Frontiers in Pharmacology | Inflammation Pharmacology

Original Research

Published on 12 May 2025

Esmolol improves sepsis outcomes through cardiovascular and immune modulation

in Inflammation Pharmacology

Da Jing
Li Xiong
Rong Zhang
Hong Fang
Lin Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1498227

2,089 views
4 citations

Original Research

Published on 09 May 2025

Suppressing chondrocyte cuproptosis by syringaresinol-4-O-β-d-glucoside alleviates gouty arthritis

in Inflammation Pharmacology

Shaotian Fu
Han Du
Xiao Ling
Hanyi Wang
Jianan Chen
Hang Zhang
Wugui Chen
Chengzhao Liu
Hailong Ma
Chengshou Lin

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1565422

3,718 views
4 citations

Review

Published on 09 May 2025

Natural saponins and macrophage polarization: Mechanistic insights and therapeutic perspectives in disease management

in Inflammation Pharmacology

Beibei Xiong
Huan Wang
Yi-Xuan Song
Wen-Ying Lan
Jiangtao Li
Fang Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1584035

4,282 views
9 citations

Original Research

Published on 08 May 2025

Rutin ameliorates LPS-induced acute lung injury in mice by inhibiting the cGAS-STING-NLRP3 signaling pathway

in Inflammation Pharmacology

Xin Zhou
Zhibin Wang
Yuting Wang
Guofeng Xu
Min Luo
Mengwei Zhang
Yuying Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1590096

5,585 views
5 citations

Review

Published on 06 May 2025

Curcumin: a potential anti-photoaging agent

in Inflammation Pharmacology

Yuhong Nie
Yiming Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1559032

9,277 views
8 citations

Original Research

Published on 30 Apr 2025

Effect of methotrexate/dexamethasone combination on epithelial-mesenchymal transition and inflammation gene expression of human RPE cells in-vitro

in Inflammation Pharmacology

Fatemeh Sanie-Jahromi
Mahdi Ravankhah
Hossein Shafi Khani
Seyed Ahmad Razavizadegan
M. Hossein Nowroozzadeh

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1569703

2,068 views
1 citation

Original Research

Published on 29 Apr 2025

Irisin restrains neuroinflammation in mouse experimental autoimmune encephalomyelitis via regulating microglia activation

in Inflammation Pharmacology

Qiu-Xia Zhang
Lin-Jie Zhang
Ning Zhao
Li Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1561939

2,301 views
2 citations

Original Research

Published on 28 Apr 2025

Anti-inflammatory effect and mechanism of stytontriterpene D on RAW264.7 cells and zebrafish

in Inflammation Pharmacology

Chuqin Yu
Gao Qiu
Xiangying Liu
Quanwei Xie
Zonghao Lin
Feng Wang
Lei Cai

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1559022

4,049 views
2 citations

Original Research

Published on 25 Apr 2025

The immunostimulatory activity of Epimedium flavonoids involves toll-like receptor 7/8

in Inflammation Pharmacology

Jingyu Wu
Yi Ou
Min Yao
Jiaquan Liu
Hengxing Ran
Zhengrong Wu
Rihui Wu
Lishe Gan
Dongli Li
Jingwei Jin

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1514284

2,638 views
2 citations

Original Research

Published on 25 Apr 2025

Frailty and cardiovascular safety of JAK inhibitors versus TNF inhibitors in rheumatoid arthritis: a real-world comparative study of drug effects and patient profiles

in Inflammation Pharmacology

Ettore Silvagni
Alessandra Bortoluzzi
Giuseppe Occhino
Giuseppe Bellelli
Carlo Garaffoni
Paolo Delvino
Olivia Leoni
Maria Grazia Valsecchi
Carlo Alberto Scirè
Paola Rebora

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1565909

4,081 views
6 citations

Editorial

Published on 25 Apr 2025

Editorial: Targeting neuroinflammation for novel therapeutics in neurodegenerative diseases

in Inflammation Pharmacology

Pukar Khanal
Rupesh Chikhale
Jatin Machhi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1602495

3,273 views

Original Research

Published on 24 Apr 2025

S1PR4-dependent effects of Etrasimod on primary human myeloid immune cell activation

in Inflammation Pharmacology

Fiona K. Sailer
Megan A. Palmer
Blerina Aliraj
Jan Heering
Andreas Brockmann
Mohammed A. F. Elewa
Aissa Röhrig
Ewgenij Proschak
Dariusz T. Stepniak
Simeon Ramsey

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1590816

4,436 views

Original Research

Published on 23 Apr 2025

Tetramethylpyrazine alleviates acute pancreatitis inflammation by inhibiting pyroptosis via the NRF2 pathway

in Inflammation Pharmacology

Huangen Li
Yi Gao
Minglian Huang
Hongling Zhang
Qingqing Wu
Youpei Huang
Xiaotong Ye
Weiwen Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1557681

2,418 views
3 citations

Original Research

Published on 23 Apr 2025

An off-target effect of class A CpG-oligonucleotides on suppressing the cyclic GMP-AMP synthase signaling in fibroblastic reticular cells

in Inflammation Pharmacology

Preethi Jayakumar
Ting Jiang
Hai Huang
Meihong Deng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1576151

2,208 views
1 citation

Review

Published on 16 Apr 2025

Mechanism underlying the involvement of CXCR4/CXCL12 in diabetic wound healing and prospects for responsive hydrogel-loaded CXCR4 formulations

in Inflammation Pharmacology

Lingli Wang
Fengsong Nie
Zhaoyu Lu
Yang Chong

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1561112

3,722 views
2 citations

Original Research

Published on 09 Apr 2025

Umbilical cord stem cells therapy against bacterial pneumonia based on zebrafish pneumonia model

in Inflammation Pharmacology

Xueli Chen
Jian Jin
Xia Chen
Yabin Wu
Youjun Guo
Zuoyu Qian
Hui Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1546193

