Frontiers in Pharmacology | Neuropharmacology

Original Research

Published on 11 Jul 2025

Ursolic acid ameliorates cerebral ischemia-reperfusion injury by inhibiting NF-κB/NLRP3-mediated microglia pyroptosis and neuroinflammation

in Neuropharmacology

Junbin Liu
Xiaoting Zhang
Jingpei Guo
Yun Zhang
Jinming Fan
Junfeng Liu
Jiawen Chen
Jiawei Jiang
Benshuai Yu
Ke Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1622131

4,179 views
3 citations

Correction

Published on 11 Jul 2025

Correction: Novel multitarget analgesic candidate SZV-1287 demonstrates potential disease-modifying effects in the monoiodoacetate-induced osteoarthritis mouse model

in Neuropharmacology

Ádám István Horváth
Kata Bölcskei
Nikolett Szentes
Éva Borbély
Valéria Tékus
Bálint Botz
Kitti Rusznák
Anett Futácsi
Boldizsár Czéh
Péter Mátyus

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1646562

1,402 views
1 citation

Original Research

Published on 11 Jul 2025

Ramipril and ketogenic diet response in cognitive dysfunction of insulin-resistant rats

in Neuropharmacology

Nancy M. Abdel-Kareem
Shimaa M. Elshazly
May A. Abd El Fattah
Sawsan A. Zaitone
Thanaa A. Elmasry
Asmaa Saleh
Enas A. Abd El-Haleim

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1620139

1,949 views

Original Research

Published on 07 Jul 2025

Exploration of the potential neurotransmitter or neuromodulator-like properties of harmine: evidence from synthesis to synaptic modulation

in Neuropharmacology

Zhejun Xie
Ning Cao
Manlin Li
Hanxue Wang
Huida Guan
Xuemei Cheng
Changhong Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1588105

3,262 views

Original Research

Published on 07 Jul 2025

The kynurenine pathway as a potential link between ethanol-induced behavioral alterations and neuroinflammation

in Neuropharmacology

Leticia Gil de Biedma-Elduayen
Pablo Giménez-Gómez
Nuria Morales-Puerto
Rebeca Vidal
Álvaro Del Río-García
Carlos Núñez-de la Calle
Lluna Careaga
María Dolores Gutiérrez-López
Esther O’Shea
María Isabel Colado

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1628527

2,500 views

Original Research

Published on 02 Jul 2025

Dexmedetomidine potently and reversibly regulates stress-mediated behaviors

in Neuropharmacology

Frank D. Yocca
Dinesh K. Dhull
Subhendu Seth
Manisha Chugh
Sameer Sharma
Krishnan Nandabalan
Friso R. Postma
Michael De Vivo

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1589075

3,688 views
1 citation

Hypothesis and Theory

Published on 02 Jul 2025

The antipsychotics functional index (AFI) in schizophrenia

in Neuropharmacology

Gabriel-Cristian Marinescu
Petru Iulian Ifteni
Andreea Teodorescu
Radu Georgescu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1591763

3,052 views

Original Research

Published on 02 Jul 2025

Acute pharmacological effects of α-PVP in humans: a naturalistic observational study

in Neuropharmacology

Georgina De la Rosa
Esther Papaseit
Olga Hladun
Lourdes Poyatos
Dolly Andrea Caicedo
Martha Catalina Argote
Soraya Martín
Mireia Ventura
Nunzia La Maida
Annagiulia Di Trana

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1626692

8,822 views
4 citations

Mini Review

Published on 01 Jul 2025

Clinical characterization and management of persons with comorbid epilepsy and depression: an expert opinion paper

in Neuropharmacology

Gaia Sampogna
Roberto Brugnoli
Giuseppe Didato
Maurizio Elia
Edoardo Ferlazzo
Gianluca Serafini
Giampaolo Vatti
Umberto Volpe
Flavio Villani
Gabriele Sani

