Frontiers in Pharmacology | Experimental Pharmacology and Drug Discovery

Original Research

Published on 10 Jul 2025

A diaryl urea derivative, SMCl inhibits cell proliferation through the RAS/RAF/MEK/ERK pathway in hepatocellular carcinoma

in Experimental Pharmacology and Drug Discovery

Yue Fu
Weiyue Fang
Fuqiang Qiu
Juncai Lai
Yangjin Xu
Bin Chen
Yang Li
Xiaohui Zhu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1605515

114 views

Original Research

Accepted on 09 Jul 2025

Prophylactic administration of lecithinized superoxide dismutase for a murine model of oxaliplatin-induced myelosuppression

in Experimental Pharmacology and Drug Discovery

Mikako Shimoda
Akari Yamaguchi
Ayano Shikata
Yusuke Murakami
Masahiro Kawahara
Tohru Mizushima
Ken-ichiro Tanaka

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1607814

Original Research

Accepted on 09 Jul 2025

Crab shell polypeptides enhance calcium dynamics and osteogenic activity in osteoporosis

in Experimental Pharmacology and Drug Discovery

Xiaolei Dong
Guangmin Zhang
Chong Sun
Hui Zhang
Jinmeng Zhen
Xinlei Li
Xiaohui Xu
Jiane Liu
Xiangzhong Zhao
Ming Yi Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1605422

Editorial

Published on 09 Jul 2025

Editorial: Exploring small molecule probes: advancements and applications in pharmacological research

in Experimental Pharmacology and Drug Discovery

I-Ju Yeh

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1652445

180 views

Original Research

Published on 09 Jul 2025

Co-delivery of anti-inflammatory and antioxidant agents via polymersomes for osteoarthritis therapy

in Experimental Pharmacology and Drug Discovery

Mengjie Rui
Li Wang
Ke Mi
Yinfeng Li
Naying Fang
Yingying Ge
Qiuqi Feng
Yaqi Luo
Chunlai Feng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1635761

180 views

Original Research

Published on 09 Jul 2025

Deferoxamine prevents dexamethasone-induced muscle atrophy by reducing MuRF1 and atrogin-1

in Experimental Pharmacology and Drug Discovery

Jae-Yeop Jeong
Youngho Son
Youngha Kim
Nami Lee
Yujin Kim
Yu Jung Heo
Sung-E. Choi
Jaemyung Choi
Seung Jin Han
Jayoung Jeon

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1582216

169 views

Original Research

Accepted on 08 Jul 2025

An Immunomodulatory Photosensitizer-Mediated Photodynamic Therapy Synergizes with PD-L1 Blockade against Metastatic Triplenegative Breast Cancer

in Experimental Pharmacology and Drug Discovery

Yuetong Liu
Liming Wang
Feiyan Kong
Tianjun Liu
Hong Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1651165

265 views

Review

Accepted on 08 Jul 2025

Therapies and Delivery Systems for Diabetic Wound Care: Current Insights and Future Pathways

in Experimental Pharmacology and Drug Discovery

Preeti Yadav
Mahendra Singh
Ramachandran Vinayagam
Prashant Shukla

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1628252

116 views

Review

Accepted on 08 Jul 2025

Unlocking the Potential of GLP-1 Receptor Agonists in Ocular Therapeutics: From Molecular Pathways to Clinical Impact

in Experimental Pharmacology and Drug Discovery

Zhixuan Xie
Zuyi Yang
Dianzhe Tian
Youxin Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1618079

131 views

Original Research

Published on 08 Jul 2025

From radiolabeling to receptor quantification: preclinical assessment of [99mTc]Tc-carvedilol as a cardiac β-adrenoceptor probe

in Experimental Pharmacology and Drug Discovery

Hala F. Azhari

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1581598

460 views

Original Research

Published on 08 Jul 2025

MT2 receptor mediates melatonin-induced thermogenic program in human myoblasts: insights for circadian syndrome and diabesity treatment

in Experimental Pharmacology and Drug Discovery

Diego Salagre
Juan Sanjuán‐Hidalgo
Ehab Kotb Elmahallawy
Pedro P. Medina
Ahmad Agil

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1633326

329 views

Mini Review

Published on 08 Jul 2025

Non-hematopoietic roles of erythropoietin in inflammation and metabolic disorders

in Experimental Pharmacology and Drug Discovery

Satoru Sugimoto
Takeshi Goda

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1613849

183 views

Systematic Review

Published on 08 Jul 2025

Clinical pharmacokinetics of potassium competitive acid blockers: a systematic review and meta-analysis

in Experimental Pharmacology and Drug Discovery

Jiaqi Liu
Jongsung Hahn

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1580969

277 views

Review

Published on 08 Jul 2025

Application of artificial intelligence large language models in drug target discovery

in Experimental Pharmacology and Drug Discovery

Xinyu Liu
Jia Zhang
Xiaoran Wang
Maoda Teng
Guoying Wang
Xiaoming Zhou

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1597351

258 views

Original Research

Accepted on 07 Jul 2025

Study on the Mechanism of No. 8 Burn Ointment in Burn Treatment Based on Network Pharmacology and Experimental Verification

in Experimental Pharmacology and Drug Discovery

Le Qiu
Danlei Xing
Yuanqiang Zhu
Zhiwei Zhuang
Yexiang Sun
Peng Gong
Xu-Lin Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1511741

157 views

Brief Research Report

Accepted on 07 Jul 2025

Repurposing nicardipine leads to improved development in a young patient with Pitt-Hopkins syndrome

in Experimental Pharmacology and Drug Discovery

Marta Agnes Somorai
Sean Ekins
Clara Lettl
Claudia Rupprecht
Volker Mall

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1592011