Frontiers in Pharmacology | Experimental Pharmacology and Drug Discovery

Systematic Review

Published on 18 Nov 2024

Efficacy and safety of Epimedium total flavonoids for primary osteoporosis: a systematic review and meta-analysis

in Experimental Pharmacology and Drug Discovery

Jinkun Li
Xudong Huang
Yifeng Yuan
Haixin Zhang
Hang Zhou
Wei Xiong
Yuyi Li
Zechen Zhang
Fengqing Qie
Yingdelong Mao

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1505926

2,153 views

Original Research

Published on 18 Nov 2024

Integrated chemical analysis, metabolic profiling, network pharmacology, molecular docking and toxicity prediction to reveal the active ingredients and their safety of raw and prepared rhubarbs in the treatment of gastric ulcers

in Experimental Pharmacology and Drug Discovery

Chenxi Wang
Xin Zhao
Jingjing Jiang
Mengqi Jia
Wenqing Shi
Zhenghua Wu
Shiyu Feng
Guorong Fan
Yuefen Lou

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1481091

1,962 views
1 citation

Original Research

Published on 15 Nov 2024

Discovery of novel and highly potent dual-targeting PKMYT1/HDAC2 inhibitors for hepatocellular carcinoma through structure-based virtual screening and biological evaluation

in Experimental Pharmacology and Drug Discovery

Yang Yang
Yuting Wang
Jing Chen
Miao-Miao Niu
Yongbin Wang
Xing Jin

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1491497

1,645 views

Original Research

Published on 14 Nov 2024

Repurposed drugs as histone deacetylase 8 inhibitors: Implications in cancer and neuropathological conditions

in Experimental Pharmacology and Drug Discovery

Mohammed Alrouji
Kumar Venkatesan
Mohammed S. Alshammari
Fahad A. Alhumaydhi
Sheeba Shafi
Sharaf E. Sharaf
Moyad Shahwan
Anas Shamsi

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1488585

1,478 views

Review

Published on 13 Nov 2024

In-depth analysis of lupeol: delving into the diverse pharmacological profile

in Experimental Pharmacology and Drug Discovery

Aminah Dalimunthe
Mega Carensia Gunawan
Zahirah Dhiya Utari
Muhammad Riza Dinata
Princella Halim
Nathasya Estherina S. Pakpahan
Alex Insandus Sitohang
M. Andriansyah Sukarno
Yuandani
Yahdiana Harahap

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1461478

5,694 views
5 citations

Original Research

Published on 13 Nov 2024

Glucocorticoids influence on rat hematological parameters and catalase activity

in Experimental Pharmacology and Drug Discovery

Safija Herenda
Ivana Carev
Denis Haskovic
Sabina Prevljak
Sara Causevic
Edhem Haskovic

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1367350

848 views

Original Research

Published on 13 Nov 2024

Integration of metabolomics and transcriptomics to reveal anti-immunosuppression mechanism of Lycium barbarum polysaccharide

in Experimental Pharmacology and Drug Discovery

Jiandong Wang
Xue Zhang
Yi Wu
Qianfei Wei
Lingshan Yan
Youli Yu
Yanan Guo
Zhengqin Yu
Pan Wang
Xiaonan Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1486739

1,515 views

Review

Published on 13 Nov 2024

β-blockers and statins: exploring the potential off-label applications in breast, colorectal, prostate, and lung cancers

in Experimental Pharmacology and Drug Discovery

Pedro Gabriel Senger Braga
Janaína da Silva Vieira
Aline Rachel Bezerra Gurgel
Patricia Chakur Brum

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1423502

2,223 views
1 citation

Original Research

Published on 13 Nov 2024

Herbal formula xuling-jiangu improves bone metabolic balance in rats with ovariectomy-induced osteoporosis via the gut-bone axis

in Experimental Pharmacology and Drug Discovery

Juan Chen
Szetuen Ng
Pengchao Xu
Sainan Chen
Shengqiang Li
Xuan Chen
Lihua Xie
Jirong Ge

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1505231

1,706 views

Original Research

Published on 12 Nov 2024

Preparation and anti-colon cancer effect of a novel curcumin analogue (CA8): in vivo and in vitro evaluation

in Experimental Pharmacology and Drug Discovery

Jie Wen
Lingmao Zhao
Zhuohan Li
Chao Pi
Xianhu Feng
Peng Shi
Hongru Yang
Ligang Chen
Xiaodong Wang
Furong Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1464626

1,176 views
1 citation

Original Research

Published on 12 Nov 2024

Development of bombesin-tubulysin conjugates using multicomponent chemistry to functionalize both the payload and the homing peptide

in Experimental Pharmacology and Drug Discovery

Dayma Llanes
Robert Rennert
Paul Jänicke
Ibrahim Morgan
Leslie Reguera
Daniel G. Rivera
Manuel G. Ricardo
Ludger A. Wessjohann

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1408091

1,434 views

Original Research

Published on 11 Nov 2024

Nanotechnological prospective for enhancing the antibacterial activity of mupirocin and cinnamon essential oil: a combination therapy

in Experimental Pharmacology and Drug Discovery

Bandar Aldhubiab
Rashed M. Almuqbil
Tamer M. Shehata
Wafaa E. Soliman
Heba S. Elsewedy

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1468374

1,112 views

Original Research

Published on 11 Nov 2024

Enhanced anticancer effect of thymidylate synthase dimer disrupters by promoting intracellular accumulation

in Experimental Pharmacology and Drug Discovery

Gaetano Marverti
Maria Gaetana Moschella
Alice Belardo
Michele Lamesta
Giada Mercanile
Lorenzo Tagliazucchi
Daniele Aiello
Alberto Venturelli
Davide Illuminati
Remo Guerrini

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1477318

1,352 views
1 citation

Original Research

Published on 06 Nov 2024

Structure-guided drug repurposing identifies aristospan as a potential inhibitor of β-lactamase: insights from virtual screening and molecular dynamics simulations

in Experimental Pharmacology and Drug Discovery

Moyad Shahwan
Mohd Shahnawaz Khan
Azna Zuberi
Nojood Altwaijry
Anas Shamsi

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1459822

1,165 views

Mini Review

Published on 06 Nov 2024

Recent advances in extracellular matrix manipulation for kidney organoid research

in Experimental Pharmacology and Drug Discovery

Ren Wang
Yufei Sui
Qiuyan Liu
Yucui Xiong
Shanshan Li
Wu Guo
Yiwei Xu
Sheng Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1472361

2,378 views
1 citation

Original Research

Published on 06 Nov 2024

Berberine ameliorates septic cardiomyopathy through protecting mitochondria and upregulating Notch1 signaling in cardiomyocytes

in Experimental Pharmacology and Drug Discovery

Qi Shen
Yufan Yuan
Zelin Li
Ying Ling
Jian Wang
Mingjing Gao
Peng Wang
Mengli Li
Lizhong Lai
Jinlan Jin

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1502354

2,209 views
5 citations