Frontiers in Pharmacology | Experimental Pharmacology and Drug Discovery

Original Research

Published on 08 May 2025

Mangiferin mitigates dexamethasone-induced insulin resistance in rats: insight into vascular dysfunction and hepatic steatosis

in Experimental Pharmacology and Drug Discovery

Abdullah Q. Alsaedi
Manar A. Nader
Dalia H. El-Kashef
Marwa E. Abdelmageed

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1572758

1,416 views

Original Research

Published on 08 May 2025

Reduced abundance of Fusobacterium signifies cardiovascular benefits of sodium glucose cotransporter 2 inhibitor in type 2 diabetes: a single arm clinical trial

in Experimental Pharmacology and Drug Discovery

Shuhui Yang
Jiankun Deng
Xiaoxu Weng
Zhaojie Ma
Nie Lin
Yili Xiao
Rui Zuo
Yufei Hu
Canbin Zheng
Xiaoshan Zeng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1600464

1,087 views

Original Research

Published on 08 May 2025

Investigation of Fructus sophorae extract’s therapeutic mechanism in atrophic vaginitis based on network pharmacology and experimental validation

in Experimental Pharmacology and Drug Discovery

Jiarui Zheng
Weiming Wang
Wenting Song
Yehao Zhang
Mingjiang Yao
Guangrui Wang
Zishan Huang
Feng Li
Junguo Ren
Li Lin

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1571976

1,246 views

Original Research

Published on 02 May 2025

Gen-miR-5 derived from Gentianella acuta inhibits PFKP to prevent fibroblast activation and alleviate myocardial fibrosis

in Experimental Pharmacology and Drug Discovery

Hongyao Ge
Zhenyu Du
Weizhe Liu
Letian Wang
Junyang Li
Gaoshan Yang
Aiying Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1578877

1,099 views

Original Research

Published on 02 May 2025

Synthesis, target analysis, and cerebroprotective effects of novel imide antioxidants via the Nrf2/HO-1 pathway in cerebral ischemia-reperfusion injury

in Experimental Pharmacology and Drug Discovery

Lili Huang
Yinqi Chen
Hua Zhou
Huihui Chen
Xiping Wu
Zhuochao Wu
Zhoudi Liu
Zhiwei Zheng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1552717

832 views

Original Research

Published on 02 May 2025

Compatibility optimization of the traditional Chinese medicines ‘Eczema mixture’ based on back-propagation artificial neural network and non-dominated sorting genetic algorithm

in Experimental Pharmacology and Drug Discovery

Xin He
Zhijie Song
Yanqun Yang
Siqi Wu
Shuo Meng
Huanyu E
Hongfei Li
Guoyu Ding

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1593783

1,150 views

Original Research

Published on 30 Apr 2025

Acrylamide and bisphenol A: two plastic additives increase platelet activation, via oxidative stress

in Experimental Pharmacology and Drug Discovery

C. F. Burgos
D. Méndez
S. Quintana
S. Gonkowski
A. Trostchansky
M. Alarcón

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1526374

1,582 views

Original Research

Published on 30 Apr 2025

Canagliflozin alleviates progestin resistance by suppressing RARβ/CRABP2 signaling in THRB knockout endometrial cancer cells

in Experimental Pharmacology and Drug Discovery

Ye Yang
Jieyun Zhou
Qiaoying Lv
Qicheng Ni
Baichun Hu
Yulong Wang
Shuning Qu
Guoting Li
Wenjie Yang
Ruihua Zhong

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1573032

1,490 views

Review

Published on 30 Apr 2025

Advancing precision oncology with AI-powered genomic analysis

in Experimental Pharmacology and Drug Discovery

Ruby Srivastava

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1591696

1,978 views

Original Research

Published on 29 Apr 2025

Quercetin in Shengxian Decoction exhibits anti-ferroptosis protective roles in a myocardial infarction model via targeting DPP4/ HMOX1, based on network pharmacology and molecular docking

in Experimental Pharmacology and Drug Discovery

Yuming Zhai
Jiamei Fu
Jianfei Yang
Yabin Zhou

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1583509

1,697 views

Original Research

Published on 29 Apr 2025

Wuling capsule alleviates hyperuricaemia and protects UA- injured HK-2 cells by regulating uric acid transporter proteins

in Experimental Pharmacology and Drug Discovery

Nan Li
Hongna Liu
Zhongxing Song
Rui Zhou
Zhishu Tang
Hongbo Xu
Xinbo Shi
Yanru Liu
Jian Ni

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1563676

1,868 views

Original Research

Published on 29 Apr 2025

Dl-3-n-butylphthalide attenuates DOX-induced cardiotoxicity in mice by inhibiting Nrf2/Keap1 complex formation

in Experimental Pharmacology and Drug Discovery

Yixiao Yan
Mingzhen Fang
Cong Zhao
Xinru Lin
Chen Tong
Cheng Xiang
Ya Ran
Xuelian Wang
Shuixin Li
Gaozhi Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1542296

996 views
1 citation

Original Research

Published on 29 Apr 2025

Ginsenoside Rg1 controls CKLF1-mediated apoptosis to reduce hypoxic/reoxygenation injury in HT22 cells

in Experimental Pharmacology and Drug Discovery

Jinping Liang
Xuan Zhu
Feng Li
Yan Yang
Yuchen Zhu
Shasha Liu
Yang Sun
Boyu Kuang
Junpeng Long
Qian Yan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1525605

1,002 views

Review

Published on 28 Apr 2025

Exosomes as natural vectors for therapeutic delivery of bioactive compounds in skin diseases

in Experimental Pharmacology and Drug Discovery

Somayeh Keshtkar
Zahra Asvar
Haniyeh Najafi
Mozhdeh Heidari
Maryam Kaviani
Fatemeh Sabet Sarvestani
Ali Mohammad Tamaddon
Maryam Sadat Sadati
Nasrin Hamidizadeh
Negar Azarpira

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1485769

1,310 views

Review

Published on 28 Apr 2025

The research progress on radionuclides in osteoporosis diagnosis and drug efficacy monitoring

in Experimental Pharmacology and Drug Discovery

Jie Fu
Chi Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1594903

1,046 views

Original Research

Published on 28 Apr 2025

Irisin attenuates cardiac injury and improves prognosis in rats with hemorrhagic shock by maintaining mitochondrial homeostasis via the AMPK/Drp1 pathway

in Experimental Pharmacology and Drug Discovery

Zheng Zhang
Yufang Zhang
Xiaofang Zou
Jiake Li
Yunfei Chi
Hailiang Bai
Bin Wei
Huiting Yun
Quanxi Zhang
Weihua Cao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1560608

1,658 views