Frontiers in Pharmacology | Experimental Pharmacology and Drug Discovery

Original Research

Published on 09 Oct 2024

Combining mathematical modeling, in vitro data and clinical target expression to support bispecific antibody binding affinity selection: a case example with FAP-4-1BBL

in Experimental Pharmacology and Drug Discovery

Javier Sanchez
Christina Claus
Christine McIntyre
Tamara Tanos
Axel Boehnke
Lena E. Friberg
Siv Jönsson
Nicolas Frances

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1472662

1,465 views

Original Research

Published on 09 Oct 2024

The long non-coding RNA GAS5 contributes to the suppression of inflammatory responses by inhibiting NF-κB activity

in Experimental Pharmacology and Drug Discovery

Debora Curci
Biljana Stankovic
Nikola Kotur
Letizia Pugnetti
Vladimir Gasic
Maurizio Romano
Branka Zukic
Giuliana Decorti
Gabriele Stocco
Marianna Lucafò

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1448136

745 views
1 citation

Original Research

Published on 09 Oct 2024

Synthesis and characterization of activated carbon-supported magnetic nanocomposite (MNPs-OLAC) obtained from okra leaves as a nanocarrier for targeted delivery of morin hydrate

in Experimental Pharmacology and Drug Discovery

Cem Öziç
Erdal Ertaş
Mehmet Fırat Baran
Ayşe Baran
Elham Ahmadian
Aziz Eftekhari
Rovshan Khalilov
Elvin Aliyev
Mahmut Yıldıztekin

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1482130

903 views

Original Research

Published on 09 Oct 2024

The NEDD4/FLRT2 axis regulates NSCLC cell stemness

in Experimental Pharmacology and Drug Discovery

Yuping Yang
Fei Yan
Ziwei Gao
Houke Li
Shengke Wen
Qi Li
Jiayuan Li
Na Huang
Wei Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1459978

914 views

Original Research

Published on 08 Oct 2024

FOXO1-mediated autophagy regulation by miR-223 in sepsis-induced immunosuppression

in Experimental Pharmacology and Drug Discovery

Guoan Xiang
Qi Li
Di Lian
Chengcheng Su
Xin Li
Shoulong Deng
Lixin Xie

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1469286

1,020 views

Review

Published on 03 Oct 2024

Salvia miltiorrhiza in osteoporosis: a review of its phytochemistry, traditional clinical uses and preclinical studies (2014–2024)

in Experimental Pharmacology and Drug Discovery

Lili Wang
Shan Wang
Xuan Dai
Gaiyue Yue
Jiyuan Yin
Tianshu Xu
Hanfen Shi
Tianyuan Liu
Zhanhong Jia
Dieter Brömme

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1483431

2,185 views

Original Research

Published on 01 Oct 2024

Xiaoyin-anshen formula alleviates psoriasis complicated by sleep disturbances by regulating melatonin, antioxidant enzymes, and pro-inflammatory cytokines in mice

in Experimental Pharmacology and Drug Discovery

Zebing Zhu
Qiang Yin
Xingwu Duan

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1427985

1,308 views

Original Research

Published on 01 Oct 2024

PBPK-based translation from preclinical species to humans for the full-size IgG therapeutic efalizumab

in Experimental Pharmacology and Drug Discovery

Maria Franz
Ravi Kumar Jairam
Lars Kuepfer
Nina Hanke

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1418870

1,214 views

Original Research

Published on 01 Oct 2024

Drug repurposing to tackle parainfluenza 3 based on multi-similarities and network proximity analysis

in Experimental Pharmacology and Drug Discovery

Xinyue Chen
Bo Zhou
Xinyi Jiang
Huayu Zhong
Aijing You
Taiyan Zou
Chengcheng Zhou
Xiaoxiao Liu
Yonghong Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1428925

700 views

Original Research

Published on 01 Oct 2024

KS18, a Mcl-1 inhibitor, improves the effectiveness of bortezomib and overcomes resistance in refractory multiple myeloma by triggering intrinsic apoptosis

in Experimental Pharmacology and Drug Discovery

Omar S. Al-Odat
Weam Othman Elbezanti
Krishne Gowda
Sandeep K. Srivastava
Shantu G. Amin
Subash C. Jonnalagadda
Tulin Budak-Alpdogan
Manoj K. Pandey

