Frontiers in Pharmacology | Neuropharmacology

Original Research

Published on 26 Nov 2025

Intranasal Galanin (1–15) modulates alcohol self-administration and depressive-like behavior in rats and shows a favorable safety profile

in Neuropharmacology

Noelia Cantero-García
Antonio Flores-Burgess
Marta Flores-Gómez
Juan Pedro Pineda-Gómez
Maria C. Ramos
Caridad Diaz
Carmelo Millón
Zaida Díaz-Cabiale

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1719440

1,186 views

Review

Published on 26 Nov 2025

Targeting the P2X7 receptor in cerebrovascular diseases: from molecular mechanisms to preclinical therapeutic potential

in Neuropharmacology

Ziyan Hu
Shujing Xie
Cheng Chen
Zhihui Luo
Xiao Deng
Renjie Xiao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1713748

1,165 views
1 citation

Original Research

Published on 25 Nov 2025

ER stress in D1-MSNs mediates cocaine-induced behavioral plasticity via the ATF4–SPTLC1 axis

in Neuropharmacology

Yue Zhao
Shu Li
Linhong Jiang
Ying Zhao
Weihong Kuang
Qingfan Wei
Yuanyi Zhou
Shuang Han
Liang Wang
Hongchun Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1677343

1,161 views

Original Research

Published on 25 Nov 2025

Pathogenic variants at the N-terminal arginine residue 44 disrupt human GABA transporter 1 function: insights from Drosophila epilepsy models

in Neuropharmacology

Nikita Shah
Ameya Sanjay Kasture
Vasylyna Kovalchuk
Lara Bjeletic
Thomas Hummel
Harald H. Sitte
Sonja Sucic

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1674737

1,363 views

Original Research

Published on 24 Nov 2025

Methamphetamine and neuroHIV suppress astrocytic potassium channel function in the medial prefrontal cortex via different mechanisms

in Neuropharmacology

Lihua Chen
Stefanie L. Cassoday
Joao I. Mamede
Lena Al-Harthi
Xiu-Ti Hu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1691165

993 views

Clinical Trial

Published on 24 Nov 2025

Remimazolam combined with propofol for intraoperative wake-up testing in scoliosis correction surgery: a prospective, blind, randomized controlled trial

in Neuropharmacology

Jing Luo
Da-Lin Chen
Zong-Long Lv
Hui Zhong
Yong-Hui Zhao
Yu-Jin Li
Xin-Nan Li
Jing-Ce Chen
Wen-Bao Shi
Yun Bo

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1685683

1,283 views

Review

Published on 21 Nov 2025

Gepants: targeting the CGRP pathway for migraine relief

in Neuropharmacology

Bernadetta Jakubowska
Magdalena Sowa-Kućma

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1708226

4,464 views
1 citation

Systematic Review

Published on 21 Nov 2025

Neuroprotective role of carvacrol in ischemic brain injury: a systematic review of preclinical evidence and proposed TRPM7 involvement

in Neuropharmacology

Abdulrahman M. Khojah
Hussain Al Dera

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1687119

1,571 views

Original Research

Published on 20 Nov 2025

Receptor interaction profiles of 4-alkoxy-2,6-dimethoxyphenethylamines (Ψ derivatives) and related amphetamines

in Neuropharmacology

Karolina E. Kolaczynska
Daniel Trachsel
Marius C. Hoener
Matthias E. Liechti
Dino Luethi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1703480

2,923 views

Original Research

Published on 19 Nov 2025

Integrated metabolomics and gut microbiota analysis to explore the potential mechanism of levo-tetrahydropalmatine against ketamine addiction

in Neuropharmacology

Yan Du
Qing Ma
Xingcui Gao
Hongliang Su
Keming Yun
Li Du

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1698866

3,688 views

Original Research

Published on 19 Nov 2025

Health risks of cocaine adulteration: local anesthetics as modulators of monoamine and organic cation transporters

in Neuropharmacology

Oliver Kudlacek
Niklas Senning
Alexandra Karden
Iina Ludwig
Julia Bicher
Fatemeh Kooti
Marion Holy
Thomas Stockner
Anton Luf
Harald H. Sitte

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1699035

3,930 views

Original Research

Published on 19 Nov 2025

Novel floxed cannabinoid receptor 2 mouse line combines knockout capability with dual fluorescent reporters

in Neuropharmacology

Kathryn J. Laloli
Peggy Rentsch
Sandy Stayte
Bryce Vissel

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1682979

3,482 views

Original Research

Published on 14 Nov 2025

Time-dependent biphasic alterations in brain metabolism following chronic ketamine exposure in mice

in Neuropharmacology

Seo-Hyun Lim
Young-Suk Choi
Eosu Kim
Chul Hoon Kim
Ho-Taek Song

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1629824

8,381 views

Review

Published on 13 Nov 2025

The role of Panax notoginseng saponins in cerebrovascular neurological disorders: an overview of mechanisms and functions

in Neuropharmacology

Bin Wang
Xu Gao
Yali Zhang
Yuhua Xiao
Tong Chen
Zhouying Shi
Yue Yuan
Ping Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1693253

9,810 views

Original Research

Published on 13 Nov 2025

From heart to brain: cognitive potential of propranolol and diltiazem through cholinergic enhancement via butyrylcholinesterase inhibition

in Neuropharmacology

Celtia Domínguez-Fernández
Amit Kumar
Rajnish Kumar
Taher Darreh-Shori

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1694610

10,010 views

Original Research

Published on 12 Nov 2025

TAAR9 knockout increases hippocampal serotonin and alters grooming behavior in rats

in Neuropharmacology

Ilya S. Zhukov
Inessa V. Karpova
Ramilya Z. Murtazina
Yazen Alnefeesi
Olga M. Korenkova
Ilia Yu. Tissen
Svetlana A. Palchikova
Lydia A. Tokareva
Sarng S. Pyurveev
Petr D. Shabanov

