Frontiers in Pharmacology | Gastrointestinal and Hepatic Pharmacology

Original Research

Published on 24 Oct 2025

Rituximab in PR3-ANCA positive patients with moderately to severely active ulcerative colitis: a multicenter real-world pilot study

in Gastrointestinal and Hepatic Pharmacology

Qi Yu
Yiyu Cheng
Huan Wang
Yidong Chen
Fang Liu
Xiaopeng Zhang
Xiaoyu Fu
Jiamin Li
Junrong Li
Ying Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1621795

1,214 views

Original Research

Published on 20 Oct 2025

Therapeutic effects of three-strain probiotic combination on slow transit constipation: mechanistic insights into MAPK signaling pathway and gut microbiota restoration

in Gastrointestinal and Hepatic Pharmacology

Liya Liu
Peiyao Li
Youqin Chen
Guangqing Yang
Ying Cheng
Sijia Liu
Xinran Zhang
Yulun Wu
Qihong Liu
Peilin Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1684442

1,950 views

Original Research

Published on 20 Oct 2025

The use of magnesium sulfate can reduce the mortality risk of cirrhosis patients: a retrospective cohort study

in Gastrointestinal and Hepatic Pharmacology

Boxian Chen
Yuping Yang
Mouji Liang
Yanqi Kou
Ruyin Ye
Liping Zhan
Yujie Huang
Qing Zhang
Haoyuan Huang
Jieming Zheng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1551495

1,999 views

Original Research

Published on 15 Oct 2025

Efficacy and safety of live combined Bacillus subtilis and Enterococcus faecium in patients with constipation: a meta-analysis of randomized controlled trials

in Gastrointestinal and Hepatic Pharmacology

Wenwen Li
Yingying Liang
Guangcai Li
Dandan Yang
Xiaoqian Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1688544

1,905 views

Mini Review

Published on 13 Oct 2025

The role of cuproptosis in the occurrence and development of gastric cancer

in Gastrointestinal and Hepatic Pharmacology

Ling Lu
Wenhui Yang
Yuning Gu
Longtao Jin
Zhaofeng Liang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1664200

1,322 views

Original Research

Published on 09 Oct 2025

Identification of galangin as a therapeutic candidate for primary biliary cholangitis via systematic druggable genome-wide Mendelian randomization analysis and experimental validation

in Gastrointestinal and Hepatic Pharmacology

Weirui Ren
Chuang Zhang
Hanyan Wang
Hongzhao Song
Xuejuan Zhu
Zhijun Zhang
Suxian Zhao
Junmin Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1674693

2,115 views

Original Research

Published on 08 Oct 2025

Barnesiella intestinihominis improves gut microbiota disruption and intestinal barrier integrity in mice with impaired glucose regulation

in Gastrointestinal and Hepatic Pharmacology

Xiaojia Liu
Ling Wang
Bing Huang
Yi Jiao
Yaqun Guan
Rebiya Nuli

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1635579

2,344 views
1 citation

Original Research

Published on 08 Oct 2025

Proton pump inhibitor use and pancreatic risk: evidence from the UK biobank participants and animal experiments

in Gastrointestinal and Hepatic Pharmacology

Xin Gao
Zouhua Xu
Qingxie Liu
Chenchen Yuan
Xiaowu Dong
Xiaolei Shi
Qingtian Zhu
Keyan Wu
Hongwei Xu
Jiajia Pan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1673200

2,113 views

Review

Published on 03 Oct 2025

The endocannabinoid system as a therapeutic target in intestinal fibrosis

in Gastrointestinal and Hepatic Pharmacology

Zofia Misztal
Alicja Kaśniewska-Kosińska
Maria Wołyniak
Ewa Małecka-Wojciesko
Adam Fabisiak

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1669951

3,328 views

Original Research

Published on 26 Sep 2025

Pretreatment with Astragalus polysaccharide alleviates heat stroke–induced intestinal injury in mice

in Gastrointestinal and Hepatic Pharmacology

Niqi Shan
Linxiao Wang
Chujun Duan
Yilin Wu
Yangmengjie Jing
Hanyin Fan
Shuai Wang
Yuling Wang
Shijia Wang
Hui Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1612852

