Frontiers in Pharmacology | Inflammation Pharmacology

Original Research

Published on 01 Apr 2025

Metal-phenolic nanozyme as a ferroptosis inhibitor for alleviating cisplatin-induced acute kidney injury

in Inflammation Pharmacology

Yunfeng Xiong
Huimin Kang
Yanping Rao
Xiayu Huang
Yang Zhu
Lixin Wei

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1535969

3,734 views
7 citations

Original Research

Published on 01 Apr 2025

A real-world pharmacovigilance analysis of omadacycline in FDA adverse event reporting system (FAERS) database

in Inflammation Pharmacology

Xueping Shi
Chen Wang
Xiang Liu
Li Zou
Pei Guo

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1558868

4,484 views
3 citations

Clinical Trial

Published on 01 Apr 2025

First-in-human study of CPL’116 – a dual JAK/ROCK inhibitor – in healthy subjects

in Inflammation Pharmacology

Piotr J. Rudzki
Katarzyna Jarus-Dziedzic
Dorota Włodarczyk
Michał Kaza
Piotr Pankiewicz
Agnieszka Gierczak-Pachulska
Martyna Banach
Beata Zygmunt
Cezary Piwowarczyk
Paweł Żero

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1583723

3,096 views
1 citation

Original Research

Published on 01 Apr 2025

Dexmedetomidine alleviates lung ischemia-reperfusion injury by inhibiting cuproptosis: an in vivo study

in Inflammation Pharmacology

Hanqun Liu
Zicheng Wang
Tong Qiu
Wenxing Du
Zhe Wu
Sheng Chen
Wenjie Jiao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1562535

2,487 views

Review

Published on 01 Apr 2025

Region-specific mitophagy in nucleus pulposus, annulus fibrosus, and cartilage endplate of intervertebral disc degeneration: mechanisms and therapeutic strategies

in Inflammation Pharmacology

Chaoqun Feng
Ziang Hu
Min Zhao
Chuan Leng
Guangye Li
Fei Yang
Xiaohong Fan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1579507

6,397 views
6 citations

Original Research

Published on 27 Mar 2025

Homoplantaginin exerts therapeutic effects on intervertebral disc degeneration by alleviating TNF-α-induced nucleus pulposus cell senescence and inflammation

in Inflammation Pharmacology

Jiadong Guo
Pu Zhang
Xiao Yang
Xin Wang
Xiankun Cao
Jie Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1526107

2,189 views
2 citations

Original Research

Published on 26 Mar 2025

Senecio scandens Buch.-Ham. polysaccharides exert anti-atopic dermatitis effects by modulating gut microbiota and the MAPK/NF-κB pathway

in Inflammation Pharmacology

Zhi-Qin Hu
Shu-Shu Xie
Ming-Yuan Zhou
Yu-Chi Chen
Fang-Mei Zhou
Zhi-Shan Ding
Xiao-Qing Ye

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1573135

2,758 views
3 citations

Original Research

Published on 25 Mar 2025

Phenylethyl isothiocyanate mitigates drug-induced liver injury in mice by inhibiting hepatocyte pyroptosis through the NLRP3-caspase-1-GSDMD pathway

in Inflammation Pharmacology

Ning An
Xiaoru Wang
Jia Qin
Meng Cheng
Mei Bai
Jingcai Cheng
Qiang Xu
Xuefeng Wu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1539934

2,577 views
2 citations

Review

Published on 21 Mar 2025

Cell death in acute lung injury: caspase-regulated apoptosis, pyroptosis, necroptosis, and PANoptosis

in Inflammation Pharmacology

Jun Xiao
Lichuan Wang
Bohan Zhang
Ana Hou

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1559659

7,174 views
12 citations

Original Research

Published on 20 Mar 2025

Inflammation and platelet hyperresponsiveness in coronary artery disease and the influence of Talin-1/αIIbβ3-mediated bidirectional signaling pathway

in Inflammation Pharmacology

Shengnan Shi
Jiaming Gao
Yehao Zhang
Min Zhan
Zhanfei Tan
Peili Wang
Jianhua Fu
Jianxun Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1535182

