Frontiers in Pharmacology | Pharmacogenetics and Pharmacogenomics

Review

Published on 15 May 2023

Pharmacogenomic-guided dosing of fluoropyrimidines beyond DPYD: time for a polygenic algorithm?

in Pharmacogenetics and Pharmacogenomics

Anthi Maslarinou
Vangelis G. Manolopoulos
Georgia Ragia

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1184523

7,629 views
20 citations

Original Research

Published on 15 May 2023

Ten-year experience with pharmacogenetic testing for DPYD in a national cancer center in Italy: Lessons learned on the path to implementation

in Pharmacogenetics and Pharmacogenomics

A. Bignucolo
E. De Mattia
R. Roncato
E. Peruzzi
L. Scarabel
M. D’Andrea
F. Sartor
G. Toffoli
E. Cecchin

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1199462

4,630 views
12 citations

Original Research

Published on 12 May 2023

Identification of a lipid metabolism-related gene for cancer immunotherapy

in Pharmacogenetics and Pharmacogenomics

Xin Jiang
Wenqi Du
Ce Shi
Mengjie Kang
Qiuya Song
Lansheng Zhang
Dongsheng Pei

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1186064

3,885 views
1 citation

Original Research

Published on 11 May 2023

An updated examination of the perception of barriers for pharmacogenomics implementation and the usefulness of drug/gene pairs in Latin America and the Caribbean

in Pharmacogenetics and Pharmacogenomics

Aimeé Salas-Hernández
Macarena Galleguillos
Matías Carrasco
Andrés López-Cortés
María Ana Redal
Dora Fonseca-Mendoza
Patricia Esperón
Farith González-Martínez
Ismael Lares-Asseff
Alberto Lazarowski

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1175737

10,069 views
25 citations

Original Research

Published on 11 May 2023

A senescence-associated signature refines the classification of different modification patterns and characterization of tumor immune microenvironment infiltration in triple-negative breast cancer

in Pharmacogenetics and Pharmacogenomics

Renhong Huang
Han Wang
Jin Hong
Zheng Wang
Jiayi Wu
Ou Huang
Jianrong He
Weiguo Chen
Yafen Li
Xiaosong Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1191910

5,404 views
8 citations

Original Research

Published on 10 May 2023

Characterization of pharmacogenomic variants in a Brazilian admixed cohort of elderly individuals based on whole-genome sequencing data

in Pharmacogenetics and Pharmacogenomics

Luciana Bertholim-Nasciben
Marilia O. Scliar
Guilherme Debortoli
Bhooma Thiruvahindrapuram
Stephen W. Scherer
Yeda A. O. Duarte
Mayana Zatz
Guilherme Suarez-Kurtz
Esteban J. Parra
Michel S. Naslavsky

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1178715

4,652 views
10 citations

Case Report

Published on 09 May 2023

Case report: NUDT15 polymorphism and severe azathioprine-induced myelosuppression in a young Chinese female with systematic lupus erythematosus: a case analysis and literature review

in Pharmacogenetics and Pharmacogenomics

Juan Gu
Yupei Lin
Yuhe Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1001559

3,370 views
5 citations

Brief Research Report

Published on 09 May 2023

Functional single nucleotide polymorphisms in dopaminergic receptors D2 predict clinical response to Cariprazine

in Pharmacogenetics and Pharmacogenomics

Marco De Pieri
Marco Ferrari
Franca Marino
Rafael Traber
Emilio Bolla
Marco Cosentino

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1182393

2,513 views
3 citations

Original Research

Published on 09 May 2023

Genetic variants of genes involved in thiopurine metabolism pathway are associated with 6-mercaptopurine toxicity in pediatric acute lymphoblastic leukemia patients from Ethiopia

in Pharmacogenetics and Pharmacogenomics

Awol Mekonnen Ali
Haileyesus Adam
Daniel Hailu
Ephrem Engidawork
Rawleigh Howe
Teferra Abula
Marieke J. H. Coenen

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1159307

4,554 views
6 citations

Editorial

Published on 03 May 2023

Editorial: Pharmacogenetics and pharmacogenomics in Latin America: ethnic variability, new insights in advances and perspectives: a RELIVAF-CYTED initiative, Volume II

in Pharmacogenetics and Pharmacogenomics

Andrés López-Cortés
Patricia Esperón
Matías F. Martínez
María A. Redal
Alberto Lazarowski
Nelson M. Varela
Ismael Lares-Asseff
Luis A. Quiñones

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1211712

2,330 views
4 citations

Case Report

Published on 02 May 2023

Case report: Hepatotoxicity and nephrotoxicity induced by methotrexate in a paediatric patient, what is the role of precision medicine in 2023?