2,468 views

Original Research

Published on 23 Sep 2025

Novel insights into the hepatoprotective mechanisms of SGLT2 inhibitor empagliflozin in Zucker diabetic fatty rats

in Gastrointestinal and Hepatic Pharmacology

F. Comella
A. Aragón-Herrera
S. Melini
N. Opallo
S. Feijóo-Bandín
N. P. Navatti
G. Mattace Raso
O. Gualillo
C. Pirozzi
F. Lago-Paz

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1649630

3,589 views

Systematic Review

Published on 19 Sep 2025

Comparative gastrointestinal adverse effects of GLP-1 receptor agonists and multi-target analogs in type 2 diabetes: a Bayesian network meta-analysis

in Gastrointestinal and Hepatic Pharmacology

Xingmiao Xie
Shuiyuan Yang
Shuzhen Deng
Yuying Liu
Zhibin Xu
Binghong He

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1613610

6,724 views

Original Research

Published on 19 Sep 2025

Comparative efficacy of postoperative adjuvant transcatheter arterial chemoembolization and hepatic artery infusion chemotherapy in patients with BCLC stage 0-B hepatocellular carcinoma at high risk of recurrence following radical resection

in Gastrointestinal and Hepatic Pharmacology

Xu Feng
Yupei Ao
Jiarui Liu
Jue Yuan
Zhengrong Shi
Chengjia Tang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1657794

2,095 views

Original Research

Published on 15 Sep 2025

Mechanistic study on the restoration of intestinal barrier integrity and alleviation of inflammatory bowel disease by rhynchophylline via the AhR-NR4A1 pathway

in Gastrointestinal and Hepatic Pharmacology

Xuwen Mao
Lufeng Cheng
Yu Liu
Yuche Wu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1629012

1,943 views
1 citation

Original Research

Published on 12 Sep 2025

Ramucirumab plus paclitaxel as switch maintenance in patients with advanced HER2-negative gastric or gastro-oesophageal junction cancer: a cost-effectiveness analysis

in Gastrointestinal and Hepatic Pharmacology

Jiefeng Luo
Zhengxiong Li
Qiong Du
Jiyong Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1616826

2,432 views
1 citation

Review

Published on 10 Sep 2025

Mechanisms and advantages of natural derived small molecule compounds in the prevention and treatment of colorectal cancer: a review

in Gastrointestinal and Hepatic Pharmacology

Ming-Jie Liao
Hao-Yu Dong
Gang Chen
Wei-Wei Li
Guo-Feng Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1658493

2,755 views
1 citation

Systematic Review

Published on 09 Sep 2025

Efficacy and safety of fruquintinib in the treatment of colorectal cancer: a systematic review and meta-analysis of studies in China

in Gastrointestinal and Hepatic Pharmacology

Yuan Feng
Yu Shu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1590782

2,218 views

Original Research

Published on 05 Sep 2025

Pharmacological characterization of linaprazan glurate (X842), a novel potassium-competitive acid blocker, in vitro and in vivo

in Gastrointestinal and Hepatic Pharmacology

Ming Lu
Yi Cui
Nailin Li
Yan He
Ling Zhou
Jin Xiu
Pingsheng Hu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1636523

2,376 views

Mini Review

Published on 03 Sep 2025

NASH-related Hepatocellular carcinoma: current therapeutic approaches and the emerging role of sodium homeostasis as a novel targeting strategy

in Gastrointestinal and Hepatic Pharmacology

Abdulsalam Ashkar
Simone Fiorilla
Francesco Tasso
Rita Carini

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1671001

2,537 views

Perspective

Published on 01 Sep 2025

The macrogol revolution in the treatment of chronic constipation. A short history of laxatives

in Gastrointestinal and Hepatic Pharmacology

Enrico Stefano Corazziari

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1662224

3,466 views

Review

Published on 29 Aug 2025

Barriers and facilitators to non-pharmacological management of metabolic dysfunction-associated steatotic liver disease: a qualitative evidence synthesis

in Gastrointestinal and Hepatic Pharmacology

Yusuf Yilmaz

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1615809

2,770 views

Systematic Review

Published on 29 Aug 2025

Biochemical changes associated with non-alcoholic fatty liver disease in response to berberine treatment: a systematic review and meta-analysis of clinical and preclinical research

in Gastrointestinal and Hepatic Pharmacology

Wenyu Zhu
Lele Yang
Yufan Dai
Hanyang Wang
Jiaxuan Zhou
Lina Xia
Tao Shen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1460643

