Frontiers in Pharmacology | Experimental Pharmacology and Drug Discovery

Original Research

Published on 28 Nov 2025

A natural PCID2-Targeting compound suppresses hepatocellular carcinoma progression: evidence from structure-based discovery and biological evaluation

in Experimental Pharmacology and Drug Discovery

Zebanuer Yuemaierjiang
Jingjing Sun
Jiamin Song
Jiaping Huang
Huiyu Zhang
Lili Xi
Jingjing Guo
Xinyi Luo

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1687517

704 views

Original Research

Published on 28 Nov 2025

Different degrees of expression of pulmonary fibrosis signs with intratracheal administration of bleomycin at different doses in male SD rats (a study aimed at helping to select the optimal bleomycin dose for modeling pulmonary fibrosis)

in Experimental Pharmacology and Drug Discovery

Elena A. Tukhovskaya
Yulia A. Palikova
Maria S. Severyukhina
Alina M. Ismailova
Victor Palikov
Gulsara A. Slashcheva
Natalya A. Borozdina
Evgeniy S. Mikhaylov
Irina N. Kravchenko
Vitaly Kazakov

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1702991

560 views

Systematic Review

Published on 28 Nov 2025

Systematic review and network meta-analysis of the effects of plant active substance on quality of life in breast cancer patients

in Experimental Pharmacology and Drug Discovery

Lu Wang
Xiaofan Xu
Mengmeng Guo
Yanxu Dong
Helin Ding
Shuai Hao
Liqun Huo
Yuqing Song
Jun Gu
Zhenghong Yu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1622479

760 views

Original Research

Accepted on 27 Nov 2025

DDI-AttendNet: Cross Attention with Structured Graph Learning for Inter-Drug Connectivity Analysis

in Experimental Pharmacology and Drug Discovery

Jing Wang
Huili Du

Frontiers in Pharmacology

Mini Review

Published on 27 Nov 2025

The risk of developing more potent fentanyl analogs: a mini review

in Experimental Pharmacology and Drug Discovery

Benjamín Bustamante-Elgueta
Maikol D. Andrade
Cristóbal A. Quintul
Daniel A. Medina
Javier Campanini-Salinas

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1723733

874 views

Systematic Review

Published on 27 Nov 2025

The impact of SGLT2 inhibitors on cardiac remodeling after myocardial infarction: an updated meta-analysis of randomized controlled trials

in Experimental Pharmacology and Drug Discovery

Ma Li Xu
Hui Wang
Dan Ouyang
Hang Qi
Xin Hui Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1699066

1,077 views
1 citation

Original Research

Published on 27 Nov 2025

Photodynamic therapy with a novel photosensitizer inhibits BLM-induced pulmonary fibrosis in mice via MRC1-mediated pathway

in Experimental Pharmacology and Drug Discovery

Minghui Zhu
Nan Wang
Feiyu Zhang
Yumei Rong
Zhenyu Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1714450

810 views

Original Research

Published on 26 Nov 2025

Pentoxifylline vaginal gel improves sperm motility and vitality in asthenozoospermic males: A randomized, blinded, in vitro study

in Experimental Pharmacology and Drug Discovery

Cristina Trilla
Lidia Navarro
Mariona Rius
Juan José Espinós

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1669045

611 views

Original Research

Published on 26 Nov 2025

Resveratrol attenuates pulmonary fibrosis by inhibiting alveolar epithelial senescence via targeting SASP-related proteins: an integrated bioinformatics-experimental study

in Experimental Pharmacology and Drug Discovery

Biao Zuo
Su Yuan
Chen Luo
Xu-Qin Du
Yong-Can Wu
Li-Peng Shi
Jin-Xin Chen
Bo-Tao Chen
Jie Zhou
Yi Ren

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1680998

1,794 views

Original Research

Published on 26 Nov 2025

Identification of a novel dual-targeting peptide inhibitor of SARS-CoV-2 RBD and NRP1 through structure-based virtual screening

in Experimental Pharmacology and Drug Discovery

Nan Yao
Lixia Guan
Li Feng
Gang Wang
Yuting Wang
Miao-Miao Niu
Mei Yu
Shengnan Yin

