Frontiers in Pharmacology | Neuropharmacology

Original Research

Accepted on 03 Dec 2025

Therapeutic effects of Lactobacillus rhamnosus and/or thymol against neurotoxicity in propionic acid (PA)-induced autistic rats: Insights for the role of Nrf2/HO-1, Wnt3/β-Catenin/GSK3β BDNF/p-TrkB/CREB, pI3K/Akt/mTOR, AMPK/SIRT-1 and PERK/CHOP/Bcl-2 pathways

in Neuropharmacology

Hoda A. Salem
Nermin Rizk
Moustafa H Abdelsalam
Rehab Ahmed
Hebatallah Atteia
Ahmed M.E. Hamdan
Areej A. Alghamdi
Manar A. Alghusn
Renad A. Alatawi
Rawan A. Atallah

Frontiers in Pharmacology

234 views

Systematic Review

Accepted on 03 Dec 2025

The Potential Role of GLP-1 Receptor Agonists in Substance Use Disorders: A Systematic Review

in Neuropharmacology

Kim Martina Völker
Bastian Lucas Holger Prechtl
Nicholas Bormann
Doo-Sup Choi

Frontiers in Pharmacology

225 views

Systematic Review

Accepted on 03 Dec 2025

Optimizing Phenytoin Therapy: A Systematic Review of Clinically Relevant Food and Herb Interactions

in Neuropharmacology

ADRIANA MONSERRATH ORELLANA PAUCAR
Erick Thomas Mosquera-Lopez
Nancy Michelle Bustamante-Alvarez
María Gabriela Machado-Orellana
Daniela Alejandra Vintimilla-Rojas
John Diego Atiencia-Palacios
Ana Cristina Espinoza Fajardo

Frontiers in Pharmacology

175 views

Original Research

Accepted on 03 Dec 2025

DX243 counteracts both acoustic trauma-induced reduction in cortical brain oscillations and cochlear synaptopathy

in Neuropharmacology

Stefan Fink
Csaba Harasztosi
Li Xie
Stephane Silvente
Pierre Attali
Nicolas Caron
Wibke Singer
Lukas Rüttiger
Marlies Knipper

Frontiers in Pharmacology

221 views

Correction

Published on 03 Dec 2025

Correction: The role of panax notoginseng saponins in cerebrovascular neurological disorders: an overview of mechanisms and functions

in Neuropharmacology

Bin Wang
Xu Gao
Yali Zhang
Yuhua Xiao
Tong Chen
Zhouying Shi
Yue Yuan
Ping Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1750932

372 views

Original Research

Published on 03 Dec 2025

T817MA attenuates oxidative stress and ER stress via the HSP70–HSP90 pathway after brain ischemia in vitro and in vivo

in Neuropharmacology

Tao Wang
Ya-Juan Pan
Mei-Mei Zhang
Xuan Wang
Wei Li
Jian-Meng Lv

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1701967

689 views

Original Research

Published on 01 Dec 2025

Striatal M4 muscarinic receptors determine the biological rhythm of activity, with a supportive role of M1 muscarinic receptors

in Neuropharmacology

Katerina Janisova
Monika Uhlirova
Sandor Forczek
Jaromir Myslivecek

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1691118

604 views

Systematic Review

Published on 01 Dec 2025

Efficacy and safety of esketamine for pain control after cesarean delivery: a systematic review and meta-analysis of randomized controlled trials

in Neuropharmacology

Tingyu Jiang
Rui Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1708221

765 views

Original Research

Published on 28 Nov 2025

Kappa-opioid receptor gene (OPRK1) variations associated with opioid abstinence behaviors among chronic heroin users

in Neuropharmacology

Mark K. Greenwald
Catherine Demery
Tabitha E. H. Moses
Margit Burmeister

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1714546

795 views

Original Research

Published on 27 Nov 2025

Functional interaction between orexin/dynorphin transmission in the posterior paraventricular nucleus of the thalamus following alcohol dependence: mediation of alcohol-seeking behavior

in Neuropharmacology

Francisco J. Flores-Ramirez
Glenn Pascasio
Rémi Martin-Fardon

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1718540

772 views

Correction

Published on 26 Nov 2025

Correction: Lack of the Nlrp3 inflammasome improves mice recovery following traumatic brain injury

in Neuropharmacology

Natasha Irrera
Gabriele Pizzino
Margherita Calò
Giovanni Pallio
Federica Mannino
Fausto Famà
Vincenzo Arcoraci
Vincenzo Fodale
Antonio David
Francesca Cosentino

