Frontiers in Pharmacology | Integrative and Regenerative Pharmacology

Original Research

Published on 16 Jan 2020

Intracellular ATP Delivery Causes Rapid Tissue Regeneration via Upregulation of Cytokines, Chemokines, and Stem Cells

in Integrative and Regenerative Pharmacology

Yiqun Mo
Harshini Sarojini
Rong Wan
Qunwei Zhang
Jianpu Wang
Sarah Eichenberger
Girish J. Kotwal
Sufan Chien

Frontiers in Pharmacology

doi 10.3389/fphar.2019.01502

8,187 views
25 citations

Original Research

Published on 31 Oct 2019

Leptin-Induced Angiogenesis of EA.Hy926 Endothelial Cells via the Akt and Wnt Signaling Pathways In Vitro and In Vivo

in Integrative and Regenerative Pharmacology

Fei Yu
Runqing Fu
Lu Liu
Xiaoting Wang
Tingting Wu
Wei Shen
Zhipeng Gui
Xiumei Mo
Bing Fang
Lunguo Xia

Frontiers in Pharmacology

doi 10.3389/fphar.2019.01275

7,625 views
25 citations

Original Research

Published on 13 Jun 2019

mTORC1 Activation in Osteoclasts Prevents Bone Loss in a Mouse Model of Osteoporosis

in Integrative and Regenerative Pharmacology

Manami Hiraiwa
Kakeru Ozaki
Takanori Yamada
Takashi Iezaki
Gyujin Park
Kazuya Fukasawa
Tetsuhiro Horie
Hikari Kamada
Kazuya Tokumura
Mei Motono

Frontiers in Pharmacology

doi 10.3389/fphar.2019.00684

8,594 views
34 citations

Original Research

Published on 07 Jun 2019

Losmapimod Protected Epileptic Rats From Hippocampal Neuron Damage Through Inhibition of the MAPK Pathway

in Integrative and Regenerative Pharmacology

Min Li
Lexiang Cui
Xuemin Feng
Chao Wang
Yinmeng Zhang
Lijie Wang
Ying Ding
Teng Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2019.00625

4,207 views
18 citations

Original Research

Published on 05 Jun 2019

KR-12-a5 Reverses Adverse Effects of Lipopolysaccharides on HBMSC Osteogenic Differentiation by Influencing BMP/Smad and P38 MAPK Signaling Pathways

in Integrative and Regenerative Pharmacology

Hui Li
Shutao Zhang
Bin’en Nie
Teng Long
Xinhua Qu
Bing Yue

Frontiers in Pharmacology

doi 10.3389/fphar.2019.00639

5,164 views
16 citations

Original Research

Published on 24 Jan 2019

Enhanced Anti-diabetic Effect of Berberine Combined With Timosaponin B2 in Goto-Kakizaki Rats, Associated With Increased Variety and Exposure of Effective Substances Through Intestinal Absorption

in Integrative and Regenerative Pharmacology

Xiaoting Tian
Fang Liu
Zhixiong Li
Yunfei Lin
Huan Liu
Pei Hu
Mingcang Chen
Zhaolin Sun
Zhou Xu
Yiting Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2019.00019

6,010 views
19 citations

Original Research

Published on 08 Jan 2019

Chitosan Membrane Modified With a New Zinc(II)-Vanillin Complex Improves Skin Wound Healing in Diabetic Rats

in Integrative and Regenerative Pharmacology

Emanuella de Aragão Tavares
Wendy Marina Toscano Queiroz de Medeiros
Talita Pereira de Assis Pontes
Maisie Mitchele Barbosa
Aurigena Antunes de Araújo
Raimundo Fernandes de Araújo
Jozi Godoy Figueiredo
Renata Carvalho Leitão
Conceição da Silva Martins
Francisco Ordelei Nascimento da Silva