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1592650

2,760 views
1 citation

Original Research

Published on 01 Jul 2025

Glutamatergic mechanisms in early salience processing

in Neuropharmacology

Denise Elfriede Liesa Lockhofen
Nils Hübner
Ranjan Debnath
Karl Philipp Rumpf
Michael Sander
Matthias Wolff
Daniel Luxi
Lukas Roller
Christoph Mulert

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1601797

1,817 views

Review

Published on 30 Jun 2025

Orexin-A and motion sickness: a systematic review of animal model studies

in Neuropharmacology

Xu Cai
Long Zhao
Xin Wang
Jiahui Chen
Ying Yuan
Biao Gao
Yanli You

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1624080

2,498 views

Review

Published on 27 Jun 2025

Preclinical and experimental evidence of salvianolic acid B in the treatment of neurological diseases

in Neuropharmacology

Shijun Bi
Shibing Liu
Kunyuan Zhu
Dandan Gao
Ligang Chen
Chunyong Yu
Guobiao Liang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1606146

4,003 views

Original Research

Published on 26 Jun 2025

Validating the antiseizure effects of vitexin and related flavone glycosides in zebrafish

in Neuropharmacology

Audrey Breckenridge
Sanskriti Basnyat
Eva Fitch
Colleen Carpenter-Swanson

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1628324

2,677 views
1 citation

Review

Published on 25 Jun 2025

Gut-brain axis in post-traumatic stress disorder: microbial - mediated mechanisms and new therapeutic approaches - A narrative review

in Neuropharmacology

Jiayue Pan
Shuairong Lin
Qiuling Qian
Shanni Fu
Xiaoliu Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1621678

4,591 views
4 citations

Editorial

Published on 25 Jun 2025

Editorial: Innovative therapies against neurodegenerative disorders: from new active molecules to novel drug delivery systems

in Neuropharmacology

Panoraia I. Siafaka
Mehmet Evren Okur
Neslihan Üstündağ Okur

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1640758

1,773 views

Review

Published on 25 Jun 2025

Ketogenic therapy for schizophrenia: evidence, mechanisms, and clinical perspectives

in Neuropharmacology

Cristiano Chaves
Jennifer Fabe
Fabiano A. Gomes
Heather McNeely
Massimo Tusconi
Mauro Giovanni Carta
Serdar M. Dursun
Jaime E. C. Hallak
Elisa Brietzke

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1603722

7,468 views
3 citations

Mini Review

Published on 24 Jun 2025

Research on the effects of GLP-1 receptor agonists in treating cognitive dysfunction and gait disorders in elderly patients with diabetes

in Neuropharmacology

Yang Yang
Lifeng Chen
Yanjun Zhang
Wenqian Fu
Dandan Liu
Tianyu Jiang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1607443

3,136 views
1 citation

Review

Published on 23 Jun 2025

Unveiling the therapeutic potential of natural products in Alzheimer’s disease: insights from in vitro, in vivo, and clinical studies

in Neuropharmacology

Nahida Aktary
Yerim Jeong
Seungji Oh
Yeju Shin
Yoonsoo Sung
Muntajin Rahman
Livia Ramos Santiago
Jinwon Choi
Han Gyeul Song
Fahrul Nurkolis

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1601712

10,564 views
10 citations

Original Research

Published on 20 Jun 2025

Age-specific effects of synthetic cannabinoids on cognitive function and hippocampal gene expression in mice: insights from behavioral and molecular correlates

in Neuropharmacology

Kaixi Li
Yuanyuan Chen
Yawen Xu
Yuan Pang
Yongli Bao
Simeng Zhang
Xuesong Shi
Jingzhi Ran
Yanling Qiao
Yizhao Xu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1618929

