Frontiers in Pharmacology | Experimental Pharmacology and Drug Discovery

Original Research

Accepted on 28 Jan 2025

Microbiota and Metabolomic Profiling Coupled with Machine Learning to Identify Biomarkers and Drug Targets in Nasopharyngeal Carcinoma

in Experimental Pharmacology and Drug Discovery

Jun Song Liu
Chongwen Xu
Rui Wang
Jianhua Huang
Ruimin Zhao
Rui Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1551411

Review

Published on 28 Jan 2025

A current review on animal models of anti-asthmatic drugs screening

in Experimental Pharmacology and Drug Discovery

Shivam Singh
Sunita Kularia
Shivakshi Shukla
Mithilesh Singh
Manish Kumar
Ashish Kumar Sharma

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1508460

401 views

Original Research

Published on 28 Jan 2025

3D-QSAR, design, molecular docking and dynamics simulation studies of novel 6-hydroxybenzothiazole-2-carboxamides as potentially potent and selective monoamine oxidase B inhibitors

in Experimental Pharmacology and Drug Discovery

Dong Xie
Yongzheng Tian
Li Cao
Penghang Guo
Zhibiao Cai
Jie Zhou

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1545791

249 views

Original Research

Published on 28 Jan 2025

Compound identification of Shuangxinfang and its potential mechanisms in the treatment of myocardial infarction with depression: insights from LC-MS/MS and bioinformatic prediction

in Experimental Pharmacology and Drug Discovery

Yize Sun
Haibin Zhao
Zheyi Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1499418

443 views

Original Research

Published on 28 Jan 2025

Molecular mechanism underlying cardioprotective effect of dehydroepiandrosterone on endoplasmic reticulum stress induced apoptosis in human vascular smooth muscle cells and human umbilical vein endothelial cells

in Experimental Pharmacology and Drug Discovery

Ye Zhu
Junxiu Wei
Xin Yang
Wei Zhu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1496393

350 views

Original Research

Accepted on 27 Jan 2025

Identification of telomere-related gene subtypes and prognostic signatures in osteosarcoma

in Experimental Pharmacology and Drug Discovery

Zhaoguang Song
Wenyan Yu
Xuqing Yin

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1545913

Original Research

Accepted on 27 Jan 2025

Identification of Novel Amides and Alkaloids as Putative Inhibitors of Dopamine Transporters for Schizophrenia Using Computer-Aided Virtual Screening

in Experimental Pharmacology and Drug Discovery

Mohibullah Shah
Iqra Ahmad
Anam Tassawer
Muhammad Shehroz
Umar Nishan
Sheheryar Sheheryar
Arlindo A Moura
Riaz Ullah
Abdelaaty A Shahat
Hanna Dib

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1509263

141 views

Original Research

Accepted on 27 Jan 2025

Prognostic Value and Immune Landscape Association of LRFN4 in Lung Adenocarcinoma

in Experimental Pharmacology and Drug Discovery

Nana Wang
Shuming Cao
Xiaofeng Tan
Meirong Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1540636

Original Research

Published on 27 Jan 2025

A telomere-related signature for predicting prognosis and assessing immune microenvironment in osteosarcoma

in Experimental Pharmacology and Drug Discovery

Shihao Li
Lina Zhang
Haiyang Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1532610

271 views

Original Research

Published on 24 Jan 2025

Shengxue Busui Decoction activates the PI3K/Akt and VEGF pathways, enhancing vascular function and inhibiting osteocyte apoptosis to combat steroid-induced femoral head necrosis

in Experimental Pharmacology and Drug Discovery

Manting Liu
Jiexiang Ye
Runtian Wu
Dongqiang Luo
Tao Huang
Dandan Dai
Kexin Wang
Yanping Du
Junwen Ou

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1506594

623 views

Original Research

Published on 24 Jan 2025

Identification of retinol dehydrogenase 10 as a shared biomarker for metabolic dysfunction-associated steatotic liver disease and type 2 diabetes mellitus

in Experimental Pharmacology and Drug Discovery

Fangyu Li
Rui Li
Hongjun Deng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1521416

