Frontiers in Pharmacology | Experimental Pharmacology and Drug Discovery

Original Research

Published on 09 Jan 2025

Polydatin enhances oxaliplatin-induced cell death by activating NOX5-ROS-mediated DNA damage and ER stress in colon cancer cells

in Experimental Pharmacology and Drug Discovery

Qi Zhao
Yan Zhang
Jieyu Liu
Peipei Chen
Annabeth Onga
Namki Cho
Ri Cui
Chenguo Zheng

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1532695

595 views

Original Research

Published on 09 Jan 2025

Integrating traditional machine learning with qPCR validation to identify solid drug targets in pancreatic cancer: a 5-gene signature study

in Experimental Pharmacology and Drug Discovery

Xiaoyan Wang
Pengcheng Yu
Wei Jia
Bingbing Wan
Zhougui Ling
Yangyang Tang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1539120

479 views

Original Research

Published on 08 Jan 2025

The efficacy and safety of remimazolam besylate, ciprofol, and propofol during hysteroscopy

in Experimental Pharmacology and Drug Discovery

Weifeng Shan
Shuying Gao
Mengting Ai
Haiyan Lan
Gongchen Duan
Xiaoli Dong
Qiaomin Xu
Yini Wu
Jimin Wu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1427755

542 views

Original Research

Published on 08 Jan 2025

ITGAX promotes gastric cancer progression via epithelial-mesenchymal transition pathway

in Experimental Pharmacology and Drug Discovery

Jiali Hu
Jing Cao
Shanshan Huang
Yang Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1536478

516 views

Original Research

Published on 08 Jan 2025

Photodynamic therapy with a novel photosensitizer inhibits DSS-induced ulcerative colitis in rats via the NF-κB signaling pathway

in Experimental Pharmacology and Drug Discovery

Yumei Rong
Minghui Zhu
Nan Wang
Feiyu Zhang
Tianjun Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1539363

444 views

Original Research

Published on 07 Jan 2025

Therapeutic effects of composite probiotics derived from fermented camel milk on metabolic dysregulation and intestinal barrier integrity in type 2 diabetes rats

in Experimental Pharmacology and Drug Discovery

Tabusi Manaer
Jialehasibieke Sailike
Xin Sun
Baheban Yeerjiang
Xinhua Nabi

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1520158

704 views

Review

Published on 07 Jan 2025

Unlocking the therapeutic mechanism of Caesalpinia sappan: a comprehensive review of its antioxidant and anti-cancer properties, ethnopharmacology, and phytochemistry

in Experimental Pharmacology and Drug Discovery

Estéfani Alves Asevedo
Livia Ramos Santiago
Hyo Jeong Kim
Rony Abdi Syahputra
Moon Nyeo Park
Rosy Iara Maciel Azambuja Ribeiro
Bonglee Kim

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1514573

726 views

Original Research

Published on 07 Jan 2025

Artificial intelligence-driven identification and mechanistic exploration of synergistic anti-breast cancer compound combinations from Prunella vulgaris L.-Taraxacum mongolicum Hand.-Mazz. herb pair

in Experimental Pharmacology and Drug Discovery

Chunlai Feng
Jiaxi Cheng
Mengqiu Sun
Chunxue Qiao
Qiuqi Feng
Naying Fang
Yingying Ge
Mengjie Rui

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1522787

427 views

Original Research

Published on 06 Jan 2025

Efficacy of the Bushen Jianpi Huoxue Formula on Beclin-1/Bcl-2-mediated autophagy and apoptosis in osteoblasts

in Experimental Pharmacology and Drug Discovery

Yanping Lin
Rui Zhao
Jiachun Huang
Tongying Chen
Haolin Yang
Haiwei Guo
Lei Wan
Zhihai Zhang
Ying Li
Genfu Zhu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1513298

557 views

Correction

Published on 06 Jan 2025

Corrigendum: Ginkgolide C alleviates myocardial ischemia/reperfusion-induced inflammatory injury via inhibition of CD40-NF-κB pathway

in Experimental Pharmacology and Drug Discovery

Rui Zhang
Dan Han
Zhenyu Li
Chengwu Shen
Yahui Zhang
Jun Li
Genquan Yan
Shasha Li
Bo Hu
Jiangbing Li

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1492520

326 views

Original Research

Published on 06 Jan 2025

Salidroside enhances 5-fluorouracil sensitivity against hepatocellular carcinoma via YIPF5-induced mitophagy

in Experimental Pharmacology and Drug Discovery

Sumin Sun
Haili Hu
Feiyu Li
Sheng Huan
Long Chen
Jiahui Chen
Peihua Sun
Xiaoqing Dong

