Frontiers in Pharmacology | Gastrointestinal and Hepatic Pharmacology

Systematic Review

Accepted on 30 Dec 2025

Efficacy of Selected Dietary Supplements and Pharmacological Agents on Metabolic and Oxidative Stress Outcomes in Metabolic Dysfunction–Associated Fatty Liver Disease (MAFLD): A Bayesian Network Meta-analysis

in Gastrointestinal and Hepatic Pharmacology

Yunyi Yang
Xiaoli He
Yanming He
Jiayuan Cai
Tan Shufa
Jiawen You
Zheng Yao
Hongjie Yang

Frontiers in Pharmacology

Review

Accepted on 24 Dec 2025

Epidemiology and diagnostic of MASLD in Latin America: A yet to be met challenge

in Gastrointestinal and Hepatic Pharmacology

Carolina Elizabeth Olaez-Ramos
Karla Lizette Mojica-Zamudio
Ana Sandoval-Rodríguez
Juan Armendariz-Borunda

Frontiers in Pharmacology

Systematic Review

Accepted on 24 Dec 2025

Efficacy and safety of opioid-receptor antagonists for opioid-induced constipation: a systematic review and meta-analysis

in Gastrointestinal and Hepatic Pharmacology

Yuanlin Li
Yuyuan Tu
ZiHao Zhou
Defu Liao
Ziyan He
Yan Li
Boyu Li
Zhiren Liu
Zugang Zhou
Shuangchun AI

Frontiers in Pharmacology

Original Research

Accepted on 22 Dec 2025

Risk prediction model for severe potential drug-drug interactions in colorectal cancer patients: A real-world data study

in Gastrointestinal and Hepatic Pharmacology

Xiaomei Pei
Xiaohu Yang
Lingti Kong

Frontiers in Pharmacology

Original Research

Accepted on 22 Dec 2025

Urolithin A regulates gut:liver axis to ameliorate alcohol-associated liver disease

in Gastrointestinal and Hepatic Pharmacology

Sweta Ghosh
Rajbir Singh
Zachary Matthew Vanwinkle
Craig James McClain
Vatsalya Vatsalya
Bodduluri Haribabu
Praveen Kumar Vemula
Venkatakrishna Rao Jala

Frontiers in Pharmacology

200 views

Review

Published on 22 Dec 2025

Targeting γ-aminobutyric acid pathways in irritable bowel syndrome: bridging central nervous system, enteric dysfunction, and the microbiota-gut-brain axis

in Gastrointestinal and Hepatic Pharmacology

Christian Lambiase
Francesco Rettura
Giusi Desirè Sciumè
Riccardo Tedeschi
Antonio Grosso
Lorenzo Cancelli
Andrea Bottari
Matteo Fornai
Luca Antonioli
Nicola de Bortoli

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1677037

604 views

Systematic Review

Accepted on 17 Dec 2025

Efficacy and safety of efruxifermin for patients with NASH/MASH:an updated systematic review and meta-analysis

in Gastrointestinal and Hepatic Pharmacology

Yajun Xiao
Xue-Ping Liu
Yan-Ling Zhang
Xiao-Li Tian
Yan-Qun Liu
Yan Cheng
Cunliang Deng
Hao Sun

Frontiers in Pharmacology

109 views

Original Research

Accepted on 17 Dec 2025

Recombinant Human Thrombopoietin as a Novel Platelet-Driven Regulator Accelerating Hepatic Regeneration in Acute Liver Failure

in Gastrointestinal and Hepatic Pharmacology

Yunzhi Shen
Fengzheng Han
Tao Wang
Li Jing
Ying Luo
Fushuang Ha
Yongping Lu
Liang Jing

Frontiers in Pharmacology

Original Research

Accepted on 17 Dec 2025

Comparative Efficacy and Safety of Mesalazine‑Based Regimens with Traditional Chinese Medicines in Mild‑to‑Moderate Ulcerative Colitis

in Gastrointestinal and Hepatic Pharmacology

Bin Huang
Honglin An
Liming Chen
Huimin Lin
Huaping Wu
Ruofei Li
Yaping Su
Jiumao Lin
Dan Shi

Frontiers in Pharmacology

104 views

Review

Published on 17 Dec 2025

Research progress on the regulatory effects and mechanisms of natural active products on intestinal barrier function

in Gastrointestinal and Hepatic Pharmacology

Fuyixuan Zheng
Yuemei Sun
Minghui Zhao
Rong Wang
Wenbin Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1673568

