Frontiers in Pharmacology | Gastrointestinal and Hepatic Pharmacology

Review

Published on 08 Apr 2025

Endogenous micropeptides as potential diagnostic biomarkers and therapeutic drugs

in Gastrointestinal and Hepatic Pharmacology

Aixi Zhong
Shuai Li
Jingxuan Zhang
Jingyuan Zhao
Chenhui Yao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1545575

2,384 views
3 citations

Review

Published on 07 Apr 2025

Dual signaling pathways of TGF-β superfamily cytokines in hepatocytes: balancing liver homeostasis and disease progression

in Gastrointestinal and Hepatic Pharmacology

Roohi Chaudhary
Ralf Weiskirchen
Marcelo Ehrlich
Yoav I. Henis

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1580500

5,791 views
7 citations

Original Research

Published on 07 Apr 2025

Alteration of salivary Streptococcus is associated with statin therapy in older adults: a cohort study

in Gastrointestinal and Hepatic Pharmacology

Daisuke Hisamatsu
Yusuke Ogata
Wataru Suda
Yo Mabuchi
Yuna Naraoka
Taku Yamato
Akimi Ikeba
Kyoko Kumagai
Masahira Hattori
Chihiro Akazawa

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1455753

2,648 views
1 citation

Original Research

Published on 07 Apr 2025

Citral protects against metabolic endotoxemia, and systemic disorders caused by high-fat diet-induced obesity via intestinal modulation

in Gastrointestinal and Hepatic Pharmacology

Maycon Tavares Emílio-Silva
Vinicius Peixoto Rodrigues
Mariana Moraes Fioravanti
Antonio Jesús Ruiz-Malagon
Matheus Naia Fioretto
Priscila Romano Raimundo
Rie Ohara
Renata Assunção
Gabriela Bueno
Felipe Lima Dario

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1567217

2,905 views
3 citations

Original Research

Published on 04 Apr 2025

Suppressed intestinal secondary bile acids in moxifloxacin-induced hyperglycemia: studies in normal and diabetic GK rats

in Gastrointestinal and Hepatic Pharmacology

Yewen Sun
Yuchen Qu
Zhuan Yang
Bo Lv
Guanjun Wang
Kai Fan
Yuyuan Wang
Jie Pan
Ziyan Du
Yunli Yu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1569856

2,256 views

Original Research

Published on 04 Apr 2025

MiR-3613-5p targets AQP4 to promote the progression of chronic atrophic gastritis to gastric cancer

in Gastrointestinal and Hepatic Pharmacology

Jian Bi
Yufen Wang
Yingde Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1523689

2,881 views
2 citations

Original Research

Published on 04 Apr 2025

Alpha-estradiol and (R)-(−)-ibuprofen inhibit gastric cancer progression via GLI1 G-quadruplex

in Gastrointestinal and Hepatic Pharmacology

Qiang Li
Pan Pan
Qingqing Xian
Jingtan Li
Jingting Wang
Jiaying Cai
Jing Wang
Yanfei Jia
Haiji Sun
Lulu Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1492694

1,672 views

Original Research

Published on 03 Apr 2025

Paricalcitol alleviates intestinal ischemia-reperfusion injury via inhibition of the ATF4-CHOP pathway

in Gastrointestinal and Hepatic Pharmacology

Jiawei Zhang
Tingting Liu
Tongqing Xue
Zhongzhi Jia

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1529343

2,386 views

Brief Research Report

Published on 02 Apr 2025

Andrographis paniculata restores gut health by suppressing inflammation and strengthening mucosal immunity

in Gastrointestinal and Hepatic Pharmacology

Vidushi Tyagi
Ashish Kumar
Karuna Shanker
Anirban Pal

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1536683

4,886 views
3 citations

Systematic Review

Published on 01 Apr 2025

Inflammatory bowel disease therapeutics: a bibliometric analysis of tofacitinib research in ulcerative colitis

in Gastrointestinal and Hepatic Pharmacology

Jianping Zhou
Yuting Xi
Yaping Zhang
Rui Zhang
Hao Fu
Ce Zhou

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1570238

2,772 views

Systematic Review

Published on 28 Mar 2025

Research trends of nanomaterials in Helicobacter pylori: a bibliometric analysis from 2003 to 2023

in Gastrointestinal and Hepatic Pharmacology

Yeqing Lei
Tao Chen
Qin Du
Weihua Yu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1546395

