Frontiers in Pharmacology | Pharmacogenetics and Pharmacogenomics

Original Research

Published on 08 Jun 2023

The impact of CYP2C19 genotype on phenoconversion by concomitant medication

in Pharmacogenetics and Pharmacogenomics

Laura M. de Jong
Soukayna Boussallami
Elena Sánchez-López
Martin Giera
Maarten E. Tushuizen
Menno Hoekstra
Lukas J. A. C. Hawinkels
Robert Rissmann
Jesse J. Swen
Martijn L. Manson

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1201906

6,693 views
11 citations

Original Research

Published on 31 May 2023

Impact of CYP2D6 genotype on opioid use disorder deprescription: an observational prospective study in chronic pain with sex-differences

in Pharmacogenetics and Pharmacogenomics

Javier Muriel
Jordi Barrachina
Guillermo Del Barco
Cristian Carvajal
Mónica Escorial
César Margarit
Pura Ballester
Ana María Peiró

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1200430

2,912 views
6 citations

Original Research

Published on 24 May 2023

Integrated high-throughput analysis identifies super enhancers in metastatic castration-resistant prostate cancer

in Pharmacogenetics and Pharmacogenomics

Jie Zeng
Jiahong Chen
Maozhang Li
Chuanfan Zhong
Zezhen Liu
Yan Wang
Yuejiao Li
Funeng Jiang
Shumin Fang
Weide Zhong

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1191129

3,378 views

Original Research

Published on 23 May 2023

Characterization of 15 CYP2J2 variants identified in the Chinese Han population on the metabolism of ebastine and terfenadine in vitro

in Pharmacogenetics and Pharmacogenomics

Li-Li Zou
Fang-Ling Zhao
Yu-Ying Qi
Shuang-Hu Wang
Quan Zhou
Pei-Wu Geng
Yun-Fang Zhou
Qing Zhang
Hao Chen
Da-Peng Dai

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1186824

1,929 views
3 citations

Original Research

Published on 22 May 2023

The pharmacogenomic landscape of an Indigenous Australian population

in Pharmacogenetics and Pharmacogenomics

Sumudu Rangika Samarasinghe
Wendy Hoy
Sudhir Jadhao
Brendan J. McMorran
Henk-Jan Guchelaar
Shivashankar H. Nagaraj

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1180640

5,427 views
8 citations

Review

Published on 18 May 2023

Pharmacogenomics in practice: a review and implementation guide

in Pharmacogenetics and Pharmacogenomics

Danya Kabbani
Reem Akika
Ahmed Wahid
Ann K. Daly
Ingolf Cascorbi
Nathalie Khoueiry Zgheib

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1189976

26,762 views
41 citations

Systematic Review

Published on 16 May 2023

Genetic polymorphisms influencing deferasirox pharmacokinetics, efficacy, and adverse drug reactions: a systematic review and meta-analysis

in Pharmacogenetics and Pharmacogenomics

Kittika Yampayon
Puree Anantachoti
Bunchai Chongmelaxme
Varalee Yodsurang

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1069854

2,401 views
2 citations

Review

Published on 15 May 2023

Pharmacogenomic-guided dosing of fluoropyrimidines beyond DPYD: time for a polygenic algorithm?

in Pharmacogenetics and Pharmacogenomics

Anthi Maslarinou
Vangelis G. Manolopoulos
Georgia Ragia

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1184523

4,700 views
10 citations

Original Research

Published on 15 May 2023

Ten-year experience with pharmacogenetic testing for DPYD in a national cancer center in Italy: Lessons learned on the path to implementation

in Pharmacogenetics and Pharmacogenomics

A. Bignucolo
E. De Mattia
R. Roncato
E. Peruzzi
L. Scarabel
M. D’Andrea
F. Sartor
G. Toffoli
E. Cecchin

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1199462

3,323 views
9 citations

Original Research

Published on 12 May 2023

Identification of a lipid metabolism-related gene for cancer immunotherapy

in Pharmacogenetics and Pharmacogenomics

Xin Jiang
Wenqi Du
Ce Shi
Mengjie Kang
Qiuya Song
Lansheng Zhang
Dongsheng Pei

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1186064

2,821 views
1 citation

Original Research

Published on 11 May 2023

An updated examination of the perception of barriers for pharmacogenomics implementation and the usefulness of drug/gene pairs in Latin America and the Caribbean

in Pharmacogenetics and Pharmacogenomics

Aimeé Salas-Hernández
Macarena Galleguillos
Matías Carrasco
Andrés López-Cortés
María Ana Redal
Dora Fonseca-Mendoza
Patricia Esperón
Farith González-Martínez
Ismael Lares-Asseff
Alberto Lazarowski

