Frontiers in Pharmacology | Pharmacoepidemiology

Systematic Review

Published on 24 Sep 2025

Dental safety of short-term doxycycline use in children under 8 years: a systematic review and meta-analysis

in Pharmacoepidemiology

Anusiga Sigamani Rajan
Muthu Gopal
Madhumidha Periyathambi
Vijesh Sreedhar Kuttiatt

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1646638

2,815 views

Original Research

Published on 23 Sep 2025

Impact of post-admission changes in potentially inappropriate medication use on risk of subsequent hospitalization among nursing home residents

in Pharmacoepidemiology

Jing Zhao
Hyunwoo Chae
Young-Mi Ah
Kwanghee Jun
Ju-Yeun Lee

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1655681

2,020 views

Systematic Review

Published on 22 Sep 2025

Efficacy and safety of aldosterone synthase inhibitors for uncontrolled hypertension: a meta-analysis of randomized controlled trials and systematic review

in Pharmacoepidemiology

Yifan Gao
Xu Mu
Xingxue Pang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1664810

3,513 views

Original Research

Published on 22 Sep 2025

Burden of drug use disorders from 1990 to 2021 and projection to 2050 in China: findings from the 2021 global burden of disease study

in Pharmacoepidemiology

Shuzheng Yu
Yanting Chen
Shaohua Huang
Bing Wang
Qingrong Wu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1625873

2,435 views

Original Research

Published on 22 Sep 2025

Tracing the evolution of polypharmacy and contraindicated drug‒drug interactions in people living with HIV in Belgium

in Pharmacoepidemiology

Victoria Lopez Delhoulle
Li-Cécile Destordeur
Nathalie Maes
Karine Fombellida
Majdouline El Moussaoui
Gilles Darcis

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1632108

1,348 views

Brief Research Report

Published on 19 Sep 2025

Single-versus multiple-inhaler triple therapy in patients with COPD in Spain: a retrospective cohort study comparing adherence, persistence, risk of exacerbations and economic outcomes

in Pharmacoepidemiology

M. Asunción González-González
M. Aránzazu Pedrosa-Naudín
Diego Fernández-Lázaro
Isabel Díaz Planelles
F. Javier Álvarez
Eduardo Gutiérrez-Abejón

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1642470

2,764 views

Original Research

Published on 17 Sep 2025

Drug-induced agranulocytosis: a disproportionality analysis and umbrella review

in Pharmacoepidemiology

Yajie Lu
Bin Wu
Kunyu Li
Zhonglin Liu
Yuxi Chen
Ting Xu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1641747

3,112 views
1 citation

Original Research

Published on 16 Sep 2025

Difference in outcome event coverage between insurance-based and hospital-based databases: a methodological study of diabetes drug use and cardiovascular events in Japan

in Pharmacoepidemiology

Takashi Ando
Tomoaki Hasegawa
Chieko Ishiguro
Jun Komiyama
Toshiki Kuno
Masao Iwagami

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1642522

2,405 views

Original Research

Published on 12 Sep 2025

Global burden and trends of adverse effects of medical treatment, 1990–2021: an analysis from the global burden of disease study 2021

in Pharmacoepidemiology

Keqing Zhang
Yuhai Gao
Yunfei Lu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1655864

2,983 views

Original Research

Published on 09 Sep 2025

Urinary tract infections in women in Catalonia, Spain: a population-based observational cohort study in primary care

in Pharmacoepidemiology

Silvia Fernández-García
Ana Moragas
Maria Giner-Soriano
Rosa Morros
Dan Ouchi
Ana García-Sangenís
Carl Llor

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1593910

2,131 views
1 citation

Brief Research Report

Published on 02 Sep 2025

Trends in the use of validated claims-based algorithms in Japanese post-marketing database studies

in Pharmacoepidemiology

Chieko Ishiguro
Takahiro Nonaka

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1642490

1,213 views

Original Research

Published on 01 Sep 2025

Comparative assessment of antibacterial drugs used at the hospital level before and during COVID-19, according to the WHO AWaRe classification

in Pharmacoepidemiology

Aigerim A. Balapasheva
Gaziza A. Smagulova
Aigul Z. Mussina
Daniyar S. Dilmagambetov
Kalzhan Zh. Yermekbayeva
Mirsaid S. Kelimberdiev
Mariya S. Kulnazarova
Lazzat S. Balymbetova
Liliya E. Ziganshina

