variants, E354 and Q354

in Experimental Pharmacology and Drug Discovery

Tayla A. Rees
Benjamin J. Buttle
Zoe Tasma
Sung-Hyun Yang
Paul W. R. Harris
Christopher S. Walker

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1463313

1,849 views
1 citation

Original Research

Published on 10 Oct 2024

CircFOXO3 upregulation mediates the radioresistance of glioblastoma by affecting cellular metabolome

in Experimental Pharmacology and Drug Discovery

Hao Xu
Jin Xing
Lilin Cheng
Zhihan Wang
Liang Zhao
Li Ren
Shuai Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1479480

750 views

Original Research

Published on 09 Oct 2024

Identification of high-affinity Monoamine oxidase B inhibitors for depression and Parkinson’s disease treatment: bioinformatic approach of drug repurposing

in Experimental Pharmacology and Drug Discovery

Moyad Shahwan
Pratibha Prasad
Dharmendra Kumar Yadav
Nojood Altwaijry
Mohd Shahnawaz Khan
Anas Shamsi

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1422080

914 views

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Articles

Exploring the antioxidant and protective effects of Marsdenia thyrsiflora Hook.f. leaf extract against carbon tetrachloride-induced hepatic damage in rat models

Sodium danshensu modulates skeletal muscle fiber type formation and metabolism by inhibiting pyruvate kinase M1

Exploring the effects of moxibustion on cognitive function in rats with multiple cerebral infarctions from the perspective of glial vascular unit repairing

PACAP38 synergizes with irradiation to suppress the proliferation of multiple cancer cells via regulating SOX6/Wnt/β-catenin signaling

Design, synthesis, and biological evaluation of 2,4-dimorpholinopyrimidine-5-carbonitrile derivatives as orally bioavailable PI3K inhibitors

Corrigendum: Combination of rapamycin and MK-2206 induced cell death via autophagy and necroptosis in MYCN-amplified neuroblastoma cell lines

Apoptotic and proliferative processes in the small intestine of rats with type 2 diabetes mellitus after metformin and propionic acid treatment

Editorial: Modulation of immune function: drug discovery and translational application

Family Malvaceae: a potential source of secondary metabolites with chemopreventive and anticancer activities supported with in silico pharmacokinetic and pharmacodynamic profiles

Corrigendum: An orally available small molecule that targets soluble TNF to deliver anti-TNF biologic-like efficacy in rheumatoid arthritis

The single-strand DNA-binding protein SSB1 is involved in the expression of salivary gland radiation injury repair

Corrigendum: Novel chemical scaffolds to inhibit the neutral amino acid transporter B0AT1 (SLC6A19), a potential target to treat metabolic diseases.

Mitochondrial proteins as therapeutic targets in diabetic ketoacidosis: evidence from Mendelian randomization analysis

Tirzepatide, GIP(1-42) and GIP(1-30) display unique signaling profiles at two common GIP receptor variants, E354 and Q354

CircFOXO3 upregulation mediates the radioresistance of glioblastoma by affecting cellular metabolome

Identification of high-affinity Monoamine oxidase B inhibitors for depression and Parkinson’s disease treatment: bioinformatic approach of drug repurposing