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1733683

374 views

Review

Published on 26 Nov 2025

Bortezomib-induced peripheral neuropathy: from molecular mechanisms to clinical management

in Neuropharmacology

Yuting Yan
Yanqi Song
Quan Zhang
Lingwei Hu
Aidi Wang
Honglei Guo
Zhen Wang
Lin Ma
Baoshan Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1719384

1,253 views

Review

Published on 26 Nov 2025

Signal transduction, dimerization, and therapeutic targeting of Orexin and receptor systems

in Neuropharmacology

Shengnan Zhang
Peixiang Wang
Bingyuan Ji
Yuming Shao
Sen Hou
Jing Chen
Chunmei Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1697406

1,199 views

Original Research

Published on 26 Nov 2025

Intranasal Galanin (1–15) modulates alcohol self-administration and depressive-like behavior in rats and shows a favorable safety profile

in Neuropharmacology

Noelia Cantero-García
Antonio Flores-Burgess
Marta Flores-Gómez
Juan Pedro Pineda-Gómez
Maria C. Ramos
Caridad Diaz
Carmelo Millón
Zaida Díaz-Cabiale

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1719440

793 views

Review

Published on 26 Nov 2025

Targeting the P2X7 receptor in cerebrovascular diseases: from molecular mechanisms to preclinical therapeutic potential

in Neuropharmacology

Ziyan Hu
Shujing Xie
Cheng Chen
Zhihui Luo
Xiao Deng
Renjie Xiao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1713748

726 views

Original Research

Published on 25 Nov 2025

ER stress in D1-MSNs mediates cocaine-induced behavioral plasticity via the ATF4–SPTLC1 axis

in Neuropharmacology

Yue Zhao
Shu Li
Linhong Jiang
Ying Zhao
Weihong Kuang
Qingfan Wei
Yuanyi Zhou
Shuang Han
Liang Wang
Hongchun Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1677343

757 views

Original Research

Published on 25 Nov 2025

Pathogenic variants at the N-terminal arginine residue 44 disrupt human GABA transporter 1 function: insights from Drosophila epilepsy models

in Neuropharmacology

Nikita Shah
Ameya Sanjay Kasture
Vasylyna Kovalchuk
Lara Bjeletic
Thomas Hummel
Harald H. Sitte
Sonja Sucic

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1674737

871 views

Original Research

Published on 24 Nov 2025

Methamphetamine and neuroHIV suppress astrocytic potassium channel function in the medial prefrontal cortex via different mechanisms

in Neuropharmacology

Lihua Chen
Stefanie L. Cassoday
Joao I. Mamede
Lena Al-Harthi
Xiu-Ti Hu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1691165

717 views

Clinical Trial

Published on 24 Nov 2025

Remimazolam combined with propofol for intraoperative wake-up testing in scoliosis correction surgery: a prospective, blind, randomized controlled trial

in Neuropharmacology

Jing Luo
Da-Lin Chen
Zong-Long Lv
Hui Zhong
Yong-Hui Zhao
Yu-Jin Li
Xin-Nan Li
Jing-Ce Chen
Wen-Bao Shi
Yun Bo

