Frontiers in Pharmacology | Experimental Pharmacology and Drug Discovery

Original Research

Published on 06 Feb 2025

Preclinical pharmaco-toxicological screening of biomimetic melanin-like nanoparticles as a potential therapeutic strategy for cutaneous melanoma

in Experimental Pharmacology and Drug Discovery

Iasmina Marcovici
Raul Chioibas
Istvan Zupko
Iulia Pinzaru
Alina Moaca
Adriana Ledeti
Lucian Barbu-Tudoran
Andreea Geamantan
Iasmina Predescu
Cristina Adriana Dehelean

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1487854

203 views

Review

Published on 05 Feb 2025

SOX9: a key transcriptional regulator in organ fibrosis

in Experimental Pharmacology and Drug Discovery

Yishuo Li
Yue Xing
Ning Liu
Bin Liu
Zhihui Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1507282

210 views

Original Research

Published on 05 Feb 2025

Discovering broad-spectrum inhibitors for SARS-CoV-2 variants: a cheminformatics and biophysical approach targeting the main protease

in Experimental Pharmacology and Drug Discovery

Safar M. Alqahtani

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1459581

414 views

Original Research

Accepted on 03 Feb 2025

Discovery of highly potent and novel LSD inhibitors for the treatment of acute myeloid leukemia: structure-based virtual screening, molecular dynamics simulation, and biological evaluation

in Experimental Pharmacology and Drug Discovery

Ziyi Hao
Yuting Wang
Xingxia Zhang
Yejun Si
Guoqiang Lin
Shurong Zhang
Miao-Miao Niu
Yanming Zhang
Xiaotian Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1510319

Review

Accepted on 03 Feb 2025

The Role of Neuropeptides in Bone Metabolism and Their Regulation by Anti-Osteoporosis Traditional Chinese Medicine The role of neuropeptides in bone metabolism and related anti-osteoporosis traditional Chinese medicine

in Experimental Pharmacology and Drug Discovery

Qing Lin
Biyi Zhao
Rumeng Chen
Jiajia Huang
Weipeng Sun
Qianyun Ye
Yang Li
Xiaofeng Zhu
Xiaoyun Li
Ronghua Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1516038

Original Research

Published on 03 Feb 2025

Discovery of novel and highly potent small molecule inhibitors targeting FLT3-ITD for the treatment of acute myeloid leukemia using structure-based virtual screening and biological evaluation

in Experimental Pharmacology and Drug Discovery

Kun Shi
Ye Hong
Huajing Liu
Xiaotian Yang
Fengzhen Wang
Yanming Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1511257

340 views

Original Research

Published on 03 Feb 2025

Gallic acid protects intervertebral disc cells from ferroptosis and alleviates intervertebral disc degeneration by regulating key factors of oxidative stress

in Experimental Pharmacology and Drug Discovery

Zaishi Zhu
Zeling Huang
Chaofeng Zhang
Bo Xu
Hua Chen
Shuai Pei
Baofei Zhang
Lishi Jie
Xiaoqing Shi
Yujiang Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1501725

327 views

Original Research

Published on 31 Jan 2025

Corneal protective effects of a new ophthalmic formulation based on vitamin B12 and sodium hyaluronate

in Experimental Pharmacology and Drug Discovery

Francesca Lazzara
Federica Conti
Grazia Maugeri
Velia D’Agata
Ludovica Sotera
Claudio Bucolo

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1548213

418 views

Original Research

Published on 31 Jan 2025

Preparation of Tragopogon graminifolius-loaded electrospun nanofibers and evaluating its wound healing activity in a rat model of skin scar

in Experimental Pharmacology and Drug Discovery

Leila Almasi
Elham Arkan
Mohammad Hosein Farzaei
Amin Iranpanah
Cyrus Jalili
Fatemeh Abbaszadeh
Faranak Aghaz
Sajad Fakhri
Javier Echeverría

