Frontiers in Pharmacology | Pharmacoepidemiology

Original Research

Published on 13 Feb 2026

A real-world study of adverse event profiles associated with the four key components of antibody–drug conjugates based on the FAERS database

in Pharmacoepidemiology

Shuning Zhang
Chun Ye
Jiaxuan Zhu
Miao Wang
Yanyan Xu

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1702195

410 views

Original Research

Accepted on 12 Feb 2026

Will the Introduction of β-Lactamase Inhibitors Alter the Adverse Event Profile of Parent Penicillins Antibiotics? A Pharmacovigilance Study Based on Amoxicillin-Clavulanate and Ampicillin-Sulbactam

in Pharmacoepidemiology

Yanlang He
Yunxia Liao
Guier Xiao
Dinghui Zhou
Liuyun Huang
Sheng Wei

Frontiers in Pharmacology

Original Research

Accepted on 12 Feb 2026

Impact of the 2017 ACC/AHA Hypertension Guidelines on Antihypertensive Prescribing in the United States: Real-World Evidence from a Nationally Representative Population

in Pharmacoepidemiology

Eissa A. Jafari

Frontiers in Pharmacology

Original Research

Published on 12 Feb 2026

Age and gender disparities in oral anticoagulant use: a nine-year nationwide drug utilization analysis

in Pharmacoepidemiology

Ahmed A. A. Omer
Márta Csatordai
Réka Viola
Péter Doró

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1770826

401 views

Original Research

Accepted on 11 Feb 2026

QT-Related Adverse Events With Ondansetron and Olanzapine: A Real-World FAERS Analysis With Implications for Oncology Anti-Emetic Practice

in Pharmacoepidemiology

Ayush Gandhi
Alireza Parhizgar
Viraj Bhise

Frontiers in Pharmacology

112 views

Original Research

Accepted on 10 Feb 2026

Hydrochlorothiazide and Chlorthalidone Use and Glaucoma Risk: Pharmacovigilance Analysis and Nationwide Cohort Study

in Pharmacoepidemiology

Jooyoung Yoon
Jiyeong Kim
Ko Eun Kim
Jee-Eun Chung
Seong Joon Ahn

Frontiers in Pharmacology

317 views

Original Research

Accepted on 10 Feb 2026

Risk Assessment of Drug-Associated Miscarriage Using XGBoost and SHAP Explainability: A Real-World Pharmacovigilance Analysis Based on the FAERS Database

in Pharmacoepidemiology

Sen Lin
Lanyue Ma
Ruiqi Zhao
Lisheng Peng
Xinyu Zhang
Bei Zhang
Danfei Li
Yijia Li
Li He

Frontiers in Pharmacology

Original Research

Published on 10 Feb 2026

Impact of non-steroidal anti-inflammatory drugs on malignant transformation in oral lichen planus: insights from a real-world cohort study

in Pharmacoepidemiology

Christian Seebauer
Ralf Ludwig
Peter Sieg
Henning Olbrich
Philip Curman

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1752108

387 views

Systematic Review

Published on 10 Feb 2026

Reassessing cancer risk with GLP-1 receptor agonists: a comprehensive meta-analysis of gastrointestinal malignancies

in Pharmacoepidemiology

Adil Farooq Wali
Imran Rangraze
Shehla Khan
Uwais Bashir Mufti
Mohamed El-Tanani
Manfredi Rizzo

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1736380

544 views

Original Research

Published on 09 Feb 2026

Early metoprolol use in ICU patients with congestive heart failure is associated with increased 30-day mortality: a causal machine learning study

in Pharmacoepidemiology

Yunzhu Chen
Tianyou Li

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1771969

308 views

Original Research

Published on 09 Feb 2026

Changes in youth public psychiatric service utilization during the COVID-19 pandemic in Italy: an observational study

in Pharmacoepidemiology

Ippazio Cosimo Antonazzo
Carla Fornari
Manuel Zamparini
Giacomo Crotti
Alberto Zucchi
Pietro Ferrara
Alexandra Maria Piraino
Paolo Angelo Cortesi
Lorenzo Losa
Giampiero Mazzaglia