in Pharmacogenetics and Pharmacogenomics

Ali El Rida El Masri
Caroline Tobler
Breunis Willemijn
Andre O. Von Bueren
Marc Ansari
Caroline Flora Samer

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1130548

6,304 views
10 citations

Mini Review

Published on 26 Apr 2023

Current understanding of genetic associations with delayed hypersensitivity reactions induced by antibiotics and anti-osteoporotic drugs

in Pharmacogenetics and Pharmacogenomics

Chih-Hsuan Wung
Chuang-Wei Wang
Kuo-Chu Lai
Chun-Bing Chen
Wei-Ti Chen
Shuen-Iu Hung
Wen-Hung Chung
Taiwan Severe Cutaneous Adverse Reaction Consortium

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1183491

6,854 views
7 citations

Review

Published on 19 Apr 2023

The landscape of exosomal non-coding RNAs in breast cancer drug resistance, focusing on underlying molecular mechanisms

in Pharmacogenetics and Pharmacogenomics

Malihe Rezaee
Fatemeh Mohammadi
Atoosa Keshavarzmotamed
Sheida Yahyazadeh
Omid Vakili
Yaser Eshaghi Milasi
Vida Veisi
Rohollah Mousavi Dehmordi
Sepideh Asadi
Seyedeh Sara Ghorbanhosseini

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1152672

7,865 views
37 citations

Editorial

Published on 12 Apr 2023

Editorial: Liquid biopsy as a tool for precision oncology: New challenges to assess clinical response, Volume II

in Pharmacogenetics and Pharmacogenomics

Paola Ulivi

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1192549

1,215 views

Original Research

Published on 06 Apr 2023

Omics data integration facilitates target selection for new antiparasitic drugs against TriTryp infections

in Pharmacogenetics and Pharmacogenomics

Martin Rivara-Espasandín
Miranda Clara Palumbo
Ezequiel J. Sosa
Santiago Radío
Adrián G. Turjanski
José Sotelo-Silveira
Dario Fernandez Do Porto
Pablo Smircich

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1136321

3,040 views
7 citations

Review

Published on 03 Apr 2023

Non-coding and intergenic genetic variants of human arylamine N-acetyltransferase 2 (NAT2) gene are associated with differential plasma lipid and cholesterol levels and cardiometabolic disorders

in Pharmacogenetics and Pharmacogenomics

Kyung U. Hong
Kennedy M. Walls
David W. Hein

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1091976

3,479 views
6 citations

Review

Published on 31 Mar 2023

Non-coding RNAs: The recently accentuated molecules in the regulation of cell autophagy for ovarian cancer pathogenesis and therapeutic response

in Pharmacogenetics and Pharmacogenomics

Bi Peng
Jing Li
Yuanliang Yan
Yuanhong Liu
Qiuju Liang
Wei Liu
Abhimanyu Thakur
Kui Zhang
Zhijie Xu
Jian Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1162045

3,376 views
10 citations

Editorial

Published on 29 Mar 2023

Editorial: Pharmacogenomics and ethnicity: Prevalence and clinical significance of pharmacogenomic biomarkers in indigenous and other populations

in Pharmacogenetics and Pharmacogenomics

George P. Patrinos
Luis Abel Quinones
Chonlaphat Sukasem

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1180487

3,670 views
7 citations

Original Research

Published on 20 Mar 2023

Pharmacogenomic profile of actionable molecular variants related to drugs commonly used in anesthesia: WES analysis reveals new mutations

in Pharmacogenetics and Pharmacogenomics

Juan Fernando Parada-Márquez
Nicolás David Maldonado-Rodriguez
Paula Triana-Fonseca
Nora Constanza Contreras-Bravo
Carlos Alberto Calderón-Ospina
Carlos M. Restrepo
Adrien Morel
Oscar Javier Ortega-Recalde
Daniel Felipe Silgado-Guzmán
Mariana Angulo-Aguado

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1047854

5,440 views
1 citation

Original Research

Published on 14 Mar 2023

Evaluation of limited-sampling strategies to calculate AUC(0–24) and the role of CYP3A5 in Chilean pediatric kidney recipients using extended-release tacrolimus

in Pharmacogenetics and Pharmacogenomics

Carla Galvez
Pía Boza
Mariluz González
Catalina Hormazabal
Marlene Encina
Manuel Azócar
Luis E. Castañeda
Angélica Rojo
María Luisa Ceballos
Paola Krall