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1175737

6,865 views
14 citations

Original Research

Published on 11 May 2023

A senescence-associated signature refines the classification of different modification patterns and characterization of tumor immune microenvironment infiltration in triple-negative breast cancer

in Pharmacogenetics and Pharmacogenomics

Renhong Huang
Han Wang
Jin Hong
Zheng Wang
Jiayi Wu
Ou Huang
Jianrong He
Weiguo Chen
Yafen Li
Xiaosong Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1191910

3,899 views
5 citations

Original Research

Published on 10 May 2023

Characterization of pharmacogenomic variants in a Brazilian admixed cohort of elderly individuals based on whole-genome sequencing data

in Pharmacogenetics and Pharmacogenomics

Luciana Bertholim-Nasciben
Marilia O. Scliar
Guilherme Debortoli
Bhooma Thiruvahindrapuram
Stephen W. Scherer
Yeda A. O. Duarte
Mayana Zatz
Guilherme Suarez-Kurtz
Esteban J. Parra
Michel S. Naslavsky

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1178715

3,128 views
5 citations

Case Report

Published on 09 May 2023

Case report: NUDT15 polymorphism and severe azathioprine-induced myelosuppression in a young Chinese female with systematic lupus erythematosus: a case analysis and literature review

in Pharmacogenetics and Pharmacogenomics

Juan Gu
Yupei Lin
Yuhe Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1001559

2,241 views
1 citation

Brief Research Report

Published on 09 May 2023

Functional single nucleotide polymorphisms in dopaminergic receptors D2 predict clinical response to Cariprazine

in Pharmacogenetics and Pharmacogenomics

Marco De Pieri
Marco Ferrari
Franca Marino
Rafael Traber
Emilio Bolla
Marco Cosentino

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1182393

1,516 views
3 citations

Original Research

Published on 09 May 2023

Genetic variants of genes involved in thiopurine metabolism pathway are associated with 6-mercaptopurine toxicity in pediatric acute lymphoblastic leukemia patients from Ethiopia

in Pharmacogenetics and Pharmacogenomics

Awol Mekonnen Ali
Haileyesus Adam
Daniel Hailu
Ephrem Engidawork
Rawleigh Howe
Teferra Abula
Marieke J. H. Coenen

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1159307

2,843 views

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Articles

The impact of CYP2C19 genotype on phenoconversion by concomitant medication

Impact of CYP2D6 genotype on opioid use disorder deprescription: an observational prospective study in chronic pain with sex-differences

Integrated high-throughput analysis identifies super enhancers in metastatic castration-resistant prostate cancer

Characterization of 15 CYP2J2 variants identified in the Chinese Han population on the metabolism of ebastine and terfenadine in vitro

The pharmacogenomic landscape of an Indigenous Australian population

Pharmacogenomics in practice: a review and implementation guide

Genetic polymorphisms influencing deferasirox pharmacokinetics, efficacy, and adverse drug reactions: a systematic review and meta-analysis

Pharmacogenomic-guided dosing of fluoropyrimidines beyond DPYD: time for a polygenic algorithm?

Ten-year experience with pharmacogenetic testing for DPYD in a national cancer center in Italy: Lessons learned on the path to implementation

Identification of a lipid metabolism-related gene for cancer immunotherapy

An updated examination of the perception of barriers for pharmacogenomics implementation and the usefulness of drug/gene pairs in Latin America and the Caribbean

A senescence-associated signature refines the classification of different modification patterns and characterization of tumor immune microenvironment infiltration in triple-negative breast cancer

Characterization of pharmacogenomic variants in a Brazilian admixed cohort of elderly individuals based on whole-genome sequencing data

Case report: NUDT15 polymorphism and severe azathioprine-induced myelosuppression in a young Chinese female with systematic lupus erythematosus: a case analysis and literature review

Functional single nucleotide polymorphisms in dopaminergic receptors D2 predict clinical response to Cariprazine

Genetic variants of genes involved in thiopurine metabolism pathway are associated with 6-mercaptopurine toxicity in pediatric acute lymphoblastic leukemia patients from Ethiopia