Frontiers in Pharmacology | Neuropharmacology

Original Research

Published on 24 Sep 2025

Pharmacovigilance study on old drugs repurposed for rare diseases across different indications: the case of fenfluramine

in Neuropharmacology

Jiahong Zhong
Zhuomiao Lin
Junling Xue
Xihui Yu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1682788

2,547 views

Review

Published on 23 Sep 2025

Neuroprotective mechanisms of Buyang Huanwu decoction in ischemic stroke

in Neuropharmacology

Yuanyuan Qin
Shiliang Hu
Shiman Mawen
Shanyao Pan
Yaping Huai
Guoqiang Liang
Ting Chen
Feiyan Zhao
Hongli Dong
Xuyi Yao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1620533

4,006 views

Mini Review

Published on 22 Sep 2025

Paclitaxel-induced cognitive impairment: mechanistic insights

in Neuropharmacology

Ahmad Hamad Alhowail

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1684006

2,946 views

Original Research

Published on 22 Sep 2025

Naloxone reversal of the cardiorespiratory depressant effects of opioids and mixtures of opioids and stimulants in rats

in Neuropharmacology

Jacqueline M. Vazquez
Robert W. Seaman
Drew Caldron
Gregory T. Collins

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1654791

2,128 views

Original Research

Published on 22 Sep 2025

Clinical predictors and concomitant antiseizure medications effects on seizure control in relation to plasma cenobamate concentration: a multicenter retrospective study

in Neuropharmacology

Francesca Felicia Operto
Viviana Izzo
Giovanni Assenza
Anna Chiara Balsamo
Laura Canafoglia
Emanuele Cerulli Irelli
Albino Coglianese
Carlo Di Bonaventura
Antonio Gambardella
Claudio Liguori

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1668382

2,714 views

Review

Published on 19 Sep 2025

Research progress on plant-derived natural compounds regulating the MAPK signaling pathway for the prevention and therapy of Alzheimer’s disease

in Neuropharmacology

Xinyue Zhang
Shujia Huang
Hongfeng Xu
Yanan Hu
Ling Gao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1666082

3,505 views
1 citation

Original Research

Published on 19 Sep 2025

Rational design of indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors featuring 1,2,3-triazole derivatives with enhanced anti-inflammatory and analgesic efficacy

in Neuropharmacology

Qingying Liu
Xixi Hou
Yueliang Wang
Mingyue Tian
Baoyu He
Jingjing Guo
Jianxue Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1574007

1,532 views

Original Research

Published on 19 Sep 2025

Cannabidiol combined with GABAergic drugs but not with sodium channel blockers prevents the development of drug-resistance seizures in a preclinical model

in Neuropharmacology

Monserrat Fuentes-Mejia
Maximiliano J. Fallico
Alan Talevi
Luciana Gavernet
Sandra A. Orozco-Suárez
Luisa Rocha

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1644018

1,959 views

Study Protocol

Published on 17 Sep 2025

Esketamine versus fentanyl as adjuncts to hepatic hilar nerve block for ambulatory percutaneous liver tumor ablation focusing on respiratory safety: protocol for a randomized controlled trial

in Neuropharmacology

Xiao Wang
Lijuan Yan
Jiaying Cai
Jianfei Wei
Zuobing Zhang
Bin Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1644029

1,889 views
1 citation

Review

Published on 17 Sep 2025

The influence of targeted therapies in the inner ear

in Neuropharmacology

Tony Bonilla
Jake DiFatta
Esperanza Bas Infante
Stefania Goncalves

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1620679

1,787 views

Review

Published on 15 Sep 2025

Dual GSK3β/SIRT1 modulators for Alzheimer’s: mechanisms, drug discovery and future perspectives

in Neuropharmacology

Afeez I. Kareem
Erika Kapp
Jacques Joubert
Xiaoqin Zou

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1662241

3,573 views

Systematic Review

Published on 12 Sep 2025

The effect of intraperitoneal instillation of drugs on postoperative analgesia after laparoscopic cholecystectomy: a network meta-analysis

in Neuropharmacology

Dongmei Zhang
Xiaojiao Wang
Xiaoli Yang
Dajian Xia

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1646917

1,894 views

Review

Published on 11 Sep 2025

Exploring how levetiracetam mitigates toxicity and ameliorates memory impairment

in Neuropharmacology

Ahmad H. Alhowail
Abeer M. Alharbi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1651414

2,469 views
1 citation

Review

Published on 10 Sep 2025

Opioid-free anesthesia in enhanced recovery after surgery for gastrointestinal surgery: current status, challenges, and prospects

in Neuropharmacology

Yongxing Xu
Maolin Zhong
Shihong Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1662818

3,528 views
1 citation

Original Research

Published on 10 Sep 2025

Baicalein improves motor dysfunction and cognitive impairment while promoting remyelination in an animal model of multiple sclerosis through the antioxidant mechanism

in Neuropharmacology

Qin Wang
Ziwen Wang
Yutong Li
Qiongzhang Wang
Yanran Chen
Benhao Xu
Haiyun Xu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1659631

2,215 views

Review

Published on 08 Sep 2025

Research progress on natural products in regulating the gut microbiota in Parkinson’s disease

in Neuropharmacology

Ying Jia
Yuanyuan Zhang
Xin Tai
Tengyu Zhao
Hanwen Zhang
Haichun Zhou

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1667694

2,634 views
1 citation

Study Protocol

Published on 05 Sep 2025

Safety and efficacy of esketamine combined with propofol or ciprofol sedation for electroconvulsive therapy in patients with major depressive disorder: protocol for a randomized, double-blind, controlled trial with factorial design

in Neuropharmacology

Yuan Zhang
De-zhen Su
Rong Chen
Zhong-yuan Xia
Yan-ling Peng
Shen-hong Weng
Qing-tao Meng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1622672