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1684029

9,922 views

Original Research

Published on 12 Nov 2025

Molecular genetic basis of the primary emotions in young adults: an exploratory analysis of genetic polymorphisms across dopamine, serotonin, oxytocin, endogenous opioid, and neurotrophic factor pathways

in Neuropharmacology

Timotej Glavač
Maruša Barbo
Metka Ravnik-Glavač
Maja Zupančič
Vita Dolžan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1675538

9,054 views

Original Research

Accepted on 10 Nov 2025

Functional and Transcriptomic Insights Into Amlodipine's Anti-Inflammatory Effects

in Neuropharmacology

Muhammed Yusuf

Frontiers in Pharmacology

234 views

Original Research

Published on 07 Nov 2025

Deciphering the effects of polydatin on neuropathic pain and motor performance in a chronic constriction injury model: role of GABA and opioid receptors and neuroprotective properties

in Neuropharmacology

Sadaf Abdian
Sajad Fakhri
Amir Kiani
Mohammad Mehdi Gravandi
Fatemeh Abbaszadeh
Mohammad Hosein Farzaei
Ehsan Mohammadi-Noori
Javier Echeverría

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1691130

12,627 views

Brief Research Report

Published on 07 Nov 2025

Neuro-functional correlates of personality dimensions in Parkinson’s disease

in Neuropharmacology

Mathilde Boussac
Estelle Harroch
Karel Joineau
Emeline Descamps
Christine Brefel-Courbon

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1705937

7,986 views

Systematic Review

Published on 07 Nov 2025

The effect of esketamine on postoperative delirium in patients undergoing general anesthesia: a systematic review and meta-analysis

in Neuropharmacology

Chao-Xu
Rui-Jun Tong
Qi-Hong Shen
Jing Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1681531

12,862 views

Original Research

Published on 06 Nov 2025

The development and verification of clinical medication pathway for tic disorder in west China

in Neuropharmacology

Dan Li
Chunsong Yang
Jianhua Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1682518

6,616 views

Opinion

Published on 06 Nov 2025

Glucose may be biotransformed and then react with alcohol, fats, endocannabinoids, or various amino acids to form dopamine or norepinephrine in vivo

in Neuropharmacology

Paul J. Fitzgerald

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1715092

7,817 views

Original Research

Published on 06 Nov 2025

Efficacy analysis of remifentanil mild sedation anesthesia for painless gastroscopy

in Neuropharmacology

Dongfeng Xi
Huiling Zhang
Mengyuan Gu
Yao Wang
Jiangbo Qu
Huibin Mao
Lina Mi
Bin Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1692910

7,869 views

2,654 articles

articles

Intranasal Galanin (1–15) modulates alcohol self-administration and depressive-like behavior in rats and shows a favorable safety profile

Targeting the P2X7 receptor in cerebrovascular diseases: from molecular mechanisms to preclinical therapeutic potential

ER stress in D1-MSNs mediates cocaine-induced behavioral plasticity via the ATF4–SPTLC1 axis

Pathogenic variants at the N-terminal arginine residue 44 disrupt human GABA transporter 1 function: insights from Drosophila epilepsy models

Methamphetamine and neuroHIV suppress astrocytic potassium channel function in the medial prefrontal cortex via different mechanisms

Remimazolam combined with propofol for intraoperative wake-up testing in scoliosis correction surgery: a prospective, blind, randomized controlled trial

Gepants: targeting the CGRP pathway for migraine relief

Neuroprotective role of carvacrol in ischemic brain injury: a systematic review of preclinical evidence and proposed TRPM7 involvement

Receptor interaction profiles of 4-alkoxy-2,6-dimethoxyphenethylamines (Ψ derivatives) and related amphetamines

Integrated metabolomics and gut microbiota analysis to explore the potential mechanism of levo-tetrahydropalmatine against ketamine addiction

Health risks of cocaine adulteration: local anesthetics as modulators of monoamine and organic cation transporters

Novel floxed cannabinoid receptor 2 mouse line combines knockout capability with dual fluorescent reporters

Time-dependent biphasic alterations in brain metabolism following chronic ketamine exposure in mice

The role of Panax notoginseng saponins in cerebrovascular neurological disorders: an overview of mechanisms and functions

From heart to brain: cognitive potential of propranolol and diltiazem through cholinergic enhancement via butyrylcholinesterase inhibition

TAAR9 knockout increases hippocampal serotonin and alters grooming behavior in rats

Molecular genetic basis of the primary emotions in young adults: an exploratory analysis of genetic polymorphisms across dopamine, serotonin, oxytocin, endogenous opioid, and neurotrophic factor pathways

Functional and Transcriptomic Insights Into Amlodipine's Anti-Inflammatory Effects

Deciphering the effects of polydatin on neuropathic pain and motor performance in a chronic constriction injury model: role of GABA and opioid receptors and neuroprotective properties

Neuro-functional correlates of personality dimensions in Parkinson’s disease

The effect of esketamine on postoperative delirium in patients undergoing general anesthesia: a systematic review and meta-analysis

The development and verification of clinical medication pathway for tic disorder in west China

Glucose may be biotransformed and then react with alcohol, fats, endocannabinoids, or various amino acids to form dopamine or norepinephrine in vivo

Efficacy analysis of remifentanil mild sedation anesthesia for painless gastroscopy