2,770 views

Original Research

Published on 29 Aug 2025

Ruxolitinib alleviates DSS-induced acute ulcerative colitis by inhibiting STAT1 phosphorylation and reducing MDSC infiltration

in Gastrointestinal and Hepatic Pharmacology

Lu Xu
Fangyue Xu
Qinghua Yao
Vincent Kam Wai Wong

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1572534

1,911 views

Original Research

Published on 26 Aug 2025

Berberine protects against gefitinib-induced liver injury by inhibiting the HMGB1/TLR4/NF-κB pathway

in Gastrointestinal and Hepatic Pharmacology

Qiongyin Zhang
Na Li
Xue Ma
Yue Qiu
Chao Li
Ya Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1645634

2,312 views

1,288 articles

articles

Rituximab in PR3-ANCA positive patients with moderately to severely active ulcerative colitis: a multicenter real-world pilot study

Therapeutic effects of three-strain probiotic combination on slow transit constipation: mechanistic insights into MAPK signaling pathway and gut microbiota restoration

The use of magnesium sulfate can reduce the mortality risk of cirrhosis patients: a retrospective cohort study

Efficacy and safety of live combined Bacillus subtilis and Enterococcus faecium in patients with constipation: a meta-analysis of randomized controlled trials

The role of cuproptosis in the occurrence and development of gastric cancer

Identification of galangin as a therapeutic candidate for primary biliary cholangitis via systematic druggable genome-wide Mendelian randomization analysis and experimental validation

Barnesiella intestinihominis improves gut microbiota disruption and intestinal barrier integrity in mice with impaired glucose regulation

Proton pump inhibitor use and pancreatic risk: evidence from the UK biobank participants and animal experiments

The endocannabinoid system as a therapeutic target in intestinal fibrosis

Pretreatment with Astragalus polysaccharide alleviates heat stroke–induced intestinal injury in mice

Novel insights into the hepatoprotective mechanisms of SGLT2 inhibitor empagliflozin in Zucker diabetic fatty rats

Comparative gastrointestinal adverse effects of GLP-1 receptor agonists and multi-target analogs in type 2 diabetes: a Bayesian network meta-analysis

Comparative efficacy of postoperative adjuvant transcatheter arterial chemoembolization and hepatic artery infusion chemotherapy in patients with BCLC stage 0-B hepatocellular carcinoma at high risk of recurrence following radical resection

Mechanistic study on the restoration of intestinal barrier integrity and alleviation of inflammatory bowel disease by rhynchophylline via the AhR-NR4A1 pathway

Ramucirumab plus paclitaxel as switch maintenance in patients with advanced HER2-negative gastric or gastro-oesophageal junction cancer: a cost-effectiveness analysis

Mechanisms and advantages of natural derived small molecule compounds in the prevention and treatment of colorectal cancer: a review

Efficacy and safety of fruquintinib in the treatment of colorectal cancer: a systematic review and meta-analysis of studies in China

Pharmacological characterization of linaprazan glurate (X842), a novel potassium-competitive acid blocker, in vitro and in vivo

NASH-related Hepatocellular carcinoma: current therapeutic approaches and the emerging role of sodium homeostasis as a novel targeting strategy

The macrogol revolution in the treatment of chronic constipation. A short history of laxatives

Barriers and facilitators to non-pharmacological management of metabolic dysfunction-associated steatotic liver disease: a qualitative evidence synthesis

Biochemical changes associated with non-alcoholic fatty liver disease in response to berberine treatment: a systematic review and meta-analysis of clinical and preclinical research

Ruxolitinib alleviates DSS-induced acute ulcerative colitis by inhibiting STAT1 phosphorylation and reducing MDSC infiltration

Berberine protects against gefitinib-induced liver injury by inhibiting the HMGB1/TLR4/NF-κB pathway