Frontiers in Pharmacology

doi 10.3389/fphar.2018.01511

6,319 views
33 citations

Original Research

Published on 11 Dec 2018

5-HT1A Receptor Function Makes Wound Healing a Happier Process

in Integrative and Regenerative Pharmacology

Alia Sadiq
Isabella Menchetti
Ahmed Shah
Marc G. Jeschke
Cassandra Belo
Wendolyn Carlos-Alcalde
Muhammad Qasim Hayat
Saeid Amini-Nik

Frontiers in Pharmacology

doi 10.3389/fphar.2018.01406

10,298 views
26 citations

Review

Published on 21 Nov 2018

Targeted Delivery of Bioactive Molecules for Vascular Intervention and Tissue Engineering

in Integrative and Regenerative Pharmacology

Hannah A. Strobel
Elisabet I. Qendro
Eben Alsberg
Marsha W. Rolle

Frontiers in Pharmacology

doi 10.3389/fphar.2018.01329

9,375 views
28 citations

Original Research

Published on 26 Sep 2018

PAI-1 Exacerbates White Adipose Tissue Dysfunction and Metabolic Dysregulation in High Fat Diet-Induced Obesity

in Integrative and Regenerative Pharmacology

Lin Wang
Liyuan Chen
Zheran Liu
Yaofang Liu
Mao Luo
Ni Chen
Xin Deng
Yulin Luo
Jing He
Liping Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2018.01087

8,568 views
70 citations

General Commentary

Published on 25 Sep 2018

Commentary: A Cell Line for Detection of Botulinum Neurotoxin Type B

in Integrative and Regenerative Pharmacology

Andy Pickett

Frontiers in Pharmacology

doi 10.3389/fphar.2018.01056

2,948 views
2 citations

Original Research

Published on 18 Sep 2018

Urolithin A Inhibits the Catabolic Effect of TNFα on Nucleus Pulposus Cell and Alleviates Intervertebral Disc Degeneration in vivo

in Integrative and Regenerative Pharmacology

Huiyong Liu
Honglei Kang
Chao Song
Zuowei Lei
Li Li
Jianfeng Guo
Yong Xu
Hanfeng Guan
Zhong Fang
Feng Li

Frontiers in Pharmacology

doi 10.3389/fphar.2018.01043

9,133 views
48 citations

Original Research

Published on 31 Aug 2018

Gene Therapy Using Plasmid DNA Encoding VEGF164 and FGF2 Genes: A Novel Treatment of Naturally Occurring Tendinitis and Desmitis in Horses

in Integrative and Regenerative Pharmacology

Milomir Kovac
Yaroslav A. Litvin
Ruslan O. Aliev
Elena Y. Zakirova
Catrin S. Rutland
Andrey P. Kiyasov
Albert A. Rizvanov

Frontiers in Pharmacology

doi 10.3389/fphar.2018.00978

8,837 views
35 citations

Original Research

Published on 30 Jul 2018

In vitro and in vivo Assessment of Keratose as a Novel Excipient of Paclitaxel Coated Balloons

in Integrative and Regenerative Pharmacology

Emily Turner
Megan Erwin
Marzieh Atigh
Uwe Christians
Justin M. Saul
Saami K. Yazdani

Frontiers in Pharmacology

doi 10.3389/fphar.2018.00808

5,231 views
19 citations

Review

Published on 16 Jul 2018

Nanotherapeutics to Modulate the Compromised Micro-Environment for Lung Cancers and Chronic Obstructive Pulmonary Disease

in Integrative and Regenerative Pharmacology

Dhruv R. Seshadri
Anand Ramamurthi

Frontiers in Pharmacology

doi 10.3389/fphar.2018.00759

6,936 views
16 citations

Review

Published on 09 Jul 2018

Advancements in Regenerative Strategies Through the Continuum of Burn Care

in Integrative and Regenerative Pharmacology

Randolph Stone II
Shanmugasundaram Natesan
Christine J. Kowalczewski
Lauren H. Mangum
Nicholas E. Clay
Ryan M. Clohessy
Anders H. Carlsson
David H. Tassin
Rodney K. Chan
Julie A. Rizzo

