Frontiers in Pharmacology | Inflammation Pharmacology

Original Research

Published on 10 Nov 2025

Modulation of TNFα-driven neuroinflammation by Gardenin A: insights from in vitro, in vivo, and in silico studies

in Inflammation Pharmacology

Prashsti Chadha
Hiral Aghara
Harshrajsinh Solanki
Manali Patel
Dhrubjyoti Sharma
Vijay Thiruvenkatam
Palash Mandal

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1681403

2,092 views

Review

Published on 07 Nov 2025

AMPK signaling in osteoarthritis: from mechanisms to targeted therapeutics

in Inflammation Pharmacology

Lin Chen
Xiu-Hua Hu
Xin-Yi Wu
Xin Zhang
Yu-Xin Han
Yi Liu
Guang-Yao Chen
Qing-Wen Tao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1681610

1,631 views
2 citations

Systematic Review

Published on 06 Nov 2025

Clinical benefits and complication profile of IL-23 inhibitors in patients with psoriatic arthritis: a systematic review and meta-analysis

in Inflammation Pharmacology

Jingxin Zeng
Ling Lin
Wei Li
Xinjing Gao
Qian Li
Xin Zhou
Weiyu Liu
Xuelian Zhong
Yunqing Yang
Xibao Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1669786

1,984 views

Original Research

Published on 30 Oct 2025

1-stearoyl-2-arachidonoyl-driven B Cell metabolic dysregulation in chronic rhinosinusitis with nasal polyps: insights from Mendelian randomization and single-cell RNA sequencing

in Inflammation Pharmacology

Jian Wu
Yifang Sun
Shuyue Wang
Qian Zhang
Ying Lin
Caipeng Liu
Maomao Ai
Feng Yu
Lei Cao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1719897

1,243 views

Original Research

Published on 28 Oct 2025

Regulation of inflammatory pathways by cannabigerol in the collagen induced arthritis model in rats

in Inflammation Pharmacology

Monika Šteigerová
Michaela Sklenárová
Mykhaylo Bazyuk
Luděk Záveský
Petr Jelínek
Mahak Arora
Daniel Stránský
Tomáš Kučera
Bruno Sepodes
Miroslav Šoóš

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1705962

1,989 views

Systematic Review

Published on 27 Oct 2025

Comparison of multiple doses of corticosteroids in Kawasaki disease: a Bayesian network analysis

in Inflammation Pharmacology

Xuan Li
Xuan Tang
Daoping Yang
Miao Hou
Qiuqin Xu
Yunjia Tang
Bo Wang
Hongbiao Huang
Ye Chen
Zhiheng Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1661380

2,391 views

Original Research

Published on 22 Oct 2025

CU06-1004 inhibits the progression of chronic colitis and colitis-associated colorectal cancer by suppressing inflammation

in Inflammation Pharmacology

Dongyeop Kim
Yeomyeong Kim
Haiying Zhang
Ye-Seul Kim
Minyoung Noh
Cho-Rong Bae
Young-Guen Kwon
Sang-Jun Ha

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1684870

2,027 views
1 citation

Original Research

Published on 21 Oct 2025

The selective ERβ agonist AC 186 reduces polyinosinic:polycytidylic acid (poly I:C)-induced inflammatory responses in BEAS-2B lung epithelial cells

in Inflammation Pharmacology

Olumayokun A. Olajide
Hope A. Ogiogio

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1706638

1,386 views

Original Research

Published on 17 Oct 2025

A double layer oral film loaded with doxepin hydrochloride for the treatment of chemotherapy-induced oral mucositis

in Inflammation Pharmacology

Peiyan Wang
Tianlu Wang
Hui Zhang
Pei Sun
Changqing Yuan
Yiqing Guo
Zhaochen Liu
Mengyu Jiao
Jingwen Chi
Kexin Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1673190

