Frontiers in Pharmacology | Inflammation Pharmacology

Original Research

Published on 08 Sep 2025

Empagliflozin targeting STAT3/Akt/Nrf2 axis promoting diabetic wound healing in rat model

in Inflammation Pharmacology

Rania Magadmi
Dalal Alfawaz
Ahmed Bakhshwin
Fatmah Binzomah Alghamdi
Sultan A. Alfawaz
Duaa M. Bakhshwin
Maha H. Jamal
Roba A. Sofi
Ahmed Esmat

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1678552

2,562 views
1 citation

Original Research

Published on 04 Sep 2025

Mitochondria-target ubiquinone attenuates bleomycin-induced pulmonary fibrosis

in Inflammation Pharmacology

Ying Jiang
Zhenghui Huang
Ting Zhou
Mi Wu
Juan Zhao
Zheyi Xiong
Rui Wang
Limin Chen
Xiufang Weng
Lan Lin

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1661644

3,399 views
1 citation

Original Research

Published on 02 Sep 2025

In situ sustained release of icariin from injectable thermosensitive PLGA-PEG-PLGA hydrogels combined with core decompression for steroid-induced osteonecrosis of femoral head

in Inflammation Pharmacology

Yingxing Xu
Kaige Xu
Zehua Wang
Xinyu Tang
Yaping Jiang
Tao Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1643316

2,708 views

Original Research

Published on 01 Sep 2025

Exploring the potential of a thermosensitive in situ gel with Periplaneta americana extracts for efficient wound healing

in Inflammation Pharmacology

Shuai Liu
Shuohan Xu
Hang Lu
Xueyu Gong
Huaipeng Li
Xinyu Fan
Hongwei Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1672818

1,851 views

Original Research

Published on 28 Aug 2025

Opposing profiles of Netrin-1 and adiponectin in metabolic inflammation and insulin resistance

in Inflammation Pharmacology

María Guadalupe Ramos-Zavala
Jesús Jonathan García-Galindo
Alberto Beltrán-Ramírez
Luis Ricardo Balleza-Alejandri
Emiliano Peña-Durán
Alfredo Huerta-Huerta
Edy David Rubio-Arellano
Luis Daniel López-Murillo
Sara Pascoe-Gonzalez
Tannia Isabel Campos-Bayardo

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1632956

2,725 views

Review

Published on 21 Aug 2025

Apremilast treatment of immune-mediated inflammatory skin diseases: a narrative review

in Inflammation Pharmacology

Xiaoqian Liang
Jiecheng Zheng
Xueyi Huang
Min Tan
Jia Liao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1633426

4,355 views
2 citations

Systematic Review

Published on 21 Aug 2025

Efficacy and safety of topical vs. oral calcium channel blockers for chronic anal fissures: a systematic review and meta-analysis

in Inflammation Pharmacology

Tianshuo Li
Pengfei Ye
Xinli He
Chen Li
Lanlan Xi
Zuowu Xi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1642347

2,656 views

Correction

Published on 21 Aug 2025

Correction: α-Mangostin alleviated inflammation in rats with adjuvant-induced arthritis by disrupting adipocytes-mediated metabolism-immune feedback

in Inflammation Pharmacology

Ying-Hao Hu
Jun Han
Lin Wang
Chao Shi
Yan Li
Opeyemi Joshua Olatunji
Xiu Wang
Jian Zuo

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1671368

1,018 views

Systematic Review

Published on 11 Aug 2025

Safety of oral JAK inhibitors in treating alopecia areata: a systematic review and network meta-analysis

in Inflammation Pharmacology

Ziyu Qi
Yan Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1576553

5,895 views
3 citations

Clinical Trial

Published on 07 Aug 2025

The anti-inflammatory and antioxidant effects of astaxanthin as an adjunctive therapy in community-acquired pneumonia: a randomized controlled trial

in Inflammation Pharmacology

Fatma Makram Youssef
Hayam Ateyya
Amir Eskander Hanna Samy
Eman Mohamed Elmokadem

