Frontiers in Pharmacology | Experimental Pharmacology and Drug Discovery

Original Research

Published on 23 Sep 2024

Mangiferin ameliorates polycystic ovary syndrome in rats by modulating insulin resistance, gut microbiota, and ovarian cell apoptosis

in Experimental Pharmacology and Drug Discovery

Zhang Yong
Chen Mimi
Li Yingjie
Guo Yichen
Yu Yansu
Zhou Zhi
Lu Hui
Yao Si
Wu Chongming
Zhang Xiaopo

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1457467

2,257 views
1 citation

Review

Published on 23 Sep 2024

Isoalantolactone: a review on its pharmacological effects

in Experimental Pharmacology and Drug Discovery

Guang Yang
Longfei Yang
Fei Xu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1453205

1,034 views
1 citation

Original Research

Published on 23 Sep 2024

Receptor activity-modifying protein modulation of parathyroid hormone-1 receptor function and signaling

in Experimental Pharmacology and Drug Discovery

Paris Avgoustou
Ameera B. A. Jailani
Aditya J. Desai
David J. Roberts
Ewan R. Lilley
Grant W. Stothard
Timothy M. Skerry
Gareth O. Richards

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1455231

1,184 views

Original Research

Published on 23 Sep 2024

Design, synthesis and neuroprotective activity of compound derived from Gastrodia elata Blume and borneol

in Experimental Pharmacology and Drug Discovery

Lijuan Zhi
Huan Li
Baimei Shi
Tao Yu
Xiaoni Jia
Hui Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1437806

874 views

Original Research

Published on 23 Sep 2024

Computational insights into the inhibitory mechanism of type 2 diabetes mellitus by bioactive components of Oryza sativa L. indica (black rice)

in Experimental Pharmacology and Drug Discovery

Kashaf Rasool
Attya Bhatti
Abid Majeed Satti
Rehan Zafar Paracha
Peter John

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1457383

1,393 views
1 citation

Original Research

Published on 20 Sep 2024

Evaluation of the beneficial effects of a GABA-based product containing Melissa officinalis on post-inflammatory irritable bowel syndrome: a preclinical study

in Experimental Pharmacology and Drug Discovery

Elena Lucarini
Laura Benvenuti
Clelia Di Salvo
Vanessa D’Antongiovanni
Carolina Pellegrini
Giulia Valdiserra
Clara Ciampi
Luca Antonioli
Christian Lambiase
Lorenzo Cancelli

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1466824

1,801 views

Correction

Published on 20 Sep 2024

Corrigendum: Nonmuscle myosin heavy chain IIA-mediated exosome release via regulation of the rho-associated kinase 1/myosin light chains/actin pathway

in Experimental Pharmacology and Drug Discovery

Yanni Lv
Jin Chen
Jinfang Hu
Yisong Qian
Ying Kong
Longsheng Fu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1465932

441 views

Review

Published on 20 Sep 2024

Mediating kinase activity in Ras-mutant cancer: potential for an individualised approach?

in Experimental Pharmacology and Drug Discovery

Fiona M. Healy
Amy L. Turner
Vanessa Marensi
David J. MacEwan

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1441938

1,174 views

Original Research

Published on 20 Sep 2024

Antioxidant properties of allium turcicum Özhatay & cowley plant extract, its effects on the proliferation and migration of cancer cells

in Experimental Pharmacology and Drug Discovery

Polat İPEK
Ayse Baran
Deniz Barış Cebe
Elham Ahmadian
Aziz Eftekhari
Mehmet Fırat Baran

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1438634

982 views

Review

Published on 19 Sep 2024

Applications and challenges of photodynamic therapy in the treatment of skin malignancies

in Experimental Pharmacology and Drug Discovery

Yunqi Hua
Xiaoling Tian
Xinyi Zhang
Ge Song
Yubo Liu
Ye Zhao
Yuqian Gao
Fangrui Yin

