Frontiers in Pharmacology | Integrative and Regenerative Pharmacology

Original Research

Accepted on 25 Sep 2025

Combined multi-omics approach to identify the key metabolites, key microorganisms and biomarkers correlated with the neutrophil extracellular traps-associated gene TIMP1 in osteoarthritis

in Integrative and Regenerative Pharmacology

Yaoyu Xiang
Jizheng Li
Xidan Hu
Xianguang Yang
Fei Sun
Jing Yang
Weiqing Ge
Tao Zhou
En Song

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1665228

863 views

Review

Published on 25 Sep 2025

Adipose-derived stem cell exosomes: emerging roles and therapeutic application

in Integrative and Regenerative Pharmacology

Yuhan Gong
Hui Ma
Zhongren Zheng
Xinjie Wang
Jiahua Zhang
Xiaowei Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1637342

2,108 views

Mini Review

Published on 22 Sep 2025

Serotonin-modulating therapies for the management of chronic wounds

in Integrative and Regenerative Pharmacology

Anuj Budhiraja
Alisha Mehta
Johanna Ghebrehiwet-Kuflom
Janmesh D. Patel
Christiane How-Volkman
Lara Ali
Sara Dahle
Roslyn Rivkah Isseroff

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1656302

2,530 views

Review

Accepted on 18 Sep 2025

3D In Vitro Blood–Brain Barrier Models: Recent Advances and Their Role in Brain Disease Research and Therapy

in Integrative and Regenerative Pharmacology

Laura O'Halloran
Olutoyosi Akinsete
A. Leah Kogan
Michelle Wrona
Amira F Mahdi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1637602

1,915 views

Correction

Published on 17 Sep 2025

Correction: Resveratrol and Angiogenin-2 combined with PEGDA/TCS hydrogel for the targeted therapy of hypoxic bone defects via activation of the autophagy pathway

in Integrative and Regenerative Pharmacology

Dehui Fan
Hengping Liu
Zhenning Zhang
Meiyi Su
Zhixian Yuan
Ying Lin
Shuquan Yang
Wenqiang Li
Xintao Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1597755

1,071 views

Original Research

Published on 15 Sep 2025

Modulation of ASC-derived extracellular vesicles containing cargo that specifically enhances wound healing

in Integrative and Regenerative Pharmacology

Jodi P. Gurney
John W. Ludlow
Michael J. Van Kanegan
Robin L. Smith

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1635151

1,063 views

Review

Published on 12 Sep 2025

Mesenchymal stromal cell-laden hydrogels in tissue regeneration: insights from preclinical and clinical research

in Integrative and Regenerative Pharmacology

Silvia Barbon
Senthilkumar Rajendran
Antara Banerjee
Pier Paolo Parnigotto
Raffaele De Caro
Veronica Macchi
Andrea Porzionato

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1670649

2,439 views

Review

Published on 03 Sep 2025

Efficacy of platelet-rich plasma injection with percutaneous endoscopic lumbar discectomy for lumbar disc herniation: a systematic review and meta-analysis

in Integrative and Regenerative Pharmacology

Yu Zhang
Jidong Ju
Jinchun Wu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1622974

3,303 views

Original Research

Published on 28 Aug 2025

A comprehensive bibliometric exploration of hydrogel applications in spinal cord injury

in Integrative and Regenerative Pharmacology

Guosong Han
Huihui Zhang
Zhixiang Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1606186

1,900 views

Original Research

Published on 21 Aug 2025

2′-Fucosyllactose mitigates cognitive deficits in Alzheimer models: targeting amyloid pathology, oxidative stress, and synaptic plasticity

in Integrative and Regenerative Pharmacology

Yeasmin Akter Munni
Khoa Nguyen Tran
Seon-Min Jeon
Meeyul Hwang
Jong-Won Yoon
Young-Ha Song
Tae Woo Oh
Sang Il Gum
In-Jun Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1598030

2,036 views

Original Research

Published on 30 Jun 2025

Narirutin treatment accelerates the process of diabetic wound repair by regulating phenotype switching of macrophages through affecting metabolic reprogramming

in Integrative and Regenerative Pharmacology

Liang Liu
Han Wang
Juan Zhou
Jing Lu
Yan Zhang
Haiyan Liu
Li Lu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1614967

2,149 views

Review

Published on 24 Jun 2025

Advances in hydrogel-based materials for breast cancer bone metastasis: from targeted drug delivery to bone microenvironment remodeling

in Integrative and Regenerative Pharmacology

Jiayi Chen
Jun Ma
Zhuoming Xu
Huanhuan Luo
Chenhong Qian

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1627883

1,930 views
1 citation

Review

Published on 24 Jun 2025

The impacts of natural polyphenols and exercise alone or together on microRNAs and angiogenic signaling

in Integrative and Regenerative Pharmacology

Yanna Sun
Linlin Chen
Lili Xiao
Xiaofang Wang
Jamal Hallajzadeh

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1560305

1,569 views

Review

Published on 18 Jun 2025

Recent advances in dermal fibroblast senescence and skin aging: unraveling mechanisms and pioneering therapeutic strategies

in Integrative and Regenerative Pharmacology

Li Nan
Pengchao Guo
Wang Hui
Fang Xia
Chenggang Yi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1592596

5,530 views
3 citations

Correction

Published on 16 Jun 2025

Correction: Biomineralized composite liquid crystal fiber scaffold promotes bone regeneration by enhancement of osteogenesis and angiogenesis

in Integrative and Regenerative Pharmacology

Yi Zhan
Bing Deng
Huixian Wu
Changpeng Xu
Ruiying Wang
Wenqiang Li
Zhixiong Pan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1617849

688 views

Original Research

Published on 04 Jun 2025

BaDuShengJi hydrogel accelerates diabetic wounds healing and regeneration of deep burn injury by anti-bacteria, anti-inflammation and promoting epithelialization

in Integrative and Regenerative Pharmacology

Yuxiang Zhang
Yuanyuan Yu
Lien Yu
Fang Wang
Fuwei Yang
Shiyu Liang
Wen Xu
Mengying Ji
Yinuo Geng
Jingwei Xue

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1580994

1,743 views