413 views

Review

Accepted on 16 Dec 2025

The Aryl Hydrocarbon Receptor in Liver Injury: A Double-Edged Sword in Roles, Mechanisms, and Future Perspectives

in Gastrointestinal and Hepatic Pharmacology

Yupeng Wang
Ren Tianqi
Yikun Zhang
Shuangxing Li
Yanwei Yang
Chao Wang
Xingchao Geng

Frontiers in Pharmacology

Systematic Review

Accepted on 16 Dec 2025

Safety and Efficacy of Different JAK Inhibitors in the Treatment of Inflammatory Bowel Disease: A Network Meta-analysis

in Gastrointestinal and Hepatic Pharmacology

Haidong Wu
Yongci Zhou
Xuyong Chen
Liudan Wang
Yifan Guo
Xiaxia Du
Xinpu Miao

Frontiers in Pharmacology

119 views

Original Research

Published on 11 Dec 2025

Fraxin modulates lipid metabolism as well as gut flora to avert NAFLD

in Gastrointestinal and Hepatic Pharmacology

Yang Jing
Dong Huicong
Guo Xuanchi
Li Cao
Zhang Huanhuan
Guo Yongze

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1657966

607 views

Systematic Review

Published on 10 Dec 2025

From mechanisms to anti-fibrotic drugs in hepatic stellate cell research: a global bibliometric analysis with patent and clinical perspectives (2000–2025)

in Gastrointestinal and Hepatic Pharmacology

Xiaowen Mao
Peng Chen
Palidan Wubur
Yi Liu
Yuan Zhao
Siwei Zhang
Na Guan
Bin Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1734449

1,169 views

Original Research

Published on 09 Dec 2025

Disrupting cell death: ferroptosis and pyroptosis inhibition in hepatic ischemia-reperfusion injury via modulation of GPX4 and cGAS pathways by deferoxamine and octreotide

in Gastrointestinal and Hepatic Pharmacology

Rasha A. Tawfiq
Yasmeen M. Attia
Hameis M. Sleem
Mai El-Sayed Ghoneim

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1610718

769 views

Review

Accepted on 08 Dec 2025

Bile Acids as Therapeutic Agents

in Gastrointestinal and Hepatic Pharmacology

Brandon Vu
Ryo Kawamoto
Priscila Villalba-Davila
Xinzhong Dong
Wikrom Karnsakul

Frontiers in Pharmacology

178 views

Original Research

Accepted on 08 Dec 2025

A Life-Threatening Crisis: The Unique Symphony of Aconitine Poisoning-Induced Cardiac Arrest and Hepatic Portal Venous Gas

in Gastrointestinal and Hepatic Pharmacology

Yonghong Wang
Wei Pan
Wentao Tao
Junping Zhu
YANG Xianyi

Frontiers in Pharmacology

Original Research

Accepted on 04 Dec 2025

Erythrosine-Induced Hepatic Biomarkers and Histopathological Changes in Male Rats: Protective Effects of Lycopene and Anthocyanin

in Gastrointestinal and Hepatic Pharmacology

Dr.SAFAA H QAHAL
Fatimah A Alqahtani
Haleema Al-Nahari
Fawzyah A Alghamdi
Fatimah H Khouja
Amna H Khouja

Frontiers in Pharmacology

143 views

Original Research

Accepted on 04 Dec 2025

Economic Value and Clinical Impact Association of a Supervised Lifestyle-improving Program for MASLD

in Gastrointestinal and Hepatic Pharmacology

Maurizio Gaetano Polignano
Antonella Bianco
Davide Guido
Pietro Trisolini
Isabella Franco
Caterina Bonfiglio
Gianluigi Giannelli

