Frontiers in Pharmacology | Experimental Pharmacology and Drug Discovery

Original Research

Published on 28 Aug 2024

Physiologically based pharmacokinetic models for systemic disposition of protein therapeutics in rabbits

in Experimental Pharmacology and Drug Discovery

Ravi Kumar Jairam
Maria Franz
Nina Hanke
Lars Kuepfer

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1427325

1,177 views
1 citation

Review

Published on 28 Aug 2024

Gut microecology: effective targets for natural products to modulate uric acid metabolism

in Experimental Pharmacology and Drug Discovery

Hui Wang
Yixuan Zheng
Mengfan Yang
Lu Wang
Yao Xu
Siqi You
Nan Mao
Junming Fan
Sichong Ren

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1446776

1,592 views
4 citations

Original Research

Published on 28 Aug 2024

Model informed dose regimen optimizing in development of leritrelvir for the treatment of mild or moderate COVID-19

in Experimental Pharmacology and Drug Discovery

Kun Wang
Haijun Li
Youyun Li
Fengyan Xu
Zhongyi Sun
Yuting Yang
Jufang Huang
Xiaoxin Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1449583

806 views
1 citation

Editorial

Published on 27 Aug 2024

Editorial: The pharmacological modulation of angiogenesis

in Experimental Pharmacology and Drug Discovery

Emanuela Pessolano
Raffaella Belvedere
Simona Federica Spampinato

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1474918

402 views

Editorial

Published on 27 Aug 2024

Editorial: Cancer and inflammatory diseases research: from the basics to the precision medicine

in Experimental Pharmacology and Drug Discovery

Adriano Sabino
Masamitsu Kanada
Elaine Leite
Mariana Quezado
Whocely Victor de Castro

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1477963

485 views

Original Research

Published on 26 Aug 2024

The cell-permeant antioxidant D-thiol ester D-cysteine ethyl ester overcomes physical dependence to morphine in male Sprague Dawley rats

in Experimental Pharmacology and Drug Discovery

Paulina M. Getsy
Gregory A. Coffee
James N. Bates
Theodore Parran
Lee Hoffer
Santhosh M. Baby
Peter M. MacFarlane
Zackery T. Knauss
Derek S. Damron
Yee-Hsee Hsieh

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1444574

817 views

Original Research

Published on 23 Aug 2024

Hypoxic-preconditioned mesenchymal stem cell-derived small extracellular vesicles inhibit neuronal death after spinal cord injury by regulating the SIRT1/Nrf2/HO-1 pathway

in Experimental Pharmacology and Drug Discovery

Jian Rao
Haishu Xie
Zeyan Liang
Zhelun Yang
Pingping Chen
Maochao Zhou
Xiongjie Xu
Yike Lin
Fabin Lin
Rui Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1419390

1,673 views
1 citation

Original Research

Published on 23 Aug 2024

Design and evaluation of magnetic-targeted bilosomal gel for rheumatoid arthritis: flurbiprofen delivery using superparamagnetic iron oxide nanoparticles

in Experimental Pharmacology and Drug Discovery

Rayan Y. Mushtaq
Nimbagal Raghavendra Naveen
Krishna Jayanth Rolla
Humood Al Shmrany
Sameer Alshehri
Ahmad Salawi
Mallesh Kurakula
Majed A. Alghamdi
Waleed Y. Rizg
Rana B. Bakhaidar

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1433734

2,422 views
1 citation

Original Research

Published on 22 Aug 2024

E-learning pills on immunotherapy in urothelial carcinoma: The E-PIMUC program for continuing medical education

in Experimental Pharmacology and Drug Discovery

Olga Romero-Clarà
Clara Madrid
Juan Carlos Pardo
Vicenç Ruiz de Porras
Olatz Etxaniz
Deborah Moreno-Alonso
Albert Font

