Frontiers in Pharmacology | Gastrointestinal and Hepatic Pharmacology

Original Research

Published on 18 Feb 2026

Quercetin attenuates acute alcohol-induced liver injury in mice by modulating lipid metabolism, oxidative stress, and inflammation

in Gastrointestinal and Hepatic Pharmacology

Wenjing He
Binbin Zhang
Siwei Li
Yuanyuan Qian

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1702639

378 views

Original Research

Published on 18 Feb 2026

Analysis of risk factors for herb-induced liver injury: a retrospective study from China

in Gastrointestinal and Hepatic Pharmacology

Pengchong Wang
Xinyan Liang
Guangyu Cheng
Qimeng Fan
Qing Li
Fengshou Dai
Yajun Liu
Zhenzhou Jiang
Tianjiong Luo
Jingwen Hu

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1766238

Review

Published on 18 Feb 2026

Dietary strategies for chronic constipation: smartly targeting hormonal and reflex pathways for optimal recovery

in Gastrointestinal and Hepatic Pharmacology

Emanuela Ribichini
Giulia Scalese
Chiara Mocci
Natascia De Amicis
Carola Severi

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1738562

133 views

Editorial

Published on 17 Feb 2026

Editorial: Pharmacological and nutritional approaches to metabolic associated fatty liver disease: a step towards achieving SDG 3

in Gastrointestinal and Hepatic Pharmacology

Mahmut Bodur
Bojana Vidović
Anastasios Nikolaou
Birsen Yilmaz

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1802444

133 views

Review

Published on 16 Feb 2026

Preclinical approaches to studying liver and kidney fibrosis: models and methodologies

in Gastrointestinal and Hepatic Pharmacology

Abhilasha Tiwari
Shivam Singh
Rajesh Kumar Sharma
Sandeep Kumar

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1718048

224 views

Original Research

Accepted on 13 Feb 2026

Investigation of the voltage-gated Ca++ channels and phosphodiesterase enzyme inhibitory-like potential explains the medicinal use of Otostegia fruticosa in diarrhea and hypermotile gut

in Gastrointestinal and Hepatic Pharmacology

Najeeb Ur Rehman
Dr Mohd Nazam Ansari
Nasser Abdulaziz Alalaiwah
Eyad Omar Alotibi
Aman Karim
Tiegist Bahta
Khalil Y Abujheisha
Muhammad Noman

Frontiers in Pharmacology

Review

Published on 13 Feb 2026

Research progress and controversies in the treatment of functional constipation-related depression with probiotics and prebiotics: a narrative review

in Gastrointestinal and Hepatic Pharmacology

Qiuhua Dai
Zhongyu Duan
Chao Fang
Rong Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1735614

400 views

Original Research

Accepted on 11 Feb 2026

Safe dosage and potential risks of chlorogenic acid: insights from in vitro and in vivo studies

in Gastrointestinal and Hepatic Pharmacology

Yilin Pang
Mengyao Jiang
Ge Binjie
Lin Huang
Xiaoyu Rao
Xueqing Wang
Huaibin Zhou
Jianxin Lyu
Zheng Wang
Guoqiang Tan

Frontiers in Pharmacology

Original Research

Published on 10 Feb 2026

Sevelamer inhibits the formation of cholesterol gallstones by modulating bile acid metabolism

in Gastrointestinal and Hepatic Pharmacology

Shuang Shen
Min Ning
Muhan Li
Shengnan Qian
Xin Ye
Qian Zhuang
Shan Wu
Xinjian Wan
Zhixia Dong

