Frontiers in Pharmacology | Pharmacogenetics and Pharmacogenomics

Original Research

Published on 19 Nov 2025

Pharmacogenetic associations of CYP2D6 and CYP2C19 variants with anticholinergic drug burden and hyposalivation

in Pharmacogenetics and Pharmacogenomics

Olga A. Korczeniewska
Scott Diehl
Abdul Basir Barmak
Tong Tong Wu
Eli Eliav
Szilvia Arany

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1713345

867 views

Mini Review

Published on 13 Nov 2025

Inhibition of mesenchymal drift as a strategy for rejuvenation

in Pharmacogenetics and Pharmacogenomics

Lucas Paulo de Lima Camillo

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1715559

2,319 views

Original Research

Published on 30 Oct 2025

Persistent benefit of pharmacogenomic testing on initial remission and response rates in patients with major depressive disorder

in Pharmacogenetics and Pharmacogenomics

Daniel Hain
Andria L. Del Tredici
Ryan B. Griggs
Rebecca Law
Brent Mabey
Holly L. Johnson
Katherine Johansen Taber
Kevin G. Lynch
Alexander Gutin
David W. Oslin

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1658616

2,792 views
1 citation

Review

Published on 30 Oct 2025

Epigenetic pharmacology in aging: from mechanisms to therapies for age-related disorders

in Pharmacogenetics and Pharmacogenomics

Haikuan Yu
Taojin Feng
Chengcheng Zhang
Zhouguang Jiao
Wenkai Fan
Rongxian Jiang
Dewen Kong
Fubing Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1699296

4,014 views

Original Research

Published on 09 Oct 2025

Patient and clinician perspectives on pharmacogenetic testing for antipsychotics

in Pharmacogenetics and Pharmacogenomics

Maria Richards-Brown
Yiran Wei
Rosemary Abidoph
Lauren Varney
Marius Cotic
Stephen Murtough
Daniele Panconesi
Daisy Mills
Alvin Richards-Belle
Noushin Saadullah Khani

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1689300

3,309 views

Original Research

Published on 08 Oct 2025

A digital twin of glimepiride for personalized and stratified diabetes treatment

in Pharmacogenetics and Pharmacogenomics

Michelle Elias
Matthias König

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1686415

2,315 views
1 citation

Original Research

Published on 02 Oct 2025

Genetic and serum biomarkers of NSAID hypersensitivity reactions

in Pharmacogenetics and Pharmacogenomics

G. Amo
J. M. García-Menaya
M. Martí
J. Gómez-Tabales
J. A. Cornejo-García
N. Blanca-López
G. Canto
I. Doña
M. Blanca
M. J. Torres

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1502755

2,784 views
1 citation

Review

Published on 01 Oct 2025

Pharmacogenomics of antibiotic-induced hypersensitivity reactions: current evidence and implications in clinical practice

in Pharmacogenetics and Pharmacogenomics

Mohitosh Biswas
Murshadul Alam Murad
Md. Ismail Hossain Ashik
Maliheh Ershadian
Chonlaphat Sukasem

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1651909

3,630 views
1 citation

Original Research

Published on 25 Sep 2025

Pharmacogenomic biomarkers of ACE inhibitor–induced cough in a multi-ethnic UAE cohort

in Pharmacogenetics and Pharmacogenomics

Sahar M. Altoum
Zeina N. Al-Mahayri
Lubna Q. Khasawneh
Mais N. Alqasrawi
Lilas Dabaghie
Dana Hamza
Bassam R. Ali

