Frontiers in Pharmacology | Experimental Pharmacology and Drug Discovery

Original Research

Published on 21 Jan 2025

A novel α-conotoxin [D1G, ΔQ14] LvIC decreased mouse locomotor activity

in Experimental Pharmacology and Drug Discovery

Wen Wang
Meiting Wang
Huanbai Wang
Weifeng Xu
Conggang Wang
Jie Pei
Xiaodan Li
Dongting Zhangsun

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1466504

517 views

Original Research

Published on 21 Jan 2025

Astaxanthin mitigates doxorubicin-induced cardiotoxicity via inhibiting ferroptosis and autophagy: a study based on bioinformatic analysis and in vivo/vitro experiments

in Experimental Pharmacology and Drug Discovery

Bowen Yin
Jingyi Ren
Xuanyi Liu
Yadong Zhang
Jinshi Zuo
Rui Wen
Huanting Pei
Miaomiao Lu
Siqi Zhu
Zhenao Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1524448

798 views

Original Research

Accepted on 20 Jan 2025

Deciphering the Role of Wnt/β-Catenin and miR-214 in Knee Osteoarthritis: Molecular and Clinical Insights

in Experimental Pharmacology and Drug Discovery

waad A Samman
Esraa M. Mosalam
Dalia S. Saif
Mahmoud S. Abdallah
Abdel-Aziz Awad Zidan
Amany Said Sallam
Shimaa Abdelsattar
Fatma Khalil
Amany E. Elashkar
Somia Mokabel Mohamed

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1507693

Original Research

Published on 20 Jan 2025

α-methyltryptophan-mediated protection against diabetic nephropathy in db/db mice as studied with a metabolomics approach

in Experimental Pharmacology and Drug Discovery

Aimin Cai
Dingchao Shen
Qiushuang Xiong
Jie Ding
Yang Ding
Xinlu Lin
Lijia Chen
Qing Yao
Guangyong Lin
Ruijie Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1463673

586 views

Original Research

Published on 20 Jan 2025

4,6-Disubstituted pyrimidine-based microtubule affinity-regulating kinase 4 (MARK4) inhibitors: synthesis, characterization, in-vitro activity and in-silico studies

in Experimental Pharmacology and Drug Discovery

Ashanul Haque
Khalaf M. Alenezi
Mohd. Saeed Maulana Abdul Rasheed
Md. Ataur Rahman
Saleha Anwar
Shahzaib Ahamad
Dinesh Gupta

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1517504

521 views

Original Research

Published on 20 Jan 2025

Nicotine’s impact on platelet function: insights into hemostasis mechanisms

in Experimental Pharmacology and Drug Discovery

Xiayu Wu
Yongjun Liu
Changhao Zou
Fuqin He
Fang Guo
Sijia Liu
Yi Fan
Xuedong Zhu
Qianyi Zhou
Dan Shu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1512142

673 views

Review

Published on 20 Jan 2025

Research progress of GLP-1RAs in the treatment of type 2 diabetes mellitus

in Experimental Pharmacology and Drug Discovery

Xu He
Wei Zhao
PeiHang Li
YinJiang Zhang
GuoHua Li
HongYu Su
BiNan Lu
ZongRan Pang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1483792

1,163 views

Original Research

Published on 17 Jan 2025

Elocalcitol, a fluorinated vitamin D derivative, prevents high-fat diet-induced obesity via SCAP downregulation and miR-146a-associated mechanisms

in Experimental Pharmacology and Drug Discovery

Monika Jürgenson
Keerthana Chithanathan
Aivar Orav
Külli Jaako
Janeli Viil
Mithu Guha
Kalev Kask
Alexander Zharkovsky

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1505729

1,315 views

Original Research

Published on 15 Jan 2025

The chiisanoside derivatives present in the leaves of Acanthopanax sessiliflorus activate autophagy through the LRP6/GSK3β axis and thereafter inhibit oxidative stress, thereby counteracting cisplatin-induced ototoxicity

in Experimental Pharmacology and Drug Discovery

Wenxin Zhang
Hongbo Teng
Tianyi Zhao
Roberts I. Eglitis
Xv Wang
Zhengxuan Yu
Shurong Qu
Haijing Wang
Yaru Zhao
Bowen Fan

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1518810

684 views

Original Research

Published on 15 Jan 2025

Dexmedetomidine improves clinical outcomes in sepsis-induced myocardial injury: a retrospective cohort study

in Experimental Pharmacology and Drug Discovery

Yuan Liu
Jianjie Ouyang
Cuicui Zhang
Pingping Niu
Baoling Shang
Gengzhen Yao
Yongyong Shi
Xu Zou

