Frontiers in Pharmacology | Neuropharmacology

Original Research

Published on 27 Oct 2025

Neuroprotective mechanisms of valproic acid and alpha-lipoic acid in ALS: a network pharmacology-based investigation

in Neuropharmacology

Dongmei Zhang
Ling Han
Wenmo Zhang
Di Wang
Di Huo
Xingli Tan
Xiaoli Su
Ming Wang
Jing Xu
Jiling Cheng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1681929

5,252 views

Original Research

Published on 24 Oct 2025

Hydrogen sulphide alleviates depression-like behaviors by suppressing the hippocampal necroptosis-neuroinflammation-KP imbalance axis

in Neuropharmacology

San-Qiao Yang
Yu-Hui Tang
Si-Min Chen
Fen Liu
Ping Zhang
Wei Zou
Bo Wang
Xiao-Qing Tang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1691204

5,164 views

Original Research

Published on 21 Oct 2025

NeuproGemp, a polyphenol-rich botanical formula, ameliorates Alzheimer’s-like pathology in APP/PS1 mice via inhibition of human glutaminyl cyclase

in Neuropharmacology

Tien-Sheng Tseng
Chia-Ching Liaw
Young-Ji Shiao
Ya-I Huang
Yu-Hsiu Cheng
Wang-Chuan Chen
Keng-Chang Tsai

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1673532

6,026 views

Review

Published on 20 Oct 2025

The dual role of glycogen synthase kinase-3 beta (GSK3β) in neurodegenerative pathologies: interplay between autophagy and disease progression

in Neuropharmacology

Hassan H. Alhassan
Komal Janiyani
Malvi Surti
Mohd Adnan
Mitesh Patel

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1693805

7,543 views
1 citation

Systematic Review

Published on 17 Oct 2025

Systematic review and network meta-analysis of the effects of bioactive compounds on pain intensity and quality of life in neuropathic pain patients

in Neuropharmacology

Rong Tang
Chao-Yang Gong
Yu-Qian Liu
Yingbin Wang
Hai-Yu Zhou

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1656400

6,050 views

Original Research

Published on 16 Oct 2025

Reducing stress and alcohol-related behaviors by targeting D1-CRHR1 receptor interactions in the amygdala

in Neuropharmacology

Laura Broccoli
Rick E. Bernardi
Francesco Giannone
Anika Hoppe
Kay Jungling
Dasiel O. Borroto-Escuela
Roberto Rimondini-Giorgini
Miguel Pérez de la Mora
Oliver von Bohlen und Halbach
Kjell Fuxe

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1677510

6,963 views

Original Research

Published on 15 Oct 2025

Epigallocatechin-3-gallate conjugated with selenium nanoparticles prevents neurological complications in rats exhibiting schizophrenia-like behaviors

in Neuropharmacology

Hadeer M. Gamal El-Deen
Amina E. Essawy
Nema A. Mohammed
Mohamed S. Abdelfattah
Ayah S. Fathalla
Manal F. El-khadragy
Ahmed E. Abdel Moniem

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1680380

4,465 views

Original Research

Published on 13 Oct 2025

Evaluating the risk of osteopenia-related adverse events with antiepileptic drugs: a pharmacovigilance study based on the FAERS database

in Neuropharmacology

Nan Yang
Xiang Han
Hongning Hua
Yumeng Wang
Yulin Chen
Yue Zhou
Haoyu Feng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1685289

2,884 views

Systematic Review

Published on 13 Oct 2025

Therapeutic efficacy of botanicals in psychological disorders in menopausal women: a systematic and scoping review

in Neuropharmacology

Arshiya Sultana
Md Belal Bin Heyat
Khaleequr Rahman
Zahoor Ahmed
Faijan Akhtar
Ansari Uzma Shamim
Khadija Khaleeq
Abdullah Y. Muaad

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1661035

5,422 views

Mini Review

Published on 10 Oct 2025

Dexmedetomidine for postoperative delirium in surgical patients: a mini-review of mechanisms, clinical evidence, and practical implementation

in Neuropharmacology

Xiao-yan Li
Jing-yi Yang
Yi Qiu
Cai-xia Wang
Xiao-dong Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1702862

2,232 views
2 citations

Review

Published on 08 Oct 2025

Anti-inflammatory effect of curcumin on neurological disorders: a narrative review

in Neuropharmacology

Baoyin Zhou
Binbin Hu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1658115

2,708 views

Original Research

Published on 08 Oct 2025

Prophylactic administration of metformin alleviates withdrawal symptoms associated with heroin

in Neuropharmacology

Minghong Liu
Junyu Jiang
Xiaolong Wu
Jiaxin Liu
Yang Liu
Shanshan Ling
Huichun Chen
Gongliang Zhang
Yuanhai Li
Gang Pang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1647624