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1621308

6,249 views
4 citations

Review

Published on 06 Aug 2025

Research progress in treatment of rheumatoid arthritis with Sinomenine and related formulations based on different administration routes

in Inflammation Pharmacology

Wenya Wang
Zihui Wang
Aixia Ling
Chunyan Zhang
Mei Lv
Lufen Huang
Yanlian Niu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1613679

4,415 views
2 citations

Review

Published on 06 Aug 2025

Exploring dupilumab for asthma: from mechanistic insights to clinical outcomes, safety, and cost-effectiveness

in Inflammation Pharmacology

Omar Z. Ameer
Ghaith K. Mansour
Raghad S. Al-Amoudi
Fahmi M. Abu‐Owaimer

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1631321

9,569 views
3 citations

Original Research

Published on 25 Jul 2025

Unique compound with anti-allergic action: inhibition of Lyn kinase activity by KIRA6

in Inflammation Pharmacology

Goshi Matsushima
Yuri Matsui
Hanano Okamoto
Nagisa Umeda
Mai Kakimoto
Megumi Mino
Tadashi Nakagawa
Kaori Ishii
Yoshimi Matsuo
Daiki Matsubara

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1625798

2,479 views
1 citation

Original Research

Published on 23 Jul 2025

Degradation of IRAK4 for the treatment of lipopolysaccharide-induced acute lung injury in mice

in Inflammation Pharmacology

Bijun Ye
Shiyan Chen
Xiaohao Huang
Yinhong Qiu
Ruixiang Luo
Lulu Zheng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1609923

3,680 views
1 citation

Original Research

Published on 21 Jul 2025

Role of homovanillic acid esters in the regulation of skin inflammatory pathways and their effect on tight junction protein expression

in Inflammation Pharmacology

Maria Fernanda Cervantes Recalde
Elena Zoe Bogensperger
Joachim Hans
Dominik Stuhlmann
Veronika Somoza
Barbara Lieder

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1629941

1,437 views
1 citation

Correction

Published on 14 Jul 2025

Correction: Berberine ameliorates subarachnoid hemorrhage injury via induction of Sirtuin 1 and inhibiting HMGB1/Nf-κB pathway

in Inflammation Pharmacology

Xiang-Hua Zhang
Lei Peng
Jing Zhang
Yi-Peng Dong
Cheng-Jun Wang
Cang Liu
Da-Yong Xia
Xiang-Sheng Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1540873

1,020 views

Original Research

Published on 11 Jul 2025

Lumefantrine ameliorates DSS-induced colitis by targeting FLI-1 to suppress NF-κB signaling

in Inflammation Pharmacology

Ji Yang
Peng Guo
Hongtao Luo
Xin Tang
Wei Liu
Xiaolin Ren

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1614978

2,130 views
1 citation

Original Research

Published on 07 Jul 2025

Antagonizing IL-6 receptor restores pancreatic tissue resident NK cells activation and ameliorates pancreatic injury in the mouse model of MASH

in Inflammation Pharmacology

Johnny Amer
Diana Abu Arra
Ahmad Salhab
Faris Kayed
Muneer Maali
Raghad Shweiki
Mustafa Ghanim

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1611637

2,781 views
1 citation

Original Research

Published on 02 Jul 2025

Exploring the beneficial effects of GHK-Cu on an experimental model of colitis and the underlying mechanisms

in Inflammation Pharmacology

Shuzhen Mao
Jiahui Huang
Junyan Li
Fang Sun
Qilian Zhang
Qing Cheng
Wei Zeng
Dongya Lei
Shiyan Wang
Jing Yao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1551843

17,487 views
1 citation

Correction

Published on 01 Jul 2025

Correction: Mechanism underlying the involvement of CXCR4/CXCL12 in diabetic wound healing and prospects for responsive hydrogel-loaded CXCR4 formulations

in Inflammation Pharmacology

Lingli Wang
Fengsong Nie
Zhaoyu Lu
Yang Chong

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1646006

1,586 views
3 citations

Systematic Review

Published on 01 Jul 2025

Immunomodulatory effects of ulinastatin combined with continuous blood purification in sepsis: a systematic review and meta-analysis

in Inflammation Pharmacology

Hui Gao
Zhiqiang Tang
Shucheng Zhao
Yuanjun Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1591470