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1737631

360 views

Review

Accepted on 05 Feb 2026

Nanomaterial-Mediated Modulation of Gut Microbiota for Precision Diagnosis and Treatment of Colorectal Cancer: A Comprehensive Review

in Gastrointestinal and Hepatic Pharmacology

Ying Yang
Shihan Feng
Yunqing Cheng
Min Zhang

Frontiers in Pharmacology

115 views

Original Research

Published on 05 Feb 2026

Sacubitril/valsartan mitigates cisplatin-induced liver injury through modulation of oxidative stress, Caspase-3 activity, and RXR-α signaling in experimental rats

in Gastrointestinal and Hepatic Pharmacology

Majed N. Alshammari
Ahmad H. Alhowail
Mohamed S. Abdel-Bakky
Maha A. Aldubayan

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1745023

595 views

Systematic Review

Published on 30 Jan 2026

Efficacy and safety of cinobufacini capsules combined with oxaliplatin-based chemotherapy for advanced colorectal cancer: a human systematic review and meta-analysis

in Gastrointestinal and Hepatic Pharmacology

Jian Wang
Qijia Gao
Yangming Que
Dingting Zheng
Jianxin Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1709044

538 views

Mini Review

Published on 29 Jan 2026

Advancing ulcerative colitis therapy: a review of 5-ASA synergy with traditional Chinese medicine and natural bioactive compounds

in Gastrointestinal and Hepatic Pharmacology

Weiwei Dong
Hengquan Wu
Tao Liu
Wenting He

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1738151

632 views

Systematic Review

Published on 29 Jan 2026

Efficacy of selected dietary supplements and pharmacological agents on metabolic and oxidative stress outcomes in metabolic dysfunction–associated fatty liver disease (MAFLD): a Bayesian network meta-analysis

in Gastrointestinal and Hepatic Pharmacology

Yunyi Yang
Xiaoli He
Jiayuan Cai
Xiaoxiao Qu
Shufa Tan
Jiawen You
Yanming He
Zheng Yao
Hongjie Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1682688

909 views

Original Research

Accepted on 28 Jan 2026

Different treatments for Crohn's disease complicated with severe acute lower Gastrointestinal bleeding: Infliximab therapy is critical and cannot be ignored

in Gastrointestinal and Hepatic Pharmacology

Shuoyi Yao
Zheyu Wang
Mingyan Xie
Shengnan Wu
Yingjuan Feng
Xiaoming Liu
Fen Wang

Frontiers in Pharmacology

Original Research

Published on 28 Jan 2026

Prediction of infliximab and anti-drug antibody concentrations in patients with inflammatory bowel disease using machine learning models with real-world data from a prospective cohort study

in Gastrointestinal and Hepatic Pharmacology

Minjung Kim
Joo Hye Song
Sung Noh Hong
Myeong Gyu Kim
Eun Ran Kim
Dong Kyung Chang
Young-Ho Kim

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1731193

546 views

Original Research

Accepted on 27 Jan 2026

Acetylshikonin mitigates diet-induced MASLD by targeting PPARγ-mediated metabolic dysfunction

in Gastrointestinal and Hepatic Pharmacology

Ling Ou
Qian Du
yang jia liu
yan hai tai
han yin chai
qiong xiao tan
bing li
li rong tan
Ying Cao
ting ting zhu

Frontiers in Pharmacology

136 views

Systematic Review

Published on 27 Jan 2026

Safety and efficacy of different JAK inhibitors in the treatment of inflammatory bowel disease: a network meta-analysis

in Gastrointestinal and Hepatic Pharmacology

Haidong Wu
Yongci Zhou
Xuyong Chen
Liudan Wang
Yifan Guo
Xiaxia Du
Xinpu Miao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1699928

756 views

Review

Published on 26 Jan 2026

Epidemiology and diagnostic of MASLD in Latin America: a yet to be met challenge

in Gastrointestinal and Hepatic Pharmacology

Carolina Elizabeth Olaez-Ramos
Karla Lizette Mojica-Zamudio
Ana Sandoval-Rodríguez
Juan Armendáriz-Borunda

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1700072

672 views

Systematic Review

Published on 26 Jan 2026

Pharmacological mechanisms of traditional Chinese medicine in treating gastric cancer: a focus on the ferroptosis regulation

in Gastrointestinal and Hepatic Pharmacology

Shanshan Gao
Huijuan Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1700849

819 views

Review

Published on 23 Jan 2026

Silent inflammation: a hidden cause of liver fibrosis

in Gastrointestinal and Hepatic Pharmacology

Hans-Theo Schon
Ralf Weiskirchen

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1676534

683 views
1 citation

Original Research

Published on 23 Jan 2026

EMMPRIN deficiency alleviated metabolic-associated steatohepatitis progression via regulation of the UBA52–MCT1 axis

in Gastrointestinal and Hepatic Pharmacology

Linying Lai
Baoyuan Huang
Ziping Song
Xinyan Zhu
Wenzhuo Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1706859