2,281 views
1 citation

Original Research

Published on 19 Mar 2025

Effect of anti-interleukin-5 antibody on development of vasculitis in an ovalbumin-induced eosinophilic vasculitis mouse model

in Inflammation Pharmacology

Kiyoto Kageyama
Eri Kikuchi
Nao Hoshino

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1546785

2,272 views
1 citation

Mini Review

Published on 19 Mar 2025

Interplay between endogenous hormones and immune systems in human metapneumovirus pathogenesis and management

in Inflammation Pharmacology

Viviana A. Ruiz-Pozo
Santiago Cadena-Ullauri
Rafael Tamayo-Trujillo
Patricia Guevara-Ramírez
Elius Paz-Cruz
Mayra A. Castañeda Cataña
Ana Karina Zambrano

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1568828

3,422 views
5 citations

Review

Published on 18 Mar 2025

Ferroptosis and hyperoxic lung injury: insights into pathophysiology and treatment approaches

in Inflammation Pharmacology

Xiaoqiong Zhou
Lei Tian
Wenyan Xiong
Yulan Li
Qian Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1568246

3,161 views
2 citations

Original Research

Published on 18 Mar 2025

The role and impact of the IL-6 mediated JAK2-STAT1/3 signaling pathway in the pathogenesis of gout

in Inflammation Pharmacology

Zeng Zhang
Peng Wang
Tianyi Lei
Jianwei Guo
Yi Jiang
Yanhui Li
Jianxiong Zheng
Shunbing Wang
Haimuzi Xu
Guilin Jian

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1480844

5,731 views
9 citations

Original Research

Published on 13 Mar 2025

Mechanism of nimodipine in treating neurodegenerative diseases: in silico target identification and molecular dynamic simulation

in Inflammation Pharmacology

Shuang Zheng
Yin Wang
Shuainan Tang
Yuntao Guo
Duan Ma
Xin Jiang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1549953

5,097 views
6 citations

Original Research

Published on 12 Mar 2025

Deciphering the role of IGFBP5 in delaying fibrosis and sarcopenia in aging skeletal muscle: therapeutic implications and molecular mechanisms

in Inflammation Pharmacology

Luze Shi
Zheci Ding
Jiwu Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1557703

4,159 views
1 citation

Mini Review

Published on 12 Mar 2025

Salt-sensitive hypertension: role of endothelial and vascular dysfunction and sex

in Inflammation Pharmacology

Helen M. Butler
Marice K. McCrorey
Lada Palygina
Ryan Lacey
Justin P. Van Beusecum

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1565962

5,179 views
3 citations

Brief Research Report

Published on 07 Mar 2025

Efficacy and safety of conventional disease-modifying antirheumatic drugs in VEXAS syndrome: real-world data from the international AIDA network

in Inflammation Pharmacology

Antonio Vitale
Flavia Leone
Valeria Caggiano
Andrea Hinojosa-Azaola
Eduardo Martín-Nares
Guillermo Arturo Guaracha-Basañez
Jiram Torres-Ruiz
Perla Ayumi Kawakami-Campos
Pravin Hissaria
Alicia Callisto

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1539756

4,887 views
5 citations

Case Report

Published on 06 Mar 2025

Case report: Effectiveness of Janus kinase inhibitors in the management of isolated noninfectious uveitis: a case series

in Inflammation Pharmacology

Nina Vidic Krhlikar
Matija Tomšič
Polona Jaki Mekjavić
Pia Klobučar
Nataša Vidović Valentinčič

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1509404

2,258 views
1 citation

Original Research

Published on 04 Mar 2025

Aspirin is associated with improved 30-day mortality in patients with sepsis-associated liver injury: a retrospective cohort study based on MIMIC IV database

in Inflammation Pharmacology

Jianbao Wang
Xuemei Hu
Susu Cao
Yiwen Zhao
Mengting Chen
Tianfeng Hua
Min Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1514392

4,713 views
3 citations

Review

Published on 03 Mar 2025

Inflammation pathways as therapeutic targets in angiotensin II induced atrial fibrillation

in Inflammation Pharmacology

Ailin Hou
Dazhuo Shi
Hongbo Huang
Yuxuan Liu
Ying Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1515864