1,527 views

Original Research

Published on 08 Oct 2025

Dopaminergic REST is implicated in the tamoxifen-induced neuroprotection against manganese toxicity in female mice

in Neuropharmacology

Edward Pajarillo
Alexis Digman
Itunu Ajayi
Sanghoon Kim
Deok-Soo Son
Michael Aschner
Eunsook Lee

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1627400

1,275 views
2 citations

Original Research

Published on 07 Oct 2025

3-Hydroxytyrosol as a phenolic cholinesterase inhibitor with antiamnesic activity: a multimethodological study of selected plant phenolics

in Neuropharmacology

Tugba Ucar Akyurek
F. Sezer Senol Deniz
Ipek Suntar
Gokcen Eren
Onur Kenan Ulutas
Ilkay Erdogan Orhan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1640034

3,680 views

Study Protocol

Published on 07 Oct 2025

Synergistic effect of Chaihu-Shugan-San combined with paroxetine tablets in the treatment of acquired premature ejaculation: study protocol for a randomized controlled proof-of-concept trial

in Neuropharmacology

Shengqiang Qian
Jintao Wei
Peihai Zhang
Ziyang Ma
Yu Guo
Feiqiang Ren
Wei Xiong

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1651654

3,788 views

Review

Published on 07 Oct 2025

Rheumatoid arthritis-associated depression: focusing on the interactions between mitochondria and endoplasmic reticulum

in Neuropharmacology

Mingqin Shi
Xinyao Li
Haimei Zhou
Zhenmin Li
Yuanyuan Wei
Zihui Wang
Yuqing She
Xuelian Zou
Xiangdian Xiao
Jiashun Zeng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1549060

2,345 views

Original Research

Published on 07 Oct 2025

Computational and experimental identification of putative αTAT1 modulators: implications for nervous system function

in Neuropharmacology

Oksana Rybachuk
Alexey Rayevsky
Mariia Styhylias
Dariia Samofalova
Elijah Bulgakov
Maxym Platonov
Yaroslav Blume
Pavel Karpov

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1654114

1,472 views

Original Research

Published on 01 Oct 2025

Ferulic acid mitigates 3-Nitropropionic acid-induced Huntington’s disease via modulation of Nrf2/HO-1, TLR4/NF-κB, and SIRT1/p53 signaling pathways

in Neuropharmacology

Mohamed A. Abdelgawad
Abdallah M. Gendy
Sameh S. Zaghlool
Wessam H. Elesawy
Mai F. Ragab
Mohamed I. Kotb El-Sayed
Alaadin E. El-Haddad
Hussein S. Mohamed
Izzeddin Alsalahat
Marwa A. Essa

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1678724

2,246 views

Correction

Published on 30 Sep 2025

Correction: Research progress on plant-derived natural compounds regulating the MAPK signaling pathway for the prevention and therapy of Alzheimer’s disease

in Neuropharmacology

Xinyue Zhang
Shujia Huang
Hongfeng Xu
Yanan Hu
Ling Gao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1710820

937 views

Original Research

Published on 29 Sep 2025

Therapeutic potential of extracellular vesicles derived from Platycladus Orientalis leaf in treating anxiety, depression, and insomnia

in Neuropharmacology

Peiyu Liu
Guiyang He
Yaoxin Lu
Juanjuan He
Faliang Wu
Meng Jia
Shaochang Jia
Ruijie Fan
Hongwei Liang
Bing Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1693106

2,994 views

Original Research

Published on 29 Sep 2025

Desensitization of TRPA1 by dimethyl itaconate attenuates acute and chronic pain in mice

in Neuropharmacology

Sen Xu
Jia-Yue Zhao
Jun-Yi Ma
Xia-Lin Cui
Jia-Hui Lin
Shi-Yu Sun
Si-Jia Liu
Guo-Kun Zhou
Jiang-Tao Zhang
Peipei Kang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1671461

2,580 views

Review

Published on 26 Sep 2025

Pharmacological modulation of the gut-brain axis: psychobiotics in focus for depression therapy

in Neuropharmacology

Zakirah Zainal Abidin
Zaw Myo Hein
Che Mohd Nasril Che Mohd Nassir
Norshafarina Shari
Muhammad Danial Che Ramli

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1665419

12,043 views
1 citation

Original Research

Published on 25 Sep 2025

Stable interindividual differences in modafinil’s effect on vigilance during sleep deprivation

in Neuropharmacology

Jeroen Van Cutsem
Martine Van Puyvelde
Nicholas H. Van den Berg
Emilie Dessy
Frederic Detaille
An Van Rompay
Olivier Mairesse
Catherine Drogou
Fabien Sauvet
Xavier Neyt

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1607444

2,761 views

Systematic Review

Published on 24 Sep 2025

Efficacy and safety of vesicular monoamine transporter 2 inhibitors for Huntington’s disease chorea based on network meta-analysis

in Neuropharmacology

Jing Huang
Fei-Fei Chen
Si-Yuan Wen
Pan Tao
Chi Meng
Wei Chen
Chang-Qing Zhou

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1637577

2,705 views
1 citation