471 views

Original Research

Published on 23 Jan 2025

hERG activators exhibit antitumor effects in breast cancer through calcineurin and β-catenin-mediated signaling pathways

in Experimental Pharmacology and Drug Discovery

Yan Yu
Chengchun Zhu
Xiao Wang
Ying Shi
Yiping Gao
Zhiyi Yu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1545300

601 views

Original Research

Published on 23 Jan 2025

Chemical characterization and encapsulation of Ganoderma pfeifferi extract with cytotoxic properties

in Experimental Pharmacology and Drug Discovery

Jan Šťastný
Ángela Morellá-Aucejo
Tomáš Skala
Andrea Bernardos
Petr Maršík
Araceli Lérida-Viso
Jaroslav Matějka
Anna Mascellani Bergo
María Dolores Marcos
Ramón Martínez-Máñez

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1526502

345 views

Review

Published on 23 Jan 2025

A review on eye diseases induced by blue light: pathology, model, active ingredients and mechanisms

in Experimental Pharmacology and Drug Discovery

Yuan Yan
Yiyao Wu
Yu Zhao
Yaguang Yang
Guangtao An
Zhidong Liu
Dongli Qi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1513406

550 views

Original Research

Accepted on 21 Jan 2025

Melatonin protects retinal pigment epithelium cells against ferroptosis in AMD via the PI3K/AKT/MDM2/P53 pathway

in Experimental Pharmacology and Drug Discovery

Ping Wu
Long Zhao
Yong Du
Jing Lu
Yuxia He
Qinxin Shu
Hui Peng
Xing Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1543575

Editorial

Published on 21 Jan 2025

Editorial: Methods in experimental pharmacology 2023

in Experimental Pharmacology and Drug Discovery

Somasundaram Arumugam
Amit Khurana
Kala Kumar Bharani

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1531464

440 views

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Articles

Microbiota and Metabolomic Profiling Coupled with Machine Learning to Identify Biomarkers and Drug Targets in Nasopharyngeal Carcinoma

A current review on animal models of anti-asthmatic drugs screening

3D-QSAR, design, molecular docking and dynamics simulation studies of novel 6-hydroxybenzothiazole-2-carboxamides as potentially potent and selective monoamine oxidase B inhibitors

Compound identification of Shuangxinfang and its potential mechanisms in the treatment of myocardial infarction with depression: insights from LC-MS/MS and bioinformatic prediction

Molecular mechanism underlying cardioprotective effect of dehydroepiandrosterone on endoplasmic reticulum stress induced apoptosis in human vascular smooth muscle cells and human umbilical vein endothelial cells

Identification of telomere-related gene subtypes and prognostic signatures in osteosarcoma

Identification of Novel Amides and Alkaloids as Putative Inhibitors of Dopamine Transporters for Schizophrenia Using Computer-Aided Virtual Screening

Prognostic Value and Immune Landscape Association of LRFN4 in Lung Adenocarcinoma

A telomere-related signature for predicting prognosis and assessing immune microenvironment in osteosarcoma

Shengxue Busui Decoction activates the PI3K/Akt and VEGF pathways, enhancing vascular function and inhibiting osteocyte apoptosis to combat steroid-induced femoral head necrosis

Identification of retinol dehydrogenase 10 as a shared biomarker for metabolic dysfunction-associated steatotic liver disease and type 2 diabetes mellitus

hERG activators exhibit antitumor effects in breast cancer through calcineurin and β-catenin-mediated signaling pathways

Chemical characterization and encapsulation of Ganoderma pfeifferi extract with cytotoxic properties

A review on eye diseases induced by blue light: pathology, model, active ingredients and mechanisms

Melatonin protects retinal pigment epithelium cells against ferroptosis in AMD via the PI3K/AKT/MDM2/P53 pathway

Editorial: Methods in experimental pharmacology 2023