Frontiers in Pharmacology | Neuropharmacology

Original Research

Published on 19 Nov 2025

Health risks of cocaine adulteration: local anesthetics as modulators of monoamine and organic cation transporters

in Neuropharmacology

Oliver Kudlacek
Niklas Senning
Alexandra Karden
Iina Ludwig
Julia Bicher
Fatemeh Kooti
Marion Holy
Thomas Stockner
Anton Luf
Harald H. Sitte

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1699035

3,316 views

Original Research

Published on 19 Nov 2025

Novel floxed cannabinoid receptor 2 mouse line combines knockout capability with dual fluorescent reporters

in Neuropharmacology

Kathryn J. Laloli
Peggy Rentsch
Sandy Stayte
Bryce Vissel

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1682979

3,034 views

Original Research

Published on 14 Nov 2025

Time-dependent biphasic alterations in brain metabolism following chronic ketamine exposure in mice

in Neuropharmacology

Seo-Hyun Lim
Young-Suk Choi
Eosu Kim
Chul Hoon Kim
Ho-Taek Song

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1629824

8,013 views

Review

Published on 13 Nov 2025

The role of Panax notoginseng saponins in cerebrovascular neurological disorders: an overview of mechanisms and functions

in Neuropharmacology

Bin Wang
Xu Gao
Yali Zhang
Yuhua Xiao
Tong Chen
Zhouying Shi
Yue Yuan
Ping Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1693253

8,990 views

Original Research

Published on 13 Nov 2025

From heart to brain: cognitive potential of propranolol and diltiazem through cholinergic enhancement via butyrylcholinesterase inhibition

in Neuropharmacology

Celtia Domínguez-Fernández
Amit Kumar
Rajnish Kumar
Taher Darreh-Shori

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1694610

9,466 views

Original Research

Published on 12 Nov 2025

TAAR9 knockout increases hippocampal serotonin and alters grooming behavior in rats

in Neuropharmacology

Ilya S. Zhukov
Inessa V. Karpova
Ramilya Z. Murtazina
Yazen Alnefeesi
Olga M. Korenkova
Ilia Yu. Tissen
Svetlana A. Palchikova
Lydia A. Tokareva
Sarng S. Pyurveev
Petr D. Shabanov

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1684029

9,493 views

Original Research

Published on 12 Nov 2025

Molecular genetic basis of the primary emotions in young adults: an exploratory analysis of genetic polymorphisms across dopamine, serotonin, oxytocin, endogenous opioid, and neurotrophic factor pathways

in Neuropharmacology

Timotej Glavač
Maruša Barbo
Metka Ravnik-Glavač
Maja Zupančič
Vita Dolžan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1675538

8,436 views

Original Research

Accepted on 10 Nov 2025

Functional and Transcriptomic Insights Into Amlodipine's Anti-Inflammatory Effects

in Neuropharmacology

Muhammed Yusuf

Frontiers in Pharmacology

109 views

Original Research

Published on 07 Nov 2025

Deciphering the effects of polydatin on neuropathic pain and motor performance in a chronic constriction injury model: role of GABA and opioid receptors and neuroprotective properties

in Neuropharmacology

Sadaf Abdian
Sajad Fakhri
Amir Kiani
Mohammad Mehdi Gravandi
Fatemeh Abbaszadeh
Mohammad Hosein Farzaei
Ehsan Mohammadi-Noori
Javier Echeverría

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1691130

12,360 views

Brief Research Report

Published on 07 Nov 2025

Neuro-functional correlates of personality dimensions in Parkinson’s disease

in Neuropharmacology

Mathilde Boussac
Estelle Harroch
Karel Joineau
Emeline Descamps
Christine Brefel-Courbon

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1705937

7,808 views

Systematic Review

Published on 07 Nov 2025

The effect of esketamine on postoperative delirium in patients undergoing general anesthesia: a systematic review and meta-analysis

in Neuropharmacology

Chao-Xu
Rui-Jun Tong
Qi-Hong Shen
Jing Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1681531

12,304 views

Original Research

Published on 06 Nov 2025

The development and verification of clinical medication pathway for tic disorder in west China

in Neuropharmacology

Dan Li
Chunsong Yang
Jianhua Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1682518

6,360 views

Original Research

Published on 06 Nov 2025

Efficacy analysis of remifentanil mild sedation anesthesia for painless gastroscopy

in Neuropharmacology

Dongfeng Xi
Huiling Zhang
Mengyuan Gu
Yao Wang
Jiangbo Qu
Huibin Mao
Lina Mi
Bin Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1692910

7,252 views

Opinion

Published on 06 Nov 2025

Glucose may be biotransformed and then react with alcohol, fats, endocannabinoids, or various amino acids to form dopamine or norepinephrine in vivo

in Neuropharmacology

Paul J. Fitzgerald

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1715092

7,556 views

Mini Review

Published on 06 Nov 2025

Post-traumatic epilepsy: bridging pathogenesis, diagnosis, and pharmacotherapeutic strategies

in Neuropharmacology

Xiaoyu Yang
Siyang Chen
Haozhou Wang
Tong Sun
Ke Wu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1697391

6,844 views

Case Report

Published on 04 Nov 2025

Case Report: Carbonic anhydrase inhibitor brinzolamide dramatically improved the morphology and also function of a patient with RS1 mutation

in Neuropharmacology

Yue Ren
Shu Liu
Jia Rong
Di Wang
Miao Diao
Yaqi Zhang
Shimiao Tian
Mingxin Shang
Chuqiao Song
Yan Guan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1706488

3,968 views

Original Research

Published on 03 Nov 2025

Avenanthramide C mitigates cisplatin-induced hippocampal neurotoxicity and cognitive impairment in rats via suppression of neuroinflammation and neuronal apoptosis

in Neuropharmacology

Maha Abdulrahman Aldubayan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1706224