Frontiers in Pharmacology

doi 10.3389/fphar.2018.00672

29,911 views
114 citations

Original Research

Published on 25 Jun 2018

Inhibition of Sarco-Endoplasmic Reticulum Ca2+ ATPase Extends the Lifespan in C. elegans Worms

in Integrative and Regenerative Pharmacology

Paloma García-Casas
Jessica Arias-del-Val
Pilar Alvarez-Illera
Rosalba I. Fonteriz
Mayte Montero
Javier Alvarez

Frontiers in Pharmacology

doi 10.3389/fphar.2018.00669

7,104 views
25 citations

Original Research

Published on 05 Jun 2018

Development of a Porcine Full-Thickness Burn Hypertrophic Scar Model and Investigation of the Effects of Shikonin on Hypertrophic Scar Remediation

in Integrative and Regenerative Pharmacology

Xingwang Deng
Qian Chen
Lijuan Qiang
Mingwei Chi
Nan Xie
Yinsheng Wu
Ming Yao
Dan Zhao
Jiaxiang Ma
Ning Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2018.00590

7,554 views
31 citations

Review

Published on 29 May 2018

Biomaterials for the Delivery of Growth Factors and Other Therapeutic Agents in Tissue Engineering Approaches to Bone Regeneration

in Integrative and Regenerative Pharmacology

Christine J. Kowalczewski
Justin M. Saul

Frontiers in Pharmacology

doi 10.3389/fphar.2018.00513

21,206 views
159 citations

Review

Published on 17 May 2018

Current Therapeutic Strategies for Adipose Tissue Defects/Repair Using Engineered Biomaterials and Biomolecule Formulations

in Integrative and Regenerative Pharmacology

Christopher M. Mahoney
Cayla Imbarlina
Cecelia C. Yates
Kacey G. Marra

Frontiers in Pharmacology

doi 10.3389/fphar.2018.00507

10,332 views
46 citations

Original Research

Published on 10 Apr 2018

Adipose-Derived Mesenchymal Stem Cell Application Combined With Fibrin Matrix Promotes Structural and Functional Recovery Following Spinal Cord Injury in Rats

in Integrative and Regenerative Pharmacology

Yana O. Mukhamedshina
Elvira R. Akhmetzyanova
Alexander A. Kostennikov
Elena Y. Zakirova
Luisa R. Galieva
Ekaterina E. Garanina
Alexander A. Rogozin
Andrey P. Kiassov
Albert A. Rizvanov

Frontiers in Pharmacology

doi 10.3389/fphar.2018.00343

7,801 views
61 citations

Original Research

Published on 28 Mar 2018

Localized Delivery of Cl-Amidine From Electrospun Polydioxanone Templates to Regulate Acute Neutrophil NETosis: A Preliminary Evaluation of the PAD4 Inhibitor for Tissue Engineering

in Integrative and Regenerative Pharmacology

Allison E. Fetz
Indira Neeli
Karyl K. Buddington
Robert W. Read
Matthew P. Smeltzer
Marko Z. Radic
Gary L. Bowlin

Frontiers in Pharmacology

doi 10.3389/fphar.2018.00289

4,918 views
16 citations

Original Research

Published on 26 Mar 2018

Exposure to Silver Nanospheres Leads to Altered Respiratory Mechanics and Delayed Immune Response in an in Vivo Murine Model

in Integrative and Regenerative Pharmacology

Danielle Botelho
Bey F. Leo
Christopher Massa
Srijata Sarkar
Terry Tetley
Kian F. Chung
Shu Chen
Mary P. Ryan
Alexandra Porter
Elena N. Atochina-Vasserman

