Frontiers in Pharmacology | Experimental Pharmacology and Drug Discovery

Original Research

Published on 29 Jul 2024

Potential mechanism of Luoshi Neiyi prescription in endometriosis based on serum pharmacochemistry and network pharmacology

in Experimental Pharmacology and Drug Discovery

Lizheng Wu
Shuhong Lin
Yongjun Hu
Shangwen Jing
Bowen Sun
Xiaoxin Chen
Jinjin Jia
Cheng Zeng
Fangli Pei

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1395160

2,419 views

Original Research

Published on 26 Jul 2024

LSD1 inhibition by tranylcypromine hydrochloride reduces alkali burn-induced corneal neovascularization and ferroptosis by suppressing HIF-1α pathway

in Experimental Pharmacology and Drug Discovery

Qian Deng
Yuelan Gao
Yujin Wang
Jiewen Mao
Yulin Yan
Zixian Yang
Yuyu Cong
Yanning Yang
Shanshan Wan

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1411513

1,994 views

Original Research

Published on 26 Jul 2024

Huanshaodan regulates microglial glucose metabolism reprogramming to alleviate neuroinflammation in AD mice through mTOR/HIF-1α signaling pathway

in Experimental Pharmacology and Drug Discovery

Congcong Shang
Yunfang Su
Jinlian Ma
Zhonghua Li
Pan Wang
Huifen Ma
Junying Song
Zhenqiang Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1434568

2,143 views

Original Research

Published on 26 Jul 2024

Gestodene, a novel positive allosteric modulator of PAR1, enhances PAR1-mediated human platelet aggregation

in Experimental Pharmacology and Drug Discovery

So-Hyeon Park
Yunkyung Heo
Il Kwon
Sungwoo Jo
Hyejin Jeon
Yechan Lee
Jieun Kim
Ji Hoe Heo
Wan Namkung

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1430548

1,217 views
1 citation

Review

Published on 25 Jul 2024

Current concepts of the crosstalk between lncRNA and E2F1: shedding light on the cancer therapy

in Experimental Pharmacology and Drug Discovery

Peng Huang
Feng Wen
Qiu Li

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1432490

1,400 views
1 citation

Original Research

Published on 24 Jul 2024

Mechanisms of Puerariae Lobatae Radix in regulating sebaceous gland secretion: insights from network pharmacology and experimental validation

in Experimental Pharmacology and Drug Discovery

Du Yijie
Zhao Siqi
Huang Ruiyin
Shi YuJing
Meng Hong
Dong Yinmao
Yang Tao
Luo Changyong

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1414856

1,483 views
1 citation

General Commentary

Published on 24 Jul 2024

Commentary: Effect of curcumin nanoparticles on proliferation and migration of mouse airway smooth muscle cells and airway inflammatory infiltration

in Experimental Pharmacology and Drug Discovery

Fabien Beaufils
Patrick Berger

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1432397

606 views

Original Research

Published on 22 Jul 2024

Synthesis, characterization, and mechanistic insights into the enhanced anti-inflammatory activity of baicalin butyl ester via the PI3K-AKT pathway

in Experimental Pharmacology and Drug Discovery

Hongxu Du
Zhangxun Li
Lijuan Su
Zhengke He
Xiaoyan Tan
Fengzhi Hou
Tanjie He
Yu Pan
Shuang Xu
Liting Cao

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1417372

1,159 views

Original Research

Published on 19 Jul 2024

YinChen WuLing powder attenuates non-alcoholic steatohepatitis through the inhibition of the SHP2/PI3K/NLRP3 pathway

in Experimental Pharmacology and Drug Discovery

Xingxing Yuan
Liuxin Yang
Tinting Gao
Jiawei Gao
Bingyu Wang
Chengxiang Liu
Wei Yuan

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1423903

2,101 views
1 citation

Original Research

Published on 19 Jul 2024

V-doped MoS2 nanozymes providing reactive oxygen species and depleting glutathione for photothermally-enhanced nanocatalytic therapy

in Experimental Pharmacology and Drug Discovery

Haiyan Wang
Pengle Xia
Mekhrdod S. Kurboniyon
Shuhong Fang
Kunying Huang
Shufang Ning
Guanqiao Jin
Litu Zhang
Chen Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1448867

