Frontiers in Pharmacology | Neuropharmacology

Original Research

Published on 14 Nov 2025

Time-dependent biphasic alterations in brain metabolism following chronic ketamine exposure in mice

in Neuropharmacology

Seo-Hyun Lim
Young-Suk Choi
Eosu Kim
Chul Hoon Kim
Ho-Taek Song

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1629824

770 views

Review

Published on 13 Nov 2025

The role of Panax notoginseng saponins in cerebrovascular neurological disorders: an overview of mechanisms and functions

in Neuropharmacology

Bin Wang
Xu Gao
Yali Zhang
Yuhua Xiao
Tong Chen
Zhouying Shi
Yue Yuan
Ping Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1693253

1,900 views

Original Research

Published on 13 Nov 2025

From heart to brain: cognitive potential of propranolol and diltiazem through cholinergic enhancement via butyrylcholinesterase inhibition

in Neuropharmacology

Celtia Domínguez-Fernández
Amit Kumar
Rajnish Kumar
Taher Darreh-Shori

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1694610

2,208 views

Original Research

Published on 12 Nov 2025

TAAR9 knockout increases hippocampal serotonin and alters grooming behavior in rats

in Neuropharmacology

Ilya S. Zhukov
Inessa V. Karpova
Ramilya Z. Murtazina
Yazen Alnefeesi
Olga M. Korenkova
Ilia Yu. Tissen
Svetlana A. Palchikova
Lydia A. Tokareva
Sarng S. Pyurveev
Petr D. Shabanov

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1684029

3,335 views

Original Research

Published on 12 Nov 2025

Molecular genetic basis of the primary emotions in young adults: an exploratory analysis of genetic polymorphisms across dopamine, serotonin, oxytocin, endogenous opioid, and neurotrophic factor pathways

in Neuropharmacology

Timotej Glavač
Maruša Barbo
Metka Ravnik-Glavač
Maja Zupančič
Vita Dolžan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1675538

3,507 views

Review

Accepted on 11 Nov 2025

Signal transduction, Dimerization, and Therapeutic Targeting of Orexin and Receptor Systems

in Neuropharmacology

Shengnan Zhang
Peixiang Wang
Bingyuan Ji
Yuming Shao
Sen Hou
Jing Chen
Chunmei Wang

Frontiers in Pharmacology

Original Research

Accepted on 10 Nov 2025

ER Stress in D1-MSNs Mediates Cocaine-Induced Behavioral Plasticity via the ATF4–SPTLC1 Axis

in Neuropharmacology

Yue Zhao
Shu Li
Linhong Jiang
Ying Zhao
Weihong Kuang
Qingfan Wei
Yuanyi Zhou
Shuang Han
Liang Wang
Hongchun Li

Frontiers in Pharmacology

113 views

Original Research

Accepted on 10 Nov 2025

Kappa-opioid receptor gene (OPRK1) variations associated with opioid abstinence behaviors among chronic heroin users

in Neuropharmacology

Mark K Greenwald
Catherine Demery
Tabitha E.H. Moses
Margit Burmeister

Frontiers in Pharmacology

125 views

Clinical Trial

Accepted on 10 Nov 2025

Remimazolam Combined with Propofol for Intraoperative Wake-up Testing in Scoliosis Correction Surgery: A Prospective, Blind, Randomized Controlled Trial

in Neuropharmacology

Jing Luo
Da-lin Chen
Zong-long Lv
Hui Zhong
Yong-hui Zhao
Yu-jin Li
Xin-nan Li
Jing-ce Chen
Wen-bao Shi
Yun Bo

Frontiers in Pharmacology

Original Research

Accepted on 10 Nov 2025

Functional and Transcriptomic Insights Into Amlodipine's Anti-Inflammatory Effects

in Neuropharmacology

Muhammed Yusuf

Frontiers in Pharmacology

Systematic Review

Accepted on 10 Nov 2025

Efficacy and Safety of Esketamine For Pain Control After Cesarean Delivery: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

in Neuropharmacology

Tingyu Jiang
Rui Zhao

Frontiers in Pharmacology

Original Research

Accepted on 10 Nov 2025

Intranasal Galanin (1-15) modulates alcohol self-administration and depressive-like behavior in rats and shows a favorable safety profile

in Neuropharmacology

Noelia Cantero-García
Antonio Flores-Burgess
Marta Flores-Gómez
Juan Pedro Pineda-Gómez
Carmen Ramos
Caridad Díaz
Carmelo Millón
Zaida Diaz Cabiale

Frontiers in Pharmacology

Original Research

Published on 07 Nov 2025

Deciphering the effects of polydatin on neuropathic pain and motor performance in a chronic constriction injury model: role of GABA and opioid receptors and neuroprotective properties

in Neuropharmacology

Sadaf Abdian
Sajad Fakhri
Amir Kiani
Mohammad Mehdi Gravandi
Fatemeh Abbaszadeh
Mohammad Hosein Farzaei
Ehsan Mohammadi-Noori
Javier Echeverría

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1691130

7,893 views

Brief Research Report

Published on 07 Nov 2025

Neuro-functional correlates of personality dimensions in Parkinson’s disease

in Neuropharmacology

Mathilde Boussac
Estelle Harroch
Karel Joineau
Emeline Descamps
Christine Brefel-Courbon

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1705937

6,895 views

Systematic Review

Published on 07 Nov 2025

The effect of esketamine on postoperative delirium in patients undergoing general anesthesia: a systematic review and meta-analysis

in Neuropharmacology

Chao-Xu
Rui-Jun Tong
Qi-Hong Shen
Jing Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1681531

7,790 views

Original Research

Published on 06 Nov 2025

The development and verification of clinical medication pathway for tic disorder in west China

in Neuropharmacology

Dan Li
Chunsong Yang
Jianhua Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1682518

5,992 views