1,857 views

Review

Published on 09 Apr 2025

Oxidative stress in vascular surgical diseases: mechanisms, impacts and therapeutic perspectives

in Inflammation Pharmacology

Haosen Xu
Jin Yang
Zhanhui Wei
Shijie Bao
Zhuo Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1527684

3,472 views
9 citations

Review

Published on 08 Apr 2025

Anti-inflammatory drugs as potential antimicrobial agents: a review

in Inflammation Pharmacology

Onyedika Emmanuel Okpala
Johana Rondevaldova
Ladislav Kokoska

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1557333

12,323 views
9 citations

Review

Published on 07 Apr 2025

Paeoniflorin: a review of its pharmacology, pharmacokinetics and toxicity in diabetes

in Inflammation Pharmacology

Xue Ou
Zhijie Yu
Chuanyu Pan
Xi Zheng
Dandan Li
Zhenzhen Qiao
Xiaoyuan Zheng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1551368

4,545 views
8 citations

Review

Published on 07 Apr 2025

Research progress on the mechanism of curcumin anti-oxidative stress based on signaling pathway

in Inflammation Pharmacology

Jie Cui
Haonan Li
Tianyi Zhang
Fengli Lin
Meiyun Chen
Guimin Zhang
Zhong Feng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1548073

7,249 views
29 citations

Review

Published on 04 Apr 2025

The emerging role of vascular endothelial cell-mediated angiogenesis in the imbalance of RA synovial microenvironment and its clinical relevance

in Inflammation Pharmacology

Xingxing Huo
Yanhui Peng
Hui Li
Chen Li
Faxue Liao
Chenggui Miao
Yurong Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1481089

2,633 views
7 citations

Original Research

Published on 03 Apr 2025

Exploring the mechanism of triptolide inhibiting the motility of fibroblast-like synoviocytes in rheumatoid arthritis via RhoA/Rho-associated kinase axis, based on network pharmacology, molecular docking and molecular dynamics simulations

in Inflammation Pharmacology

Jiacheng Shen
Yuxuan Fang
Nan Xu
Hongyi Chen
Miao Zhu
Dan Li
Zewen Chu
Masataka Sunagawa
Yanqing Liu
Haibo Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1545514

4,732 views
3 citations

Original Research

Published on 03 Apr 2025

Circ_0098181 binds PKM2 to attenuate liver fibrosis

in Inflammation Pharmacology

Yuan-Yuan Luo
Ya-Ping Guan
Hong-Fei Zhan
Chun-Yan Sun
Ling-Yan Cai
Ke-Gong Tao
Yong Lin
Xin Zeng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1517250

3,011 views
1 citation

Original Research

Published on 02 Apr 2025

Dynamic risk stratification and treatment optimization in sepsis: the role of NLPR

in Inflammation Pharmacology

Qiqi Chen
Ming Zhang
Yuxin Xia
Ya Deng
Yanna Yang
Lili Dai
Hongxia Niu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1572677

3,962 views
5 citations

1,846 articles

articles

Esmolol improves sepsis outcomes through cardiovascular and immune modulation

Suppressing chondrocyte cuproptosis by syringaresinol-4-O-β-d-glucoside alleviates gouty arthritis

Natural saponins and macrophage polarization: Mechanistic insights and therapeutic perspectives in disease management

Rutin ameliorates LPS-induced acute lung injury in mice by inhibiting the cGAS-STING-NLRP3 signaling pathway

Curcumin: a potential anti-photoaging agent

Effect of methotrexate/dexamethasone combination on epithelial-mesenchymal transition and inflammation gene expression of human RPE cells in-vitro

Irisin restrains neuroinflammation in mouse experimental autoimmune encephalomyelitis via regulating microglia activation

Anti-inflammatory effect and mechanism of stytontriterpene D on RAW264.7 cells and zebrafish

The immunostimulatory activity of Epimedium flavonoids involves toll-like receptor 7/8

Frailty and cardiovascular safety of JAK inhibitors versus TNF inhibitors in rheumatoid arthritis: a real-world comparative study of drug effects and patient profiles

Editorial: Targeting neuroinflammation for novel therapeutics in neurodegenerative diseases

S1PR4-dependent effects of Etrasimod on primary human myeloid immune cell activation

Tetramethylpyrazine alleviates acute pancreatitis inflammation by inhibiting pyroptosis via the NRF2 pathway

An off-target effect of class A CpG-oligonucleotides on suppressing the cyclic GMP-AMP synthase signaling in fibroblastic reticular cells

Mechanism underlying the involvement of CXCR4/CXCL12 in diabetic wound healing and prospects for responsive hydrogel-loaded CXCR4 formulations

Umbilical cord stem cells therapy against bacterial pneumonia based on zebrafish pneumonia model

Oxidative stress in vascular surgical diseases: mechanisms, impacts and therapeutic perspectives

Anti-inflammatory drugs as potential antimicrobial agents: a review

Paeoniflorin: a review of its pharmacology, pharmacokinetics and toxicity in diabetes

Research progress on the mechanism of curcumin anti-oxidative stress based on signaling pathway

The emerging role of vascular endothelial cell-mediated angiogenesis in the imbalance of RA synovial microenvironment and its clinical relevance

Exploring the mechanism of triptolide inhibiting the motility of fibroblast-like synoviocytes in rheumatoid arthritis via RhoA/Rho-associated kinase axis, based on network pharmacology, molecular docking and molecular dynamics simulations

Circ_0098181 binds PKM2 to attenuate liver fibrosis

Dynamic risk stratification and treatment optimization in sepsis: the role of NLPR