Frontiers in Pharmacology | Experimental Pharmacology and Drug Discovery

Original Research

Published on 11 Sep 2024

Kaempferol activates chloride secretion via the cAMP/PKA signaling pathway and expression of CFTR in T84 cells

in Experimental Pharmacology and Drug Discovery

Janjira Thaweewattanodom
Chatsri Deachapunya
Sutthasinee Poonyachoti

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1401273

809 views
1 citation

Original Research

Published on 10 Sep 2024

Mechanisms of action of Sappan lignum for prostate cancer treatment: network pharmacology, molecular docking and experimental validation

in Experimental Pharmacology and Drug Discovery

Wenna Li
Honglin Jiang
Weina Zhang
Qiuyue Sun
Qiaoli Zhang
Jingnan Xu
Jinchang Huang
Yuxiang Wan

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1407525

1,623 views
1 citation

Original Research

Published on 10 Sep 2024

Discovery of key biomarkers in tourette syndrome by network pharmacology

in Experimental Pharmacology and Drug Discovery

Jiali Zhao
Xiaohong Bai

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1397203

1,282 views

Systematic Review

Published on 10 Sep 2024

Effects of total flavonoids of Rhizoma Drynariae on biochemical indicators of bone metabolism: a systematic review and meta-analysis

in Experimental Pharmacology and Drug Discovery

Wei Li
Zechen Zhang
Yuyi Li
Zhenyu Wu
Chengjie Wang
Zhen Huang
Baisheng Ye
Xin Jiang
Xiaolong Yang
Xiaolin Shi

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1443235

866 views

Review

Published on 05 Sep 2024

Unraveling the nexus of age, epilepsy, and mitochondria: exploring the dynamics of cellular energy and excitability

in Experimental Pharmacology and Drug Discovery

Wen Xie
Sushruta Koppula
Mayur B. Kale
Lashin S. Ali
Nitu L. Wankhede
Mohit D. Umare
Aman B. Upaganlawar
Ahmed Abdeen
Elturabi E. Ebrahim
Mohamed El-Sherbiny

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1469053

3,071 views
3 citations

Original Research

Published on 04 Sep 2024

Mechanistic study of leukopenia treatment by Qijiao shengbai Capsule via the Bcl2/Bax/CASAPSE3 pathway

in Experimental Pharmacology and Drug Discovery

Siyue Jiang
Pengjiao Wang
Xiaodong Sun
Min Zhang
Shuo Zhang
Yu Cao
Yuben Wang
Li Liu
Xiuli Gao

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1451553

1,246 views

Original Research

Published on 04 Sep 2024

A general prediction model for compound-protein interactions based on deep learning

in Experimental Pharmacology and Drug Discovery

Wei Ji
Shengnan She
Chunxue Qiao
Qiuqi Feng
Mengjie Rui
Ximing Xu
Chunlai Feng

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1465890

1,581 views

Original Research

Published on 04 Sep 2024

The influence of modified Qing E Formula on the differential expression of serum exosomal miRNAs in postmenopausal osteoporosis patients

in Experimental Pharmacology and Drug Discovery

Junjie Lu
Hui Wu
Huan Jin
Ziyi He
Lin Shen
Chen Ma
Xiaojuan Xu
Zixian Wang
Bo Shuai

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1467298

1,158 views

Original Research

Published on 04 Sep 2024

Analysis of gut microbiota-derived metabolites regulating pituitary neuroendocrine tumors through network pharmacology

in Experimental Pharmacology and Drug Discovery

Min Cao
Ping Huang
Lun-shan Xu
Yi-hua Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1403864

1,184 views

Review

Published on 02 Sep 2024

Aberrant glycosylation in schizophrenia: insights into pathophysiological mechanisms and therapeutic potentials

in Experimental Pharmacology and Drug Discovery

Yanchen Feng
Lu Sun
Xue Dang
Diyan Liu
Ziyun Liao
Jianping Yao
Yunke Zhang
Ziqi Deng
Jinyao Li
Min Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1457811

