Frontiers in Pharmacology | Gastrointestinal and Hepatic Pharmacology

Original Research

Published on 26 Aug 2025

Gastrentrological clinical trials in Italy: an association study on regional economic factors and healthcare system efficiency

in Gastrointestinal and Hepatic Pharmacology

Maurizio Polignano
Davide Guido
Giuseppe Dalfino
Gianluigi Giannelli

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1594504

1,446 views

Original Research

Published on 20 Aug 2025

Clinical efficacy and regulatory mechanisms of Shi Pi Zeng Ye formula in treating functional constipation comorbid with depression: integrating clinical observation, mass spectrometry, bioinformatics, and molecular docking

in Gastrointestinal and Hepatic Pharmacology

Ling Yao
Xiaoqiang Jia
Yufei Li
Haixia Li
Zhuhui Zhang
Longfang Quan
Qiuling Liu
Jie Dai
Xuedi Lei
Huashang Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1645277

1,966 views

Systematic Review

Published on 15 Aug 2025

Comparison of ciprofol and propofol for endoscopic retrograde cholangio-pancreatography anesthesia: a systematic review and meta-analysis

in Gastrointestinal and Hepatic Pharmacology

Kai Wu
Min Liao
Juan Deng
Yunfeng Yu
Yuman Yin
Xinyu Yang
Rong Yu
Zhenjie Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1592781

2,272 views

Original Research

Published on 14 Aug 2025

Exercise ameliorates hepatic lipid accumulation via upregulating serum PRL and activating hepatic PRLR-mediated JAK2/STAT5 signaling pathway in NAFLD mice

in Gastrointestinal and Hepatic Pharmacology

Jia Fan
Kaidi Nie
Xiaobing Liu
Jiao Liu
Binghua Shao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1647231

1,919 views
1 citation

Systematic Review

Published on 11 Aug 2025

Potential of ciprofol as an alternative to propofol in elderly patients undergoing gastrointestinal endoscopy: a meta-analysis and trial sequential analysis

in Gastrointestinal and Hepatic Pharmacology

Yunfeng Yu
Min Liao
Juan Deng
Xinyu Yang
Yuman Yin
Zhenjie Liu
Guomin Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1644182

1,982 views

Original Research

Published on 08 Aug 2025

Hydrogen gas (H2) delivered by intraperitoneal injection alleviated methionine- and choline-deficient diet-induced metabolic dysfunction–associated steatotic liver disease in mice via inhibiting GSDMD- and GSDME-mediated pyroptosis

in Gastrointestinal and Hepatic Pharmacology

Yun Chen
Kangrong Wang
Wenhai Guo
Chengqin Lu
Wenting Suo
Qiuling Li
Yao Deng
Xinling Chen
Min Dai
Xiaodong Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1575106

3,428 views

Original Research

Published on 06 Aug 2025

A pharmacovigilance study of the association between linaclotide/plecanatide and muscle spasms based on food and drug administration adverse event reporting system

in Gastrointestinal and Hepatic Pharmacology

Xue Fan
Yuan Li
Xiangchun Lin

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1635792

2,183 views
1 citation

Editorial

Published on 31 Jul 2025

Editorial: Advanced therapeutic strategies in digestive and circulatory health: nanomedicine and beyond

in Gastrointestinal and Hepatic Pharmacology

Dan Li
Peng Zhang
Hui Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1666774

1,040 views

Correction

Published on 30 Jul 2025

Correction: Understanding the role of the gut microbiome in gastrointestinal cancer: A review

in Gastrointestinal and Hepatic Pharmacology

Duygu Agagündüz
Ermelinda Cocozza
Özge Cemali
Ayşe Derya Bayazıt
Maria Francesca Nanì
Ida Cerqua
Floriana Morgillo
Suna Karadeniz Saygılı
Roberto Berni Canani
Paola Amero

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1662597

1,199 views

Review

Published on 25 Jul 2025

The role of gallic acid in liver disease: a review of its phytochemistry, pharmacology, and safety

in Gastrointestinal and Hepatic Pharmacology

Peiyu Li
Yifan Song
Linlin Lv
Wenshuo Zhang
Aixi Jia
Deshi Dong
Xiaohan Zhai

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1595508

3,523 views
1 citation

Correction

Published on 24 Jul 2025

Correction: A pathology-attention multi-instance learning framework for multimodal classification of colorectal lesions

in Gastrointestinal and Hepatic Pharmacology

Fanglei Fu
Xuemei Zhang
Zhaoxuan Wang
Luxi Xie
Mingxi Fu
Jing Peng
Jianfeng Wu
Zhe Wang
Tian Guan
Yonghong He

