Frontiers in Pharmacology | Experimental Pharmacology and Drug Discovery

Original Research

Accepted on 17 Feb 2025

Semaglutide promotes the proliferation and osteogenic differentiation of bone-derived mesenchymal stem cells through activation of the Wnt/LRP5/β-catenin signaling pathway

in Experimental Pharmacology and Drug Discovery

Yawei Tian
Huiming Liu
Xiaoxue Bao
Yukun Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1539411

Original Research

Accepted on 17 Feb 2025

PDP1 related ferroptosis risk signature indicates distinct immune microenvironment and prognosis of breast cancer patients

in Experimental Pharmacology and Drug Discovery

Huifen Dang
Gongjian Zhu
Chen Gao
Yingxia Tian
Yingxia Tian

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1551325

Original Research

Accepted on 14 Feb 2025

Obesity promotes immunotherapy efficacy by up-regulating the glycolyticmediated histone lactacylation modification of CD8+ T cells

in Experimental Pharmacology and Drug Discovery

Xinghao Ai
Kaixuan Wang
Dongmin Shi
Jingyuan Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1533464

Original Research

Published on 14 Feb 2025

Zebularine showed anti-tumor efficacy in clear cell renal cell carcinoma

in Experimental Pharmacology and Drug Discovery

Haoyu Xu
Senlin Peng
Junwu Li
Yuanyuan Bai
Guozhi Zhao
Simin Liang
Wei Tang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1531056

235 views

Original Research

Published on 14 Feb 2025

COL7A1 indicates crucial potential as a basal membrane-related prognostic biomarker and therapeutic target in lung adenocarcinoma

in Experimental Pharmacology and Drug Discovery

Jiao Zhang
Rui Zi
Ping Hu
Zongying Jiang
Ye Lv
Haixia Zhang
Yanjiao Zhao
Yan Wang
Lujun Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1543193

165 views

Original Research

Published on 14 Feb 2025

Unveiling the effects of Rosa canina oligosaccharide liposome on neuropathic pain and motor dysfunction following spinal cord injury in rats: relevance to its antioxidative effects

in Experimental Pharmacology and Drug Discovery

Yasaman Ahmadpour
Gholamreza Bahrami
Elham Arkan
Fatemeh Abbaszadeh
Faranak Aghaz
Sajad Fakhri
Javier Echeverría

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1533025

194 views

Review

Accepted on 13 Feb 2025

Advanced materials for cancer treatment and beyond

in Experimental Pharmacology and Drug Discovery

Lei Zhang
Yanan Wang
Yangjia Li
Zhe-Sheng Chen
Chaohua Hu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1557155

Original Research

Accepted on 13 Feb 2025

Efficient substructure feature encoding based on graph neural network blocks for drug-target interaction prediction

in Experimental Pharmacology and Drug Discovery

Guojian Deng
Changsheng Shi
Ruiquan Ge
Riqian Hu
Changmiao Wang
Feiwei Qin
Cheng Pan
Haixia Mao
Qing Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1553743

Original Research

Published on 13 Feb 2025

Saliva-derived components can enhance the performance of toluidine blue in photodynamic therapy

in Experimental Pharmacology and Drug Discovery

Nicolas Macri
Luana Mendonça Dias
Ana Claudia Pavarina
Walter L. Siqueira
Felipe Fornias Sperandio

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1538520

168 views

Review

Published on 13 Feb 2025

The role and application of bioinformatics techniques and tools in drug discovery

in Experimental Pharmacology and Drug Discovery

Shujun Zhang
Kaijie Liu
Yafeng Liu
Xinjun Hu
Xinyu Gu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1547131

171 views

Review

Published on 13 Feb 2025

Recent development of mitochondrial metabolism and dysfunction in osteoarthritis

in Experimental Pharmacology and Drug Discovery

Pengchao Guo
Ahmad Alhaskawi
Safwat Adel Abdo Moqbel
Zhijun Pan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1538662

153 views

Original Research

Published on 13 Feb 2025

Novel human single-domain antibodies exert potent anti-tumor activity by targeting EGF-like repeat epitope of EpCAM

in Experimental Pharmacology and Drug Discovery

Xiaofeng Zhou
Zhifang Liu
Weixiong Zhang
Lin Dai
Tao Chen
Zexiong Lin
Hong Pan
Qi Qi
Henry Wei

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1530268

189 views

Original Research

Published on 13 Feb 2025

Development of a phenotypic screening assay to measure activation of cancer-associated fibroblasts

in Experimental Pharmacology and Drug Discovery

Marcus M. Ilg
Alice R. Lapthorn
Sophie L. Harding
Tariq Minhas
Gouri Koduri
Stephen A. Bustin
Selim Cellek

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1526495

349 views

Mini Review

Accepted on 12 Feb 2025

Therapeutic modulation of protein RBM3 for ischemic stroke treatment

in Experimental Pharmacology and Drug Discovery

Paulo Ávila-Gómez
Alva Vieites-Prado
Clara Correa-Paz
Lucía Del Pozo-Filíu
Nuria Palomar-Alonso
Francisco Campos
Esteban López-Arias

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1555115

Original Research

Accepted on 11 Feb 2025

Pharmacophore screening, molecular docking, and MD simulations for identification of VEGFR-2 and c-Met potential dual inhibitors

in Experimental Pharmacology and Drug Discovery

Junmin Dong
Xiaohua Hao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1534707

Review

Accepted on 11 Feb 2025

Exploring Manzamine A: A Promising Anti-lung cancer Agent from Marine Sponge Haliclona sp

in Experimental Pharmacology and Drug Discovery

Min Su
Jie Zhu
Luyuan Bai
Yu Cao
Shaohui Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1525210

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Articles

Semaglutide promotes the proliferation and osteogenic differentiation of bone-derived mesenchymal stem cells through activation of the Wnt/LRP5/β-catenin signaling pathway

PDP1 related ferroptosis risk signature indicates distinct immune microenvironment and prognosis of breast cancer patients

Obesity promotes immunotherapy efficacy by up-regulating the glycolyticmediated histone lactacylation modification of CD8+ T cells

Zebularine showed anti-tumor efficacy in clear cell renal cell carcinoma

COL7A1 indicates crucial potential as a basal membrane-related prognostic biomarker and therapeutic target in lung adenocarcinoma

Unveiling the effects of Rosa canina oligosaccharide liposome on neuropathic pain and motor dysfunction following spinal cord injury in rats: relevance to its antioxidative effects

Advanced materials for cancer treatment and beyond

Efficient substructure feature encoding based on graph neural network blocks for drug-target interaction prediction

Saliva-derived components can enhance the performance of toluidine blue in photodynamic therapy

The role and application of bioinformatics techniques and tools in drug discovery

Recent development of mitochondrial metabolism and dysfunction in osteoarthritis

Novel human single-domain antibodies exert potent anti-tumor activity by targeting EGF-like repeat epitope of EpCAM

Development of a phenotypic screening assay to measure activation of cancer-associated fibroblasts

Therapeutic modulation of protein RBM3 for ischemic stroke treatment

Pharmacophore screening, molecular docking, and MD simulations for identification of VEGFR-2 and c-Met potential dual inhibitors

Exploring Manzamine A: A Promising Anti-lung cancer Agent from Marine Sponge Haliclona sp