1,456 views
1 citation

Review

Published on 30 Aug 2024

Gastrointestinal tract organoids as novel tools in drug discovery

in Experimental Pharmacology and Drug Discovery

Li Zhou
Dan Luo
Wei Lu
Jun Han
Maoyuan Zhao
Xueyi Li
Tao Shen
Zhao Jin
Jinhao Zeng
Yueqiang Wen

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1463114

3,469 views

Original Research

Published on 29 Aug 2024

Investigating the therapeutic potential of hesperidin targeting CRISP2 in intervertebral disc degeneration and cancer risk mitigation

in Experimental Pharmacology and Drug Discovery

Hui Zhang
Wei Jiang
Yuqing Jiang
Nanwei Xu
Luming Nong
Tengfei Li
Ruiping Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1447152

1,437 views

Original Research

Published on 29 Aug 2024

Identification of biomarkers and potential drug targets in osteoarthritis based on bioinformatics analysis and mendelian randomization

in Experimental Pharmacology and Drug Discovery

Feng Cheng
Mengying Li
Haotian Hua
Ruikun Zhang
Yiwen Zhu
Yingjia Zhu
Yang Zhang
Peijian Tong

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1439289

3,187 views

Original Research

Published on 29 Aug 2024

Development of an in vitro compound screening system that replicate the in vivo spine phenotype of idiopathic ASD model mice

in Experimental Pharmacology and Drug Discovery

Kazuma Maeda
Miki Tanimura
Yusaku Masago
Tsukasa Horiyama
Hiroshi Takemoto
Takuya Sasaki
Ryuta Koyama
Yuji Ikegaya
Koichi Ogawa

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1455812

1,290 views

Mini Review

Published on 29 Aug 2024

The future of pharmacology and therapeutics of the arachidonic acid cascade in the next decade: Innovative advancements in drug repurposing

in Experimental Pharmacology and Drug Discovery

Paola Patrignani
Annalisa Contursi
Stefania Tacconelli
Dieter Steinhilber

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1472396

1,305 views
1 citation

Original Research

Published on 28 Aug 2024

Physiologically based pharmacokinetic models for systemic disposition of protein therapeutics in rabbits

in Experimental Pharmacology and Drug Discovery

Ravi Kumar Jairam
Maria Franz
Nina Hanke
Lars Kuepfer

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1427325

1,177 views
1 citation

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Articles

Kaempferol activates chloride secretion via the cAMP/PKA signaling pathway and expression of CFTR in T84 cells

Mechanisms of action of Sappan lignum for prostate cancer treatment: network pharmacology, molecular docking and experimental validation

Discovery of key biomarkers in tourette syndrome by network pharmacology

Effects of total flavonoids of Rhizoma Drynariae on biochemical indicators of bone metabolism: a systematic review and meta-analysis

Unraveling the nexus of age, epilepsy, and mitochondria: exploring the dynamics of cellular energy and excitability

Mechanistic study of leukopenia treatment by Qijiao shengbai Capsule via the Bcl2/Bax/CASAPSE3 pathway

A general prediction model for compound-protein interactions based on deep learning

The influence of modified Qing E Formula on the differential expression of serum exosomal miRNAs in postmenopausal osteoporosis patients

Analysis of gut microbiota-derived metabolites regulating pituitary neuroendocrine tumors through network pharmacology

Aberrant glycosylation in schizophrenia: insights into pathophysiological mechanisms and therapeutic potentials

Gastrointestinal tract organoids as novel tools in drug discovery

Investigating the therapeutic potential of hesperidin targeting CRISP2 in intervertebral disc degeneration and cancer risk mitigation

Identification of biomarkers and potential drug targets in osteoarthritis based on bioinformatics analysis and mendelian randomization

Development of an in vitro compound screening system that replicate the in vivo spine phenotype of idiopathic ASD model mice

The future of pharmacology and therapeutics of the arachidonic acid cascade in the next decade: Innovative advancements in drug repurposing

Physiologically based pharmacokinetic models for systemic disposition of protein therapeutics in rabbits