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1666330

776 views

Original Research

Published on 23 Jul 2025

Exploring the molecular characteristics of inflammatory bowel disease from the perspective of hypoxia-related genes

in Gastrointestinal and Hepatic Pharmacology

Lei Zheng
Lin Mou
Lingying Hao
Rui Chen
Yifei Wang
Miao Yu
Xueyan Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1612676

2,018 views

Study Protocol

Published on 21 Jul 2025

Brucea javanica oil emulsion plus supportive care for refractory advanced colorectal cancer: a pilot RCT protocol

in Gastrointestinal and Hepatic Pharmacology

Liyuan Fang
Yan Wang
Yuhang Fang
Runxi Wang
Yi Xie
Shuhan Yang
Suying Liu
Ying Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1610575

2,030 views

Original Research

Published on 16 Jul 2025

Analyzing the potential targets and mechanisms of liver damage induced by acetyl tributyl citrate plasticizer using network toxicology, molecular docking and in vitro experiments

in Gastrointestinal and Hepatic Pharmacology

Dong-qun Guo
Yu-ming Fang
Zhen-dong Sun
Ya-fen Zeng
Gui-dan Wang
Jin-wei Liang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1636576

3,023 views

Review

Published on 11 Jul 2025

Beyond antibiotics: probiotics as a promising ally against Helicobacter pylori

in Gastrointestinal and Hepatic Pharmacology

Lin Yuan
Chong Yang
Ying Han
Fan Yang
Huabing Tu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1620870

8,288 views
1 citation

Original Research

Published on 11 Jul 2025

Evaluating the risk of osteoporosis-related adverse events with proton pump inhibitors: a pharmacovigilance study

in Gastrointestinal and Hepatic Pharmacology

Jingkai Di
Nan Yang
Yicong Zhao
Shuai Chen
Zijian Guo
Dongdong He
Chuan Xiang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1582908

3,985 views
1 citation

Systematic Review

Published on 11 Jul 2025

What is the optimal biological therapy for moderate to severe ulcerative colitis: a systematic review and network meta-analysis

in Gastrointestinal and Hepatic Pharmacology

Longbin Huang
Chen Kong
Ningning Yue
Hailan Zhao
Yuan Zhang
Chengmei Tian
Zhiliang Mai
Daoru Wei
Ruiyue Shi
Jun Yao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1602024

4,384 views
1 citation

Review

Published on 11 Jul 2025

Role of the Annexin A protein family in liver diseases: insights and therapeutic opportunities

in Gastrointestinal and Hepatic Pharmacology

Mingyang Feng
Yong He
Hui Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1569927

2,862 views
2 citations

Original Research

Published on 09 Jul 2025

D-glucaro-1,4-lactone alleviates acetaminophen-induced hepatotoxicity in mice via modulating gut microbiota and metabolites associated with Lactobacillus–glutamine and nicotinic acid pathways

in Gastrointestinal and Hepatic Pharmacology

Zhiying Song
Yiran Pan
Zeyu Wang
Yujing Chen
Yufeng Deng
Lele Wang
Qi Hu
Wenxiang Huang
Shuilin Sun
Baogang Xie

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1627850

1,632 views

Original Research

Published on 08 Jul 2025

Glucagon-like peptide-1 receptor agonist-induced cholecystitis and cholelithiasis: a real-world pharmacovigilance analysis using the FAERS database

in Gastrointestinal and Hepatic Pharmacology

Chao Tao
Yinhui Zhang
Tenggang Wan
Wenting Zhao
Jing Chen
Ke Wang
Liuxuan Yang
Guojun Wang
Qian Ding
Jinlu Shang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1557691

4,825 views

Original Research

Published on 02 Jul 2025

Nimotuzumab plus chemotherapy and immunotherapy as first-line/neoadjuvant therapy for advanced esophageal squamous cell carcinoma

in Gastrointestinal and Hepatic Pharmacology

Qi Wang
Zhi Cui
Muhong Deng
Guoqing Zhang
Fangfang Jing
Yue Ma
Fang Pang
Quanli Han

