Frontiers in Pharmacology | Experimental Pharmacology and Drug Discovery

Original Research

Accepted on 17 Jun 2025

PolyLLM: Polypharmacy Side Effect Prediction via LLM-Based SMILES Encodings

in Experimental Pharmacology and Drug Discovery

Sadra Hakim
Alioune Ngom

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1617142

156 views

Original Research

Published on 17 Jun 2025

Decoding the therapeutic mechanism of Conocarpus lancifolius in hepatocellular carcinoma: network pharmacology, molecular docking, and LC-MS QTOF insights

in Experimental Pharmacology and Drug Discovery

Poojaben M. Prajapati
Saumya K. Patel
Rakesh M. Rawal
Komal G. Lakhani
Rasmieh Hamid
Bharat B. Maitreya

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1582374

754 views

Review

Accepted on 16 Jun 2025

Synthetic and semi-synthetic antioxidants in medicine and food industry: A review

in Experimental Pharmacology and Drug Discovery

Jan Tauchen
Lukáš Huml
Michal Jurášek
Joe M Regenstein
Fatih Ozogul

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1599816

198 views

Original Research

Accepted on 16 Jun 2025

MT2 Receptor Mediates Melatonin-Induced Thermogenic Program in Human Myoblasts: Insights for Circadian Syndrome and Diabesity Treatment

in Experimental Pharmacology and Drug Discovery

DIEGO SALAGRE
Juan Sanjuán-Hidalgo
Ehab Kotb Elmahallawy
Pedro P Medina
Ahmad Agil

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1633326

132 views

Original Research

Published on 13 Jun 2025

The anti-depressive role of the Pei Yuan Kai Yu formula in cerebral small vessel disease based on gut microbiota

in Experimental Pharmacology and Drug Discovery

Lixuan Yang
Yutian Ao
Yannan Li
Baoan Dai
Junnan Li
Wenzhe Duan
Kaiqiang Dong
Zhenyun Han
Rongjuan Guo

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1510250

453 views

Editorial

Published on 13 Jun 2025

Editorial: Multi-target drug discovery and design for complex health disorders

in Experimental Pharmacology and Drug Discovery

Farid A. Badria
Barbara De Filippis
Mohammed Abu El-Magd
Mostafa M. Elbadawi
Abdelrahman Hamdi
Abdullah A. Elgazar

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1633600

647 views

Review

Published on 13 Jun 2025

Lactate-induced lactylation: from basic research to clinical perspectives

in Experimental Pharmacology and Drug Discovery

Henghe Shi
Yifei Zou
Sijie Jin
Junduo Wu
Bin Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1586973

577 views

Original Research

Published on 13 Jun 2025

Reversal of ABCG2-mediated drug resistance by tinodasertib (ETC-206)

in Experimental Pharmacology and Drug Discovery

Haigan Yang
Zheshen Li
Zhuoxun Wu
Xiang Chen
Letao Bo
Harsh Patel
Bohan Zhang
Wenjun Xiong
Wei Wang
Zhe-Sheng Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1606857

394 views

Methods

Published on 12 Jun 2025

The flexibility of SABRE, a new quantitative receptor function model, when fitting challenging concentration-effect data

in Experimental Pharmacology and Drug Discovery

Barbara Olah
Vera Tarjanyi
Barbara Takacs
Edua Pluzsnyik
Gabor Viczjan
Ignac Ovari
Zoltan Szilvassy
Bela Juhasz
Judit Zsuga
Tamas Erdei

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1591761

649 views

Original Research

Published on 12 Jun 2025

Flavonoid-mediated biofilm inhibition and toxicological evaluation of Atriplex laciniata against multidrug-resistant MRSA

in Experimental Pharmacology and Drug Discovery

Bandar Almutairy

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1577052

568 views

Correction

Published on 12 Jun 2025

Corrigendum: A telomere-related signature for predicting prognosis and assessing immune microenvironment in osteosarcoma

in Experimental Pharmacology and Drug Discovery

Shihao Li
Lina Zhang
Haiyang Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1600217

548 views

Opinion

Published on 12 Jun 2025

Prodrug–carboxypeptidase G2 therapy: certain concerns on carboxypeptidase G2

in Experimental Pharmacology and Drug Discovery

Tinghe Yu
Tianran Yu
Xinya Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1560834

1,063 views

Original Research

Published on 11 Jun 2025

Understanding the molecular basis of herbal medicines for cough variant asthma under the guidance of traditional herbal theories

in Experimental Pharmacology and Drug Discovery

Rui Liu
Jiaqi Yao
Yihang Sui
Yinnan Zhang
Boon Seng Kho
Yingli Zhu
Ninghua Tan
Yinyin Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1594308

626 views

Review

Published on 11 Jun 2025

Potential of functional flavonoids in targeting vasospasm through modulation of oxidative stress and SPC-induced signaling pathways

in Experimental Pharmacology and Drug Discovery

Ying Zhang
Sho Maejima
Kentaro Matsuzaki
Hiroko Kishi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1594060

532 views

Systematic Review

Published on 10 Jun 2025

Analysis of research trends and development prospects of soluble guanylate cyclase stimulators/activators: using bibliometric methods

in Experimental Pharmacology and Drug Discovery

Bing Ju Yan
Jing Zhang
Jun Wang
Hong Xia Yuan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1501330

979 views

Correction

Published on 10 Jun 2025

Corrigendum: Neuroprotective effects of a novel peptide through the Rho-integrin-Tie2 and PI3K/Akt pathways in experimental autoimmune encephalomyelitis model

in Experimental Pharmacology and Drug Discovery

Wen Zhou
Han Qu
Xiao-Xiao Fu
Miao-Miao Xu
Qiang Li
Yuan Jiang
Shu Han

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1611105

476 views