Frontiers in Pharmacology | Experimental Pharmacology and Drug Discovery

Original Research

Accepted on 08 Apr 2025

Mangiferin mitigates dexamethasone-induced insulin resistance in rats: insight on vascular dysfunction and hepatic steatosis

in Experimental Pharmacology and Drug Discovery

Abdullah Q Alsaedi
Manar Nader
Dalia H. El-Kashef
Marwa Abdelmageed

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1572758

Original Research

Published on 08 Apr 2025

Identification of novel amides and alkaloids as putative inhibitors of dopamine transporter for schizophrenia using computer-aided virtual screening

in Experimental Pharmacology and Drug Discovery

Iqra Ahmad
Anam Tassawer
Muhammad Umer Khan
Muhammad Shehroz
Umar Nishan
Sheheryar Sheheryar
Hanna Dib
Mohamed A. O. Abdelfattah
Mohibullah Shah

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1509263

570 views

Hypothesis and Theory

Published on 08 Apr 2025

Quantification of signal amplification for receptors: the Kd/EC50 ratio of full agonists as a gain parameter

in Experimental Pharmacology and Drug Discovery

Peter Buchwald

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1541872

201 views

Original Research

Published on 08 Apr 2025

Molecular mechanisms of the anchang group prescription in treating radiation enteritis: network pharmacology analysis and experimental evidence

in Experimental Pharmacology and Drug Discovery

Wei Liang
Bo Li
Yuehong Sun
Dapeng Jia
Tingting Hu
Rujing Huang
Zhilong Liu
Huan Yang
Baocai Chen
Xiaoming Yin

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1524925

241 views

Original Research

Published on 08 Apr 2025

Synergistic chemo-immunotherapy for osteosarcoma via a pH-responsive multi-component nanoparticle system

in Experimental Pharmacology and Drug Discovery

Dapeng Li
Yuanfan Li
Jie Cang
Xianwen Yan
Feipeng Wu
Xuan Sun
Wenchao Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1584245

209 views

Original Research

Accepted on 07 Apr 2025

Acrylamide and Bisphenol A: Two Plastic Additives Increase Platelet Activation, via Oxidative Stress

in Experimental Pharmacology and Drug Discovery

Carlos Felipe Burgos
Diego Mendez
Santiago Quintana
Slawomir Gonkowski
Andrés Trostchansky
Marcelo Alarcon

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1526374

132 views

Original Research

Accepted on 07 Apr 2025

7-α-O-Methylmorroniside ameliorated brain injury in 5×FAD mice by regulating the gut microbiome and NMDAR2B

in Experimental Pharmacology and Drug Discovery

Fengxiao Hao
Mengnan Zeng
Bing Cao
Xiwen Liang
Zhiyou Hao
Kaili Ye
Xinmian Jiao
Weisheng Feng
Xiaoke Zheng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1545566

Original Research

Accepted on 07 Apr 2025

Comprehensive characterisation of the active ingredients of Smilax glabra Roxb based on chemical fingerprinting, metabolic fingerprinting and pharmacodynamic fingerprinting

in Experimental Pharmacology and Drug Discovery

Yuefen Lou
Wenqing Shi
Mengqi Jia
Xiao Li
Xin Zhao
Chenxi Wang
Guorong Fan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1519054

Review

Accepted on 07 Apr 2025

Exosomes as natural vectors for therapeutic delivery of bioactive compounds in skin diseases

in Experimental Pharmacology and Drug Discovery

Somayeh Keshtkar
Haniyeh Najafi
Mozhdeh Heidari
Maryam Kaviani
Fatemeh Sabet Sarvestani
Zahra Asvar
Alimohammad Tamaddon
Maryam Sadat Sadati
Nasrin Hamidizadeh
Negar Azarpira

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1485769

Original Research

Published on 07 Apr 2025

Pharmacophore-based virtual screening and in silico investigations of small molecule library for discovery of human hepatic ketohexokinase inhibitors for the treatment of fructose metabolic disorders

in Experimental Pharmacology and Drug Discovery

Tilal Elsaman
Magdi Awadalla Mohamed
Abozer Y. Elderdery
Abdullah Alsrhani
Badr Alzahrani
Heba Bassiony Ghanem
Jeremy Mills
Musaed Rayzah
Nasser A. N. Alzerwi
Afnan Al-sultan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1531512

361 views

Original Research

Published on 07 Apr 2025

Ocular pharmacokinetics of intravitreal conbercept in a rabbit model following retinal scatter laser photocoagulation

in Experimental Pharmacology and Drug Discovery

Lanlan Chen
Hua Liu
Qingrong Zhang
Houbin Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1534048

190 views

Original Research

Accepted on 04 Apr 2025

Irisin Attenuates Cardiac Injury and Improves Prognosis in Rats with Hemorrhagic Shock by Maintaining Mitochondrial Homeostasis via the AMPK/Drp1 Pathway

in Experimental Pharmacology and Drug Discovery

Zheng Zhang
Zheng Zhang
Xiaofang Zou
Jiake Li
Yunfei Chi
Hailiang Bai
Bin Wei
Huiting Yu
Quanxi Zhang
Weihua Cao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1560608

313 views

Original Research

Accepted on 04 Apr 2025

The Protective Role of Vitamin C against Linezolid Induced Hepato-Renal Toxicity in Rat Model

in Experimental Pharmacology and Drug Discovery

Shaimaa M Azzam
Hend M Anwar
Ahmed Altantewy
Marwa S M Diab
Halima Mohamed Ibrahim
Abdalrahman Mohammed Yousef
Fatma Sabry
Ibrahim Darwish
Kalidasan Kaliyamoorthy
Gad Elsayed Mohamed Salem

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1551062

Review

Published on 03 Apr 2025

Protein structure prediction via deep learning: an in-depth review

in Experimental Pharmacology and Drug Discovery

Yajie Meng
Zhuang Zhang
Chang Zhou
Xianfang Tang
Xinrong Hu
Geng Tian
Jialiang Yang
Yuhua Yao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1498662

729 views

Original Research

Published on 03 Apr 2025

Transdermal delivery of traditional Chinese medicine patch vs. NSAIDs patch for alleviating inflammation and relieving pain for early-stage knee osteoarthritis: a retrospective case control study

in Experimental Pharmacology and Drug Discovery

Shoufeng Wang
Jingtao Guan
Wanran Gong
Bingbo Bao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1549883

342 views

Original Research

Published on 02 Apr 2025

Chromium and formoterol therapy for obesity-induced asthma in rats

in Experimental Pharmacology and Drug Discovery

Rania T. Ibrahim
Yasser M. Moustafa
Maha Abdullah Alwaili
Amjad N. Alrebdi
Afaf Alharthi
Noha R. Noufal
Dina M. Khodeer

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1537022

547 views