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1380954

787 views
1 citation

Review

Published on 22 Aug 2024

Therapeutic potential of arginine deprivation therapy for gliomas: a systematic review of the existing literature

in Experimental Pharmacology and Drug Discovery

Chen Yuxiao
Wang Jiachen
Lan Yanjie
Li Shenglan
Wang Yuji
Li Wenbin

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1446725

2,107 views
1 citation

Original Research

Published on 22 Aug 2024

Theoretical study on the design of allosteric inhibitors of diabetes associated protein PTP1B

in Experimental Pharmacology and Drug Discovery

Jiuyu Zhan
Zhenyang Liu
Hongwei Gao

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1423029

905 views

Review

Published on 21 Aug 2024

A review of the fernane-type triterpenoids as anti-fungal drugs

in Experimental Pharmacology and Drug Discovery

Chun-Yue Liu
Lu Zhang
Si-Xuan Liu
Yong-Fu Lu
Chang Li
Yue-Hu Pei

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1447450

1,166 views

Original Research

Published on 21 Aug 2024

Analysis of microRNAs and the microRNA-messengerRNA regulatory network in chronic alcohol exposure

in Experimental Pharmacology and Drug Discovery

Ailin Du
Yingying Chen
Siyu Qiao
Jiaxing Dong
Yulin Li
Bokai Cao
Rongyu Zhao
Ruiling Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1377501

1,049 views

Original Research

Published on 21 Aug 2024

In silico and in vivo evaluations of multistage antiplasmodial potency and toxicity profiling of n-Hexadecanoic acid derived from Vernonia amygdalina

in Experimental Pharmacology and Drug Discovery

F. I. D. Afolayan
R. A. Odeyemi
R. A. Salaam

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1445905

1,284 views
1 citation

Original Research

Published on 21 Aug 2024

Transcriptome analysis of the aged SAMP8 mouse model of Alzheimer’s disease reveals novel molecular targets of formononetin protection

in Experimental Pharmacology and Drug Discovery

Bo Liu
Di Cui
Jie Liu
Jing-Shan Shi

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1440515

1,313 views
2 citations

Original Research

Published on 21 Aug 2024

The therapeutic targets and signaling mechanisms of ondansetron in the treatment of critical illness in the ICU

in Experimental Pharmacology and Drug Discovery

Lili Tao
Zhenhui Zhang
Chuang Li
Minxuan Huang
Ping Chang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1443169

2,133 views

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Articles

Physiologically based pharmacokinetic models for systemic disposition of protein therapeutics in rabbits

Gut microecology: effective targets for natural products to modulate uric acid metabolism

Model informed dose regimen optimizing in development of leritrelvir for the treatment of mild or moderate COVID-19

Editorial: The pharmacological modulation of angiogenesis

Editorial: Cancer and inflammatory diseases research: from the basics to the precision medicine

The cell-permeant antioxidant D-thiol ester D-cysteine ethyl ester overcomes physical dependence to morphine in male Sprague Dawley rats

Hypoxic-preconditioned mesenchymal stem cell-derived small extracellular vesicles inhibit neuronal death after spinal cord injury by regulating the SIRT1/Nrf2/HO-1 pathway

Design and evaluation of magnetic-targeted bilosomal gel for rheumatoid arthritis: flurbiprofen delivery using superparamagnetic iron oxide nanoparticles

E-learning pills on immunotherapy in urothelial carcinoma: The E-PIMUC program for continuing medical education

Therapeutic potential of arginine deprivation therapy for gliomas: a systematic review of the existing literature

Theoretical study on the design of allosteric inhibitors of diabetes associated protein PTP1B

A review of the fernane-type triterpenoids as anti-fungal drugs

Analysis of microRNAs and the microRNA-messengerRNA regulatory network in chronic alcohol exposure

In silico and in vivo evaluations of multistage antiplasmodial potency and toxicity profiling of n-Hexadecanoic acid derived from Vernonia amygdalina

Transcriptome analysis of the aged SAMP8 mouse model of Alzheimer’s disease reveals novel molecular targets of formononetin protection

The therapeutic targets and signaling mechanisms of ondansetron in the treatment of critical illness in the ICU