2,190 views
1 citation

Review

Published on 27 Mar 2025

Mechanism and therapeutic potential of liver injury induced by cholesterol-associated proteins

in Gastrointestinal and Hepatic Pharmacology

Yourong Zhou
Yashi Cao
Yiming Yin
Zhifei Xu
Xiaochun Yang
Bo Yang
Peihua Luo
Hao Yan
Qiaojun He

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1572592

2,784 views
2 citations

Correction

Published on 27 Mar 2025

Corrigendum: Cynaroside ameliorates TNBS-induced colitis by inhibiting intestinal epithelial cell apoptosis via the PI3K/AKT signalling pathway

in Gastrointestinal and Hepatic Pharmacology

Ju Huang
Jing Li
Zhijun Geng
Lixia Yin
Minzhu Niu
Qingqing Li
Xinyue Liu
Xinke Cheng
Xiaofeng Zhang
Xue Song

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1591086

1,171 views

Original Research

Published on 27 Mar 2025

Gut microbiota and HMGB1/NLRP3/GSDMD inflammasome-dependent pyroptosis: mechanisms by physcion ameliorates alcoholic liver fibrosis

in Gastrointestinal and Hepatic Pharmacology

Ting Bai
Hao-Lin Guo
Fei Wang
Yan-Yu Kang
Hao-Tian Zhang
Lu Dong
Yong Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1532590

3,947 views
2 citations

Original Research

Published on 26 Mar 2025

Proactive pharmacogenomics in azathioprine-treated pediatric inflammatory bowel disease at a Chinese tertiary hospital

in Gastrointestinal and Hepatic Pharmacology

Cai-Yun Long
Ying Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1558897

1,646 views
1 citation

Original Research

Published on 24 Mar 2025

Chitinase 3-like protein 1 deficiency ameliorates drug-induced acute liver injury by inhibition of neutrophil recruitment through lipocalin-2

in Gastrointestinal and Hepatic Pharmacology

Ji Hye Kim
In Jun Yeo
Dong Ju Son
Sang Bae Han
Do Young Yoon
Dong Hun Lee
Jin Tae Hong

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1548832

2,532 views

Clinical Trial

Published on 24 Mar 2025

Efficacy and cost-effectiveness analysis of 10-day versus 14-day eradication of Helicobacter pylori infection with vonoprazan amoxicillin: a prospective, multicenter, randomized controlled trial

in Gastrointestinal and Hepatic Pharmacology

Yunfan Dong
Zhaotao Duan
Min Liu
Yanbing Ding
Guangxia Chen
Ruifang Wang
Xiaodan Xu
Lixia Ding
Qiang Zhan
Chengyu Pan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1543352

3,498 views

Review

Published on 21 Mar 2025

Recent advancement in prevention against hepatotoxicity, molecular mechanisms, and bioavailability of gallic acid, a natural phenolic compound: challenges and perspectives

in Gastrointestinal and Hepatic Pharmacology

Peng Chen
Fanzhao Zou
Wei Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1549526

4,449 views
12 citations

Original Research

Published on 20 Mar 2025

Licorice attenuates cisplatin-induced hepatotoxicity by alleviating endoplasmic reticulum stress and apoptosis

in Gastrointestinal and Hepatic Pharmacology

Jie Li
Xiujuan Yang
Xiaolong Lian
Baojian Li
Quhuan Ma
Lingling Yang
Guangmiao Gao
Yi Deng
Zhijun Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1557125

3,070 views
7 citations

Original Research

Published on 19 Mar 2025

Akkermansia muciniphila ameliorates olanzapine-induced metabolic dysfunction-associated steatotic liver disease via PGRMC1/SIRT1/FOXO1 signaling pathway

in Gastrointestinal and Hepatic Pharmacology

Hui Chen
Ting Cao
ChenQuan Lin
ShiMeng Jiao
YiFang He
ZhenYu Zhu
QiuJin Guo
RenRong Wu
HuaLin Cai
BiKui Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1550015

3,578 views
2 citations

Original Research

Published on 18 Mar 2025

A real-world disproportionality analysis of ripretinib data mining of the public version of FDA adverse event reporting system

in Gastrointestinal and Hepatic Pharmacology

Yingkai Feng
Xinyu Fa
Yifei Wang
Tao Zhang
Xuan Sun
Faping Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1469597