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1642830

1,563 views

Original Research

Published on 29 Aug 2025

High persistence of biologic therapy in patients with Psoriatic arthritis: a real-world evidence from a high-complexity hospital in Colombia

in Pharmacoepidemiology

Andrés Hormaza-Jaramillo
Leidy Johanna Hurtado-Bermudez
Daniela Peñaloza Gonzalez
Tatiana Delgado-Mora

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1559168

2,116 views

Opinion

Published on 29 Aug 2025

Is it appropriate to conduct a disproportionality analysis using a spontaneous reporting database to investigate whether drug-related adverse events are dose-dependent?

in Pharmacoepidemiology

Yoshihiro Noguchi
Tomoya Tachi
Tomoaki Yoshimura

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1563524

1,347 views
1 citation

Brief Research Report

Published on 29 Aug 2025

Perception of falsified and counterfeit medicines among adults living in Mexico City and the metropolitan area: an underappreciated health risk

in Pharmacoepidemiology

Jessica Citlalli Celaya Pérez
Tania Ibargüengoitia Larios
Maria de los Angeles Frías Fernández
Manuel Abraham Gómez Martínez
Kenneth Rubio Carrasco
Raúl Lugo Villegas
Arely Vergara-Castañeda

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1654822

1,632 views

Mini Review

Published on 26 Aug 2025

Polypharmacy driven synergistic toxicities in elderly breast cancer chemotherapy drug management and adverse drug reactions: a mini review

in Pharmacoepidemiology

Xiran Wang
Jin Yang
Jieying Zhang
Hong Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1654353

3,017 views

Original Research

Published on 22 Aug 2025

Use of over-the-counter antiallergic products–analysis of sales data in Poland from 2020 to 2023

in Pharmacoepidemiology

Łukasz Dudziński
Marcin Weiner
Tomasz Kubiak
Julia Grochowska
Robert Gałązkowski
Lukasz Czyzewski

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1649349

1,932 views

Original Research

Published on 22 Aug 2025

Association of first-trimester exposure to Kampo medicines containing Prunus persica kernel with preterm birth and major congenital malformations: a Japanese database study

in Pharmacoepidemiology

Satoko Suzuki
Ryutaro Arita
Taku Obara
Tomofumi Ishikawa
Tadaharu Kunitoki
Takamasa Sakai
Aoi Noda
Genki Shinoda
Mami Ishikuro
Masatsugu Orui

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1562724

1,910 views

Original Research

Published on 22 Aug 2025

Cost-effectiveness analysis of pembrolizumab plus chemotherapy versus placebo plus chemotherapy for patients with previously untreated locally recurrent inoperable or metastatic triple-negative breast cancer in China

in Pharmacoepidemiology

Yibing Hou
Shuo Yang
Xiaohui Wang
Shan Zhao
Huanlong Liu
Shuo Kang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1654177

2,022 views

Review

Published on 18 Aug 2025

Metformin in polycystic ovary syndrome: unraveling multi-stage therapeutic mechanisms from puberty to long-term health outcomes

in Pharmacoepidemiology

Weiwei Zeng
Yuning Luo
Juanfeng Ou
Dali Gan
Min Huang
Brian Tomlinson
Yiming Jiang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1654372

4,036 views
1 citation

Original Research

Published on 18 Aug 2025

Trends in prescription opioid use in Europe: A DARWIN EU® multinational cohort study including seven European countries

in Pharmacoepidemiology

Junqing Xie
Mike Du
Yuchen Guo
Cesar Barboza
James T. Brash
Antonella Delmestri
Talita Duarte-Salles
Jasmine Gratton
Romain Griffier
Raivo Kolde