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1476228

1,396 views
3 citations

Review

Published on 18 Sep 2024

N-terminal domain of androgen receptor is a major therapeutic barrier and potential pharmacological target for treating castration resistant prostate cancer: a comprehensive review

in Experimental Pharmacology and Drug Discovery

Ye Chen
Tian Lan

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1451957

2,316 views
1 citation

Review

Published on 18 Sep 2024

Extracellular vesicles affecting embryo development in vitro: a potential culture medium supplement

in Experimental Pharmacology and Drug Discovery

Yamei Xue
Haixia Zheng
Yuping Xiong
Kun Li

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1366992

2,004 views
1 citation

Data Report

Published on 18 Sep 2024

WWAD: the most comprehensive small molecule World Wide Approved Drug database of therapeutics

in Experimental Pharmacology and Drug Discovery

Polina Savosina
Dmitry Druzhilovskiy
Dmitry Filimonov
Vladimir Poroikov

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1473279

1,312 views
1 citation

Original Research

Published on 16 Sep 2024

The identification of potent dual-target monopolar spindle 1 (MPS1) and histone deacetylase 8 (HDAC8) inhibitors through pharmacophore modeling, molecular docking, molecular dynamics simulations, and biological evaluation

in Experimental Pharmacology and Drug Discovery

Huilian Hua
Lixia Guan
Bo Pan
Junyi Gao
Yifei Geng
Miao-Miao Niu
Zhiqin Li
Jindong Li

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1454523

910 views

Original Research

Published on 11 Sep 2024

DJ-1 regulates mitochondrial function and promotes retinal ganglion cell survival under high glucose-induced oxidative stress

in Experimental Pharmacology and Drug Discovery

Hanhan Peng
Haoyu Li
Benteng Ma
Xinyue Sun
Baihua Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1455439

1,323 views
1 citation

Original Research

Published on 11 Sep 2024

The energy metabolism-promoting effect of aconite is associated with gut microbiota and bile acid receptor TGR5-UCP1 signaling

in Experimental Pharmacology and Drug Discovery

Dandan Zhang
Hao Cheng
Jing Wu
Yaochuan Zhou
Fei Tang
Juan Liu
Wuwen Feng
Cheng Peng

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1392385

1,061 views

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Articles

Mangiferin ameliorates polycystic ovary syndrome in rats by modulating insulin resistance, gut microbiota, and ovarian cell apoptosis

Isoalantolactone: a review on its pharmacological effects

Receptor activity-modifying protein modulation of parathyroid hormone-1 receptor function and signaling

Design, synthesis and neuroprotective activity of compound derived from Gastrodia elata Blume and borneol

Computational insights into the inhibitory mechanism of type 2 diabetes mellitus by bioactive components of Oryza sativa L. indica (black rice)

Evaluation of the beneficial effects of a GABA-based product containing Melissa officinalis on post-inflammatory irritable bowel syndrome: a preclinical study

Corrigendum: Nonmuscle myosin heavy chain IIA-mediated exosome release via regulation of the rho-associated kinase 1/myosin light chains/actin pathway

Mediating kinase activity in Ras-mutant cancer: potential for an individualised approach?

Antioxidant properties of allium turcicum Özhatay & cowley plant extract, its effects on the proliferation and migration of cancer cells

Applications and challenges of photodynamic therapy in the treatment of skin malignancies

N-terminal domain of androgen receptor is a major therapeutic barrier and potential pharmacological target for treating castration resistant prostate cancer: a comprehensive review

Extracellular vesicles affecting embryo development in vitro: a potential culture medium supplement

WWAD: the most comprehensive small molecule World Wide Approved Drug database of therapeutics

The identification of potent dual-target monopolar spindle 1 (MPS1) and histone deacetylase 8 (HDAC8) inhibitors through pharmacophore modeling, molecular docking, molecular dynamics simulations, and biological evaluation

DJ-1 regulates mitochondrial function and promotes retinal ganglion cell survival under high glucose-induced oxidative stress

The energy metabolism-promoting effect of aconite is associated with gut microbiota and bile acid receptor TGR5-UCP1 signaling