Frontiers in Pharmacology

doi 10.3389/fphar.2018.00213

4,569 views
17 citations

Original Research

Published on 06 Mar 2018

Allogenic Adipose Derived Stem Cells Transplantation Improved Sciatic Nerve Regeneration in Rats: Autologous Nerve Graft Model

in Integrative and Regenerative Pharmacology

Ruslan Masgutov
Galina Masgutova
Liliya Mukhametova
Ekaterina Garanina
Svetlana S. Arkhipova
Elena Zakirova
Yana O. Mukhamedshina
Zhuravleva Margarita
Zarema Gilazieva
Valeriia Syromiatnikova

Frontiers in Pharmacology

doi 10.3389/fphar.2018.00086

7,229 views
22 citations

286 articles

articles

Intracellular ATP Delivery Causes Rapid Tissue Regeneration via Upregulation of Cytokines, Chemokines, and Stem Cells

Leptin-Induced Angiogenesis of EA.Hy926 Endothelial Cells via the Akt and Wnt Signaling Pathways In Vitro and In Vivo

mTORC1 Activation in Osteoclasts Prevents Bone Loss in a Mouse Model of Osteoporosis

Losmapimod Protected Epileptic Rats From Hippocampal Neuron Damage Through Inhibition of the MAPK Pathway

KR-12-a5 Reverses Adverse Effects of Lipopolysaccharides on HBMSC Osteogenic Differentiation by Influencing BMP/Smad and P38 MAPK Signaling Pathways

Enhanced Anti-diabetic Effect of Berberine Combined With Timosaponin B2 in Goto-Kakizaki Rats, Associated With Increased Variety and Exposure of Effective Substances Through Intestinal Absorption

Chitosan Membrane Modified With a New Zinc(II)-Vanillin Complex Improves Skin Wound Healing in Diabetic Rats

5-HT1A Receptor Function Makes Wound Healing a Happier Process

Targeted Delivery of Bioactive Molecules for Vascular Intervention and Tissue Engineering

PAI-1 Exacerbates White Adipose Tissue Dysfunction and Metabolic Dysregulation in High Fat Diet-Induced Obesity

Commentary: A Cell Line for Detection of Botulinum Neurotoxin Type B

Urolithin A Inhibits the Catabolic Effect of TNFα on Nucleus Pulposus Cell and Alleviates Intervertebral Disc Degeneration in vivo

Gene Therapy Using Plasmid DNA Encoding VEGF164 and FGF2 Genes: A Novel Treatment of Naturally Occurring Tendinitis and Desmitis in Horses

In vitro and in vivo Assessment of Keratose as a Novel Excipient of Paclitaxel Coated Balloons

Nanotherapeutics to Modulate the Compromised Micro-Environment for Lung Cancers and Chronic Obstructive Pulmonary Disease

Advancements in Regenerative Strategies Through the Continuum of Burn Care

Inhibition of Sarco-Endoplasmic Reticulum Ca2+ ATPase Extends the Lifespan in C. elegans Worms

Development of a Porcine Full-Thickness Burn Hypertrophic Scar Model and Investigation of the Effects of Shikonin on Hypertrophic Scar Remediation

Biomaterials for the Delivery of Growth Factors and Other Therapeutic Agents in Tissue Engineering Approaches to Bone Regeneration

Current Therapeutic Strategies for Adipose Tissue Defects/Repair Using Engineered Biomaterials and Biomolecule Formulations

Adipose-Derived Mesenchymal Stem Cell Application Combined With Fibrin Matrix Promotes Structural and Functional Recovery Following Spinal Cord Injury in Rats

Localized Delivery of Cl-Amidine From Electrospun Polydioxanone Templates to Regulate Acute Neutrophil NETosis: A Preliminary Evaluation of the PAD4 Inhibitor for Tissue Engineering

Exposure to Silver Nanospheres Leads to Altered Respiratory Mechanics and Delayed Immune Response in an in Vivo Murine Model

Allogenic Adipose Derived Stem Cells Transplantation Improved Sciatic Nerve Regeneration in Rats: Autologous Nerve Graft Model