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1685683

690 views

Review

Published on 21 Nov 2025

Gepants: targeting the CGRP pathway for migraine relief

in Neuropharmacology

Bernadetta Jakubowska
Magdalena Sowa-Kućma

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1708226

2,504 views

Systematic Review

Published on 21 Nov 2025

Neuroprotective role of carvacrol in ischemic brain injury: a systematic review of preclinical evidence and proposed TRPM7 involvement

in Neuropharmacology

Abdulrahman M. Khojah
Hussain Al Dera

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1687119

1,108 views

Original Research

Accepted on 20 Nov 2025

Legislating novel psychoactive substances: Lessons from 15 years of UK mortality data (2007-2022)

in Neuropharmacology

Kirsten Rock
Richard Treble
Caroline S Copeland

Frontiers in Pharmacology

399 views

Original Research

Published on 20 Nov 2025

Receptor interaction profiles of 4-alkoxy-2,6-dimethoxyphenethylamines (Ψ derivatives) and related amphetamines

in Neuropharmacology

Karolina E. Kolaczynska
Daniel Trachsel
Marius C. Hoener
Matthias E. Liechti
Dino Luethi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1703480

2,389 views

Original Research

Published on 19 Nov 2025

Integrated metabolomics and gut microbiota analysis to explore the potential mechanism of levo-tetrahydropalmatine against ketamine addiction

in Neuropharmacology

Yan Du
Qing Ma
Xingcui Gao
Hongliang Su
Keming Yun
Li Du

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1698866

3,308 views

2,620 articles

articles

Therapeutic effects of Lactobacillus rhamnosus and/or thymol against neurotoxicity in propionic acid (PA)-induced autistic rats: Insights for the role of Nrf2/HO-1, Wnt3/β-Catenin/GSK3β BDNF/p-TrkB/CREB, pI3K/Akt/mTOR, AMPK/SIRT-1 and PERK/CHOP/Bcl-2 pathways

The Potential Role of GLP-1 Receptor Agonists in Substance Use Disorders: A Systematic Review

Optimizing Phenytoin Therapy: A Systematic Review of Clinically Relevant Food and Herb Interactions

DX243 counteracts both acoustic trauma-induced reduction in cortical brain oscillations and cochlear synaptopathy

Correction: The role of panax notoginseng saponins in cerebrovascular neurological disorders: an overview of mechanisms and functions

T817MA attenuates oxidative stress and ER stress via the HSP70–HSP90 pathway after brain ischemia in vitro and in vivo

Striatal M4 muscarinic receptors determine the biological rhythm of activity, with a supportive role of M1 muscarinic receptors

Efficacy and safety of esketamine for pain control after cesarean delivery: a systematic review and meta-analysis of randomized controlled trials

Kappa-opioid receptor gene (OPRK1) variations associated with opioid abstinence behaviors among chronic heroin users

Functional interaction between orexin/dynorphin transmission in the posterior paraventricular nucleus of the thalamus following alcohol dependence: mediation of alcohol-seeking behavior

Correction: Lack of the Nlrp3 inflammasome improves mice recovery following traumatic brain injury

Bortezomib-induced peripheral neuropathy: from molecular mechanisms to clinical management

Signal transduction, dimerization, and therapeutic targeting of Orexin and receptor systems

Intranasal Galanin (1–15) modulates alcohol self-administration and depressive-like behavior in rats and shows a favorable safety profile

Targeting the P2X7 receptor in cerebrovascular diseases: from molecular mechanisms to preclinical therapeutic potential

ER stress in D1-MSNs mediates cocaine-induced behavioral plasticity via the ATF4–SPTLC1 axis

Pathogenic variants at the N-terminal arginine residue 44 disrupt human GABA transporter 1 function: insights from Drosophila epilepsy models

Methamphetamine and neuroHIV suppress astrocytic potassium channel function in the medial prefrontal cortex via different mechanisms

Remimazolam combined with propofol for intraoperative wake-up testing in scoliosis correction surgery: a prospective, blind, randomized controlled trial

Gepants: targeting the CGRP pathway for migraine relief

Neuroprotective role of carvacrol in ischemic brain injury: a systematic review of preclinical evidence and proposed TRPM7 involvement

Legislating novel psychoactive substances: Lessons from 15 years of UK mortality data (2007-2022)

Receptor interaction profiles of 4-alkoxy-2,6-dimethoxyphenethylamines (Ψ derivatives) and related amphetamines

Integrated metabolomics and gut microbiota analysis to explore the potential mechanism of levo-tetrahydropalmatine against ketamine addiction