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1608051

3,839 views

Original Research

Published on 13 Aug 2025

Incident gabapentin prescribing associated with opioid and benzodiazepine/Z-drug prescribing – a population-based longitudinal study in primary care

in Pharmacoepidemiology

Kristjan Linnet
Bjarni Pall Linnet Runolfsson
Johann Agust Sigurdsson
Larus Steinthor Gudmundsson

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1583415

2,243 views

Original Research

Published on 13 Aug 2025

Statins for polycystic ovary syndrome in varying resource settings: a phenome-wide association study and evidence synthesis

in Pharmacoepidemiology

Laura A. Zahn
Taylor D. Budine
Jana K. Shirey-Rice
Meghan M. Joly
Robert S. Wallis
Gordon R. Bernard
Kenneth J. Holroyd
Jill M. Pulley
Rebecca N. Jerome

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1562587

2,207 views

Original Research

Published on 13 Aug 2025

Unveiling the hidden risk of caspofungin: insights from three adverse event reporting systems and network pharmacology integration

in Pharmacoepidemiology

Zhengfu Li
Zhiwei Cui
De Xie
Fan Zou
Chengyu Zhu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1632488

3,153 views

571 articles

articles

Dental safety of short-term doxycycline use in children under 8 years: a systematic review and meta-analysis

Impact of post-admission changes in potentially inappropriate medication use on risk of subsequent hospitalization among nursing home residents

Efficacy and safety of aldosterone synthase inhibitors for uncontrolled hypertension: a meta-analysis of randomized controlled trials and systematic review

Burden of drug use disorders from 1990 to 2021 and projection to 2050 in China: findings from the 2021 global burden of disease study

Tracing the evolution of polypharmacy and contraindicated drug‒drug interactions in people living with HIV in Belgium

Single-versus multiple-inhaler triple therapy in patients with COPD in Spain: a retrospective cohort study comparing adherence, persistence, risk of exacerbations and economic outcomes

Drug-induced agranulocytosis: a disproportionality analysis and umbrella review

Difference in outcome event coverage between insurance-based and hospital-based databases: a methodological study of diabetes drug use and cardiovascular events in Japan

Global burden and trends of adverse effects of medical treatment, 1990–2021: an analysis from the global burden of disease study 2021

Urinary tract infections in women in Catalonia, Spain: a population-based observational cohort study in primary care

Trends in the use of validated claims-based algorithms in Japanese post-marketing database studies

Comparative assessment of antibacterial drugs used at the hospital level before and during COVID-19, according to the WHO AWaRe classification

High persistence of biologic therapy in patients with Psoriatic arthritis: a real-world evidence from a high-complexity hospital in Colombia

Is it appropriate to conduct a disproportionality analysis using a spontaneous reporting database to investigate whether drug-related adverse events are dose-dependent?

Perception of falsified and counterfeit medicines among adults living in Mexico City and the metropolitan area: an underappreciated health risk

Polypharmacy driven synergistic toxicities in elderly breast cancer chemotherapy drug management and adverse drug reactions: a mini review

Use of over-the-counter antiallergic products–analysis of sales data in Poland from 2020 to 2023

Association of first-trimester exposure to Kampo medicines containing Prunus persica kernel with preterm birth and major congenital malformations: a Japanese database study

Cost-effectiveness analysis of pembrolizumab plus chemotherapy versus placebo plus chemotherapy for patients with previously untreated locally recurrent inoperable or metastatic triple-negative breast cancer in China

Metformin in polycystic ovary syndrome: unraveling multi-stage therapeutic mechanisms from puberty to long-term health outcomes

Trends in prescription opioid use in Europe: A DARWIN EU® multinational cohort study including seven European countries

Incident gabapentin prescribing associated with opioid and benzodiazepine/Z-drug prescribing – a population-based longitudinal study in primary care

Statins for polycystic ovary syndrome in varying resource settings: a phenome-wide association study and evidence synthesis

Unveiling the hidden risk of caspofungin: insights from three adverse event reporting systems and network pharmacology integration