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1503490

530 views

Review

Published on 06 Jan 2025

An updated review summarizing the anticancer potential of flavonoids via targeting NF-kB pathway

in Experimental Pharmacology and Drug Discovery

Pratibha Pandey
Sorabh Lakhanpal
Danish Mahmood
Han Na Kang
Byunggyu Kim
Sojin Kang
Jinwon Choi
Min Choi
Shivam Pandey
Mahakshit Bhat

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1513422

771 views

Original Research

Published on 06 Jan 2025

Biological activities of Usnea lethariiformis lichen extracts and UHPLC-ESI-QTOF-MS analysis of their secondary metabolites

in Experimental Pharmacology and Drug Discovery

Mauricio Piñeiro
Sofía Manrique
Jessica Gómez
Juan Manuel Rodriguez
Patricia Barrera
Duilio Caballero
Miguel A. Sosa
Gabriel Vargas-Arana
Alejandro Tapia
Beatriz Lima

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1508835

848 views

Review

Published on 06 Jan 2025

Plant and marine-derived natural products: sustainable pathways for future drug discovery and therapeutic development

in Experimental Pharmacology and Drug Discovery

Muhammad Ahmad
Maleha Tahir
Zibin Hong
Muhammad Anjum Zia
Hamza Rafeeq
Muhammad Shaheez Ahmad
Saif ur Rehman
Junming Sun

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1497668

999 views

Original Research

Published on 06 Jan 2025

A study to assess the pharmacological agent potential of gold nanoparticles and their effects on human cancer cells and hospital pathogens using in vitro methods

in Experimental Pharmacology and Drug Discovery

Ayşe Baran

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1498734

240 views

Original Research

Accepted on 03 Jan 2025

Exosomes enriched in miR-124-3p show therapeutic potential in a new microfluidic triculture model that recapitulates neuron-glia crosstalk in Alzheimer's disease

in Experimental Pharmacology and Drug Discovery

Artemizia Évora
Gonçalo Garcia
Ana Rubi
Eleonora De Vitis
Ana Teresa Matos
Ana Rita Vaz
Francesca Gervaso
Giuseppe Gigli
Alessandro Polini
Dora Brites

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1474012

278 views

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Articles

Polydatin enhances oxaliplatin-induced cell death by activating NOX5-ROS-mediated DNA damage and ER stress in colon cancer cells

Integrating traditional machine learning with qPCR validation to identify solid drug targets in pancreatic cancer: a 5-gene signature study

The efficacy and safety of remimazolam besylate, ciprofol, and propofol during hysteroscopy

ITGAX promotes gastric cancer progression via epithelial-mesenchymal transition pathway

Photodynamic therapy with a novel photosensitizer inhibits DSS-induced ulcerative colitis in rats via the NF-κB signaling pathway

Therapeutic effects of composite probiotics derived from fermented camel milk on metabolic dysregulation and intestinal barrier integrity in type 2 diabetes rats

Unlocking the therapeutic mechanism of Caesalpinia sappan: a comprehensive review of its antioxidant and anti-cancer properties, ethnopharmacology, and phytochemistry

Artificial intelligence-driven identification and mechanistic exploration of synergistic anti-breast cancer compound combinations from Prunella vulgaris L.-Taraxacum mongolicum Hand.-Mazz. herb pair

Efficacy of the Bushen Jianpi Huoxue Formula on Beclin-1/Bcl-2-mediated autophagy and apoptosis in osteoblasts

Corrigendum: Ginkgolide C alleviates myocardial ischemia/reperfusion-induced inflammatory injury via inhibition of CD40-NF-κB pathway

Salidroside enhances 5-fluorouracil sensitivity against hepatocellular carcinoma via YIPF5-induced mitophagy

An updated review summarizing the anticancer potential of flavonoids via targeting NF-kB pathway

Biological activities of Usnea lethariiformis lichen extracts and UHPLC-ESI-QTOF-MS analysis of their secondary metabolites

Plant and marine-derived natural products: sustainable pathways for future drug discovery and therapeutic development

A study to assess the pharmacological agent potential of gold nanoparticles and their effects on human cancer cells and hospital pathogens using in vitro methods

Exosomes enriched in miR-124-3p show therapeutic potential in a new microfluidic triculture model that recapitulates neuron-glia crosstalk in Alzheimer's disease