Frontiers in Pharmacology | Gastrointestinal and Hepatic Pharmacology

Original Research

Accepted on 14 Nov 2025

SLC11A1 Protein as a Key Regulator of Iron Metabolism, Ferroptosis Mediator, and Putative Therapeutic Target in Nonalcoholic Fatty Liver Disease: An Integrated Bioinformatics Analysis

in Gastrointestinal and Hepatic Pharmacology

Yang Wang
Bugao Zhou
Shanshan LI
Linxin ZHENG
Xiongfeng Huang
Huiyu WANG
Sili LI
Yuhan LIN
Yanhe XU

Frontiers in Pharmacology

Systematic Review

Published on 14 Nov 2025

Different nucleos(t)ide analogs in resected hepatitis B virus-associated hepatocellular carcinoma: a systematic review

in Gastrointestinal and Hepatic Pharmacology

Hongquan Qiu
Yu Zhang
Fengxia Xu
Songhui Xue

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1647888

182 views

Original Research

Accepted on 12 Nov 2025

Lycii Radicis Cortex Alleviates Fibrosis in hiPSC-Derived Multilineage Hepatic Organoids via the cAMP-PKA Pathway

in Gastrointestinal and Hepatic Pharmacology

Xu JM
Xiaopu Sang
Yongfei He
Jie Ke
Jiasen Xu
Tanbin Liu
Jicai Wang
Hang Zhai
Xiaoni Chen
Xianjie Shi

Frontiers in Pharmacology

131 views

Original Research

Published on 12 Nov 2025

Pharmacovigilance study of the frequency of gastrointestinal ulceration reports associated with immune checkpoint inhibitors: insights from the FDA adverse event reporting system

in Gastrointestinal and Hepatic Pharmacology

Liqiang Lei
Lifen Wang
Sugang Shen
Ge Zhao
Xingming Zhao
Honglin Dong

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1682259

244 views

Review

Accepted on 11 Nov 2025

Research progress on the use of polyphenols in the treatment of Crohn's disease

in Gastrointestinal and Hepatic Pharmacology

Xianmei Zhong
Qian Dai
Jing Xianmei Li
Jie Xianmei Yang
Xi Xi Zheng

Frontiers in Pharmacology

135 views

Original Research

Accepted on 10 Nov 2025

Disrupting Cell Death: Ferroptosis & Pyroptosis Inhibition in Hepatic Ischemia-Reperfusion Injury via modulation of GPX4 and cGAS pathways by Deferoxamine and Octreotide

in Gastrointestinal and Hepatic Pharmacology

Rasha A. Tawfiq
Yasmeen Attia
Hameis Sleem
Mai El-Sayed

Frontiers in Pharmacology

Mini Review

Published on 10 Nov 2025

Immunometabolic integration in therapeutic strategies for managing MASLD

in Gastrointestinal and Hepatic Pharmacology

Sergio González-Serrano
Alina-Iuliana Onoiu
Jordi Camps
Jorge Joven

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1693753

789 views

Original Research

Accepted on 07 Nov 2025

Glial cell line-derived neurotrophic factor inhibits mast-cell-like RBL-2H3 cells activation via Ca2+-mediated degranulation and Ca2+/CaMK Ⅱ/JNK pathway

in Gastrointestinal and Hepatic Pharmacology

Wei Huang
Li Zeng
Li Zhang
Xinxing Zhang
Qin Xie

Frontiers in Pharmacology

113 views

Original Research

Published on 07 Nov 2025

Cistanche deserticola-derived exosome-like nanovesicles target the Microbiota-GABA signaling axis to ameliorate loperamide-induced constipation

in Gastrointestinal and Hepatic Pharmacology

Xiaoyu Zhang
Keqiu Yan
Xinkun Bao
Dequn Yang
Xiaoyin Chen
Wenjie Xiao
Jinbo Zhou
Yifan Cai
Hao Wang
Guangjun Sun

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1693366

570 views

Brief Research Report

Published on 07 Nov 2025

Salivary oxidative stress persists in inflammatory bowel disease regardless of biological treatment response

in Gastrointestinal and Hepatic Pharmacology

Elisabetta Bigagli
Tommaso Innocenti
Gabriele Dragoni
Francesco Pindozzi
Andrea Galli
Maura Lodovici
Cristina Luceri

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1699252

604 views

Systematic Review

Accepted on 05 Nov 2025

Metformin for primary prevention of colorectal neoplasms in adenoma-free populations: a systematic review and dose-response meta-analysis

in Gastrointestinal and Hepatic Pharmacology

Mengdan Shen
Shan Lu
Zihao Xu
Feifei Zhou
Li-Ting Sheng
Qiang Yu

Frontiers in Pharmacology

104 views

Perspective

Published on 05 Nov 2025

Not quite a cure yet: unlocking the unfulfilled promise of live biotherapeutics for disease treatment

in Gastrointestinal and Hepatic Pharmacology

Andrea Verdugo-Meza
Han M. Chiang
Emeran A. Mayer
Deanna L. Gibson

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1695976

570 views

Original Research

Accepted on 04 Nov 2025

The therapeutic efficacy of radical resection for hepatocellular carcinoma varied markedly with tumor location, based on real-world data from a retrospective single-centre analysis

in Gastrointestinal and Hepatic Pharmacology

Xu Feng
Yiqiu Wei
Jia-Rui Liu
Zhengrong Shi
Kai Chen
Yong-Shuang Li

Frontiers in Pharmacology

108 views

Original Research

Published on 04 Nov 2025

Oral administration of the probiotic strain Lactobacillus helveticus BGRA43 reduces high-fat diet–induced hepatic steatosis in mice and restores gut microbiota composition

in Gastrointestinal and Hepatic Pharmacology

Ana Teofilović
Miloš Vratarić
Biljana Bursać
Ljupka Gligorovska
Danijela Vojnović Milutinović
Nemanja Stanisavljević
Ivana Strahinić
Danijela Mišić
Filip Nikolić
Bojan Pavlović

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1688777

607 views

Systematic Review

Accepted on 03 Nov 2025

Therapeutic effect and safety of Wei-Fu-Chun in the treatment of Chronic Atrophic gastritis: A network meta-analysis

in Gastrointestinal and Hepatic Pharmacology

Yunbo Wu
Ling Hu

Frontiers in Pharmacology

Review

Accepted on 03 Nov 2025

Research Progress on the Regulatory Effects and Mechanisms of Natural Active Products on Intestinal Barrier Function

in Gastrointestinal and Hepatic Pharmacology

FYX Z

Frontiers in Pharmacology