Frontiers in Pharmacology | Experimental Pharmacology and Drug Discovery

Review

Accepted on 11 Feb 2025

Trends in the Research and Development of Peptide Drug Conjugates: Artificial Intelligence Aided Design

in Experimental Pharmacology and Drug Discovery

Dong-E Zhang
Tong He
Tianyi Shi
Kun Huang
Anlin Peng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1553853

Original Research

Accepted on 11 Feb 2025

A universal cannabinoid CB1 and CB2 receptor TR-FRET kinetic ligand binding assay

in Experimental Pharmacology and Drug Discovery

Leire Borrega-Roman
Bradley L. Hoare
Miroslav Kosar
Roman C. Sarott
Kacper J. Patej
Jara Bouma
Morgan Scott-Dennis
Eline J. Koers
Thais Gazzi
Leonard Mach

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1469986

Review

Published on 11 Feb 2025

New strategies to enhance the efficiency and precision of drug discovery

in Experimental Pharmacology and Drug Discovery

Qi An
Liang Huang
Chuan Wang
Dongmei Wang
Yalan Tu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1550158

283 views

Methods

Published on 11 Feb 2025

KGRDR: a deep learning model based on knowledge graph and graph regularized integration for drug repositioning

in Experimental Pharmacology and Drug Discovery

Huimin Luo
Hui Yang
Ge Zhang
Jianlin Wang
Junwei Luo
Chaokun Yan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1525029

190 views

Review

Published on 11 Feb 2025

Hepatobiliary organoid research: the progress and applications

in Experimental Pharmacology and Drug Discovery

Rui-Qi Zou
Yu-Shi Dai
Fei Liu
Si-Qi Yang
Hai-Jie Hu
Fu-Yu Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1473863

166 views

Original Research

Published on 11 Feb 2025

Post-treatment of rat aflatoxicosis by camel milk and silymarin

in Experimental Pharmacology and Drug Discovery

Nahla H. Hassaneen
Shabaan A. Hemeda
Abeer F. El Nahas
Ghadeer M. Albadrani
Muath Q. Al-Ghadi
Zuhair M. Mohammedsaleh
Sabreen E. Fadl
Eman M. El-Diasty
Hader I. Sakr

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1513105

209 views

Original Research

Accepted on 10 Feb 2025

Exogenous Galectin-9 Prevents Peri-implantitis in Rats by Regulating Macrophage Polarization

in Experimental Pharmacology and Drug Discovery

Lujin Cheng
Xiaowei Ji
Huerxidai Yilihamujiang
Shuya Dong
Long Mei
Guo Lin
Qihan Tang
Zhongcheng Gong

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1533468

Original Research

Accepted on 10 Feb 2025

Novel Selective Glucocorticoid Receptor Modulator GRM-01 Demonstrates Dissociation of Anti-inflammatory Effects from Adverse Effects on Glucose and Bone Metabolism

in Experimental Pharmacology and Drug Discovery

Florian Jakob
Stephanie Hennen
MICHAEL GAUTROIS
Feras Khalil
Andrew Lockhart

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1542351

Original Research

Accepted on 10 Feb 2025

A combinatorial screening protocol for identifying novel and highly potent dual-target inhibitor of BRD4 and STAT3 for kidney cancer therapy

in Experimental Pharmacology and Drug Discovery

Shizhu Zhang
Nan Wu
Yifei Geng
Lixia Guan
Miao-Miao Niu
Jindong Li
Lusha Zhu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1560559

Review

Published on 10 Feb 2025

Optimizing therapeutic outcomes: preconditioning strategies for MSC-derived extracellular vesicles

in Experimental Pharmacology and Drug Discovery

Yuqi Song
Fengrui Liang
Weikun Tian
Erin Rayhill
Liping Ye
Xinghan Tian

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1509418

164 views

Original Research

Published on 07 Feb 2025

Anti-TNBC effects of Lappaol F by targeting epithelial-mesenchymal transition via regulation of GSK-3β/YAP/β-catenin and PI3K/AKT pathways

in Experimental Pharmacology and Drug Discovery

Qiqi Meng
Zhiping Li
Xiaofeng He
Yuanhao Hu
Guiyun Wu
Jiawen Huang
Zhuohui Luo
Yingjie Hu
Xiaoling Shen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1496511