1,441 views

Opinion

Published on 09 Oct 2025

Potential strategies for combination therapy involving medicines with differential signal transduction regulation effects and the mechanism of action of minocycline in septic neuroinflammation

in Inflammation Pharmacology

Kazuhiro Itoh
Hiroshi Tsutani
Yasuhiko Mitsuke
Masamichi Ikawa
Hiromichi Iwasaki

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1691613

1,392 views

Clinical Trial

Published on 07 Oct 2025

Preemptive flurbiprofen axetil for sleep-pain-inflammation modulation after laparoscopic gynecological surgery: a prospective, parallel-group randomized controlled trial

in Inflammation Pharmacology

Xin Huang
Wenxin Wei
Zhihao Leng
Bijia Song
Ming Fu
Jiangshan He
Junchao Zhu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1659179

2,212 views

Correction

Published on 07 Oct 2025

Correction: Anti-inflammatory effect and mechanism of stytontriterpene D on RAW264.7 cells and zebrafish

in Inflammation Pharmacology

Chuqin Yu
Gao Qiu
Xiangying Liu
Quanwei Xie
Zonghao Lin
Feng Wang
Lei Cai

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1620902

673 views
2 citations

Original Research

Published on 03 Oct 2025

Decoding monocyte heterogeneity in sepsis: a single-cell apoptotic signature for immune stratification and guiding precision therapy

in Inflammation Pharmacology

Wenjuan Duan
Qi Chen
Wei Li
Haiying Zhou
Xiaorong Deng
Yan Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1675887

3,434 views

Review

Published on 01 Oct 2025

Advances in drug delivery systems for the management of gout and hyperuricemia

in Inflammation Pharmacology

Zining Peng
Fanyu Meng
Qian Deng
Yuanbo Huang
Danning Mao
Yuan Long
Weitian Yan
Jiangyun Peng
Xingqiang Wang
Nian Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1660890

4,759 views
1 citation

Correction

Published on 01 Oct 2025

Correction: Human adipose mesenchymal stem cell-derived exosomes alleviate fibrosis by restraining ferroptosis in keloids

in Inflammation Pharmacology

Yuan Tian
Meijia Li
Rong Cheng
Xinyue Chen
Zhishan Xu
Jian Yuan
Zhiyong Diao
Lijun Hao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1705356

2,338 views

Original Research

Published on 29 Sep 2025

Targeted ferroptosis of myofibroblasts by tubeimoside I attenuates hypertrophic scar formation

in Inflammation Pharmacology

Jianzhang Wang
Chen Wang
Yulei Jia
Fengchao Chen
Youbin Wang
Juan Du

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1654108

2,121 views

Review

Published on 26 Sep 2025

The regulatory effects of luteolin, calycosin, and formononetin on the NLRP3/IL-33/ILC2s axis in the treatment of allergic rhinitis: mechanistic analysis and therapeutic potential

in Inflammation Pharmacology

Meng Jia
Xiaochun Lei
Fuwei Jiang
Detang Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1658772

4,157 views

Original Research

Published on 26 Sep 2025

Prostaglandin E2 stimulates opposing effects on inner and outer blood-retina barrier function

in Inflammation Pharmacology

Amy K. Stark
Anna R. Gilmartin
Cayla D. Ontko
Taylor E. Smith
Amanda L. Beall
Gary W. McCollum
John S. Penn

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1608376

2,038 views

Mini Review

Published on 16 Sep 2025

Promising therapeutics of enterovirus 71 infection: sunshine behind cloud

in Inflammation Pharmacology

Sheng-Yu You
Shun-Hua Chen
Shih-Min Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1652159

2,623 views
1 citation

Original Research

Published on 15 Sep 2025

Association of dexmedetomidine with short-term outcome in patients with cardiogenic shock: a retrospective propensity score-matched cohort study from MIMIC-IV

in Inflammation Pharmacology

Linfeng Xie
Jing Chen
Bryan Richard Sasmita
Yuanzhu Li
Suxin Luo
Bi Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1644635

