Frontiers in Pharmacology | Neuropharmacology

Original Research

Published on 10 Sep 2025

Baicalein improves motor dysfunction and cognitive impairment while promoting remyelination in an animal model of multiple sclerosis through the antioxidant mechanism

in Neuropharmacology

Qin Wang
Ziwen Wang
Yutong Li
Qiongzhang Wang
Yanran Chen
Benhao Xu
Haiyun Xu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1659631

2,674 views

Review

Published on 08 Sep 2025

Research progress on natural products in regulating the gut microbiota in Parkinson’s disease

in Neuropharmacology

Ying Jia
Yuanyuan Zhang
Xin Tai
Tengyu Zhao
Hanwen Zhang
Haichun Zhou

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1667694

3,257 views
1 citation

Study Protocol

Published on 05 Sep 2025

Safety and efficacy of esketamine combined with propofol or ciprofol sedation for electroconvulsive therapy in patients with major depressive disorder: protocol for a randomized, double-blind, controlled trial with factorial design

in Neuropharmacology

Yuan Zhang
De-zhen Su
Rong Chen
Zhong-yuan Xia
Yan-ling Peng
Shen-hong Weng
Qing-tao Meng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1622672

2,408 views

Systematic Review

Published on 04 Sep 2025

Oral preventive medications for migraine in adults aged 18–65: a network meta-analysis

in Neuropharmacology

Jianping Wu
Jun Wu
Jian Zhang
Bingbing Liu
Xinyuan Song
Yuanjie Wu
Fanian Tian
Yanbing Ding
Ping Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1620887

4,019 views

Original Research

Published on 04 Sep 2025

Exploring bioactive phytochemicals as ULK1 activators for enhancing cytoprotective autophagy in amyotrophic lateral sclerosis

in Neuropharmacology

Farah Anjum
Nahed Hawsawi
Abdulraheem Ali Almalki
Anas Shamsi
Maram Jameel Hulbah
Maha Bakhuraysah
Abdulaziz Alsharif
Taj Mohammad

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1661744

2,047 views

Original Research

Published on 03 Sep 2025

Cilostazol-inhibited RhoA/NF-κB signaling mitigates hippocampal inflammation and post-stroke depression

in Neuropharmacology

Yuling Zhang
Yichen Li
Yafang Wu
Xiying Tan
Tingting Ji
Chaozhi Tang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1643343

2,466 views

Opinion

Published on 03 Sep 2025

Psychedelics and mental health: reimagining care through science, insight, and compassion

in Neuropharmacology

Georgios Mikellides
Marios Kyriazis

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1649929

5,029 views
2 citations

Original Research

Published on 03 Sep 2025

Long-term gabapentin treatment impairs cognitive function in aged mice via tau hyperphosphorylation

in Neuropharmacology

Suyun Xia
Zerong You
Xinbo Wu
Jinsheng Yang
Shiyu Wang
Na Li
Jiajia Dai
Yuanlin Dong
Lucy Chen
Min Yan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1616775

2,579 views

Review

Published on 03 Sep 2025

The mechanism and therapeutic potential of SIRT3 in central nervous system diseases: a review

in Neuropharmacology

Chuanbin Hong
Yupeng Wei
Yuchen Wang
Guangfu Lv
Xinglu Dong
Xiaowei Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1652296

2,360 views
1 citation

Brief Research Report

Published on 01 Sep 2025

Combining ethanol and cocaine exposure during adolescence increased cocaine reward sensitivity in adult rats as evaluated by a single exposure place preference paradigm

in Neuropharmacology

Carles Colom-Rocha
M. Julia García-Fuster

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1668957

1,342 views

Original Research

Published on 29 Aug 2025

Zebrafish-based assessment of luteolin’s potential in modulating seizure responses

in Neuropharmacology

Sabrina Ester Schneider
Jefferson Pedroso
Cássia Alves Lima-Rezende
Samara Cristina Mazon
Aline E. dos Santos
Gean Pablo S. Aguiar
Marcelo Lanza
Mariana Appel Hort
J. Vladimir Oliveira
Angelo Piato

