Frontiers in Pharmacology | Experimental Pharmacology and Drug Discovery

Original Research

Published on 23 May 2025

No significant gender differences in driving-related skills following alcohol mixed with energy drinks during an experimental binge-drinking episode

in Experimental Pharmacology and Drug Discovery

Olga Hladun
Esther Papaseit
Lourdes Poyatos
Soraya Martín
Ana Pilar Pérez-Acevedo
Ana Maria Barriocanal
Tatiana Bustos-Cardona
Susana Malumbres
Rafael De La Torre
Klaus Langohr

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1581229

1,057 views

Original Research

Published on 22 May 2025

Repurposing of the small-molecule adrenoreceptor-inhibitor carvedilol for treatment of the fibrotic lung

in Experimental Pharmacology and Drug Discovery

Maria Jordan
Kevin Schmidt
Maximilian Fuchs
Annette Just
Angelika Pfanne
Lena Willmer
Lavinia Neubert
Christopher Werlein
Patrick Zardo
Andreas Pich

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1534989

1,601 views

Original Research

Published on 22 May 2025

Exploring the molecular mechanisms of huperzine a in the treatment of rosacea through network pharmacology, machine learning, and molecular dynamics simulations

in Experimental Pharmacology and Drug Discovery

Xin Luo
Suhan Yang
Lian Zhong
Peng Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1586829

1,126 views

Review

Published on 22 May 2025

From malaria fighter to diabetes guardian: the emerging role of artesunate in treating diabetes and diabetic complications

in Experimental Pharmacology and Drug Discovery

Dongze Li
Qingyue Liang
Linghao Xu
Li Zhang
Qiming Gong
Tingting Zhou
Changfang Luo
Wei Huang
Yuan Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1583575

989 views

Systematic Review

Published on 21 May 2025

Comparative efficacy of teriparatide and bisphosphonates or denosumab vs. teriparatide monotherapy in osteoporosis: a meta-analysis

in Experimental Pharmacology and Drug Discovery

Huan Jin
Cai Huang
Yan Zhang
Ying Dong
Qi Xiong
Di Wang
Ziyi He
Lin Shen
Chen Ma
Zixian Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1605279

1,467 views

Original Research

Published on 21 May 2025

Effectiveness and priority of irradiation and six NSAIDs in prevention heterotopic ossification after total hip arthroplasty: a network meta-analysis of randomized controlled studies

in Experimental Pharmacology and Drug Discovery

Fei Yang
Lei Wen
Changshun Chen
Qiao Zhao
Zhiwei Feng
Bin Ran
Xuwei Luo
Dongqin Xiao
Qifan Fang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1601349

912 views

Original Research

Published on 21 May 2025

Metabolomics combined with molecular docking and dynamics simulation to investigate the mechanism of action of Fibraurea recisa Pierre in the treatment of chronic urticaria

in Experimental Pharmacology and Drug Discovery

Tian Xiao
Jie Tao
Jiaoyang Tan
Zhourong Zhao
Liping Yang
Chao Zhang
Xiaohua Duan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1571819

839 views

Original Research

Published on 20 May 2025

LncRNA OIP5-AS1 suppresses lung adenocarcinoma progression and modulates macrophage polarization through the miR-429/DOCK4 regulatory axis

in Experimental Pharmacology and Drug Discovery

Yihan Liu
Yuhua Wang
Long Cui
Runze Li
Dan Xiao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1569644

883 views

Original Research

Published on 20 May 2025

Exploring the antidiabetic potential of Octhochloa compressa: a comprehensive study on chemical profiling, in vitro, in vivo and in silico pharmacological properties

in Experimental Pharmacology and Drug Discovery

Jawaria Aslam
Mirza Imran Shahzad
Hanan Y. Aati
Kashif-ur-Rehman Khan
Maria Aslam
Athar Jamal
Umar Farooq
Bilal Ahmad Ghalloo

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1541482

683 views

Systematic Review

Published on 20 May 2025

From basic to clinical translation: advances and perspectives of photodynamic nanodrugs

in Experimental Pharmacology and Drug Discovery

Shitang Ma
Shasha Shi
Xin Hu
Ye Zhao
Boran Yang
Maoliang Liao
Baowei Lu
Qilin Xu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1606372

960 views

Editorial

Published on 19 May 2025

Editorial: Exploring new therapeutic frontiers in Glaucoma: from molecular targets to patient outcomes

in Experimental Pharmacology and Drug Discovery

Silvia Sgambellone
Arianna Carolina Rosa
Ana Raquel Santiago
Ivana Josimovic
Laura Lucarini

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1624534

697 views

Original Research

Published on 19 May 2025

Gambogic acid targets HSP90 to alleviate DSS-induced colitis via inhibiting the necroptosis of intestinal epithelial cells

in Experimental Pharmacology and Drug Discovery

Yuanyuan Wang
Siqi Liu
Keyi Lu
Erping Xu
Zhibin Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1586705

1,005 views

Original Research

Published on 16 May 2025

Discovery of non-covalent rhinovirus 3Cpro inhibitors by molecular docking, in vitro assays, molecular dynamics simulations and DFT analyses

in Experimental Pharmacology and Drug Discovery

Susu Zhang
Keli Zong
Jiajun Ruan
Xiaojing Liu
Xu Zhao
Youzhi Zhang
Chun Hu
Xingzhou Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1560571

864 views

Review

Published on 16 May 2025

Circular RNAs as disease modifiers of complex neurologic disorders

in Experimental Pharmacology and Drug Discovery

Veronica Galli
Sara Vinciguerra
Marta Biagioli
Jasmin Morandell

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1577496

1,337 views

Original Research

Published on 16 May 2025

Therapeutic potential of zinc 64Zn aspartate for obesity management: impact on oxidative stress, lipid metabolism, pancreas and liver in high-calorie diet model

in Experimental Pharmacology and Drug Discovery

Max Temnik
Sergey Gurin
Alexandr Balakin
Roman Byshovets
Olesia Kalmukova
Tetiana Vovk
Tetiana Halenova
Nataliia Raksha
Tetyana Falalyeyeva
Olexiy Savchuk

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1543166

1,135 views

Original Research

Published on 15 May 2025

Nafamostat mesylate augments survival in rats afflicted by exertional heat stroke

in Experimental Pharmacology and Drug Discovery

Qingwei Lin
Zhuqing Luo
Longping He
Lincui Zhong
Qingbo Zeng
Ye Zhou
Qi Chen
Xingping Deng
Xiaomin Song
Qing Song

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1559181

864 views