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1708009

376 views

Original Research

Accepted on 04 Feb 2026

Comparative Safety Profiles of Risankizumab versus Guselkumab: A Pharmacovigilance Study Based on the FAERS Database

in Pharmacoepidemiology

Shiyi Wang
Yongyi Xu
Hangjuan Lin
Xudong Zhang
Jing Ding
Honggang Jiang
Yihong Fan
Changbo Sun

Frontiers in Pharmacology

278 views

Original Research

Accepted on 03 Feb 2026

Comparative Efficacy of Intravenous, Topical, and Combined Tranexamic Acid in Elderly Patients with Intertrochanteric Fractures Undergoing Intramedullary Nail Fixation: A Multicenter Cohort Study

in Pharmacoepidemiology

Qiushi Bai
Xiao Chang
Yuewang Li
YongMing Yang
Hongbo Zhang
Kunyu Ji
Xiongfei Zou
Baozhong Zhang

Frontiers in Pharmacology

Original Research

Accepted on 02 Feb 2026

Patterns of Neurologic and Psychiatric Toxicity Burden of Different Endocrine Therapeutics for Breast Cancer: A Global Pharmacovigilance Study Based on FAERS and VigiAccess

in Pharmacoepidemiology

Guoqiang Li
Mengqi Yang
Lei Zhang
Xin Li
Xiaoliang Wu
Feng Peng
Yajie Liu

Frontiers in Pharmacology

131 views

Original Research

Accepted on 02 Feb 2026

Aspirin use and risk of depression: a cross-sectional study

in Pharmacoepidemiology

Runa A
Huan Yu
Kun Wang
Ruotong Yang
Huairong Wang
Liuyan Zheng
Jingxian Wu
Yiqun Wu

Frontiers in Pharmacology

137 views

Original Research

Accepted on 02 Feb 2026

Temporal Trends in Stroke-Prevention Medication Use in Patients with Atrial Fibrillation and Chronic Obstructive Pulmonary Disease

in Pharmacoepidemiology

Chuan-Wei Shen
Nantawarn Kitikannakorn
Chung-Yu Chen
Buntitabhon Sirichanchuen
Rewadee Jenraumjit
Kuang-Ming Liao

Frontiers in Pharmacology

364 views

Original Research

Accepted on 30 Jan 2026

MSAT: A FAERS-Informed Heterogeneous Graph Neural Network for Pharmacovigilance Prediction of Chinese Materia Medica–Associated Adverse Drug Reactions

in Pharmacoepidemiology

Bowen Shi
Xiaojie Li
Jinghao Fang
Jisheng Chen
Jin Yang

Frontiers in Pharmacology

136 views

Original Research

Accepted on 30 Jan 2026

Prospective evaluation of medication-related problems and pharmacist interventions in liver transplant recipients

in Pharmacoepidemiology

Sena GÜZEL KARAHAN
Mefküre DURMUŞ
Ahmet ÇAKIR
Zeynep Ülkü GÜN
Sezai YILMAZ

Frontiers in Pharmacology

232 views

Review

Accepted on 30 Jan 2026

Clinical Characteristics of Myelosuppression Induced by Conventional Synthetic DMARDs in 24 Rheumatoid Arthritis Patients: A Case Series

in Pharmacoepidemiology

Jingqiao TIAN
Xiaoli PAN
Juan CHEN
Yulei AO
Mei Tian
Anmao Li

Frontiers in Pharmacology

Data Report

Published on 30 Jan 2026

Case study on adverse reactions of dulaglutide: literature review

in Pharmacoepidemiology

Yang Zhou
Weihao Jiang

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1736083

593 views

Original Research

Published on 29 Jan 2026

Drug-induced male infertility: a real-world study using FAERS and EudraVigilance databases

in Pharmacoepidemiology

Zhuozhi Gong
Jing He
Qiujian Feng
Dong Liu
Shengjing Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1765071