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1436786

1,280 views
1 citation

Original Research

Published on 27 Sep 2024

Integrating text mining with network models for successful target identification: in vitro validation in MASH-induced liver fibrosis

in Experimental Pharmacology and Drug Discovery

Jennifer Venhorst
Roeland Hanemaaijer
Remon Dulos
Martien P. M. Caspers
Karin Toet
Joline Attema
Christa de Ruiter
Gino Kalkman
Tanja Rouhani Rankouhi
Jelle C. B. C. de Jong

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1442752

1,340 views
1 citation

Original Research

Published on 26 Sep 2024

Hyaluronic acid-solid lipid nano transporter serum preparation for enhancing topical tretinoin delivery: skin safety study and visual assessment of skin

in Experimental Pharmacology and Drug Discovery

Yasir Mehmood
Hira Shahid
Syeda Momena Rizvi
Usama Jamshaid
Numera Arshad
Mohammad Nur-e-Alam
Muhammad Delwar Hussain
Mohsin Kazi

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1401594

1,242 views

Review

Published on 26 Sep 2024

The onset and the development of cardiometabolic aging: an insight into the underlying mechanisms

in Experimental Pharmacology and Drug Discovery

Sulogna Sarkar
Vani S. Prasanna
Pamelika Das
Hiroshi Suzuki
Kazuya Fujihara
Satoru Kodama
Hirohito Sone
Remya Sreedhar
Ravichandiran Velayutham
Kenichi Watanabe

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1447890

1,827 views

Original Research

Published on 25 Sep 2024

Muscarinic receptor drug trihexyphenidyl can alter growth of mesenchymal glioblastoma in vivo

in Experimental Pharmacology and Drug Discovery

Renfei Du
Ahmed Y. Sanin
Wenjie Shi
Bing Huang
Ann-Christin Nickel
Andres Vargas-Toscano
Shuran Huo
Thomas Nickl-Jockschat
Claudia A. Dumitru
Wei Hu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1468920

1,034 views

Systematic Review

Published on 25 Sep 2024

Mapping the evolution and research landscape of ferroptosis-targeted nanomedicine: insights from a scientometric analysis

in Experimental Pharmacology and Drug Discovery

Siyang Cao
Yihao Wei
Yaohang Yue
Deli Wang
Jun Yang
Ao Xiong
Hui Zeng

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1477938

1,625 views
2 citations

Original Research

Published on 24 Sep 2024

SAL0114: a novel deuterated dextromethorphan-bupropion combination with improved antidepressant efficacy and safety profile

in Experimental Pharmacology and Drug Discovery

Ying Xiao
Xuefeng Hu
Wei Xing
Jie Yan
Ruhuan Wang
Xiaoqing Li
Jiahuan Li
Zhixin Zhang
Jingchao Sun
Junjun Wu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1464564

1,397 views
1 citation

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Articles

Combining mathematical modeling, in vitro data and clinical target expression to support bispecific antibody binding affinity selection: a case example with FAP-4-1BBL

The long non-coding RNA GAS5 contributes to the suppression of inflammatory responses by inhibiting NF-κB activity

Synthesis and characterization of activated carbon-supported magnetic nanocomposite (MNPs-OLAC) obtained from okra leaves as a nanocarrier for targeted delivery of morin hydrate

The NEDD4/FLRT2 axis regulates NSCLC cell stemness

FOXO1-mediated autophagy regulation by miR-223 in sepsis-induced immunosuppression

Salvia miltiorrhiza in osteoporosis: a review of its phytochemistry, traditional clinical uses and preclinical studies (2014–2024)

Xiaoyin-anshen formula alleviates psoriasis complicated by sleep disturbances by regulating melatonin, antioxidant enzymes, and pro-inflammatory cytokines in mice

PBPK-based translation from preclinical species to humans for the full-size IgG therapeutic efalizumab

Drug repurposing to tackle parainfluenza 3 based on multi-similarities and network proximity analysis

KS18, a Mcl-1 inhibitor, improves the effectiveness of bortezomib and overcomes resistance in refractory multiple myeloma by triggering intrinsic apoptosis

Integrating text mining with network models for successful target identification: in vitro validation in MASH-induced liver fibrosis

Hyaluronic acid-solid lipid nano transporter serum preparation for enhancing topical tretinoin delivery: skin safety study and visual assessment of skin

The onset and the development of cardiometabolic aging: an insight into the underlying mechanisms

Muscarinic receptor drug trihexyphenidyl can alter growth of mesenchymal glioblastoma in vivo

Mapping the evolution and research landscape of ferroptosis-targeted nanomedicine: insights from a scientometric analysis

SAL0114: a novel deuterated dextromethorphan-bupropion combination with improved antidepressant efficacy and safety profile