3,164 views
1 citation

Original Research

Published on 17 Mar 2025

E1231/NMN protects against experimental metabolic syndrome: the central role of SIRT1 in modulating AKT/Nrf2/NFκB signaling

in Gastrointestinal and Hepatic Pharmacology

Elsayed A. Elmorsy
Hala A. Elashry
Abdullah S. Alkhamiss
Hamad Alsaykhan
Rabab S. Hamad
Mustafa Ahmed Abdel-Reheim
Mansour Alsoghair
Mariam S. Alharbi
Attia M. Gabr
Abousree T. Ellethy

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1558709

3,532 views
3 citations

Original Research

Published on 14 Mar 2025

The protective role of cannabidiol in stress-induced liver injury: modulating oxidative stress and mitochondrial damage

in Gastrointestinal and Hepatic Pharmacology

Chengyu Huang
Huichao Liang
Xiaohua Liang
Yueyi Liu
Jiaoling Wang
Haoran Jiang
Xinhui Kou
Jun Chen
Lili Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1567210

3,052 views
7 citations

Review

Published on 13 Mar 2025

Crosstalk between bile acids and gut microbiota: a potential target for precancerous lesions of gastric cancer

in Gastrointestinal and Hepatic Pharmacology

Maofu Zhang
Jialin Zhong
Yanyun Shen
Zhongyang Song

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1533141

3,029 views
2 citations

1,288 articles

articles

Endogenous micropeptides as potential diagnostic biomarkers and therapeutic drugs

Dual signaling pathways of TGF-β superfamily cytokines in hepatocytes: balancing liver homeostasis and disease progression

Alteration of salivary Streptococcus is associated with statin therapy in older adults: a cohort study

Citral protects against metabolic endotoxemia, and systemic disorders caused by high-fat diet-induced obesity via intestinal modulation

Suppressed intestinal secondary bile acids in moxifloxacin-induced hyperglycemia: studies in normal and diabetic GK rats

MiR-3613-5p targets AQP4 to promote the progression of chronic atrophic gastritis to gastric cancer

Alpha-estradiol and (R)-(−)-ibuprofen inhibit gastric cancer progression via GLI1 G-quadruplex

Paricalcitol alleviates intestinal ischemia-reperfusion injury via inhibition of the ATF4-CHOP pathway

Andrographis paniculata restores gut health by suppressing inflammation and strengthening mucosal immunity

Inflammatory bowel disease therapeutics: a bibliometric analysis of tofacitinib research in ulcerative colitis

Research trends of nanomaterials in Helicobacter pylori: a bibliometric analysis from 2003 to 2023

Mechanism and therapeutic potential of liver injury induced by cholesterol-associated proteins

Corrigendum: Cynaroside ameliorates TNBS-induced colitis by inhibiting intestinal epithelial cell apoptosis via the PI3K/AKT signalling pathway

Gut microbiota and HMGB1/NLRP3/GSDMD inflammasome-dependent pyroptosis: mechanisms by physcion ameliorates alcoholic liver fibrosis

Proactive pharmacogenomics in azathioprine-treated pediatric inflammatory bowel disease at a Chinese tertiary hospital

Chitinase 3-like protein 1 deficiency ameliorates drug-induced acute liver injury by inhibition of neutrophil recruitment through lipocalin-2

Efficacy and cost-effectiveness analysis of 10-day versus 14-day eradication of Helicobacter pylori infection with vonoprazan amoxicillin: a prospective, multicenter, randomized controlled trial

Recent advancement in prevention against hepatotoxicity, molecular mechanisms, and bioavailability of gallic acid, a natural phenolic compound: challenges and perspectives

Licorice attenuates cisplatin-induced hepatotoxicity by alleviating endoplasmic reticulum stress and apoptosis

Akkermansia muciniphila ameliorates olanzapine-induced metabolic dysfunction-associated steatotic liver disease via PGRMC1/SIRT1/FOXO1 signaling pathway

A real-world disproportionality analysis of ripretinib data mining of the public version of FDA adverse event reporting system

E1231/NMN protects against experimental metabolic syndrome: the central role of SIRT1 in modulating AKT/Nrf2/NFκB signaling

The protective role of cannabidiol in stress-induced liver injury: modulating oxidative stress and mitochondrial damage

Crosstalk between bile acids and gut microbiota: a potential target for precancerous lesions of gastric cancer