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1533010

312 views

Original Research

Published on 30 Jan 2025

Prediction of traditional Chinese medicine for diabetes based on the multi-source ensemble method

in Experimental Pharmacology and Drug Discovery

Bin Yang
Qingyun Chi
Xiang Li
Jinglong Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1454029

772 views

Original Research

Published on 29 Jan 2025

Jiawei Suanzaoren decoction for the treatment of perimenopausal insomnia: clinical observation and experimental study

in Experimental Pharmacology and Drug Discovery

Li-Qiong Chen
Yong-Can Zhou
Fang Ning
Ming-Jin Zhu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1495957

444 views

Editorial

Published on 29 Jan 2025

Editorial: Advances in the pharmacotherapy of chronic pelvic pain conditions

in Experimental Pharmacology and Drug Discovery

Elena Lucarini
Javier Aguilera-Lizarraga
Miguel Ángel Tejada

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1546059

441 views

Editorial

Published on 29 Jan 2025

Editorial: Cell cycle modulators: regulating the basic unit of life for disease treatment and tissue regeneration

in Experimental Pharmacology and Drug Discovery

Roberta Giordo
Audra N. Iness
Udhaya Kumar

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1554529

242 views

Review

Published on 29 Jan 2025

Advance in identified targets of berberine

in Experimental Pharmacology and Drug Discovery

Penghai Sun
Ziyuan Wang
Yinchao Ma
Yuan Liu
Yintong Xue
Yan Li
Xiang Gao
Yuedan Wang
Ming Chu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1500511

465 views

Review

Published on 29 Jan 2025

Polymers for the treatment of Alzheimer’s disease

in Experimental Pharmacology and Drug Discovery

Yunfeng Zhu
Haibin Xu
Chaoyan Yu
Wenting Jiang
Xiaowen Hou
Mingyue Ma
Ji Wu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1512941

460 views

Editorial

Published on 29 Jan 2025

Editorial: Activation of the cGAS-STING pathway by extra-nuclear DNA and its pharmacognostic modulation in human disease

in Experimental Pharmacology and Drug Discovery

Preston M. McCourt
Charles A. Day
Souren Paul

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1519429

393 views

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Articles

Preclinical pharmaco-toxicological screening of biomimetic melanin-like nanoparticles as a potential therapeutic strategy for cutaneous melanoma

SOX9: a key transcriptional regulator in organ fibrosis

Discovering broad-spectrum inhibitors for SARS-CoV-2 variants: a cheminformatics and biophysical approach targeting the main protease

Discovery of highly potent and novel LSD inhibitors for the treatment of acute myeloid leukemia: structure-based virtual screening, molecular dynamics simulation, and biological evaluation

The Role of Neuropeptides in Bone Metabolism and Their Regulation by Anti-Osteoporosis Traditional Chinese Medicine The role of neuropeptides in bone metabolism and related anti-osteoporosis traditional Chinese medicine

Discovery of novel and highly potent small molecule inhibitors targeting FLT3-ITD for the treatment of acute myeloid leukemia using structure-based virtual screening and biological evaluation

Gallic acid protects intervertebral disc cells from ferroptosis and alleviates intervertebral disc degeneration by regulating key factors of oxidative stress

Corneal protective effects of a new ophthalmic formulation based on vitamin B12 and sodium hyaluronate

Preparation of Tragopogon graminifolius-loaded electrospun nanofibers and evaluating its wound healing activity in a rat model of skin scar

Prediction of traditional Chinese medicine for diabetes based on the multi-source ensemble method

Jiawei Suanzaoren decoction for the treatment of perimenopausal insomnia: clinical observation and experimental study

Editorial: Advances in the pharmacotherapy of chronic pelvic pain conditions

Editorial: Cell cycle modulators: regulating the basic unit of life for disease treatment and tissue regeneration

Advance in identified targets of berberine

Polymers for the treatment of Alzheimer’s disease

Editorial: Activation of the cGAS-STING pathway by extra-nuclear DNA and its pharmacognostic modulation in human disease