5,368 views
4 citations

Original Research

Published on 28 Feb 2025

Identification of glycolysis-related gene signatures for prognosis and therapeutic targeting in idiopathic pulmonary fibrosis

in Inflammation Pharmacology

Han Gao
Zhongyi Sun
Xingxing Hu
Weiwei Song
Yuan Liu
Menglin Zou
Minghui Zhu
Zhenshun Cheng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1486357

8,236 views
1 citation

Original Research

Published on 27 Feb 2025

Unfractionated heparin may improve near-term survival in patients admitted to the ICU with sepsis attributed to pneumonia: an observational study using the MIMIC-IV database

in Inflammation Pharmacology

Shusheng Fang
Yali Wang
Wenyu Nan
Yanhao Feng
Wen Su
Yiming Wang
Xiaodong Jiang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1518716

5,671 views
2 citations

Original Research

Published on 27 Feb 2025

In vitro and in vivo characterization of oridonin analogs as anti-inflammatory agents that regulate the NF-κB and NLRP3 inflammasome axis

in Inflammation Pharmacology

Huiping Ou
Zhanpan Wu
Jinhua Ning
Qiufeng Huang
Wancun Wang
Guochun Yang
Yingxun Zhou
Anguo Hou
Peng Li
Lingyun Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1512740

4,103 views

1,846 articles

articles

Metal-phenolic nanozyme as a ferroptosis inhibitor for alleviating cisplatin-induced acute kidney injury

A real-world pharmacovigilance analysis of omadacycline in FDA adverse event reporting system (FAERS) database

First-in-human study of CPL’116 – a dual JAK/ROCK inhibitor – in healthy subjects

Dexmedetomidine alleviates lung ischemia-reperfusion injury by inhibiting cuproptosis: an in vivo study

Region-specific mitophagy in nucleus pulposus, annulus fibrosus, and cartilage endplate of intervertebral disc degeneration: mechanisms and therapeutic strategies

Homoplantaginin exerts therapeutic effects on intervertebral disc degeneration by alleviating TNF-α-induced nucleus pulposus cell senescence and inflammation

Senecio scandens Buch.-Ham. polysaccharides exert anti-atopic dermatitis effects by modulating gut microbiota and the MAPK/NF-κB pathway

Phenylethyl isothiocyanate mitigates drug-induced liver injury in mice by inhibiting hepatocyte pyroptosis through the NLRP3-caspase-1-GSDMD pathway

Cell death in acute lung injury: caspase-regulated apoptosis, pyroptosis, necroptosis, and PANoptosis

Inflammation and platelet hyperresponsiveness in coronary artery disease and the influence of Talin-1/αIIbβ3-mediated bidirectional signaling pathway

Effect of anti-interleukin-5 antibody on development of vasculitis in an ovalbumin-induced eosinophilic vasculitis mouse model

Interplay between endogenous hormones and immune systems in human metapneumovirus pathogenesis and management

Ferroptosis and hyperoxic lung injury: insights into pathophysiology and treatment approaches

The role and impact of the IL-6 mediated JAK2-STAT1/3 signaling pathway in the pathogenesis of gout

Mechanism of nimodipine in treating neurodegenerative diseases: in silico target identification and molecular dynamic simulation

Deciphering the role of IGFBP5 in delaying fibrosis and sarcopenia in aging skeletal muscle: therapeutic implications and molecular mechanisms

Salt-sensitive hypertension: role of endothelial and vascular dysfunction and sex

Efficacy and safety of conventional disease-modifying antirheumatic drugs in VEXAS syndrome: real-world data from the international AIDA network

Case report: Effectiveness of Janus kinase inhibitors in the management of isolated noninfectious uveitis: a case series

Aspirin is associated with improved 30-day mortality in patients with sepsis-associated liver injury: a retrospective cohort study based on MIMIC IV database

Inflammation pathways as therapeutic targets in angiotensin II induced atrial fibrillation

Identification of glycolysis-related gene signatures for prognosis and therapeutic targeting in idiopathic pulmonary fibrosis

Unfractionated heparin may improve near-term survival in patients admitted to the ICU with sepsis attributed to pneumonia: an observational study using the MIMIC-IV database

In vitro and in vivo characterization of oridonin analogs as anti-inflammatory agents that regulate the NF-κB and NLRP3 inflammasome axis