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1655617

2,914 views

Systematic Review

Published on 22 Sep 2025

Implementing pharmacogenetic testing in community pharmacy practice: a scoping review

in Pharmacogenetics and Pharmacogenomics

Aude Coumau
Claire Coumau
Chantal Csajka

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1659875

4,533 views

Review

Published on 19 Sep 2025

Advancing drug safety in psychiatry: insights from pharmacogenomics of hypersensitivity reactions

in Pharmacogenetics and Pharmacogenomics

Hamid A. Alhaj
Jana Samara
Alyamama Alnamous
Rama Karima
Maha Saber-Ayad

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1651898

5,021 views
1 citation

Original Research

Published on 19 Sep 2025

Prevalence of risk phenotypes associated with CYP2C92, 3, and VKORC1 c.-1639G>A genetic polymorphisms in world populations: implications in clinical practice

in Pharmacogenetics and Pharmacogenomics

Mohitosh Biswas
Murshadul Alam Murad
Maliheh Ershadian
Most. Sumaiya Khatun Kali
Maw Shin Sim
Baharudin Ibrahim
Chonlaphat Sukasem

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1597379

2,542 views
1 citation

Original Research

Published on 18 Sep 2025

Higher prevalence of NUDT15 rs116855232 compared to TPMT rs1142345 in a Chinese cohort and its implications for thiopurine therapy

in Pharmacogenetics and Pharmacogenomics

Chenyu Zhao
Hui Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1660719

2,066 views

Original Research

Published on 18 Sep 2025

DPYD-guided fluoropyrimidine dose adjustment in colorectal cancer DPYD carriers: start slower to finish stronger

in Pharmacogenetics and Pharmacogenomics

Rocío Rosas-Alonso
Nuria Rodríguez Salas
Pablo Perez Wert
Angela Hoyo
Susana Martin-López
Daniel Martínez-Pérez
Iciar Ruiz-Gutiérrez
Diego Jiménez-Bou
Jesús Peña
Pedro Arias

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1645188

2,446 views

Brief Research Report

Published on 09 Sep 2025

Comparative evaluation of Oxford Nanopore Technologies’ adaptive sampling and the Twist long-read PGx panel for pharmacogenomic profiling

in Pharmacogenetics and Pharmacogenomics

Koen Deserranno
Laurentijn Tilleman
Dieter Deforce
Filip Van Nieuwerburgh

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1653999

3,747 views
2 citations

Review

Published on 04 Sep 2025

Epigenetics in pharmacogenes encoding metabolizing enzymes of second-generation antipsychotics used in schizophrenia and its clinical implications

in Pharmacogenetics and Pharmacogenomics

Angel T. Alvarado
Amparo Iris Zavaleta
César Li-Amenero
María R. Bendezú
Jorge A. Garcia
Haydee Chávez
Juan J. Palomino-Jhong
Felipe Surco-Laos
Doris Laos-Anchante
Elizabeth J. Melgar-Merino

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1611203

3,581 views
1 citation

Original Research

Published on 01 Sep 2025

The prevalence of genetic variants of the Mas-related G-protein-coupled receptor X2 in patients does not explain perioperative hypersensitivity reactions to neuromuscular blocking agents

in Pharmacogenetics and Pharmacogenomics

Alicja Dziadowiec
Mateusz Kwitniewski
Peter Kopac
Hubert Rybka
Lenka Sedlackova
Adriana Srotova
Wojciech Dyga
Ana Koren
Joanna Gluck
Radoslaw Kitel

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1655722

2,563 views
1 citation

Original Research

Published on 29 Aug 2025

A multi-centre observational cohort study on pharmacogenomic predictors of rosuvastatin discontinuation in a multiethnic population

in Pharmacogenetics and Pharmacogenomics

Mais N. Alqasrawi
Zeina N. Al-Mahayri
Lubna Q. Khasawneh
Areej S. AlBawa’neh
Lilas Dabaghie
Sahar M. Altoum
Dana Hamza
Salahdein Aburuz
Virendra Misra
Gohar Jamil

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1656520

2,920 views

Original Research

Published on 29 Aug 2025

Pharmacogenomics and genetic ancestry in Colombia: a study on all variant drug annotations of PharmGKB

in Pharmacogenetics and Pharmacogenomics

Andy A. Acosta-Monterrosa
Kevin Fernando Montoya-Quintero
Johana Galván-Barrios
Indiana Luz Rojas Torres

