Frontiers in Pharmacology | Neuropharmacology

Original Research

Accepted on 01 Oct 2025

Evaluating the Risk of Osteopenia-Related Adverse Events with Antiepileptic Drugs: A Pharmacovigilance Study Based on the FAERS Database

in Neuropharmacology

Nan Yang
Xiang Han
Hongning Hua
Yumeng Wang
Yulin Chen
Yue Zhou
Haoyu Feng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1685289

Original Research

Published on 01 Oct 2025

Ferulic acid mitigates 3-Nitropropionic acid-induced Huntington’s disease via modulation of Nrf2/HO-1, TLR4/NF-κB, and SIRT1/p53 signaling pathways

in Neuropharmacology

Mohamed A. Abdelgawad
Abdallah M. Gendy
Sameh S. Zaghlool
Wessam H. Elesawy
Mai F. Ragab
Mohamed I. Kotb El-Sayed
Alaadin E. El-Haddad
Hussein S. Mohamed
Izzeddin Alsalahat
Marwa A. Essa

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1678724

658 views

Correction

Published on 30 Sep 2025

Correction: Research progress on plant-derived natural compounds regulating the MAPK signaling pathway for the prevention and therapy of Alzheimer’s disease

in Neuropharmacology

Xinyue Zhang
Shujia Huang
Hongfeng Xu
Yanan Hu
Ling Gao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1710820

388 views

Original Research

Accepted on 29 Sep 2025

Serum amyloid A-mediated neuro-inflammation induces hippocampal neuron apoptosis and postoperative cognitive dysfunction in mice

in Neuropharmacology

Xiaochen Fu
Cai Zhen Bin
Yuxuan Wu
Yuwen Xu
Ze Gao
Minghui Tan
Jing Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1661881

298 views

Original Research

Published on 29 Sep 2025

Therapeutic potential of extracellular vesicles derived from Platycladus Orientalis leaf in treating anxiety, depression, and insomnia

in Neuropharmacology

Peiyu Liu
Guiyang He
Yaoxin Lu
Juanjuan He
Faliang Wu
Meng Jia
Shaochang Jia
Ruijie Fan
Hongwei Liang
Bing Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1693106

799 views

Original Research

Published on 29 Sep 2025

Desensitization of TRPA1 by dimethyl itaconate attenuates acute and chronic pain in mice

in Neuropharmacology

Sen Xu
Jia-Yue Zhao
Jun-Yi Ma
Xia-Lin Cui
Jia-Hui Lin
Shi-Yu Sun
Si-Jia Liu
Guo-Kun Zhou
Jiang-Tao Zhang
Peipei Kang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1671461

960 views

Review

Accepted on 26 Sep 2025

Rheumatoid Arthritis-associated Depression: Focusing on the Interactions between Mitochondria and Endoplasmic Reticulum

in Neuropharmacology

Mingqin Shi
昕瑶李
Haimei Zhou
Zhenmin Li
Yuanyuan Wei
Zihui Wang
Yuqing She
Xuelian Zou
Xiangdian Xiao
Jiashun Zeng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1549060

631 views

Review

Published on 26 Sep 2025

Pharmacological modulation of the gut-brain axis: psychobiotics in focus for depression therapy

in Neuropharmacology

Zakirah Zainal Abidin
Zaw Myo Hein
Che Mohd Nasril Che Mohd Nassir
Norshafarina Shari
Muhammad Danial Che Ramli

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1665419

8,937 views

Original Research

Accepted on 25 Sep 2025

Reducing Stress and Alcohol-Related Behaviors by Targeting D1-CRHR1 Receptor Interactions in the Amygdala

in Neuropharmacology

Laura Broccoli
Francesco Giannone
Anika Hoppe
Kay Jüngling
Dasiel O. Borroto-Escuela
Rick E. Bernardi
Roberto Rimondini-Giorgini
Miguel Perez De La Mora
Oliver von Bohlen und Halbach
Kjell Fuxe

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1677510

666 views

Original Research

Published on 25 Sep 2025

Stable interindividual differences in modafinil’s effect on vigilance during sleep deprivation

in Neuropharmacology

Jeroen Van Cutsem
Martine Van Puyvelde
Nicholas H. Van den Berg
Emilie Dessy
Frederic Detaille
An Van Rompay
Olivier Mairesse
Catherine Drogou
Fabien Sauvet
Xavier Neyt

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1607444

1,281 views

Systematic Review

Published on 24 Sep 2025

Efficacy and safety of vesicular monoamine transporter 2 inhibitors for Huntington’s disease chorea based on network meta-analysis

in Neuropharmacology

Jing Huang
Fei-Fei Chen
Si-Yuan Wen
Pan Tao
Chi Meng
Wei Chen
Chang-Qing Zhou

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1637577

886 views

Original Research

Published on 24 Sep 2025

Pharmacovigilance study on old drugs repurposed for rare diseases across different indications: the case of fenfluramine

in Neuropharmacology

Jiahong Zhong
Zhuomiao Lin
Junling Xue
Xihui Yu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1682788

1,070 views

Review

Accepted on 23 Sep 2025

Anti-inflammatory Effect of Curcumin on Neurological Disorders: A Narrative Review

in Neuropharmacology

Baoyin Zhou
Binbin Hu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1658115

402 views

Original Research

Accepted on 23 Sep 2025

Dopaminergic REST is implicated in the tamoxifen-induced neuroprotection against manganese toxicity in female mice

in Neuropharmacology

Edward Pajarillo
Alexis Digman
Sanghoon Kim
Itunu Ajayi
Deok-Soo Son
Michael Aschner
Eunsook Lee

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1627400

265 views

Original Research

Accepted on 23 Sep 2025

Epigallocatechin-3-gallate conjugated with selenium nanoparticles prevents neurological complications in rats exhibiting schizophrenia-like behaviors

in Neuropharmacology

Hadeer M. Gamal El-Deen
Amina Essawy
Nema A. Mohammed
Mohamed Saleh Abdelfattah
Ayah S. Fathalla
Manal Elkhadragy
Ahmed Esmat Abdel Moneim

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1680380

184 views

Review

Published on 23 Sep 2025

Neuroprotective mechanisms of Buyang Huanwu decoction in ischemic stroke

in Neuropharmacology

Yuanyuan Qin
Shiliang Hu
Shiman Mawen
Shanyao Pan
Yaping Huai
Guoqiang Liang
Ting Chen
Feiyan Zhao
Hongli Dong
Xuyi Yao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1620533

1,983 views