Frontiers in Pharmacology | Experimental Pharmacology and Drug Discovery

Original Research

Published on 03 Jan 2025

Protein-ligand binding affinity prediction using multi-instance learning with docking structures

in Experimental Pharmacology and Drug Discovery

Hyojin Kim
Heesung Shim
Aditya Ranganath
Stewart He
Garrett Stevenson
Jonathan E. Allen

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1518875

857 views

Original Research

Published on 03 Jan 2025

Pathogenesis-directed therapy of methylphenidate-induced oxidative heart damage in rats

in Experimental Pharmacology and Drug Discovery

Izzet Emir
Seval Bulut
Bahadır Suleyman
Renad Mammadov
Nurinisa Yucel
Betul Cicek
Gulce Naz Yazici
Durdu Altuner
Murat Gunay
Halis Suleyman

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1503032

433 views

Original Research

Published on 03 Jan 2025

Modulation of gut microbiota, up-regulation of ZO-1, and promotion of metabolism as therapeutic mechanisms of indole-3-carbinol against obesity in mice

in Experimental Pharmacology and Drug Discovery

XuWen Mao
Guliruoyi Paerhati
Yuche Wu
Lu Feng Cheng

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1499142

773 views

Review

Published on 24 Dec 2024

Large language models facilitating modern molecular biology and novel drug development

in Experimental Pharmacology and Drug Discovery

Xiao-huan Liu
Zhen-hua Lu
Tao Wang
Fei Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1458739

1,099 views

Review

Published on 23 Dec 2024

Exosomal communication: a pivotal regulator of bone homeostasis and a potential therapeutic target

in Experimental Pharmacology and Drug Discovery

Qian-Yun Ye
Yan Cui
Hao-Yu Wang
Ling-Yu Li
Jian-Bing Chen
Xiao-Feng Zhu
Zhi-Jian Xue
Rong-Hua Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1516125

760 views

Original Research

Published on 23 Dec 2024

Biocompatible nanoparticles self-assembled by PEGylated polyphosphoesters for combination of photodynamic therapy and hypoxia-activated chemotherapy against breast cancer

in Experimental Pharmacology and Drug Discovery

Fengyu Wang
Xiaojing Zou
Chunyang Sun

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1529631

555 views

Original Research

Published on 20 Dec 2024

The novel pleuromutilin derivative 22–((4-((4-nitrophenyl)acetamido)phenyl)thio)deoxy pleuromutilin possesses robust anti-mycoplasma activity both in vitro and in vivo

in Experimental Pharmacology and Drug Discovery

Xirui Xia
Xuan Ji
Yaxi Li
Yubo Wang
Yue Zhao
Wenxiang Wang
Huanzhong Ding

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1491223

672 views

Review

Published on 20 Dec 2024

β-blockers and metabolic modulation: unraveling the complex interplay with glucose metabolism, inflammation and oxidative stress

in Experimental Pharmacology and Drug Discovery

Szymon Drygała
Michał Radzikowski
Mateusz Maciejczyk

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1489657

1,259 views

Systematic Review

Published on 20 Dec 2024

Effect of icariin on ovarian cancer: a combined network pharmacology and meta-analysis of in vitro studies approach

in Experimental Pharmacology and Drug Discovery

Shang-Mei Cao
Bo-Lin Chen
Zhen-Zhen Zou
Shao-Zhe Yang
Xiu-Hong Fu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1418111

683 views

Correction

Published on 19 Dec 2024

Corrigendum: Inhibition of coronavirus HCoV-OC43 by targeting the eIF4F complex

in Experimental Pharmacology and Drug Discovery

Yongmei Feng
Stefan Grotegut
Predrag Jovanovic
Valentina Gandin
Steven H. Olson
Rabi Murad
Anne Beall
Sharon Colayco
Paul De-Jesus
Sumit Chanda

