Frontiers in Pharmacology | Pharmacogenetics and Pharmacogenomics

Original Research

Published on 18 Sep 2025

DPYD-guided fluoropyrimidine dose adjustment in colorectal cancer DPYD carriers: start slower to finish stronger

in Pharmacogenetics and Pharmacogenomics

Rocío Rosas-Alonso
Nuria Rodríguez Salas
Pablo Perez Wert
Angela Hoyo
Susana Martin-López
Daniel Martínez-Pérez
Iciar Ruiz-Gutiérrez
Diego Jiménez-Bou
Jesús Peña
Pedro Arias

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1645188

2,163 views

Brief Research Report

Published on 09 Sep 2025

Comparative evaluation of Oxford Nanopore Technologies’ adaptive sampling and the Twist long-read PGx panel for pharmacogenomic profiling

in Pharmacogenetics and Pharmacogenomics

Koen Deserranno
Laurentijn Tilleman
Dieter Deforce
Filip Van Nieuwerburgh

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1653999

2,942 views

Review

Published on 04 Sep 2025

Epigenetics in pharmacogenes encoding metabolizing enzymes of second-generation antipsychotics used in schizophrenia and its clinical implications

in Pharmacogenetics and Pharmacogenomics

Angel T. Alvarado
Amparo Iris Zavaleta
César Li-Amenero
María R. Bendezú
Jorge A. Garcia
Haydee Chávez
Juan J. Palomino-Jhong
Felipe Surco-Laos
Doris Laos-Anchante
Elizabeth J. Melgar-Merino

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1611203

3,152 views
1 citation

Original Research

Published on 01 Sep 2025

The prevalence of genetic variants of the Mas-related G-protein-coupled receptor X2 in patients does not explain perioperative hypersensitivity reactions to neuromuscular blocking agents

in Pharmacogenetics and Pharmacogenomics

Alicja Dziadowiec
Mateusz Kwitniewski
Peter Kopac
Hubert Rybka
Lenka Sedlackova
Adriana Srotova
Wojciech Dyga
Ana Koren
Joanna Gluck
Radoslaw Kitel

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1655722

2,208 views

Original Research

Published on 29 Aug 2025

A multi-centre observational cohort study on pharmacogenomic predictors of rosuvastatin discontinuation in a multiethnic population

in Pharmacogenetics and Pharmacogenomics

Mais N. Alqasrawi
Zeina N. Al-Mahayri
Lubna Q. Khasawneh
Areej S. AlBawa’neh
Lilas Dabaghie
Sahar M. Altoum
Dana Hamza
Salahdein Aburuz
Virendra Misra
Gohar Jamil

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1656520

2,456 views

Original Research

Published on 29 Aug 2025

Pharmacogenomics and genetic ancestry in Colombia: a study on all variant drug annotations of PharmGKB

in Pharmacogenetics and Pharmacogenomics

Andy A. Acosta-Monterrosa
Kevin Fernando Montoya-Quintero
Johana Galván-Barrios
Indiana Luz Rojas Torres

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1636451

2,186 views

Review

Published on 21 Aug 2025

Epigenetic regulation of bladder cancer in the context of aging

in Pharmacogenetics and Pharmacogenomics

Xuewei Liu
Guofeng Ding
Yifan Liu
Xiaoli Yan
Yan Zhao
Hailin Lv
Xiaojuan Xu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1617452

3,491 views
2 citations

Original Research

Published on 21 Aug 2025

Analysis of six CYP450 genetic variants regarding the response to cannabidiol combined with anticonvulsant medication in mexican patients with drug-resistant epilepsy

in Pharmacogenetics and Pharmacogenomics

Iris A. Feria-Romero
Luisa Rocha
Araceli Reyes-Cuayahuitl
Iris Martínez-Juárez
Daniel San-Juan
Consuelo Escamilla-Nuñez
Sandra Orozco-Suarez

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1626054

1,756 views

Original Research

Published on 15 Aug 2025

Population-specific genetic differences of acute coronary syndrome in Han and Uyghur Chinese

in Pharmacogenetics and Pharmacogenomics

Hongmei Lai
Jinhang Zhu
Jing Tao
Zitong Guo
Xiaolin Yu
Xin Shen
Ting Wang
Ying Wang
Huan Cai
Xiao Cai

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1588658

2,012 views

Review

Published on 12 Aug 2025

Role of pharmacogenomics for prevention of hypersensitivity reactions induced by aromatic antiseizure medications

in Pharmacogenetics and Pharmacogenomics

Angel T. Alvarado
Amparo Iris Zavaleta
César Li-Amenero
María R. Bendezú
Jorge A. Garcia
Haydee Chávez
Juan J. Palomino-Jhong
Felipe Surco-Laos
Doris Laos-Anchante
Elizabeth J. Melgar-Merino

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1640401

2,460 views
3 citations

Correction

Published on 08 Aug 2025

Correction: Overexpression of Nrf2 in bone marrow mesenchymal stem cells promotes B-cell acute lymphoblastic leukemia cells invasion and extramedullary organ infiltration through stimulation of the SDF-1/CXCR4 axis

in Pharmacogenetics and Pharmacogenomics

Lin Zheng
Chengyun Pan
Dan Ma
Qin Shang
Tianzhen Hu
Tianzhuo Zhang
Qian Kang
Xiuying Hu
Shuyun Cao
Li Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1660169

948 views

Review

Published on 07 Aug 2025

Global variation in antibiotic prescribing guidelines and the implications for decreasing AMR in the future

in Pharmacogenetics and Pharmacogenomics

Emmama Jamil
Zikria Saleem
Brian Godman
Matti Ullah
Afreenish Amir
Abdul Haseeb
Johanna C. Meyer
Muhammad Usman Qamar
Safa S. Almarzoky Abuhussain