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1691679

723 views

Original Research

Published on 26 Nov 2025

Exploring the mechanism of action of Jinqiancao granules against liver cirrhosis based on the liver-gut axis

in Experimental Pharmacology and Drug Discovery

Fan-E. Cheng
Yaxi Zhang
Shihao Zheng
Wenying Qi
Xiaomei Zhang
Size Li
Qiuyue Wang
Xiangyun Zou
Xiaoke Li
Yongan Ye

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1686535

892 views

Systematic Review

Published on 25 Nov 2025

Adjunctive esketamine in propofol-based sedation for gastrointestinal endoscopy: a systematic review and meta-analysis of randomized trials

in Experimental Pharmacology and Drug Discovery

Jiazheng Qi
Mengqiang Luo
Wenru Zong
Lingjing Zhang
Baoxuan Chen
Xiaoyu Yang
Bo Xu
Xu Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1662057

774 views

Original Research

Published on 25 Nov 2025

Opioid-free anesthesia with esketamine combined with interpectoral plane block and pectoralis-serratus plane blocks in radical mastectomy: a randomized controlled trial

in Experimental Pharmacology and Drug Discovery

Wenping Ding
Youming Deng
Nuo Sun
Rongguo Wang
Qian Liu
Yan Zhang
Meiyan Zhou
Yan Liu
Liwei Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1679423

633 views

Review

Published on 25 Nov 2025

Icariin against osteoporosis: a review of advances in molecular mechanisms to biomedical applications

in Experimental Pharmacology and Drug Discovery

Boyi Fu
Shasha Yu
Shengxiong Chen
Bo Hu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1688847

1,114 views

Original Research

Published on 24 Nov 2025

Combining mechanistic quantitative systems pharmacology modeling and patient-derived organoid testing in MET-aberrant non-small cell lung cancer for high-throughput combination efficacy analysis and personalized treatment design

in Experimental Pharmacology and Drug Discovery

Jingjing Hu
Yanyong Zhao
Qi Rao
Geli Li
Zichen Jiao
Haoxiang Wang
Yuchen Qu
Shihui Xu
Zhongze Gu
Tao Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1685468

891 views

Hypothesis and Theory

Published on 24 Nov 2025

Thiamine as a putative natural modulator of PPARγ: exploring a nutrient-based approach for type 2 diabetes

in Experimental Pharmacology and Drug Discovery

Kalpana Panati
Parasuraman Aiya Subramani
Venkata Ramireddy Narala

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1712511

639 views

Original Research

Published on 24 Nov 2025

Safety profile of lutein-based blue dyes and surgical lights

in Experimental Pharmacology and Drug Discovery

Mario R. Romano
Federica Conti
Francesca Lazzara
Barbara Parolini
Mariantonia Ferrara
Claudio Bucolo

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1704098

615 views

Original Research

Published on 21 Nov 2025

THBS1 as a candidate biomarker and fibrotic mediator in radiation-induced liver injury: insights from TMT-labeled quantitative proteomics

in Experimental Pharmacology and Drug Discovery

Zixi Wang
Tong Wu
Haixu Wang
Yawen Deng
Jing Liu
Tingting Wang
Xue Ren
Ying Sun
Haibo Zhang
Defu Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1659870

900 views

Original Research

Published on 19 Nov 2025

Ultrafine garlic powder alleviates non-alcoholic steatohepatitis by inhibiting hepatocyte ferroptosis and modulating ERK-dependent oxidative stress

in Experimental Pharmacology and Drug Discovery

Junhui Yu
Ningning Shao
Jianming Yang
Long Yang
Kaiwen Hong
Yuzhu Chen
Xiaoming Zhao
Hongzhi Yu
Tao Zhang
Jinrui Dong

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1711917

1,327 views

Editorial

Published on 19 Nov 2025

Editorial: Organoids for drug discovery

in Experimental Pharmacology and Drug Discovery

Chongyang Shen
Mingliang You
Lingzhi Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1732060