2,922 views
1 citation

Original Research

Published on 20 Jun 2025

Network pharmacology-based prediction and “gut microbiota-inflammation-brain axis” validation of the active ingredients and potential mechanisms of Plantagins Herba for treating diabetes-related cognitive dysfunction

in Neuropharmacology

Zhixuan Huang
Jian Liu
Hui Li
Yangwen Ai
Dongyue Zhou

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1601689

2,894 views
1 citation

Review

Published on 19 Jun 2025

Plant-derived polyphenolic compounds for managing schizophrenia: mechanisms and therapeutic potential

in Neuropharmacology

Xiaolin Ji
Jianbo Chai
Sihan Zhao
Yonghou Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1605027

3,746 views
6 citations

Review

Published on 18 Jun 2025

Therapeutic potential of natural products in ischemic stroke: targeting angiogenesis

in Neuropharmacology

WenQiang Li
E. Liu
YiHao Zhou
ZhiChao Liao
DongYan Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1579172

5,184 views
6 citations

Correction

Published on 18 Jun 2025

Correction: Preventive strategies for reducing intraoperative awareness due to errors in anesthetic drug delivery systems: a narrative review

in Neuropharmacology

Qisheng Chen
Shixuan Peng
Wenjun Luo
Shuzhai Li
Zhiming Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1641124

1,036 views

Systematic Review

Published on 18 Jun 2025

Effectiveness and impact of intravenous magnesium sulfate in spinal surgery systematic review and meta-analysis

in Neuropharmacology

Zhaoguo Jin
Jianyong Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1624119

3,006 views
2 citations

2,657 articles

articles

Ursolic acid ameliorates cerebral ischemia-reperfusion injury by inhibiting NF-κB/NLRP3-mediated microglia pyroptosis and neuroinflammation

Correction: Novel multitarget analgesic candidate SZV-1287 demonstrates potential disease-modifying effects in the monoiodoacetate-induced osteoarthritis mouse model

Ramipril and ketogenic diet response in cognitive dysfunction of insulin-resistant rats

Exploration of the potential neurotransmitter or neuromodulator-like properties of harmine: evidence from synthesis to synaptic modulation

The kynurenine pathway as a potential link between ethanol-induced behavioral alterations and neuroinflammation

Dexmedetomidine potently and reversibly regulates stress-mediated behaviors

The antipsychotics functional index (AFI) in schizophrenia

Acute pharmacological effects of α-PVP in humans: a naturalistic observational study

Clinical characterization and management of persons with comorbid epilepsy and depression: an expert opinion paper

Glutamatergic mechanisms in early salience processing

Orexin-A and motion sickness: a systematic review of animal model studies

Preclinical and experimental evidence of salvianolic acid B in the treatment of neurological diseases

Validating the antiseizure effects of vitexin and related flavone glycosides in zebrafish

Gut-brain axis in post-traumatic stress disorder: microbial - mediated mechanisms and new therapeutic approaches - A narrative review

Editorial: Innovative therapies against neurodegenerative disorders: from new active molecules to novel drug delivery systems

Ketogenic therapy for schizophrenia: evidence, mechanisms, and clinical perspectives

Research on the effects of GLP-1 receptor agonists in treating cognitive dysfunction and gait disorders in elderly patients with diabetes

Unveiling the therapeutic potential of natural products in Alzheimer’s disease: insights from in vitro, in vivo, and clinical studies

Age-specific effects of synthetic cannabinoids on cognitive function and hippocampal gene expression in mice: insights from behavioral and molecular correlates

Network pharmacology-based prediction and “gut microbiota-inflammation-brain axis” validation of the active ingredients and potential mechanisms of Plantagins Herba for treating diabetes-related cognitive dysfunction

Plant-derived polyphenolic compounds for managing schizophrenia: mechanisms and therapeutic potential

Therapeutic potential of natural products in ischemic stroke: targeting angiogenesis

Correction: Preventive strategies for reducing intraoperative awareness due to errors in anesthetic drug delivery systems: a narrative review

Effectiveness and impact of intravenous magnesium sulfate in spinal surgery systematic review and meta-analysis