Frontiers in Pharmacology | Experimental Pharmacology and Drug Discovery

Review

Published on 23 Jun 2025

Utilizing small molecules to probe and harness the proteome by pooled protein tagging with ligandable domains

in Experimental Pharmacology and Drug Discovery

Katherine E. Larrimore
Yevgeniy V. Serebrenik

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1593844

442 views

Original Research

Accepted on 20 Jun 2025

The Effect of Preventive Administration of metaraminol on Hypothermia and Shivering in Cesarean Section Patients Randomized Clinical Trial --A randomized controlled study

in Experimental Pharmacology and Drug Discovery

Letao Yu
Qizhu FENG
Chengwen Lei
Ziyi Zhang
Lili Li
Wenzhe Shen
Jun Shi
Liu Minghong
Rui Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1631503

211 views

Original Research

Accepted on 20 Jun 2025

Molecular Mechanisms of Dose-Dependent Regulation of Hepatic Lipid Metabolism by BaP through Modulation of AhR Binding to XRE1 or XRE3

in Experimental Pharmacology and Drug Discovery

Mengdi Zhang
Xiaoli Lv
Chaojie Wang
Lei Wang
Han Wang
Xue Wang
Yulu Du
Jun Li
Xiuli Han
Lei Fan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1595566

179 views

Original Research

Published on 20 Jun 2025

KETAMIR-2, a new molecular entity and novel ketamine analog

in Experimental Pharmacology and Drug Discovery

Itzchak Angel
Rita Perelroizen
Wendy Deffains
Florian W. Adraoui
Eddy Pichinuk
Erez Aminov

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1606976

1,932 views

Original Research

Published on 20 Jun 2025

Ginsenoside Re ameliorates thioacetamide-induced acute liver injury through inhibiting autophagy-NLRP3 inflammasome pathway

in Experimental Pharmacology and Drug Discovery

Jing Lin
Huan Wang
Ruowei Zhao
Shaohua Li
Dennis Chang
Yanfang Zheng
Xian Zhou
Rui Huang
Mingqing Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1592203

324 views

Original Research

Accepted on 19 Jun 2025

Predicting protein interactions for drug target discovery using stacked denoising autoencoders and random ferns

in Experimental Pharmacology and Drug Discovery

Yang Li
Yan-Qiu Wang
ChangQing Yu
Chen Jiang
Tailong Shi
Sizhe Liang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1631327

160 views

Review

Accepted on 19 Jun 2025

Milk-Derived Extracellular Vesicles: Nature's Nanocarriers for Drug Delivery and Therapeutics

in Experimental Pharmacology and Drug Discovery

Chen Kong
Long-Bin Huang
Mei-feng Yang
Ning-Ning Yue
Yuan Zhang
Tian Cheng-mei
Yuan-Hui Wang
Dao-Ru Wei
Rui-Yue Shi
Yujie Liang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1595891

458 views

Original Research

Accepted on 19 Jun 2025

Biased antagonism of a series of bicyclic CXCR2 intracellular allosteric modulators

in Experimental Pharmacology and Drug Discovery

Brent Van Bosstraeten
Katrijn Boon
Max Van Hoof
Wim Dehaen
Martyna Szpakowska
Andy Chevigné
Dominique Schols
Steven De Jonghe
Tom Van Loy

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1631129

Original Research

Published on 18 Jun 2025

Innovative pH-responsive alginate-coated rosuvastatin-loaded chitosan nanoparticles: a targeted approach to inhibiting HMGB1-activated RAGE/TLR4-NFκB signaling in colonic inflammation in rats

in Experimental Pharmacology and Drug Discovery

Elsayed A. Elmorsy
Sameh Saber
Zubida M. Al-Majdoub
Rabab S. Hamad
Mustafa Ahmed Abdel-Reheim
Asmaa Ramadan
Norah Suliman Alsoqih
Mariam S. Alharbi
Hamad Alsaykhan
Alshaimaa A. Farrag

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1546010

622 views

Original Research

Published on 18 Jun 2025

Modified Zexie decoction improves phlegm-dampness type stage I hypertension by regulating the gut-immune-kidney axis

in Experimental Pharmacology and Drug Discovery

Zeqi Hu
Jiujie Jia
Yiyan Su
Yihao Gu
Bingbing Cheng
Ninghua Jiang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1578815

397 views

Original Research

Published on 18 Jun 2025

Eucommia ulmoides seed oil is a complementary food for suppressing digestive tumors

in Experimental Pharmacology and Drug Discovery

Jinzheng Wu
Liang Wen
Durairaj Karthick Rajan
Yan Liu
Xin Yang
Hao Jiang
Jinhua Yan
Bo Shu
Shubing Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1564999

290 views

Original Research

Published on 18 Jun 2025

Structure-based discovery and experimental validation of HIT101481851 as a potential PKMYT1 inhibitor for pancreatic cancer

in Experimental Pharmacology and Drug Discovery

Ting Wang
Jingyu Wang
Gongxiong Yao
Hongchao Zhang
Chenghui Song
Xueren Ao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1605741

383 views

Original Research

Accepted on 17 Jun 2025

From radiolabeling to receptor quantification: Preclinical assessment of [⁹⁹ᵐTc]Tc-carvedilol as a cardiac β-adrenoceptor probe

in Experimental Pharmacology and Drug Discovery

Hala F Azhari

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1581598

210 views

Original Research

Accepted on 17 Jun 2025

PolyLLM: Polypharmacy Side Effect Prediction via LLM-Based SMILES Encodings

in Experimental Pharmacology and Drug Discovery

Sadra Hakim
Alioune Ngom

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1617142

152 views

Original Research

Published on 17 Jun 2025

Decoding the therapeutic mechanism of Conocarpus lancifolius in hepatocellular carcinoma: network pharmacology, molecular docking, and LC-MS QTOF insights

in Experimental Pharmacology and Drug Discovery

Poojaben M. Prajapati
Saumya K. Patel
Rakesh M. Rawal
Komal G. Lakhani
Rasmieh Hamid
Bharat B. Maitreya

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1582374

745 views

Review

Accepted on 16 Jun 2025

Synthetic and semi-synthetic antioxidants in medicine and food industry: A review

in Experimental Pharmacology and Drug Discovery

Jan Tauchen
Lukáš Huml
Michal Jurášek
Joe M Regenstein
Fatih Ozogul

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1599816

197 views