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1528449

523 views

Review

Published on 18 Dec 2024

Why CEOs need advanced education and training for optimizing decisions in the development of innovative medicinal products? justification and recommendation

in Experimental Pharmacology and Drug Discovery

Peter-Jürgen Kramer
Gerd Bode
Rolf Bass

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1480338

488 views

Review

Published on 18 Dec 2024

Challenging directions in pediatric diabetes - the place of oxidative stress and antioxidants in systemic decline

in Experimental Pharmacology and Drug Discovery

Vasile Valeriu Lupu
Ingrith Miron
Laura Mihaela Trandafir
Elena Jechel
Iuliana Magdalena Starcea
Ileana Ioniuc
Otilia Elena Frasinariu
Adriana Mocanu
Florin Dumitru Petrariu
Ciprian Danielescu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1472670

651 views
2 citations

Review

Published on 18 Dec 2024

Pathologic function and therapeutic potential of extracellular vesicle miRNA in sepsis

in Experimental Pharmacology and Drug Discovery

Rou Deng
Xiayu Cui
Runze Zhang
Changya Liu
Jielian Luo
Liang Liu
Wen Zhang
Bangjiang Fang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1452276

757 views
1 citation

Original Research

Published on 18 Dec 2024

6-Hydroxyflavanone treats anxiety and chemotherapy-induced neuropathy in Sprague–Dawley rats

in Experimental Pharmacology and Drug Discovery

Shehla Akbar
Fazal Subhan
Rida Qamar
Aroosha Akbar
Naila Shahbaz
Muhammad Aamir
Nayyer Siddique
Salman Ul Islam

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1486918

531 views

Original Research

Published on 18 Dec 2024

Investigating the anti-obesity potential of Nelumbo nucifera leaf bioactive compounds through machine learning and computational biology methods

in Experimental Pharmacology and Drug Discovery

Hongyun Huang
Chengyu Liu
Can Cao
Moxi Chen
Ruyin Li
Jianchun Yu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1500865

745 views

Original Research

Published on 17 Dec 2024

Phytochemical characterization and anti-arthritic potential of green-synthesized CuO nanoparticles derived from the Bistorta amplexicaulis root extract

in Experimental Pharmacology and Drug Discovery

Mahrukh Babar
Bilal Aslam
Muhammad Naeem Faisal
Abdul Malik
Suhail Akhtar
Sabiha Fatima
Wafa Majeed
Asher Umer
Muhammad Akmal Farooq

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1474592

755 views

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Articles

Protein-ligand binding affinity prediction using multi-instance learning with docking structures

Pathogenesis-directed therapy of methylphenidate-induced oxidative heart damage in rats

Modulation of gut microbiota, up-regulation of ZO-1, and promotion of metabolism as therapeutic mechanisms of indole-3-carbinol against obesity in mice

Large language models facilitating modern molecular biology and novel drug development

Exosomal communication: a pivotal regulator of bone homeostasis and a potential therapeutic target

Biocompatible nanoparticles self-assembled by PEGylated polyphosphoesters for combination of photodynamic therapy and hypoxia-activated chemotherapy against breast cancer

The novel pleuromutilin derivative 22–((4-((4-nitrophenyl)acetamido)phenyl)thio)deoxy pleuromutilin possesses robust anti-mycoplasma activity both in vitro and in vivo

β-blockers and metabolic modulation: unraveling the complex interplay with glucose metabolism, inflammation and oxidative stress

Effect of icariin on ovarian cancer: a combined network pharmacology and meta-analysis of in vitro studies approach

Corrigendum: Inhibition of coronavirus HCoV-OC43 by targeting the eIF4F complex

Why CEOs need advanced education and training for optimizing decisions in the development of innovative medicinal products? justification and recommendation

Challenging directions in pediatric diabetes - the place of oxidative stress and antioxidants in systemic decline

Pathologic function and therapeutic potential of extracellular vesicle miRNA in sepsis

6-Hydroxyflavanone treats anxiety and chemotherapy-induced neuropathy in Sprague–Dawley rats

Investigating the anti-obesity potential of Nelumbo nucifera leaf bioactive compounds through machine learning and computational biology methods

Phytochemical characterization and anti-arthritic potential of green-synthesized CuO nanoparticles derived from the Bistorta amplexicaulis root extract