Frontiers in Pharmacology

138 views

Original Research

Published on 03 Dec 2025

The therapeutic efficacy of radical resection for hepatocellular carcinoma varies markedly by tumor location: a retrospective real-world study

in Gastrointestinal and Hepatic Pharmacology

Xu Feng
Yi-Qiu Wei
Jia-Rui Liu
Zheng-Rong Shi
Kai Chen
Yong-Shuang Lv

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1674998

657 views

Review

Published on 02 Dec 2025

Modulation of STAT6 signaling for hepatoprotection

in Gastrointestinal and Hepatic Pharmacology

Emmanuel Somm
Mahdi Rahman
Ildiko Szanto
Karim Gariani
François R. Jornayvaz

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1659227

896 views

Original Research

Accepted on 01 Dec 2025

Effect of gentiopicroside on endogenous formaldehyde homocysteine–pathway related proteins in rats with non-alcoholic steatohepatitis

in Gastrointestinal and Hepatic Pharmacology

Jiaxin Chen
Huiling Zuo
Yuhang Jiao
Huanhuan Zhao
Xuan Ma
娅慧肖
Xiangqiong Li
Wei Zhao
Anhua Shi
Wenhui Chen

Frontiers in Pharmacology

139 views

Systematic Review

Published on 01 Dec 2025

Microplastics in focus: a silent disruptor of liver health- a systematic review

in Gastrointestinal and Hepatic Pharmacology

Zahra Beyzaei
Bita Geramizadeh
Zahra Bagheri
Sara Karimzadeh
Ralf Weiskirchen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1721644

991 views

Systematic Review

Accepted on 30 Nov 2025

Pharmacological mechanisms of traditional Chinese medicine in treating gastric cancer:A focus on the ferroptosis regulation

in Gastrointestinal and Hepatic Pharmacology

Shanshan Gao
Huijuan Wang

Frontiers in Pharmacology

295 views

1,288 articles

articles

Efficacy of Selected Dietary Supplements and Pharmacological Agents on Metabolic and Oxidative Stress Outcomes in Metabolic Dysfunction–Associated Fatty Liver Disease (MAFLD): A Bayesian Network Meta-analysis

Epidemiology and diagnostic of MASLD in Latin America: A yet to be met challenge

Efficacy and safety of opioid-receptor antagonists for opioid-induced constipation: a systematic review and meta-analysis

Risk prediction model for severe potential drug-drug interactions in colorectal cancer patients: A real-world data study

Urolithin A regulates gut:liver axis to ameliorate alcohol-associated liver disease

Targeting γ-aminobutyric acid pathways in irritable bowel syndrome: bridging central nervous system, enteric dysfunction, and the microbiota-gut-brain axis

Efficacy and safety of efruxifermin for patients with NASH/MASH:an updated systematic review and meta-analysis

Recombinant Human Thrombopoietin as a Novel Platelet-Driven Regulator Accelerating Hepatic Regeneration in Acute Liver Failure

Comparative Efficacy and Safety of Mesalazine‑Based Regimens with Traditional Chinese Medicines in Mild‑to‑Moderate Ulcerative Colitis

Research progress on the regulatory effects and mechanisms of natural active products on intestinal barrier function

The Aryl Hydrocarbon Receptor in Liver Injury: A Double-Edged Sword in Roles, Mechanisms, and Future Perspectives

Safety and Efficacy of Different JAK Inhibitors in the Treatment of Inflammatory Bowel Disease: A Network Meta-analysis

Fraxin modulates lipid metabolism as well as gut flora to avert NAFLD

From mechanisms to anti-fibrotic drugs in hepatic stellate cell research: a global bibliometric analysis with patent and clinical perspectives (2000–2025)

Disrupting cell death: ferroptosis and pyroptosis inhibition in hepatic ischemia-reperfusion injury via modulation of GPX4 and cGAS pathways by deferoxamine and octreotide

Bile Acids as Therapeutic Agents

A Life-Threatening Crisis: The Unique Symphony of Aconitine Poisoning-Induced Cardiac Arrest and Hepatic Portal Venous Gas

Erythrosine-Induced Hepatic Biomarkers and Histopathological Changes in Male Rats: Protective Effects of Lycopene and Anthocyanin

Economic Value and Clinical Impact Association of a Supervised Lifestyle-improving Program for MASLD

The therapeutic efficacy of radical resection for hepatocellular carcinoma varies markedly by tumor location: a retrospective real-world study

Modulation of STAT6 signaling for hepatoprotection

Effect of gentiopicroside on endogenous formaldehyde homocysteine–pathway related proteins in rats with non-alcoholic steatohepatitis

Microplastics in focus: a silent disruptor of liver health- a systematic review

Pharmacological mechanisms of traditional Chinese medicine in treating gastric cancer:A focus on the ferroptosis regulation