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1044050

4,931 views

Original Research

Published on 14 Mar 2023

The cholesterol-lowering effect of statins is modified by LILRB5 intolerance genotype: Results from a recruit-by-genotype clinical trial

in Pharmacogenetics and Pharmacogenomics

Aleksi Tornio
Margherita Bigossi
Moneeza K. Siddiqui
Gwen Kennedy
Ala’a Melhem
Mehul K. Chourasia
Cyrielle Maroteau
Roberto Pola
Daniel I. Chasman
Alexander S. F. Doney

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1090010

3,356 views
1 citation

Editorial

Published on 03 Mar 2023

Editorial: Brief research reports in pharmacogenetics and pharmacogenomics: 2022

in Pharmacogenetics and Pharmacogenomics

Francesco Sessa
Tarek Magdy
Chonlaphat Sukasem
George P. Patrinos

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1172265

2,613 views
1 citation

Original Research

Published on 01 Mar 2023

From gene to dose: Long-read sequencing and *-allele tools to refine phenotype predictions of CYP2C19

in Pharmacogenetics and Pharmacogenomics

Lonneke J. Graansma
Qinglian Zhai
Loes Busscher
Roberta Menafra
Redmar R. van den Berg
Susan L. Kloet
Maaike van der Lee

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1076574

5,292 views
11 citations

Original Research

Published on 27 Feb 2023

Practice of CYP450 genotyping and phenotyping in children in a real-life setting

in Pharmacogenetics and Pharmacogenomics

Frédérique Rodieux
Youssef Daali
Victoria Rollason
Caroline F. Samer
Kuntheavy Ing Lorenzini

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1130100

3,858 views
8 citations

643 articles

articles

Pharmacogenomic-guided dosing of fluoropyrimidines beyond DPYD: time for a polygenic algorithm?

Ten-year experience with pharmacogenetic testing for DPYD in a national cancer center in Italy: Lessons learned on the path to implementation

Identification of a lipid metabolism-related gene for cancer immunotherapy

An updated examination of the perception of barriers for pharmacogenomics implementation and the usefulness of drug/gene pairs in Latin America and the Caribbean

A senescence-associated signature refines the classification of different modification patterns and characterization of tumor immune microenvironment infiltration in triple-negative breast cancer

Characterization of pharmacogenomic variants in a Brazilian admixed cohort of elderly individuals based on whole-genome sequencing data

Case report: NUDT15 polymorphism and severe azathioprine-induced myelosuppression in a young Chinese female with systematic lupus erythematosus: a case analysis and literature review

Functional single nucleotide polymorphisms in dopaminergic receptors D2 predict clinical response to Cariprazine

Genetic variants of genes involved in thiopurine metabolism pathway are associated with 6-mercaptopurine toxicity in pediatric acute lymphoblastic leukemia patients from Ethiopia

Editorial: Pharmacogenetics and pharmacogenomics in Latin America: ethnic variability, new insights in advances and perspectives: a RELIVAF-CYTED initiative, Volume II

Case report: Hepatotoxicity and nephrotoxicity induced by methotrexate in a paediatric patient, what is the role of precision medicine in 2023?

Current understanding of genetic associations with delayed hypersensitivity reactions induced by antibiotics and anti-osteoporotic drugs

The landscape of exosomal non-coding RNAs in breast cancer drug resistance, focusing on underlying molecular mechanisms

Editorial: Liquid biopsy as a tool for precision oncology: New challenges to assess clinical response, Volume II

Omics data integration facilitates target selection for new antiparasitic drugs against TriTryp infections

Non-coding and intergenic genetic variants of human arylamine N-acetyltransferase 2 (NAT2) gene are associated with differential plasma lipid and cholesterol levels and cardiometabolic disorders

Non-coding RNAs: The recently accentuated molecules in the regulation of cell autophagy for ovarian cancer pathogenesis and therapeutic response

Editorial: Pharmacogenomics and ethnicity: Prevalence and clinical significance of pharmacogenomic biomarkers in indigenous and other populations

Pharmacogenomic profile of actionable molecular variants related to drugs commonly used in anesthesia: WES analysis reveals new mutations

Evaluation of limited-sampling strategies to calculate AUC(0–24) and the role of CYP3A5 in Chilean pediatric kidney recipients using extended-release tacrolimus

The cholesterol-lowering effect of statins is modified by LILRB5 intolerance genotype: Results from a recruit-by-genotype clinical trial

Editorial: Brief research reports in pharmacogenetics and pharmacogenomics: 2022

From gene to dose: Long-read sequencing and *-allele tools to refine phenotype predictions of CYP2C19

Practice of CYP450 genotyping and phenotyping in children in a real-life setting