2,998 views

Original Research

Published on 27 Jun 2025

Protective effects of Salubrinal against H2O2-induced muscle wasting via eIF2α/ATF4 signaling pathway

in Inflammation Pharmacology

Siming Lin
Jingying Wu
Guili Lian
Weibin Wu
Weixiao Chen
Ai Chen
Li Luo
Liangdi Xie

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1607606

2,392 views
2 citations

Original Research

Published on 25 Jun 2025

Anti atherosclerosis effect and mechanism of a novel curcumin analogue CACN136: regulating macrophage M1/M2 polarization and lipid metabolism

in Inflammation Pharmacology

Qianjiao Zhao
Yueting Zhong
Zheng Li
Jia Tang
Chao Pi
Wenwu Zheng
Peng Shi
Ying Zuo
Jun Jiang
Yan Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1632647

3,370 views
3 citations

Original Research

Published on 25 Jun 2025

Impact of different treatment strategies on therapeutic efficacy and biomarkers in children with IVIG-resistant Kawasaki disease: a retrospective cohort study

in Inflammation Pharmacology

Xin Zhou
Rui Dong
Xiaoling Wei
Hao Ding
Xiaochen Wang
Wei Wu
Guiyun Kang
Lei Li
Xiang Ma

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1602637

2,016 views

1,846 articles

articles

Empagliflozin targeting STAT3/Akt/Nrf2 axis promoting diabetic wound healing in rat model

Mitochondria-target ubiquinone attenuates bleomycin-induced pulmonary fibrosis

In situ sustained release of icariin from injectable thermosensitive PLGA-PEG-PLGA hydrogels combined with core decompression for steroid-induced osteonecrosis of femoral head

Exploring the potential of a thermosensitive in situ gel with Periplaneta americana extracts for efficient wound healing

Opposing profiles of Netrin-1 and adiponectin in metabolic inflammation and insulin resistance

Apremilast treatment of immune-mediated inflammatory skin diseases: a narrative review

Efficacy and safety of topical vs. oral calcium channel blockers for chronic anal fissures: a systematic review and meta-analysis

Correction: α-Mangostin alleviated inflammation in rats with adjuvant-induced arthritis by disrupting adipocytes-mediated metabolism-immune feedback

Safety of oral JAK inhibitors in treating alopecia areata: a systematic review and network meta-analysis

The anti-inflammatory and antioxidant effects of astaxanthin as an adjunctive therapy in community-acquired pneumonia: a randomized controlled trial

Research progress in treatment of rheumatoid arthritis with Sinomenine and related formulations based on different administration routes

Exploring dupilumab for asthma: from mechanistic insights to clinical outcomes, safety, and cost-effectiveness

Unique compound with anti-allergic action: inhibition of Lyn kinase activity by KIRA6

Degradation of IRAK4 for the treatment of lipopolysaccharide-induced acute lung injury in mice

Role of homovanillic acid esters in the regulation of skin inflammatory pathways and their effect on tight junction protein expression

Correction: Berberine ameliorates subarachnoid hemorrhage injury via induction of Sirtuin 1 and inhibiting HMGB1/Nf-κB pathway

Lumefantrine ameliorates DSS-induced colitis by targeting FLI-1 to suppress NF-κB signaling

Antagonizing IL-6 receptor restores pancreatic tissue resident NK cells activation and ameliorates pancreatic injury in the mouse model of MASH

Exploring the beneficial effects of GHK-Cu on an experimental model of colitis and the underlying mechanisms

Correction: Mechanism underlying the involvement of CXCR4/CXCL12 in diabetic wound healing and prospects for responsive hydrogel-loaded CXCR4 formulations

Immunomodulatory effects of ulinastatin combined with continuous blood purification in sepsis: a systematic review and meta-analysis

Protective effects of Salubrinal against H2O2-induced muscle wasting via eIF2α/ATF4 signaling pathway

Anti atherosclerosis effect and mechanism of a novel curcumin analogue CACN136: regulating macrophage M1/M2 polarization and lipid metabolism

Impact of different treatment strategies on therapeutic efficacy and biomarkers in children with IVIG-resistant Kawasaki disease: a retrospective cohort study