543 views

Original Research

Published on 19 Nov 2025

Leveraging multimodal learning for enhanced drug-target interaction prediction

in Experimental Pharmacology and Drug Discovery

Guo Chen
Kaixin Sun

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1639979

1,348 views

Correction

Published on 18 Nov 2025

Correction: Evaluating the efficacy of HRZE-based regimens in a high-burden murine model: a back-translational assessment of rifamycins and moxifloxacin substitutions in tuberculosis treatment

in Experimental Pharmacology and Drug Discovery

Jason E. Cummings
Lisa K. Woolhiser
Vincent Guglielmi
Machenzie Wernsman
Ashley Romano
Samantha Pauly
John T. Belisle
Nicholas D. Walter
Gregory T. Robertson
Richard A. Slayden

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1733648

493 views

Original Research

Published on 18 Nov 2025

Impact of parathyroid Hormone’s dose, timing, and delivery mode on osteoclastogenesis and osteogenesis using a human periodontal ligament fibroblast model

in Experimental Pharmacology and Drug Discovery

Wael M. I. Talbi
Elizabeth Steemers
Jolanda M. A. Hogervorst
Ton Schoenmaker
Teun J. de Vries

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1661759

1,036 views

Mini Review

Published on 14 Nov 2025

Application of network pharmacology in traditional Chinese medicine for the treatment of cardiac diseases

in Experimental Pharmacology and Drug Discovery

Xi Zhai
Xingyu Chen
Xiao Xiao
Lan Wu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1703454

1,785 views

3,848 articles

articles

A natural PCID2-Targeting compound suppresses hepatocellular carcinoma progression: evidence from structure-based discovery and biological evaluation

Different degrees of expression of pulmonary fibrosis signs with intratracheal administration of bleomycin at different doses in male SD rats (a study aimed at helping to select the optimal bleomycin dose for modeling pulmonary fibrosis)

Systematic review and network meta-analysis of the effects of plant active substance on quality of life in breast cancer patients

DDI-AttendNet: Cross Attention with Structured Graph Learning for Inter-Drug Connectivity Analysis

The risk of developing more potent fentanyl analogs: a mini review

The impact of SGLT2 inhibitors on cardiac remodeling after myocardial infarction: an updated meta-analysis of randomized controlled trials

Photodynamic therapy with a novel photosensitizer inhibits BLM-induced pulmonary fibrosis in mice via MRC1-mediated pathway

Pentoxifylline vaginal gel improves sperm motility and vitality in asthenozoospermic males: A randomized, blinded, in vitro study

Resveratrol attenuates pulmonary fibrosis by inhibiting alveolar epithelial senescence via targeting SASP-related proteins: an integrated bioinformatics-experimental study

Identification of a novel dual-targeting peptide inhibitor of SARS-CoV-2 RBD and NRP1 through structure-based virtual screening

Exploring the mechanism of action of Jinqiancao granules against liver cirrhosis based on the liver-gut axis

Adjunctive esketamine in propofol-based sedation for gastrointestinal endoscopy: a systematic review and meta-analysis of randomized trials

Opioid-free anesthesia with esketamine combined with interpectoral plane block and pectoralis-serratus plane blocks in radical mastectomy: a randomized controlled trial

Icariin against osteoporosis: a review of advances in molecular mechanisms to biomedical applications

Combining mechanistic quantitative systems pharmacology modeling and patient-derived organoid testing in MET-aberrant non-small cell lung cancer for high-throughput combination efficacy analysis and personalized treatment design

Thiamine as a putative natural modulator of PPARγ: exploring a nutrient-based approach for type 2 diabetes

Safety profile of lutein-based blue dyes and surgical lights

THBS1 as a candidate biomarker and fibrotic mediator in radiation-induced liver injury: insights from TMT-labeled quantitative proteomics

Ultrafine garlic powder alleviates non-alcoholic steatohepatitis by inhibiting hepatocyte ferroptosis and modulating ERK-dependent oxidative stress

Editorial: Organoids for drug discovery

Leveraging multimodal learning for enhanced drug-target interaction prediction

Correction: Evaluating the efficacy of HRZE-based regimens in a high-burden murine model: a back-translational assessment of rifamycins and moxifloxacin substitutions in tuberculosis treatment

Impact of parathyroid Hormone’s dose, timing, and delivery mode on osteoclastogenesis and osteogenesis using a human periodontal ligament fibroblast model

Application of network pharmacology in traditional Chinese medicine for the treatment of cardiac diseases