3,438 views

Review

Published on 12 Sep 2025

Role of N6-Methyladenosine (m6A) epitranscriptomic mark in regulating viral infections and target for antiviral development

in Inflammation Pharmacology

Mahmoud Bayoumi
Vidya Manju
Luis Martinez-Sobrido
Muhammad Munir

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1667283

3,104 views
2 citations

Review

Published on 11 Sep 2025

GLP-1 receptor agonists: exploration of transformation from metabolic regulation to multi-organ therapy

in Inflammation Pharmacology

Bing Gong
Couwen Li
Zhuang’e Shi
FuPing Wang
Ruanxian Dai
Guobing Chen
Heng Su

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1675552

8,803 views
7 citations

Original Research

Published on 10 Sep 2025

Inhibition of soluble epoxide hydrolase in endotoxin induced pig lung injury

in Inflammation Pharmacology

Niklas Larsson
Cindy B. McReynolds
Sung Hee Hwang
Debin Wan
Jun Yang
Richard Lindberg
Stefan Lehtipalo
Jonas Claesson
Amanda Irgum Liljeström
Alicia Lind

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1652349

2,240 views

Correction

Published on 09 Sep 2025

Correction: Research progress in treatment of rheumatoid arthritis with Sinomenine and related formulations based on different administration routes

in Inflammation Pharmacology

Wenya Wang
Zihui Wang
Aixia Ling
Chunyan Zhang
Mei Lv
Lufen Huang
Yanlian Niu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1685111

1,315 views

1,846 articles

articles

Modulation of TNFα-driven neuroinflammation by Gardenin A: insights from in vitro, in vivo, and in silico studies

AMPK signaling in osteoarthritis: from mechanisms to targeted therapeutics

Clinical benefits and complication profile of IL-23 inhibitors in patients with psoriatic arthritis: a systematic review and meta-analysis

1-stearoyl-2-arachidonoyl-driven B Cell metabolic dysregulation in chronic rhinosinusitis with nasal polyps: insights from Mendelian randomization and single-cell RNA sequencing

Regulation of inflammatory pathways by cannabigerol in the collagen induced arthritis model in rats

Comparison of multiple doses of corticosteroids in Kawasaki disease: a Bayesian network analysis

CU06-1004 inhibits the progression of chronic colitis and colitis-associated colorectal cancer by suppressing inflammation

The selective ERβ agonist AC 186 reduces polyinosinic:polycytidylic acid (poly I:C)-induced inflammatory responses in BEAS-2B lung epithelial cells

A double layer oral film loaded with doxepin hydrochloride for the treatment of chemotherapy-induced oral mucositis

Potential strategies for combination therapy involving medicines with differential signal transduction regulation effects and the mechanism of action of minocycline in septic neuroinflammation

Preemptive flurbiprofen axetil for sleep-pain-inflammation modulation after laparoscopic gynecological surgery: a prospective, parallel-group randomized controlled trial

Correction: Anti-inflammatory effect and mechanism of stytontriterpene D on RAW264.7 cells and zebrafish

Decoding monocyte heterogeneity in sepsis: a single-cell apoptotic signature for immune stratification and guiding precision therapy

Advances in drug delivery systems for the management of gout and hyperuricemia

Correction: Human adipose mesenchymal stem cell-derived exosomes alleviate fibrosis by restraining ferroptosis in keloids

Targeted ferroptosis of myofibroblasts by tubeimoside I attenuates hypertrophic scar formation

The regulatory effects of luteolin, calycosin, and formononetin on the NLRP3/IL-33/ILC2s axis in the treatment of allergic rhinitis: mechanistic analysis and therapeutic potential

Prostaglandin E2 stimulates opposing effects on inner and outer blood-retina barrier function

Promising therapeutics of enterovirus 71 infection: sunshine behind cloud

Association of dexmedetomidine with short-term outcome in patients with cardiogenic shock: a retrospective propensity score-matched cohort study from MIMIC-IV

Role of N6-Methyladenosine (m6A) epitranscriptomic mark in regulating viral infections and target for antiviral development

GLP-1 receptor agonists: exploration of transformation from metabolic regulation to multi-organ therapy

Inhibition of soluble epoxide hydrolase in endotoxin induced pig lung injury

Correction: Research progress in treatment of rheumatoid arthritis with Sinomenine and related formulations based on different administration routes