985 views
1 citation

Original Research

Published on 19 Jul 2024

In vivo pharmacokinetics of Glycyrrhiza uralensis polysaccharides

in Experimental Pharmacology and Drug Discovery

Abudukahaer Wubuli
Junwei Chai
Haoqiang Liu
Dilaram Nijat
Jianmin Li
Guoyu Xia
Qi Cao
Saidan Zhang
Weidong Huang
Adila Aipire

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1431221

2,234 views
1 citation

Original Research

Published on 19 Jul 2024

RAB42 overexpression correlates with poor prognosis, immune cell infiltration and chemoresistance

in Experimental Pharmacology and Drug Discovery

Yang Wang
Youbang Xie
Luomeng Qian
Ran Ding
Rongqing Pang
Ping Chen
Qing Zhang
Sihe Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1445170

1,761 views
1 citation

Correction

Published on 19 Jul 2024

Corrigendum: Ginsenoside Re attenuates high glucose-induced RF/6A injury via regulating PI3K/AKT inhibited HIF-1a/VEGF signaling pathway

in Experimental Pharmacology and Drug Discovery

Weijie Xie
Ping Zhou
Muwen Qu
Ziru Dai
Xuelian Zhang
Chenyang Zhang
Xi Dong
Guibo Sun
Xiaobo Sun

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1451696

749 views

Editorial

Published on 18 Jul 2024

Editorial: Pharmacology of gangliosides

in Experimental Pharmacology and Drug Discovery

Hongda Zhuang
Zhendong Huang
Stéphane Birklé
Roger Chammas
Ritva Tikkanen
Yong Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1449928

1,004 views

Mini Review

Published on 18 Jul 2024

Medicinal polypharmacology—a scientific glossary of terminology and concepts

in Experimental Pharmacology and Drug Discovery

Sven Marcel Stefan
Muhammad Rafehi

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1419110

1,028 views
3 citations

Review

Published on 17 Jul 2024

Application of network pharmacology in traditional Chinese medicine for the treatment of digestive system diseases

in Experimental Pharmacology and Drug Discovery

Shihao Zheng
Yijun Liang
Tianyu Xue
Wei Wang
Size Li
Peng Zhang
Xiaoke Li
Xu Cao
Qiyao Liu
Wenying Qi

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1412997

2,670 views
3 citations

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Articles

Potential mechanism of Luoshi Neiyi prescription in endometriosis based on serum pharmacochemistry and network pharmacology

LSD1 inhibition by tranylcypromine hydrochloride reduces alkali burn-induced corneal neovascularization and ferroptosis by suppressing HIF-1α pathway

Huanshaodan regulates microglial glucose metabolism reprogramming to alleviate neuroinflammation in AD mice through mTOR/HIF-1α signaling pathway

Gestodene, a novel positive allosteric modulator of PAR1, enhances PAR1-mediated human platelet aggregation

Current concepts of the crosstalk between lncRNA and E2F1: shedding light on the cancer therapy

Mechanisms of Puerariae Lobatae Radix in regulating sebaceous gland secretion: insights from network pharmacology and experimental validation

Commentary: Effect of curcumin nanoparticles on proliferation and migration of mouse airway smooth muscle cells and airway inflammatory infiltration

Synthesis, characterization, and mechanistic insights into the enhanced anti-inflammatory activity of baicalin butyl ester via the PI3K-AKT pathway

YinChen WuLing powder attenuates non-alcoholic steatohepatitis through the inhibition of the SHP2/PI3K/NLRP3 pathway

V-doped MoS2 nanozymes providing reactive oxygen species and depleting glutathione for photothermally-enhanced nanocatalytic therapy

In vivo pharmacokinetics of Glycyrrhiza uralensis polysaccharides

RAB42 overexpression correlates with poor prognosis, immune cell infiltration and chemoresistance

Corrigendum: Ginsenoside Re attenuates high glucose-induced RF/6A injury via regulating PI3K/AKT inhibited HIF-1a/VEGF signaling pathway

Editorial: Pharmacology of gangliosides

Medicinal polypharmacology—a scientific glossary of terminology and concepts

Application of network pharmacology in traditional Chinese medicine for the treatment of digestive system diseases