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1636451

2,680 views

Review

Published on 21 Aug 2025

Epigenetic regulation of bladder cancer in the context of aging

in Pharmacogenetics and Pharmacogenomics

Xuewei Liu
Guofeng Ding
Yifan Liu
Xiaoli Yan
Yan Zhao
Hailin Lv
Xiaojuan Xu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1617452

4,256 views
3 citations

Original Research

Published on 21 Aug 2025

Analysis of six CYP450 genetic variants regarding the response to cannabidiol combined with anticonvulsant medication in mexican patients with drug-resistant epilepsy

in Pharmacogenetics and Pharmacogenomics

Iris A. Feria-Romero
Luisa Rocha
Araceli Reyes-Cuayahuitl
Iris Martínez-Juárez
Daniel San-Juan
Consuelo Escamilla-Nuñez
Sandra Orozco-Suarez

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1626054

2,154 views

Original Research

Published on 15 Aug 2025

Population-specific genetic differences of acute coronary syndrome in Han and Uyghur Chinese

in Pharmacogenetics and Pharmacogenomics

Hongmei Lai
Jinhang Zhu
Jing Tao
Zitong Guo
Xiaolin Yu
Xin Shen
Ting Wang
Ying Wang
Huan Cai
Xiao Cai

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1588658

2,271 views
1 citation

Review

Published on 12 Aug 2025

Role of pharmacogenomics for prevention of hypersensitivity reactions induced by aromatic antiseizure medications

in Pharmacogenetics and Pharmacogenomics

Angel T. Alvarado
Amparo Iris Zavaleta
César Li-Amenero
María R. Bendezú
Jorge A. Garcia
Haydee Chávez
Juan J. Palomino-Jhong
Felipe Surco-Laos
Doris Laos-Anchante
Elizabeth J. Melgar-Merino

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1640401

2,954 views
3 citations

Correction

Published on 08 Aug 2025

Correction: Overexpression of Nrf2 in bone marrow mesenchymal stem cells promotes B-cell acute lymphoblastic leukemia cells invasion and extramedullary organ infiltration through stimulation of the SDF-1/CXCR4 axis

in Pharmacogenetics and Pharmacogenomics

Lin Zheng
Chengyun Pan
Dan Ma
Qin Shang
Tianzhen Hu
Tianzhuo Zhang
Qian Kang
Xiuying Hu
Shuyun Cao
Li Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1660169

1,066 views

656 articles

articles

Pharmacogenetic associations of CYP2D6 and CYP2C19 variants with anticholinergic drug burden and hyposalivation

Inhibition of mesenchymal drift as a strategy for rejuvenation

Persistent benefit of pharmacogenomic testing on initial remission and response rates in patients with major depressive disorder

Epigenetic pharmacology in aging: from mechanisms to therapies for age-related disorders

Patient and clinician perspectives on pharmacogenetic testing for antipsychotics

A digital twin of glimepiride for personalized and stratified diabetes treatment

Genetic and serum biomarkers of NSAID hypersensitivity reactions

Pharmacogenomics of antibiotic-induced hypersensitivity reactions: current evidence and implications in clinical practice

Pharmacogenomic biomarkers of ACE inhibitor–induced cough in a multi-ethnic UAE cohort

Implementing pharmacogenetic testing in community pharmacy practice: a scoping review

Advancing drug safety in psychiatry: insights from pharmacogenomics of hypersensitivity reactions

Prevalence of risk phenotypes associated with CYP2C92, 3, and VKORC1 c.-1639G>A genetic polymorphisms in world populations: implications in clinical practice

Higher prevalence of NUDT15 rs116855232 compared to TPMT rs1142345 in a Chinese cohort and its implications for thiopurine therapy

DPYD-guided fluoropyrimidine dose adjustment in colorectal cancer DPYD carriers: start slower to finish stronger

Comparative evaluation of Oxford Nanopore Technologies’ adaptive sampling and the Twist long-read PGx panel for pharmacogenomic profiling

