Frontiers in Pharmacology | Experimental Pharmacology and Drug Discovery

Original Research

Published on 09 Jan 2025

Integrating traditional machine learning with qPCR validation to identify solid drug targets in pancreatic cancer: a 5-gene signature study

in Experimental Pharmacology and Drug Discovery

Xiaoyan Wang
Pengcheng Yu
Wei Jia
Bingbing Wan
Zhougui Ling
Yangyang Tang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1539120

1,515 views

Original Research

Published on 08 Jan 2025

The efficacy and safety of remimazolam besylate, ciprofol, and propofol during hysteroscopy

in Experimental Pharmacology and Drug Discovery

Weifeng Shan
Shuying Gao
Mengting Ai
Haiyan Lan
Gongchen Duan
Xiaoli Dong
Qiaomin Xu
Yini Wu
Jimin Wu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1427755

2,176 views

Original Research

Published on 08 Jan 2025

ITGAX promotes gastric cancer progression via epithelial-mesenchymal transition pathway

in Experimental Pharmacology and Drug Discovery

Jiali Hu
Jing Cao
Shanshan Huang
Yang Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1536478

1,481 views
1 citation

Original Research

Published on 08 Jan 2025

Photodynamic therapy with a novel photosensitizer inhibits DSS-induced ulcerative colitis in rats via the NF-κB signaling pathway

in Experimental Pharmacology and Drug Discovery

Yumei Rong
Minghui Zhu
Nan Wang
Feiyu Zhang
Tianjun Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1539363

1,237 views

Original Research

Published on 07 Jan 2025

Therapeutic effects of composite probiotics derived from fermented camel milk on metabolic dysregulation and intestinal barrier integrity in type 2 diabetes rats

in Experimental Pharmacology and Drug Discovery

Tabusi Manaer
Jialehasibieke Sailike
Xin Sun
Baheban Yeerjiang
Xinhua Nabi

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1520158

1,912 views

Review

Published on 07 Jan 2025

Unlocking the therapeutic mechanism of Caesalpinia sappan: a comprehensive review of its antioxidant and anti-cancer properties, ethnopharmacology, and phytochemistry

in Experimental Pharmacology and Drug Discovery

Estéfani Alves Asevedo
Livia Ramos Santiago
Hyo Jeong Kim
Rony Abdi Syahputra
Moon Nyeo Park
Rosy Iara Maciel Azambuja Ribeiro
Bonglee Kim

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1514573

3,067 views
1 citation

Original Research

Published on 07 Jan 2025

Artificial intelligence-driven identification and mechanistic exploration of synergistic anti-breast cancer compound combinations from Prunella vulgaris L.-Taraxacum mongolicum Hand.-Mazz. herb pair

in Experimental Pharmacology and Drug Discovery

Chunlai Feng
Jiaxi Cheng
Mengqiu Sun
Chunxue Qiao
Qiuqi Feng
Naying Fang
Yingying Ge
Mengjie Rui

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1522787

1,589 views
1 citation

Original Research

Published on 06 Jan 2025

Efficacy of the Bushen Jianpi Huoxue Formula on Beclin-1/Bcl-2-mediated autophagy and apoptosis in osteoblasts

in Experimental Pharmacology and Drug Discovery

Yanping Lin
Rui Zhao
Jiachun Huang
Tongying Chen
Haolin Yang
Haiwei Guo
Lei Wan
Zhihai Zhang
Ying Li
Genfu Zhu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1513298

1,631 views
2 citations

Original Research

Published on 06 Jan 2025

Salidroside enhances 5-fluorouracil sensitivity against hepatocellular carcinoma via YIPF5-induced mitophagy

in Experimental Pharmacology and Drug Discovery

Sumin Sun
Haili Hu
Feiyu Li
Sheng Huan
Long Chen
Jiahui Chen
Peihua Sun
Xiaoqing Dong

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1503490

1,509 views

Correction

Published on 06 Jan 2025

Corrigendum: Ginkgolide C alleviates myocardial ischemia/reperfusion-induced inflammatory injury via inhibition of CD40-NF-κB pathway

in Experimental Pharmacology and Drug Discovery

Rui Zhang
Dan Han
Zhenyu Li
Chengwu Shen
Yahui Zhang
Jun Li
Genquan Yan
Shasha Li
Bo Hu
Jiangbing Li

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1492520

742 views

Review

Published on 06 Jan 2025

An updated review summarizing the anticancer potential of flavonoids via targeting NF-kB pathway

in Experimental Pharmacology and Drug Discovery

Pratibha Pandey
Sorabh Lakhanpal
Danish Mahmood
Han Na Kang
Byunggyu Kim
Sojin Kang
Jinwon Choi
Min Choi
Shivam Pandey
Mahakshit Bhat

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1513422

3,268 views
9 citations

Original Research

Published on 06 Jan 2025

Biological activities of Usnea lethariiformis lichen extracts and UHPLC-ESI-QTOF-MS analysis of their secondary metabolites

in Experimental Pharmacology and Drug Discovery

Mauricio Piñeiro
Sofía Manrique
Jessica Gómez
Juan Manuel Rodriguez
Patricia Barrera
Duilio Caballero
Miguel A. Sosa
Gabriel Vargas-Arana
Alejandro Tapia
Beatriz Lima

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1508835

2,038 views
1 citation

Original Research

Published on 06 Jan 2025

A study to assess the pharmacological agent potential of gold nanoparticles and their effects on human cancer cells and hospital pathogens using in vitro methods

in Experimental Pharmacology and Drug Discovery

Ayşe Baran

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1498734

578 views

Review

Published on 06 Jan 2025

Plant and marine-derived natural products: sustainable pathways for future drug discovery and therapeutic development

in Experimental Pharmacology and Drug Discovery

Muhammad Ahmad
Maleha Tahir
Zibin Hong
Muhammad Anjum Zia
Hamza Rafeeq
Muhammad Shaheez Ahmad
Saif ur Rehman
Junming Sun

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1497668

5,349 views
3 citations

Original Research

Published on 03 Jan 2025

Modulation of gut microbiota, up-regulation of ZO-1, and promotion of metabolism as therapeutic mechanisms of indole-3-carbinol against obesity in mice

in Experimental Pharmacology and Drug Discovery

XuWen Mao
Guliruoyi Paerhati
Yuche Wu
Lu Feng Cheng

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1499142

1,700 views
2 citations

Original Research

Published on 03 Jan 2025

Pathogenesis-directed therapy of methylphenidate-induced oxidative heart damage in rats

in Experimental Pharmacology and Drug Discovery

Izzet Emir
Seval Bulut
Bahadır Suleyman
Renad Mammadov
Nurinisa Yucel
Betul Cicek
Gulce Naz Yazici
Durdu Altuner
Murat Gunay
Halis Suleyman

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1503032

1,276 views