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1656301

2,069 views

Review

Published on 29 Aug 2025

Epilepsy and migraine: a diagnostic and therapeutic challenge

in Neuropharmacology

Angelo Pascarella
Oreste Marsico
Domenico Abelardo
Roberta Cutellè
Alessandro Bulgari
Cataldo Mummolo
Anna Mammì
Vittoria Cianci
Umberto Aguglia
Edoardo Ferlazzo

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1649543

5,220 views

Original Research

Published on 29 Aug 2025

Systems pharmacology identifies ajugol-mediated NF-κB/caspase-3 inhibition and isoacteoside-driven p62/mTOR-mediated autophagy as key mechanisms of Rehmanniae Radix and its processed form in Alzheimer’s treatment

in Neuropharmacology

Xiang Han
Xianglong Meng
Yuhui Wu
Wei Xia
Simin Xue
Xiaoqin Liu
Chenzi Lyu
Ziang Li
Xiaoning Yan
Hyo Won Jung

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1644847

3,383 views

Review

Published on 29 Aug 2025

Pharmacological mechanism of natural antidepressants: the role of epigenetic modifications

in Neuropharmacology

Yitong Lu
Ruirui Shang
Xia Zhong
Jingbo Shi
Guangheng Zhang
Weijie Zhao
Jing Teng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1616322

2,860 views

Original Research

Published on 28 Aug 2025

Spirodelae Herba ethanol extract attenuates neurotoxicity in hippocampal cells and improves scopolamine-induced cognitive impairment in mice

in Neuropharmacology

Yun Hee Jeong
YeonGyun Jung
Wei Li
Hye Jin Yang
You-Chang Oh
Jong-Sup Bae

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1638068

1,948 views

Original Research

Published on 21 Aug 2025

Functional characterization of the α1-adrenoceptor in adult male rat locus coeruleus neurons ex vivo

in Neuropharmacology

Irati Rodilla
Aitziber Mendiguren
Joseba Pineda

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1626019

2,672 views

Review

Published on 21 Aug 2025

From a traditional medicine monomer to a modern neurotherapeutic scaffold: a review of SAR-Driven tetramethylpyrazine derivatives for cerebrovascular and cognitive health

in Neuropharmacology

Xiaodi Wang
Muhan Cao
Yi Xu
Xifei Yang
Qinghua Hou

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1653056

2,592 views
2 citations

Case Report

Published on 15 Aug 2025

Case Report: Syndrome of inappropriate antidiuretic hormone secretion induced by pramipexole: a case report and literature review

in Neuropharmacology

Ke-Qian Chen
Xiang Liu
Hai-Bo Lei

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1627245

2,000 views

Original Research

Published on 15 Aug 2025

Neuroprotective and anticonvulsant effect of trimetazidine in a PTZ-kindling model of mice through modulation of the IL-1β/IL-1R1 and HMGB-1/TLR-4 axis

in Neuropharmacology

Shahnawaz Ahmad
Mohammed Samim
Seema Jain
Divya Vohora
Nidhi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1621729

3,090 views
2 citations

Correction

Published on 14 Aug 2025

Correction: Synergistic effects of combined hypnotic drugs on sleep in mice

in Neuropharmacology

Frontiers Production Office

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1672624

891 views

Original Research

Published on 13 Aug 2025

Polydatin ameliorates hyperhidrosis by targeting Aqp5 in a mouse model

in Neuropharmacology

Jian-Feng Chen
Zhi Feng
Feng-Qiang Yu
Rui-Qin Qiu
Xu Li
Jian-Bo Lin

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1589143

2,247 views

Original Research

Published on 11 Aug 2025

Escalated oxycodone self-administration is associated with expression of voltage gated and calcium activated potassium channels in the mesocorticolimbic system in rats

in Neuropharmacology

Ammanuel Y. Wabreha
Nasser Adjei
Bruce Ladenheim
Jean Lud Cadet
Atul P. Daiwile

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1653356

2,258 views
2 citations

Brief Research Report

Published on 08 Aug 2025

Fenofibrate treatment during withdrawal reverses symptoms of ethanol-induced depression in male rats

in Neuropharmacology

Marcelo León
Camila Vásquez-Ulloa
Lucas Marambio-Ruiz
Diliana Pérez-Reytor
Eduardo Karahanian