220 views

Original Research

Accepted on 06 Feb 2025

High-Performance PBPK Model for Predicting CYP3A4 Induction-Mediated Drug Interactions: A Refined and Validated Approach

in Experimental Pharmacology and Drug Discovery

Cheng-guang Yang
Tao Chen
Wenteng Si
An-Hai Wang
Ren Hong-Can
Li Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1521068

Original Research

Accepted on 06 Feb 2025

Ursodeoxycholic and chenodeoxycholic bile acids alleviate endotoxininduced acute lung injury in rats by modulating aquaporin expression and pathways associated with apoptosis and inflammation

in Experimental Pharmacology and Drug Discovery

Tatjana Milivojac
Milkica Grabež
Ljiljana Amidžić
Alma Prtina
Aleksandra Krivokuća
Uglješa Maličević
Maja Barudžija
Milka Matičić
Snežana Uletilović
Nebojša Mandić-Kovačević

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1484292

Original Research

Accepted on 06 Feb 2025

Targeting TRPV1 channels in desensitized neural afferent pathways may help mitigate pain and lower urinary tract symptoms caused by prostatitis

in Experimental Pharmacology and Drug Discovery

ZhiPeng Jiang
Anguo Li
Wen Luo
Xike Luo
Decan Liang
Jing Li
Kaihua Tang
Lei Liu
Zongmin Long
Ruiyu Miao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1541684

Original Research

Accepted on 06 Feb 2025

Chromium and Formoterol Therapy for obesity-induced Asthma in Rats

in Experimental Pharmacology and Drug Discovery

Rania T Ibrahim
Yasser M Moustafa
Maha Abdullah Alwaili
Amjad N Alrebdi
Afaf Alharthi
Noha R Noufal
Dina Khodeer

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1537022

Original Research

Published on 06 Feb 2025

Exploring the CD3/CD56/TNF-α/Caspase3 pathway in pyrethroid-induced immune dysregulation: curcumin-loaded chitosan nanoparticle intervention

in Experimental Pharmacology and Drug Discovery

Nawal Alsubaie
Yasmina M. Abd-Elhakim
Amany Abdel-Rahman Mohamed
Tarek Khamis
Mohamed M. M. Metwally
Nawal Helmi
Afnan M. Alnajeebi
Badriyah S. Alotaibi
Amirah Albaqami
Wedad Mawkili

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1505432

274 views

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Articles

Trends in the Research and Development of Peptide Drug Conjugates: Artificial Intelligence Aided Design

A universal cannabinoid CB1 and CB2 receptor TR-FRET kinetic ligand binding assay

New strategies to enhance the efficiency and precision of drug discovery

KGRDR: a deep learning model based on knowledge graph and graph regularized integration for drug repositioning

Hepatobiliary organoid research: the progress and applications

Post-treatment of rat aflatoxicosis by camel milk and silymarin

Exogenous Galectin-9 Prevents Peri-implantitis in Rats by Regulating Macrophage Polarization

Novel Selective Glucocorticoid Receptor Modulator GRM-01 Demonstrates Dissociation of Anti-inflammatory Effects from Adverse Effects on Glucose and Bone Metabolism

A combinatorial screening protocol for identifying novel and highly potent dual-target inhibitor of BRD4 and STAT3 for kidney cancer therapy

Optimizing therapeutic outcomes: preconditioning strategies for MSC-derived extracellular vesicles

Anti-TNBC effects of Lappaol F by targeting epithelial-mesenchymal transition via regulation of GSK-3β/YAP/β-catenin and PI3K/AKT pathways

High-Performance PBPK Model for Predicting CYP3A4 Induction-Mediated Drug Interactions: A Refined and Validated Approach

Ursodeoxycholic and chenodeoxycholic bile acids alleviate endotoxininduced acute lung injury in rats by modulating aquaporin expression and pathways associated with apoptosis and inflammation

Targeting TRPV1 channels in desensitized neural afferent pathways may help mitigate pain and lower urinary tract symptoms caused by prostatitis

Chromium and Formoterol Therapy for obesity-induced Asthma in Rats

Exploring the CD3/CD56/TNF-α/Caspase3 pathway in pyrethroid-induced immune dysregulation: curcumin-loaded chitosan nanoparticle intervention