2,003 views

Systematic Review

Published on 04 Sep 2025

Oral preventive medications for migraine in adults aged 18–65: a network meta-analysis

in Neuropharmacology

Jianping Wu
Jun Wu
Jian Zhang
Bingbing Liu
Xinyuan Song
Yuanjie Wu
Fanian Tian
Yanbing Ding
Ping Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1620887

3,119 views

Original Research

Published on 04 Sep 2025

Exploring bioactive phytochemicals as ULK1 activators for enhancing cytoprotective autophagy in amyotrophic lateral sclerosis

in Neuropharmacology

Farah Anjum
Nahed Hawsawi
Abdulraheem Ali Almalki
Anas Shamsi
Maram Jameel Hulbah
Maha Bakhuraysah
Abdulaziz Alsharif
Taj Mohammad

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1661744

1,737 views

Original Research

Published on 03 Sep 2025

Cilostazol-inhibited RhoA/NF-κB signaling mitigates hippocampal inflammation and post-stroke depression

in Neuropharmacology

Yuling Zhang
Yichen Li
Yafang Wu
Xiying Tan
Tingting Ji
Chaozhi Tang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1643343

2,150 views

Opinion

Published on 03 Sep 2025

Psychedelics and mental health: reimagining care through science, insight, and compassion

in Neuropharmacology

Georgios Mikellides
Marios Kyriazis

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1649929

4,092 views
1 citation

Review

Published on 03 Sep 2025

The mechanism and therapeutic potential of SIRT3 in central nervous system diseases: a review

in Neuropharmacology

Chuanbin Hong
Yupeng Wei
Yuchen Wang
Guangfu Lv
Xinglu Dong
Xiaowei Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1652296

1,956 views
1 citation

Original Research

Published on 03 Sep 2025

Long-term gabapentin treatment impairs cognitive function in aged mice via tau hyperphosphorylation

in Neuropharmacology

Suyun Xia
Zerong You
Xinbo Wu
Jinsheng Yang
Shiyu Wang
Na Li
Jiajia Dai
Yuanlin Dong
Lucy Chen
Min Yan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1616775

1,940 views

Brief Research Report

Published on 01 Sep 2025

Combining ethanol and cocaine exposure during adolescence increased cocaine reward sensitivity in adult rats as evaluated by a single exposure place preference paradigm

in Neuropharmacology

Carles Colom-Rocha
M. Julia García-Fuster

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1668957

1,170 views

2,620 articles

articles

Pharmacovigilance study on old drugs repurposed for rare diseases across different indications: the case of fenfluramine

Neuroprotective mechanisms of Buyang Huanwu decoction in ischemic stroke

Paclitaxel-induced cognitive impairment: mechanistic insights

Naloxone reversal of the cardiorespiratory depressant effects of opioids and mixtures of opioids and stimulants in rats

Clinical predictors and concomitant antiseizure medications effects on seizure control in relation to plasma cenobamate concentration: a multicenter retrospective study

Research progress on plant-derived natural compounds regulating the MAPK signaling pathway for the prevention and therapy of Alzheimer’s disease

Rational design of indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors featuring 1,2,3-triazole derivatives with enhanced anti-inflammatory and analgesic efficacy

Cannabidiol combined with GABAergic drugs but not with sodium channel blockers prevents the development of drug-resistance seizures in a preclinical model

Esketamine versus fentanyl as adjuncts to hepatic hilar nerve block for ambulatory percutaneous liver tumor ablation focusing on respiratory safety: protocol for a randomized controlled trial

The influence of targeted therapies in the inner ear

Dual GSK3β/SIRT1 modulators for Alzheimer’s: mechanisms, drug discovery and future perspectives

The effect of intraperitoneal instillation of drugs on postoperative analgesia after laparoscopic cholecystectomy: a network meta-analysis

Exploring how levetiracetam mitigates toxicity and ameliorates memory impairment

Opioid-free anesthesia in enhanced recovery after surgery for gastrointestinal surgery: current status, challenges, and prospects

Baicalein improves motor dysfunction and cognitive impairment while promoting remyelination in an animal model of multiple sclerosis through the antioxidant mechanism

Research progress on natural products in regulating the gut microbiota in Parkinson’s disease

Safety and efficacy of esketamine combined with propofol or ciprofol sedation for electroconvulsive therapy in patients with major depressive disorder: protocol for a randomized, double-blind, controlled trial with factorial design

Oral preventive medications for migraine in adults aged 18–65: a network meta-analysis

Exploring bioactive phytochemicals as ULK1 activators for enhancing cytoprotective autophagy in amyotrophic lateral sclerosis

Cilostazol-inhibited RhoA/NF-κB signaling mitigates hippocampal inflammation and post-stroke depression

Psychedelics and mental health: reimagining care through science, insight, and compassion

The mechanism and therapeutic potential of SIRT3 in central nervous system diseases: a review

Long-term gabapentin treatment impairs cognitive function in aged mice via tau hyperphosphorylation

Combining ethanol and cocaine exposure during adolescence increased cocaine reward sensitivity in adult rats as evaluated by a single exposure place preference paradigm