Frontiers in Pharmacology | Experimental Pharmacology and Drug Discovery

Review

Published on 11 Jun 2025

Potential of functional flavonoids in targeting vasospasm through modulation of oxidative stress and SPC-induced signaling pathways

in Experimental Pharmacology and Drug Discovery

Ying Zhang
Sho Maejima
Kentaro Matsuzaki
Hiroko Kishi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1594060

532 views

Systematic Review

Published on 10 Jun 2025

Analysis of research trends and development prospects of soluble guanylate cyclase stimulators/activators: using bibliometric methods

in Experimental Pharmacology and Drug Discovery

Bing Ju Yan
Jing Zhang
Jun Wang
Hong Xia Yuan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1501330

979 views

Correction

Published on 10 Jun 2025

Corrigendum: Neuroprotective effects of a novel peptide through the Rho-integrin-Tie2 and PI3K/Akt pathways in experimental autoimmune encephalomyelitis model

in Experimental Pharmacology and Drug Discovery

Wen Zhou
Han Qu
Xiao-Xiao Fu
Miao-Miao Xu
Qiang Li
Yuan Jiang
Shu Han

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1611105

476 views

Original Research

Published on 10 Jun 2025

Identification and evaluation of a pinocembrin analog as a TRPV1 inhibitor with analgesic properties in murine pain models

in Experimental Pharmacology and Drug Discovery

Hanbin Chen
Guanghong Li
Lin Deng
Nan Xu
Simon Ming-Yuen Lee
Xiaowei Nie
Jin-Song Bian

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1585181

758 views

Brief Research Report

Published on 10 Jun 2025

Patient-derived organoids reveal marked heterogeneity in chemosensitivity profiles of colorectal cancer and a potential association with HER2 status

in Experimental Pharmacology and Drug Discovery

Jian Liu
Dan Li
Jing Li
Wenlan Fu
Qiang Jia
Yang Bai
Axiu Huang
Fang Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1620764

580 views

Original Research

Accepted on 09 Jun 2025

Synergistic antibacterial photodynamic therapy of lysine-porphyrin conjugate and metal ions combination against Candida albicans and Mycobacterium tuberculosis

in Experimental Pharmacology and Drug Discovery

Xueming Wang
Zhonghua Qin
Ying Wen
Mingxuan Chi
Lixia Zhang
Junping Wu
Tianjun Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1626193

134 views

Original Research

Published on 09 Jun 2025

Molecular pharmacokinetic mechanism of quercetin-encapsulated polymeric micelles in alleviating cisplatin-induced nephrotoxicity and enhancing antineoplastic effects

in Experimental Pharmacology and Drug Discovery

Tangna Hao
Xiaokui Huo
Zhen Li
Changyuan Wang
Sha Wu
Anni Song
Fengyu Zhang
Kexin Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1590688

800 views

Review

Published on 09 Jun 2025

Progress in structure-based drug development targeting chemokine receptors

in Experimental Pharmacology and Drug Discovery

Jin Wang
Chen Qu
Peng Xiao
Sijin Liu
Jin-Peng Sun
Yu-Qi Ping

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1603950

1,392 views

Systematic Review

Accepted on 06 Jun 2025

Clinical pharmacokinetics of potassium competitive acid blockers: a systematic review and meta-analysis

in Experimental Pharmacology and Drug Discovery

Jongsung Hahn
Jiaqi Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1580969

136 views

Original Research

Published on 06 Jun 2025

Machine learning-driven SLC prognostic signature for glioma: predicting survival and immunotherapy response

in Experimental Pharmacology and Drug Discovery

Jianghua Lin
Xiao Yang
Kaijun Zhao
Yu’e Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1585639

758 views

Original Research

Published on 06 Jun 2025

Endovascular management of primary long-segment inferior vena cava occlusion: treatment strategies and clinical outcomes

in Experimental Pharmacology and Drug Discovery

Jianjun Jiang
Mingli Li
Guangzhen Li
Yang Liu
Qingbo Su

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1512157

528 views

Original Research

Published on 04 Jun 2025

Antimalarial compounds exhibit variant- and cell-type-specific activity against SARS-CoV-2 isolated in Panama

in Experimental Pharmacology and Drug Discovery

Mario Quijada
Marlene Castillo-Bultron
Yamilka Díaz
Yaneth Pitti
Danilo Franco
Carolina De La Guardia
Dalkiria Campos
Eduardo Cornejo
Marlon Núñez
Lariza Mendoza

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1537053

845 views

Correction

Published on 04 Jun 2025

Corrigendum: Optimized automated radiosynthesis of 18F-JNJ64413739 for purinergic ion channel receptor 7 (P2X7R) imaging in osteoporotic model rats

in Experimental Pharmacology and Drug Discovery

Yingtong Lu
Yan Cui
Lu Hou
Yuanfang Jiang
Jingjie Shang
Lu Wang
Hao Xu
Weijian Ye
Yang Qiu
Bin Guo

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1633378

616 views

Original Research

Published on 04 Jun 2025

Phosphodiesterase 7: a potential novel therapeutic target in ovarian cancer

in Experimental Pharmacology and Drug Discovery

Nayara Gusmão Tessarollo
Isabella dos Santos Guimarães
Diandra Zipinotti dos Santos
Taciane Barbosa Henriques
Paulo Cilas Morais Lyra-Junior
Josiany Carlos de Souza
Tatiana Massariol Pimenta
Bárbara da Silva Martins
Solenny Maria Silva Butzene
José Matheus Simões Padilha

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1566330

1,036 views

Original Research

Published on 04 Jun 2025

Palmitoylation-driven immune dysregulation and prognostic signature in low-grade glioma: a multi-omics and functional validation study

in Experimental Pharmacology and Drug Discovery

Zehao Wang
Tianlun Yu
Yuqiao Liu
Yufan Wu
Jingqing Hu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1586921

986 views

Systematic Review

Published on 02 Jun 2025

Mesenchymal stem cell-derived exosomes for the treatment of knee osteoarthritis: a systematic review and meta-analysis based on rat model

in Experimental Pharmacology and Drug Discovery

Zhe Wang
Zihao Hu
Lin Niu
Yongsheng Xu
Yansong Qi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1588841

1,421 views