Frontiers in Pharmacology | Gastrointestinal and Hepatic Pharmacology

Original Research

Accepted on 24 Mar 2025

Citral protects against metabolic endotoxemia, and systemic disorders caused by high-fat diet-induced obesity via intestinal modulation

in Gastrointestinal and Hepatic Pharmacology

Maycon Tavares Emílio-Silva
Vinicius Peixoto Rodrigues
Mariana Moraes Fioravanti
Antonio Jesús Ruiz Malagón
Matheus Naia Fioretto
Priscila Romano Raimundo
Rie Ohara
Renata Assunção
Gabriela Bueno
Felipe Lima Dario

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1567217

Original Research

Published on 24 Mar 2025

Chitinase 3-like protein 1 deficiency ameliorates drug-induced acute liver injury by inhibition of neutrophil recruitment through lipocalin-2

in Gastrointestinal and Hepatic Pharmacology

Ji Hye Kim
In Jun Yeo
Dong Ju Son
Sang Bae Han
Do Young Yoon
Dong Hun Lee
Jin Tae Hong

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1548832

246 views

Clinical Trial

Published on 24 Mar 2025

Efficacy and cost-effectiveness analysis of 10-day versus 14-day eradication of Helicobacter pylori infection with vonoprazan amoxicillin: a prospective, multicenter, randomized controlled trial

in Gastrointestinal and Hepatic Pharmacology

Yunfan Dong
Zhaotao Duan
Min Liu
Yanbing Ding
Guangxia Chen
Ruifang Wang
Xiaodan Xu
Lixia Ding
Qiang Zhan
Chengyu Pan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1543352

264 views

Review

Published on 21 Mar 2025

Recent advancement in prevention against hepatotoxicity, molecular mechanisms, and bioavailability of gallic acid, a natural phenolic compound: challenges and perspectives

in Gastrointestinal and Hepatic Pharmacology

Peng Chen
Fanzhao Zou
Wei Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1549526

240 views

Original Research

Published on 20 Mar 2025

Licorice attenuates cisplatin-induced hepatotoxicity by alleviating endoplasmic reticulum stress and apoptosis

in Gastrointestinal and Hepatic Pharmacology

Jie Li
Xiujuan Yang
Xiaolong Lian
Baojian Li
Quhuan Ma
Lingling Yang
Guangmiao Gao
Yi Deng
Zhijun Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1557125

362 views

Original Research

Accepted on 19 Mar 2025

Suppressed intestinal secondary bile acids in moxifloxacin-induced hyperglycemia: studies in normal and diabetic GK rats

in Gastrointestinal and Hepatic Pharmacology

Yewen Sun
Yu-Chen Qu
Zhuan Yang
Bo Lv
Guanjun Wang
Kai Fan
Yueyuan Wang
Jie Pan
Ziyan Du
Yun-Li Yu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1569856

Original Research

Published on 19 Mar 2025

Akkermansia muciniphila ameliorates olanzapine-induced metabolic dysfunction-associated steatotic liver disease via PGRMC1/SIRT1/FOXO1 signaling pathway

in Gastrointestinal and Hepatic Pharmacology

Hui Chen
Ting Cao
ChenQuan Lin
ShiMeng Jiao
YiFang He
ZhenYu Zhu
QiuJin Guo
RenRong Wu
HuaLin Cai
BiKui Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1550015

202 views

Original Research

Published on 18 Mar 2025

A real-world disproportionality analysis of ripretinib data mining of the public version of FDA adverse event reporting system

in Gastrointestinal and Hepatic Pharmacology

Yingkai Feng
Xinyu Fa
Yifei Wang
Tao Zhang
Xuan Sun
Faping Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1469597

279 views

Original Research

Accepted on 17 Mar 2025

alpha-estradiol and (R)-(-)-ibuprofen inhibit gastric cancer progression via GLI1 Gquadruplex

in Gastrointestinal and Hepatic Pharmacology

Qiang Li
Pan Pan
Hailing Ding
Qingqing Xian
Jingtan Li
Jingting Wang
Jiaying Cai
Jing Wang
Yanfei Jia
Haiji Sun

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1492694

Original Research

Published on 17 Mar 2025

E1231/NMN protects against experimental metabolic syndrome: the central role of SIRT1 in modulating AKT/Nrf2/NFκB signaling

in Gastrointestinal and Hepatic Pharmacology

Elsayed A. Elmorsy
Hala A. Elashry
Abdullah S. Alkhamiss
Hamad Alsaykhan
Rabab S. Hamad
Mustafa Ahmed Abdel-Reheim
Mansour Alsoghair
Mariam S. Alharbi
Attia M. Gabr
Abousree T. Ellethy

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1558709

546 views

Original Research

Published on 14 Mar 2025

The protective role of cannabidiol in stress-induced liver injury: modulating oxidative stress and mitochondrial damage

in Gastrointestinal and Hepatic Pharmacology

Chengyu Huang
Huichao Liang
Xiaohua Liang
Yueyi Liu
Jiaoling Wang
Haoran Jiang
Xinhui Kou
Jun Chen
Lili Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1567210

545 views

Review

Published on 13 Mar 2025

Crosstalk between bile acids and gut microbiota: a potential target for precancerous lesions of gastric cancer

in Gastrointestinal and Hepatic Pharmacology

Maofu Zhang
Jialin Zhong
Yanyun Shen
Zhongyang Song

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1533141

194 views

Original Research

Published on 10 Mar 2025

The association between the gut microbiome and antituberculosis drug-induced liver injury

in Gastrointestinal and Hepatic Pharmacology

Shengfei Pei
Li Yang
Huixia Gao
Yuzhen Liu
Jianhua Lu
Er hei Dai
Chunyan Meng
Fumin Feng
Yuling Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1512815

730 views

Original Research

Accepted on 07 Mar 2025

MiR-3613-5p Targets AQP4 to Promote the Progression of Chronic Atrophic Gastritis to Gastric Cancer

in Gastrointestinal and Hepatic Pharmacology

Jian Bi
Yufen Wang
Yingde Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1523689

Original Research

Accepted on 05 Mar 2025

Alteration of salivary Streptococcus is associated with statin therapy in older adults: A cohort study

in Gastrointestinal and Hepatic Pharmacology

Daisuke Hisamatsu
Yusuke Ogata
Wataru Suda
Yo Mabuchi
Yuna Naraoka
Taku Yamato
Akimi Ikeba
Kyoko Kumagai
Masahira Hattori
Chihiro Akazawa

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1455753

Original Research

Published on 05 Mar 2025

Reversed role of CD36 deficiency in high-fat diet or methionine/choline-deficient diet-induced hepatic steatosis and steatohepatitis

in Gastrointestinal and Hepatic Pharmacology

Wenya Zhu
Jialing Ma
Tingting Zhang
Mengmeng Zhu
Yajun Duan
Xiaoxiao Yang
Yuanli Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1522177

651 views