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1626031

2,291 views

Correction

Published on 07 Aug 2025

Correction: Harnessing nanotechnology for stem-cell therapies: revolutionizing neurodegenerative disorder treatments – a state-of-the-art update

in Neuropharmacology

Neevashini Chengebroyen
Anmol Seelan
Kamal Yoonus Thajudeen
Saad Ali Alshehri
Aritra Biswas
Israrahmed Adur
Vino Sundararajan
Sajitha Lulu Sudhakaran
Harpreet Singh

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1674993

1,234 views

2,654 articles

articles

Baicalein improves motor dysfunction and cognitive impairment while promoting remyelination in an animal model of multiple sclerosis through the antioxidant mechanism

Research progress on natural products in regulating the gut microbiota in Parkinson’s disease

Safety and efficacy of esketamine combined with propofol or ciprofol sedation for electroconvulsive therapy in patients with major depressive disorder: protocol for a randomized, double-blind, controlled trial with factorial design

Oral preventive medications for migraine in adults aged 18–65: a network meta-analysis

Exploring bioactive phytochemicals as ULK1 activators for enhancing cytoprotective autophagy in amyotrophic lateral sclerosis

Cilostazol-inhibited RhoA/NF-κB signaling mitigates hippocampal inflammation and post-stroke depression

Psychedelics and mental health: reimagining care through science, insight, and compassion

Long-term gabapentin treatment impairs cognitive function in aged mice via tau hyperphosphorylation

The mechanism and therapeutic potential of SIRT3 in central nervous system diseases: a review

Combining ethanol and cocaine exposure during adolescence increased cocaine reward sensitivity in adult rats as evaluated by a single exposure place preference paradigm

Zebrafish-based assessment of luteolin’s potential in modulating seizure responses

Epilepsy and migraine: a diagnostic and therapeutic challenge

Systems pharmacology identifies ajugol-mediated NF-κB/caspase-3 inhibition and isoacteoside-driven p62/mTOR-mediated autophagy as key mechanisms of Rehmanniae Radix and its processed form in Alzheimer’s treatment

Pharmacological mechanism of natural antidepressants: the role of epigenetic modifications

Spirodelae Herba ethanol extract attenuates neurotoxicity in hippocampal cells and improves scopolamine-induced cognitive impairment in mice

Functional characterization of the α1-adrenoceptor in adult male rat locus coeruleus neurons ex vivo

From a traditional medicine monomer to a modern neurotherapeutic scaffold: a review of SAR-Driven tetramethylpyrazine derivatives for cerebrovascular and cognitive health

Case Report: Syndrome of inappropriate antidiuretic hormone secretion induced by pramipexole: a case report and literature review

Neuroprotective and anticonvulsant effect of trimetazidine in a PTZ-kindling model of mice through modulation of the IL-1β/IL-1R1 and HMGB-1/TLR-4 axis

Correction: Synergistic effects of combined hypnotic drugs on sleep in mice

Polydatin ameliorates hyperhidrosis by targeting Aqp5 in a mouse model

Escalated oxycodone self-administration is associated with expression of voltage gated and calcium activated potassium channels in the mesocorticolimbic system in rats

Fenofibrate treatment during withdrawal reverses symptoms of ethanol-induced depression in male rats

Correction: Harnessing nanotechnology for stem-cell therapies: revolutionizing neurodegenerative disorder treatments – a state-of-the-art update