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1529167

546 views

Systematic Review

Published on 15 Jan 2025

Protective effect of resveratrol on retinal damage in glaucoma: a systematic review and meta-analysis of preclinical studies

in Experimental Pharmacology and Drug Discovery

Feng Zhang
Tao Li
Junli Wan
Lu Wang
Wenmei Guo
Yue Hu
Hao Wang
Wei Bian

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1521188

856 views

Original Research

Accepted on 14 Jan 2025

Integrating Traditional Omics and Machine Learning Approaches to Identify Microbial Biomarkers and Therapeutic Targets in Pediatric Inflammatory Bowel Disease

in Experimental Pharmacology and Drug Discovery

Lanlan Li
Xuzai Deng
Shuge Wang
Zhuyuan Huang
Huang Tao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1545392

Editorial

Accepted on 14 Jan 2025

Editorial: Education and Training in Pharmaceutical Medicine, Medicines Development and Medicines Regulation

in Experimental Pharmacology and Drug Discovery

Bernd Rosenkranz
Tomoya Tachi
Andrei Mocan
Rolf Bass

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1544678

Original Research

Published on 14 Jan 2025

Therapeutic potential of rutin in premenstrual depression: evidence from in vivo and in vitro studies

in Experimental Pharmacology and Drug Discovery

Xiangjun Wang
Xiaowen Xia
Xianliang Song
Yi Zhou
Mingyu Ma
Yashuang Ren
Xitai Chen
Zenghui Xia
Yinghui Guo
Chunhong Song

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1525753

750 views

Original Research

Accepted on 13 Jan 2025

Celastrol reduces cisplatin-induced nephrotoxicity by downregulating SNORD3A level in kidney organoids derived from human iPSCs

in Experimental Pharmacology and Drug Discovery

Chongyang Shen
Qizheng Wang
Xun Ye
Yi Zhou
Huayang Xing
Chunjie Wu
Mingliang You

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1464525

Original Research

Published on 09 Jan 2025

Repurposing the prostaglandin analogue treprostinil and the calcium-sensing receptor modulator cinacalcet to revive cord blood as an alternate source of hematopoietic stem and progenitor cells for transplantation

in Experimental Pharmacology and Drug Discovery

Michaela Prchal-Murphy
Julia Zehenter
Marlene Fischer
Anita Pirabe
Madeleine Themanns
Behnaz Afrashteh
Eva Maria Putz
Karoline Kollmann
José Basílio
Manuel Salzmann

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1444311

650 views

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Articles

A novel α-conotoxin [D1G, ΔQ14] LvIC decreased mouse locomotor activity

Astaxanthin mitigates doxorubicin-induced cardiotoxicity via inhibiting ferroptosis and autophagy: a study based on bioinformatic analysis and in vivo/vitro experiments

Deciphering the Role of Wnt/β-Catenin and miR-214 in Knee Osteoarthritis: Molecular and Clinical Insights

α-methyltryptophan-mediated protection against diabetic nephropathy in db/db mice as studied with a metabolomics approach

4,6-Disubstituted pyrimidine-based microtubule affinity-regulating kinase 4 (MARK4) inhibitors: synthesis, characterization, in-vitro activity and in-silico studies

Nicotine’s impact on platelet function: insights into hemostasis mechanisms

Research progress of GLP-1RAs in the treatment of type 2 diabetes mellitus

Elocalcitol, a fluorinated vitamin D derivative, prevents high-fat diet-induced obesity via SCAP downregulation and miR-146a-associated mechanisms

The chiisanoside derivatives present in the leaves of Acanthopanax sessiliflorus activate autophagy through the LRP6/GSK3β axis and thereafter inhibit oxidative stress, thereby counteracting cisplatin-induced ototoxicity

Dexmedetomidine improves clinical outcomes in sepsis-induced myocardial injury: a retrospective cohort study

Protective effect of resveratrol on retinal damage in glaucoma: a systematic review and meta-analysis of preclinical studies

Integrating Traditional Omics and Machine Learning Approaches to Identify Microbial Biomarkers and Therapeutic Targets in Pediatric Inflammatory Bowel Disease

Editorial: Education and Training in Pharmaceutical Medicine, Medicines Development and Medicines Regulation

Therapeutic potential of rutin in premenstrual depression: evidence from in vivo and in vitro studies

Celastrol reduces cisplatin-induced nephrotoxicity by downregulating SNORD3A level in kidney organoids derived from human iPSCs

Repurposing the prostaglandin analogue treprostinil and the calcium-sensing receptor modulator cinacalcet to revive cord blood as an alternate source of hematopoietic stem and progenitor cells for transplantation