Frontiers in Pharmacology | Experimental Pharmacology and Drug Discovery

Methods

Published on 11 Feb 2025

KGRDR: a deep learning model based on knowledge graph and graph regularized integration for drug repositioning

in Experimental Pharmacology and Drug Discovery

Huimin Luo
Hui Yang
Ge Zhang
Jianlin Wang
Junwei Luo
Chaokun Yan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1525029

1,388 views

Review

Published on 11 Feb 2025

Hepatobiliary organoid research: the progress and applications

in Experimental Pharmacology and Drug Discovery

Rui-Qi Zou
Yu-Shi Dai
Fei Liu
Si-Qi Yang
Hai-Jie Hu
Fu-Yu Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1473863

3,935 views

Review

Published on 11 Feb 2025

New strategies to enhance the efficiency and precision of drug discovery

in Experimental Pharmacology and Drug Discovery

Qi An
Liang Huang
Chuan Wang
Dongmei Wang
Yalan Tu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1550158

3,262 views
4 citations

Original Research

Published on 11 Feb 2025

Post-treatment of rat aflatoxicosis by camel milk and silymarin

in Experimental Pharmacology and Drug Discovery

Nahla H. Hassaneen
Shabaan A. Hemeda
Abeer F. El Nahas
Ghadeer M. Albadrani
Muath Q. Al-Ghadi
Zuhair M. Mohammedsaleh
Sabreen E. Fadl
Eman M. El-Diasty
Hader I. Sakr

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1513105

1,084 views

Review

Published on 10 Feb 2025

Optimizing therapeutic outcomes: preconditioning strategies for MSC-derived extracellular vesicles

in Experimental Pharmacology and Drug Discovery

Yuqi Song
Fengrui Liang
Weikun Tian
Erin Rayhill
Liping Ye
Xinghan Tian

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1509418

3,284 views
3 citations

Original Research

Published on 07 Feb 2025

Anti-TNBC effects of Lappaol F by targeting epithelial-mesenchymal transition via regulation of GSK-3β/YAP/β-catenin and PI3K/AKT pathways

in Experimental Pharmacology and Drug Discovery

Qiqi Meng
Zhiping Li
Xiaofeng He
Yuanhao Hu
Guiyun Wu
Jiawen Huang
Zhuohui Luo
Yingjie Hu
Xiaoling Shen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1496511

1,622 views

Original Research

Published on 06 Feb 2025

Preclinical pharmaco-toxicological screening of biomimetic melanin-like nanoparticles as a potential therapeutic strategy for cutaneous melanoma

in Experimental Pharmacology and Drug Discovery

Iasmina Marcovici
Raul Chioibas
Istvan Zupko
Iulia Pinzaru
Alina Moaca
Adriana Ledeti
Lucian Barbu-Tudoran
Andreea Geamantan
Iasmina Predescu
Cristina Adriana Dehelean

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1487854

1,558 views
2 citations

Original Research

Published on 06 Feb 2025

Exploring the CD3/CD56/TNF-α/Caspase3 pathway in pyrethroid-induced immune dysregulation: curcumin-loaded chitosan nanoparticle intervention

in Experimental Pharmacology and Drug Discovery

Nawal Alsubaie
Yasmina M. Abd-Elhakim
Amany Abdel-Rahman Mohamed
Tarek Khamis
Mohamed M. M. Metwally
Nawal Helmi
Afnan M. Alnajeebi
Badriyah S. Alotaibi
Amirah Albaqami
Wedad Mawkili

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1505432

1,250 views

Original Research

Published on 05 Feb 2025

Discovering broad-spectrum inhibitors for SARS-CoV-2 variants: a cheminformatics and biophysical approach targeting the main protease

in Experimental Pharmacology and Drug Discovery

Safar M. Alqahtani

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1459581

1,089 views

Review

Published on 05 Feb 2025

SOX9: a key transcriptional regulator in organ fibrosis

in Experimental Pharmacology and Drug Discovery

Yishuo Li
Yue Xing
Ning Liu
Bin Liu
Zhihui Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1507282

2,245 views

Original Research

Published on 03 Feb 2025

Gallic acid protects intervertebral disc cells from ferroptosis and alleviates intervertebral disc degeneration by regulating key factors of oxidative stress

in Experimental Pharmacology and Drug Discovery

Zaishi Zhu
Zeling Huang
Chaofeng Zhang
Bo Xu
Hua Chen
Shuai Pei
Baofei Zhang
Lishi Jie
Xiaoqing Shi
Yujiang Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1501725

1,836 views

Original Research

Published on 03 Feb 2025

Discovery of novel and highly potent small molecule inhibitors targeting FLT3-ITD for the treatment of acute myeloid leukemia using structure-based virtual screening and biological evaluation

in Experimental Pharmacology and Drug Discovery

Kun Shi
Ye Hong
Huajing Liu
Xiaotian Yang
Fengzhen Wang
Yanming Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1511257

1,680 views
1 citation

Original Research

Published on 31 Jan 2025

Corneal protective effects of a new ophthalmic formulation based on vitamin B12 and sodium hyaluronate

in Experimental Pharmacology and Drug Discovery

Francesca Lazzara
Federica Conti
Grazia Maugeri
Velia D’Agata
Ludovica Sotera
Claudio Bucolo

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1548213

1,933 views

Original Research

Published on 31 Jan 2025

Preparation of Tragopogon graminifolius-loaded electrospun nanofibers and evaluating its wound healing activity in a rat model of skin scar

in Experimental Pharmacology and Drug Discovery

Leila Almasi
Elham Arkan
Mohammad Hosein Farzaei
Amin Iranpanah
Cyrus Jalili
Fatemeh Abbaszadeh
Faranak Aghaz
Sajad Fakhri
Javier Echeverría

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1533010

1,386 views

Original Research

Published on 30 Jan 2025

Prediction of traditional Chinese medicine for diabetes based on the multi-source ensemble method

in Experimental Pharmacology and Drug Discovery

Bin Yang
Qingyun Chi
Xiang Li
Jinglong Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1454029

1,872 views

Original Research

Published on 29 Jan 2025

Jiawei Suanzaoren decoction for the treatment of perimenopausal insomnia: clinical observation and experimental study

in Experimental Pharmacology and Drug Discovery

Li-Qiong Chen
Yong-Can Zhou
Fang Ning
Ming-Jin Zhu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1495957

2,174 views