Epigenetics in pharmacogenes encoding metabolizing enzymes of second-generation antipsychotics used in schizophrenia and its clinical implications

The prevalence of genetic variants of the Mas-related G-protein-coupled receptor X2 in patients does not explain perioperative hypersensitivity reactions to neuromuscular blocking agents

A multi-centre observational cohort study on pharmacogenomic predictors of rosuvastatin discontinuation in a multiethnic population

Pharmacogenomics and genetic ancestry in Colombia: a study on all variant drug annotations of PharmGKB

Epigenetic regulation of bladder cancer in the context of aging

Analysis of six CYP450 genetic variants regarding the response to cannabidiol combined with anticonvulsant medication in mexican patients with drug-resistant epilepsy

Population-specific genetic differences of acute coronary syndrome in Han and Uyghur Chinese

Role of pharmacogenomics for prevention of hypersensitivity reactions induced by aromatic antiseizure medications

Correction: Overexpression of Nrf2 in bone marrow mesenchymal stem cells promotes B-cell acute lymphoblastic leukemia cells invasion and extramedullary organ infiltration through stimulation of the SDF-1/CXCR4 axis

articles

Pharmacogenetic associations of CYP2D6 and CYP2C19 variants with anticholinergic drug burden and hyposalivation

Inhibition of mesenchymal drift as a strategy for rejuvenation

Persistent benefit of pharmacogenomic testing on initial remission and response rates in patients with major depressive disorder

Epigenetic pharmacology in aging: from mechanisms to therapies for age-related disorders

Patient and clinician perspectives on pharmacogenetic testing for antipsychotics

A digital twin of glimepiride for personalized and stratified diabetes treatment

Genetic and serum biomarkers of NSAID hypersensitivity reactions

Pharmacogenomics of antibiotic-induced hypersensitivity reactions: current evidence and implications in clinical practice

Pharmacogenomic biomarkers of ACE inhibitor–induced cough in a multi-ethnic UAE cohort

Implementing pharmacogenetic testing in community pharmacy practice: a scoping review

Advancing drug safety in psychiatry: insights from pharmacogenomics of hypersensitivity reactions

Prevalence of risk phenotypes associated with CYP2C9*2, *3, and VKORC1 c.-1639G>A genetic polymorphisms in world populations: implications in clinical practice

Higher prevalence of NUDT15 rs116855232 compared to TPMT rs1142345 in a Chinese cohort and its implications for thiopurine therapy

DPYD-guided fluoropyrimidine dose adjustment in colorectal cancer DPYD carriers: start slower to finish stronger

Comparative evaluation of Oxford Nanopore Technologies’ adaptive sampling and the Twist long-read PGx panel for pharmacogenomic profiling

Epigenetics in pharmacogenes encoding metabolizing enzymes of second-generation antipsychotics used in schizophrenia and its clinical implications

The prevalence of genetic variants of the Mas-related G-protein-coupled receptor X2 in patients does not explain perioperative hypersensitivity reactions to neuromuscular blocking agents

A multi-centre observational cohort study on pharmacogenomic predictors of rosuvastatin discontinuation in a multiethnic population

Pharmacogenomics and genetic ancestry in Colombia: a study on all variant drug annotations of PharmGKB

Epigenetic regulation of bladder cancer in the context of aging

Analysis of six CYP450 genetic variants regarding the response to cannabidiol combined with anticonvulsant medication in mexican patients with drug-resistant epilepsy

Population-specific genetic differences of acute coronary syndrome in Han and Uyghur Chinese

Role of pharmacogenomics for prevention of hypersensitivity reactions induced by aromatic antiseizure medications

Correction: Overexpression of Nrf2 in bone marrow mesenchymal stem cells promotes B-cell acute lymphoblastic leukemia cells invasion and extramedullary organ infiltration through stimulation of the SDF-1/CXCR4 axis

Prevalence of risk phenotypes associated with CYP2C92, 3, and VKORC1 c.-1639G>A genetic polymorphisms in world populations: implications in clinical practice