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1585048

2,232 views

Original Research

Published on 30 Jun 2025

Pharmacological basis for medicinal use of Cymbopogon proximus Hochst. ex A. Rich. Essential oil in hyperactive gastrointestinal disorders

in Gastrointestinal and Hepatic Pharmacology

Hassan N. Althurwi
Najeeb Ur Rehman
Maged S. Abdel-Kader
Faisal F. Albaqami

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1533511

1,639 views
2 citations

Systematic Review

Published on 26 Jun 2025

Effect of serum MMP-7 on the diagnostic accuracy of biliary atresia: systematic review and meta-analysis

in Gastrointestinal and Hepatic Pharmacology

Haojun Wang
Hui Liu
Wanfu Li
Ainiwaer Keranmu
Peng Liang
Yaqi Wang
Tao Zhang
Yeliaman Jiayilawu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1581053

2,108 views
1 citation

Original Research

Published on 25 Jun 2025

Explore the changes of metabolites in feces and serum of acute pancreatitis patients with different etiologies by LC-MS based metabolomics strategy

in Gastrointestinal and Hepatic Pharmacology

Meng-Yan Cui
Miao-Yan Fan
Jun Wu
Su-Min Chen
Meng-Qi Zhao
Qiao-Li Jiang
Jing-Jing Wang
Yue Zeng
Yu Zhao
Ying-Ying Lu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1614713

1,705 views

1,288 articles

articles

Gastrentrological clinical trials in Italy: an association study on regional economic factors and healthcare system efficiency

Clinical efficacy and regulatory mechanisms of Shi Pi Zeng Ye formula in treating functional constipation comorbid with depression: integrating clinical observation, mass spectrometry, bioinformatics, and molecular docking

Comparison of ciprofol and propofol for endoscopic retrograde cholangio-pancreatography anesthesia: a systematic review and meta-analysis

Exercise ameliorates hepatic lipid accumulation via upregulating serum PRL and activating hepatic PRLR-mediated JAK2/STAT5 signaling pathway in NAFLD mice

Potential of ciprofol as an alternative to propofol in elderly patients undergoing gastrointestinal endoscopy: a meta-analysis and trial sequential analysis

Hydrogen gas (H2) delivered by intraperitoneal injection alleviated methionine- and choline-deficient diet-induced metabolic dysfunction–associated steatotic liver disease in mice via inhibiting GSDMD- and GSDME-mediated pyroptosis

A pharmacovigilance study of the association between linaclotide/plecanatide and muscle spasms based on food and drug administration adverse event reporting system

Editorial: Advanced therapeutic strategies in digestive and circulatory health: nanomedicine and beyond

Correction: Understanding the role of the gut microbiome in gastrointestinal cancer: A review

The role of gallic acid in liver disease: a review of its phytochemistry, pharmacology, and safety

Correction: A pathology-attention multi-instance learning framework for multimodal classification of colorectal lesions

Exploring the molecular characteristics of inflammatory bowel disease from the perspective of hypoxia-related genes

Brucea javanica oil emulsion plus supportive care for refractory advanced colorectal cancer: a pilot RCT protocol

Analyzing the potential targets and mechanisms of liver damage induced by acetyl tributyl citrate plasticizer using network toxicology, molecular docking and in vitro experiments

Beyond antibiotics: probiotics as a promising ally against Helicobacter pylori

Evaluating the risk of osteoporosis-related adverse events with proton pump inhibitors: a pharmacovigilance study

What is the optimal biological therapy for moderate to severe ulcerative colitis: a systematic review and network meta-analysis

Role of the Annexin A protein family in liver diseases: insights and therapeutic opportunities

D-glucaro-1,4-lactone alleviates acetaminophen-induced hepatotoxicity in mice via modulating gut microbiota and metabolites associated with Lactobacillus–glutamine and nicotinic acid pathways

Glucagon-like peptide-1 receptor agonist-induced cholecystitis and cholelithiasis: a real-world pharmacovigilance analysis using the FAERS database

Nimotuzumab plus chemotherapy and immunotherapy as first-line/neoadjuvant therapy for advanced esophageal squamous cell carcinoma

Pharmacological basis for medicinal use of Cymbopogon proximus Hochst. ex A. Rich. Essential oil in hyperactive gastrointestinal disorders

Effect of serum MMP-7 on the diagnostic accuracy of biliary atresia: systematic review and meta-analysis

Explore the changes of metabolites in feces and serum of acute pancreatitis patients with different etiologies by LC-MS based metabolomics strategy