610 views

Original Research

Published on 19 Jan 2026

Urolithin A regulates gut: liver axis to ameliorate alcohol-associated liver disease

in Gastrointestinal and Hepatic Pharmacology

Sweta Ghosh
Rajbir Singh
Zachary Matthew Vanwinkle
Craig James McClain
Vatsalya Vatsalya
Bodduluri Haribabu
Praveen Kumar Vemula
Venkatakrishna Rao Jala

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1706111

1,288 views

Original Research

Published on 16 Jan 2026

Economic value and clinical association of a supervised lifestyle-improving program for MASLD

in Gastrointestinal and Hepatic Pharmacology

Maurizio Polignano
Antonella Bianco
Davide Guido
Pietro Trisolini
Isabella Franco
Caterina Bonfiglio
Gianluigi Giannelli

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1708451

814 views

1,305 articles

articles

Quercetin attenuates acute alcohol-induced liver injury in mice by modulating lipid metabolism, oxidative stress, and inflammation

Analysis of risk factors for herb-induced liver injury: a retrospective study from China

Dietary strategies for chronic constipation: smartly targeting hormonal and reflex pathways for optimal recovery

Editorial: Pharmacological and nutritional approaches to metabolic associated fatty liver disease: a step towards achieving SDG 3

Preclinical approaches to studying liver and kidney fibrosis: models and methodologies

Investigation of the voltage-gated Ca++ channels and phosphodiesterase enzyme inhibitory-like potential explains the medicinal use of Otostegia fruticosa in diarrhea and hypermotile gut

Research progress and controversies in the treatment of functional constipation-related depression with probiotics and prebiotics: a narrative review

Safe dosage and potential risks of chlorogenic acid: insights from in vitro and in vivo studies

Sevelamer inhibits the formation of cholesterol gallstones by modulating bile acid metabolism

Nanomaterial-Mediated Modulation of Gut Microbiota for Precision Diagnosis and Treatment of Colorectal Cancer: A Comprehensive Review

Sacubitril/valsartan mitigates cisplatin-induced liver injury through modulation of oxidative stress, Caspase-3 activity, and RXR-α signaling in experimental rats

Efficacy and safety of cinobufacini capsules combined with oxaliplatin-based chemotherapy for advanced colorectal cancer: a human systematic review and meta-analysis

Advancing ulcerative colitis therapy: a review of 5-ASA synergy with traditional Chinese medicine and natural bioactive compounds

Efficacy of selected dietary supplements and pharmacological agents on metabolic and oxidative stress outcomes in metabolic dysfunction–associated fatty liver disease (MAFLD): a Bayesian network meta-analysis

Different treatments for Crohn's disease complicated with severe acute lower Gastrointestinal bleeding: Infliximab therapy is critical and cannot be ignored

Prediction of infliximab and anti-drug antibody concentrations in patients with inflammatory bowel disease using machine learning models with real-world data from a prospective cohort study

Acetylshikonin mitigates diet-induced MASLD by targeting PPARγ-mediated metabolic dysfunction

Safety and efficacy of different JAK inhibitors in the treatment of inflammatory bowel disease: a network meta-analysis

Epidemiology and diagnostic of MASLD in Latin America: a yet to be met challenge

Pharmacological mechanisms of traditional Chinese medicine in treating gastric cancer: a focus on the ferroptosis regulation

Silent inflammation: a hidden cause of liver fibrosis

EMMPRIN deficiency alleviated metabolic-associated steatohepatitis progression via regulation of the UBA52–MCT1 axis

Urolithin A regulates gut: liver axis to ameliorate alcohol-associated liver disease

Economic value and clinical association of a supervised lifestyle-improving program for MASLD