878 views

Editorial

Published on 28 Jan 2026

Editorial: Advancement of RWD/RWE utilization for enhancing drug development and benefit/risk assessment

in Pharmacoepidemiology

Yoshiaki Uyama
Anick Bérard
K. Arnold Chan

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1787363

570 views

Systematic Review

Published on 26 Jan 2026

Efficacy and safety of small interfering RNA (siRNA) therapies for hypertriglyceridemia and mixed dyslipidemia: an updated systematic review and meta-analysis

in Pharmacoepidemiology

Yifan Gao
Yanmin Bai
Xu Mu
Xingxue Pang

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1736821

649 views

Original Research

Published on 23 Jan 2026

Oral iron preparations: gastrointestinal adverse events and medication adherence in female patients with iron deficiency anemia

in Pharmacoepidemiology

Xing Tan
Yu Tian
Tongtong Zhang
Qi Yao
Tingting Zhu
Wei Wang
Quanjie Wang
Haiying Fu

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1727566

754 views

601 articles

articles

A real-world study of adverse event profiles associated with the four key components of antibody–drug conjugates based on the FAERS database

Will the Introduction of β-Lactamase Inhibitors Alter the Adverse Event Profile of Parent Penicillins Antibiotics? A Pharmacovigilance Study Based on Amoxicillin-Clavulanate and Ampicillin-Sulbactam

Impact of the 2017 ACC/AHA Hypertension Guidelines on Antihypertensive Prescribing in the United States: Real-World Evidence from a Nationally Representative Population

Age and gender disparities in oral anticoagulant use: a nine-year nationwide drug utilization analysis

QT-Related Adverse Events With Ondansetron and Olanzapine: A Real-World FAERS Analysis With Implications for Oncology Anti-Emetic Practice

Hydrochlorothiazide and Chlorthalidone Use and Glaucoma Risk: Pharmacovigilance Analysis and Nationwide Cohort Study

Risk Assessment of Drug-Associated Miscarriage Using XGBoost and SHAP Explainability: A Real-World Pharmacovigilance Analysis Based on the FAERS Database

Impact of non-steroidal anti-inflammatory drugs on malignant transformation in oral lichen planus: insights from a real-world cohort study

Reassessing cancer risk with GLP-1 receptor agonists: a comprehensive meta-analysis of gastrointestinal malignancies

Early metoprolol use in ICU patients with congestive heart failure is associated with increased 30-day mortality: a causal machine learning study

Changes in youth public psychiatric service utilization during the COVID-19 pandemic in Italy: an observational study

Comparative Safety Profiles of Risankizumab versus Guselkumab: A Pharmacovigilance Study Based on the FAERS Database

Comparative Efficacy of Intravenous, Topical, and Combined Tranexamic Acid in Elderly Patients with Intertrochanteric Fractures Undergoing Intramedullary Nail Fixation: A Multicenter Cohort Study

Patterns of Neurologic and Psychiatric Toxicity Burden of Different Endocrine Therapeutics for Breast Cancer: A Global Pharmacovigilance Study Based on FAERS and VigiAccess

Aspirin use and risk of depression: a cross-sectional study

Temporal Trends in Stroke-Prevention Medication Use in Patients with Atrial Fibrillation and Chronic Obstructive Pulmonary Disease

MSAT: A FAERS-Informed Heterogeneous Graph Neural Network for Pharmacovigilance Prediction of Chinese Materia Medica–Associated Adverse Drug Reactions

Prospective evaluation of medication-related problems and pharmacist interventions in liver transplant recipients

Clinical Characteristics of Myelosuppression Induced by Conventional Synthetic DMARDs in 24 Rheumatoid Arthritis Patients: A Case Series

Case study on adverse reactions of dulaglutide: literature review

Drug-induced male infertility: a real-world study using FAERS and EudraVigilance databases

Editorial: Advancement of RWD/RWE utilization for enhancing drug development and benefit/risk assessment

Efficacy and safety of small interfering RNA (siRNA) therapies for hypertriglyceridemia and mixed dyslipidemia: an updated systematic review and meta-analysis

Oral iron preparations: gastrointestinal adverse events and medication adherence in female patients with iron deficiency anemia