Frontiers in Pharmacology | Experimental Pharmacology and Drug Discovery

Original Research

Published on 25 Feb 2025

Deciphering the role of Wnt/β-catenin and miR-214 in knee osteoarthritis: molecular and clinical insights

in Experimental Pharmacology and Drug Discovery

Waad A. Samman
Esraa M. Mosalam
Dalia S. Saif
Mahmoud S. Abdallah
Abdel-Aziz A. Zidan
Amany Said Sallam
Shimaa Abdelsattar
Fatma Omar Khalil
Amany E. Elashkar
Somia Mokabel Mohamed

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1507693

1,137 views

Original Research

Published on 21 Feb 2025

MFAP4 is a novel prognostic biomarker in glioma correlating with immunotherapy resistance and ferroptosis

in Experimental Pharmacology and Drug Discovery

Yuanhao Lv
Ying Gao
Wenyu Di
Zhaoyi Li
Yashen Shi
Tianyuan Hou
Yiyang Chen
Jiaqi Tian
Miaoming Xu
Wei Su

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1551863

1,910 views
2 citations

Original Research

Published on 20 Feb 2025

The lower rate of bone and joint infection in patients with open extremity fractures associated with vaccination prior to injury: a propensity-matched cohort study

in Experimental Pharmacology and Drug Discovery

Wencheng Hu
Saiyu Shi
Junqing Lin
Tao Gao
Junjie Shen
Yi Sun
Haifeng Wei
Xianyou Zheng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1546191

1,069 views

Brief Research Report

Published on 19 Feb 2025

The clinically applied PARP inhibitor talazoparib ameliorates imiquimod-induced psoriasis in mice without reducing skin inflammation

in Experimental Pharmacology and Drug Discovery

Petra Molnár
Máté Ágoston Demény
Beáta Várkonyi
Zsuzsanna Polgár
Ágnes Pór
Ilona Kovács
Andrea Szegedi
Attila Gábor Szöllősi
Magdolna Szántó

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1519066

1,359 views

Original Research

Published on 19 Feb 2025

Harnessing machine learning and AI-driven analytics to identify novel drug targets and predict chemotherapy efficacy in NSCLC

in Experimental Pharmacology and Drug Discovery

Shaojia Qin
Biyu Deng
Dan Mo
Zhengyou Zhang
Xuan Wei
Zhougui Ling

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1555040

1,447 views

Original Research

Published on 19 Feb 2025

Potential efficacy and mechanisms of icariin for the animal model of osteonecrosis of the femoral head

in Experimental Pharmacology and Drug Discovery

Jie Xu
Wei Deng
Xun Zhu
Deyu Han
Yu Zheng
Qun Zheng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1508971

1,077 views

Original Research

Published on 18 Feb 2025

Mechanism of PAVA-induced toxicity and inflammation in a cocultured skin cell model

in Experimental Pharmacology and Drug Discovery

Yunyang Song
Wenjie Cheng
Zhen Wang
Tianqi Zhou
Fanghui Wu
Yifeng Yin
Dan Xu
Yanli Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1531459

979 views

Original Research

Published on 18 Feb 2025

Brigatinib can inhibit proliferation and induce apoptosis of human immortalized keratinocyte cells

in Experimental Pharmacology and Drug Discovery

Qi Yang
Dan Zhao
Linjie Ju
Peng Cao
Jifu Wei
Zhixian Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1524277

1,901 views

Original Research

Published on 14 Feb 2025

Zebularine showed anti-tumor efficacy in clear cell renal cell carcinoma

in Experimental Pharmacology and Drug Discovery

Haoyu Xu
Senlin Peng
Junwu Li
Yuanyuan Bai
Guozhi Zhao
Simin Liang
Wei Tang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1531056

1,292 views

Original Research

Published on 14 Feb 2025

COL7A1 indicates crucial potential as a basal membrane-related prognostic biomarker and therapeutic target in lung adenocarcinoma

in Experimental Pharmacology and Drug Discovery

Jiao Zhang
Rui Zi
Ping Hu
Zongying Jiang
Ye Lv
Haixia Zhang
Yanjiao Zhao
Yan Wang
Lujun Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1543193

1,189 views

Original Research

Published on 14 Feb 2025

Unveiling the effects of Rosa canina oligosaccharide liposome on neuropathic pain and motor dysfunction following spinal cord injury in rats: relevance to its antioxidative effects

in Experimental Pharmacology and Drug Discovery

Yasaman Ahmadpour
Gholamreza Bahrami
Elham Arkan
Fatemeh Abbaszadeh
Faranak Aghaz
Sajad Fakhri
Javier Echeverría

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1533025

1,696 views
1 citation

Review

Published on 13 Feb 2025

Recent development of mitochondrial metabolism and dysfunction in osteoarthritis

in Experimental Pharmacology and Drug Discovery

Pengchao Guo
Ahmad Alhaskawi
Safwat Adel Abdo Moqbel
Zhijun Pan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1538662

3,343 views
2 citations

Original Research

Published on 13 Feb 2025

Saliva-derived components can enhance the performance of toluidine blue in photodynamic therapy

in Experimental Pharmacology and Drug Discovery

Nicolas Macri
Luana Mendonça Dias
Ana Claudia Pavarina
Walter L. Siqueira
Felipe Fornias Sperandio

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1538520

1,481 views

Review

Published on 13 Feb 2025

The role and application of bioinformatics techniques and tools in drug discovery

in Experimental Pharmacology and Drug Discovery

Shujun Zhang
Kaijie Liu
Yafeng Liu
Xinjun Hu
Xinyu Gu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1547131

7,777 views
3 citations

Original Research

Published on 13 Feb 2025

Novel human single-domain antibodies exert potent anti-tumor activity by targeting EGF-like repeat epitope of EpCAM

in Experimental Pharmacology and Drug Discovery

Xiaofeng Zhou
Zhifang Liu
Weixiong Zhang
Lin Dai
Tao Chen
Zexiong Lin
Hong Pan
Qi Qi
Henry Wei

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1530268

1,084 views

Original Research

Published on 13 Feb 2025

Development of a phenotypic screening assay to measure activation of cancer-associated fibroblasts

in Experimental Pharmacology and Drug Discovery

Marcus M. Ilg
Alice R. Lapthorn
Sophie L. Harding
Tariq Minhas
Gouri Koduri
Stephen A. Bustin
Selim Cellek

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1526495

2,942 views