4,695 views

Case Report

Published on 31 Oct 2025

Case Report: Near-fatal adverse effects of dopamine agonist for the treatment of restless legs syndrome

in Neuropharmacology

Jeremiah B. Joyce
Liliana Patarroyo Rodriquez
Christopher L. Sola

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1697935

7,153 views

Systematic Review

Published on 29 Oct 2025

Comparative safety and tolerability of ketamine and esketamine for major depressive disorder: a systematic review and meta-analysis

in Neuropharmacology

Haoning Guo
Liling Tang
Miaoquan He
Wencheng Tang
Jing Liu
Silin Wu
Shuying Yuan
Jisheng Wang
Xueli Tang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1681060

8,018 views

Original Research

Published on 29 Oct 2025

The neuroprotective effect of cannabidiol is enhanced by resveratrol and alpha-lipoic acid in social isolation

in Neuropharmacology

Federica Ricciardi
Andrea Maria Morace
Rebecca Limongelli
Monica Iannotta
Serena Boccella
Antimo Fusco
Roozbe Bonsale
Michela Perrone
Rosmara Infantino
Emanuele Di Martino

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1676421

7,670 views

Original Research

Published on 29 Oct 2025

Exposure to β-hydroxybutyrate reduces the operating set point and increases excitability in hippocampal circuitry of healthy mice

in Neuropharmacology

Thais Tessari Zampieri
Guilherme Shigueto Vilar Higa
Fernando S. Borges
Felipe José Costa Viana
Emily Cruvinel
Lucas Eduardo Bentivoglio
Ademar Benevolo Lugao
Henning Ulrich
Luiz Roberto Britto
Kattesh V. Katti

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1557612

8,372 views

Original Research

Published on 28 Oct 2025

The involvement of GABA-rho receptors in regulating ethanol-induced elevation of dopamine, glycine and taurine within the nucleus accumbens of Wistar rats

in Neuropharmacology

Davide Cadeddu
Anna Loftén
Karin Ademar
Bo Söderpalm
Louise Adermark
Mia Ericson

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1668669

8,064 views

Original Research

Published on 28 Oct 2025

Serum amyloid A-mediated neuro-inflammation induces hippocampal neuron apoptosis and postoperative cognitive dysfunction in mice

in Neuropharmacology

Xiaochen Fu
Zhenbin Cai
Yuxuan Wu
Yiwen Xu
Ze Gao
Minghui Tan
Jing Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1661881

6,928 views

Original Research

Published on 27 Oct 2025

Study on Chaiyuwendan decoction’s inhibition of hippocampal neuron apoptosis to alleviating depression by activating the AKT/CREB pathway

in Neuropharmacology

Shaoliang Zhang
Sijie Cheng
Huiqing Liang
Yan Qiu
Jie Ren
Yv Huang
Bangyan Zhou
Chunrong Li
Jingmin Zhang
Tianxiang Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1610899

6,880 views

2,620 articles

articles

Health risks of cocaine adulteration: local anesthetics as modulators of monoamine and organic cation transporters

Novel floxed cannabinoid receptor 2 mouse line combines knockout capability with dual fluorescent reporters

Time-dependent biphasic alterations in brain metabolism following chronic ketamine exposure in mice

The role of Panax notoginseng saponins in cerebrovascular neurological disorders: an overview of mechanisms and functions

From heart to brain: cognitive potential of propranolol and diltiazem through cholinergic enhancement via butyrylcholinesterase inhibition

TAAR9 knockout increases hippocampal serotonin and alters grooming behavior in rats

Molecular genetic basis of the primary emotions in young adults: an exploratory analysis of genetic polymorphisms across dopamine, serotonin, oxytocin, endogenous opioid, and neurotrophic factor pathways

Functional and Transcriptomic Insights Into Amlodipine's Anti-Inflammatory Effects

Deciphering the effects of polydatin on neuropathic pain and motor performance in a chronic constriction injury model: role of GABA and opioid receptors and neuroprotective properties

Neuro-functional correlates of personality dimensions in Parkinson’s disease

The effect of esketamine on postoperative delirium in patients undergoing general anesthesia: a systematic review and meta-analysis

The development and verification of clinical medication pathway for tic disorder in west China

Efficacy analysis of remifentanil mild sedation anesthesia for painless gastroscopy

Glucose may be biotransformed and then react with alcohol, fats, endocannabinoids, or various amino acids to form dopamine or norepinephrine in vivo

Post-traumatic epilepsy: bridging pathogenesis, diagnosis, and pharmacotherapeutic strategies

Case Report: Carbonic anhydrase inhibitor brinzolamide dramatically improved the morphology and also function of a patient with RS1 mutation

Avenanthramide C mitigates cisplatin-induced hippocampal neurotoxicity and cognitive impairment in rats via suppression of neuroinflammation and neuronal apoptosis

Case Report: Near-fatal adverse effects of dopamine agonist for the treatment of restless legs syndrome

Comparative safety and tolerability of ketamine and esketamine for major depressive disorder: a systematic review and meta-analysis

The neuroprotective effect of cannabidiol is enhanced by resveratrol and alpha-lipoic acid in social isolation

Exposure to β-hydroxybutyrate reduces the operating set point and increases excitability in hippocampal circuitry of healthy mice

The involvement of GABA-rho receptors in regulating ethanol-induced elevation of dopamine, glycine and taurine within the nucleus accumbens of Wistar rats

Serum amyloid A-mediated neuro-inflammation induces hippocampal neuron apoptosis and postoperative cognitive dysfunction in mice

Study on Chaiyuwendan decoction’s inhibition of hippocampal neuron apoptosis to alleviating depression by activating the AKT/CREB pathway