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1600787

5,478 views
8 citations

Review

Published on 07 Aug 2025

The role and challenges of intratumoral microbiota in colorectal cancer immunotherapy

in Pharmacogenetics and Pharmacogenomics

Miao Hao
Haiming Xu
Min Li
Dan Jiao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1634703

2,560 views
1 citation

Clinical Trial

Published on 07 Aug 2025

Clinicians’ experience on the effectiveness of pharmacotherapy in patients with first-episode depression: a randomized controlled trial based on pharmacogenomics

in Pharmacogenetics and Pharmacogenomics

Jie Tong
Jie Yuan
Yu Qin
Na Zhu
Tingting Zhang
Xiaochun Zhu
Yuanyuan Xu
Meilin Liu
Jie Zhang
Xirong Sun

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1626654

1,548 views

Original Research

Published on 21 Jul 2025

Clinical significance and gene prediction of a novel classification system based on tacrolimus concentration-to-dose ratio in the early post-liver transplant period

in Pharmacogenetics and Pharmacogenomics

Junwei Fan
Peihao Wen
Liyun Yuan
Yan Xia
Shijie Hu
Xiaoqing Zhang
Zhihai Peng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1614753

1,889 views

Mini Review

Published on 17 Jul 2025

Statins and their impact on epigenetic regulation: insights into disease

in Pharmacogenetics and Pharmacogenomics

Rafael Tamayo-Trujillo
Patricia Guevara-Ramírez
Santiago Cadena-Ullauri
Viviana A. Ruiz Pozo
Elius Paz-Cruz
Ana Karina Zambrano

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1621163

2,983 views
2 citations

Systematic Review

Published on 16 Jul 2025

Polymorphisms in CYP3A5, CYP3A4, and ABCB1 genes: implications for calcineurin inhibitors therapy in hematopoietic cell transplantation recipients—a systematic review

in Pharmacogenetics and Pharmacogenomics

Luiz Carlos da Costa-Junior
Daniely Regina Freitas-Alves
Amanda Melo Leite Leão
Hayra de Andrade Vieira Monteiro
Rita de Cássia Barbosa da Silva Tavares
Maria Claudia Rodrigues Moreira
Marília Berlofa Visacri
Teresa de Souza Fernandez
Paulo Caleb Júnior de Lima Santos

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1569353

2,457 views

Review

Published on 16 Jul 2025

Epigenetic modifications of gut microbiota and their potential role in atherosclerosis

in Pharmacogenetics and Pharmacogenomics

Shuang Guo
Junlai Zhao
Rongrong Zhu
Zhi Fan
Shibiao Liu
Weiwei Wu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1638240

2,424 views

Systematic Review

Published on 16 Jul 2025

Clinical and cost-effectiveness of pharmacogenomic testing for anthracycline-induced cardiotoxicity in childhood cancer: a systematic review and meta-analysis

in Pharmacogenetics and Pharmacogenomics

Ling Yin Fritz Wong
Alastair G. Sutcliffe
Carmen Lok Tung Ho
Yan Lu
Carrie L. Williams
Faiza Afzal
Mitana Purkayastha

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1568320

3,624 views

Editorial

Published on 15 Jul 2025

Editorial: Editor’s feature: negative findings in pharmacogenetics and pharmacogenomics volume II

in Pharmacogenetics and Pharmacogenomics

José A. G. Agúndez
Elena García-Martín
Luis Abel Quiñones

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1658876

1,109 views

Editorial

Published on 07 Jul 2025

Editorial: Post-translational modifications in human cancer: pharmacological insights and therapeutic opportunities

in Pharmacogenetics and Pharmacogenomics

Yongzhi Chen
Angelina W. Fan
Lei Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1654659

1,861 views
3 citations

Original Research

Published on 04 Jul 2025

Exploring biomarkers for noise-induced hearing loss through mitochondrial DNA methylation analysis

in Pharmacogenetics and Pharmacogenomics

Dianpeng Wang
Caiping Li
Liuwei Shi
Dafeng Lin
Shaofan Weng
Xiangli Yang
Peimao Li
Zhimin Zhang
Wen Zhang
Yan Guo

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1561791

2,497 views

Editorial

Published on 01 Jul 2025

Editorial: Pharmacogenomics for improving drug safety and efficacy in cancer

in Pharmacogenetics and Pharmacogenomics

Zhiyao He
Xuewei Fu
Zhijie Xu
Omar Alshargi
Roberto Rodríguez-Labrada
Xiao-Bo Zhong

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1649258

3,049 views
1 citation

Systematic Review

Published on 19 Jun 2025

CYP2C19 variability and clinical outcomes of clopidogrel, proton pump inhibitors, and voriconazole in Southeast Asia: a systematic review and meta-analysis

in Pharmacogenetics and Pharmacogenomics

Harri Hardi
Agian Jeffilano Barinda
Liganda Endo Mahata
Zahra Fitrianti

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1572886

4,397 views
4 citations

643 articles

articles

DPYD-guided fluoropyrimidine dose adjustment in colorectal cancer DPYD carriers: start slower to finish stronger

Comparative evaluation of Oxford Nanopore Technologies’ adaptive sampling and the Twist long-read PGx panel for pharmacogenomic profiling

Epigenetics in pharmacogenes encoding metabolizing enzymes of second-generation antipsychotics used in schizophrenia and its clinical implications

The prevalence of genetic variants of the Mas-related G-protein-coupled receptor X2 in patients does not explain perioperative hypersensitivity reactions to neuromuscular blocking agents

A multi-centre observational cohort study on pharmacogenomic predictors of rosuvastatin discontinuation in a multiethnic population

Pharmacogenomics and genetic ancestry in Colombia: a study on all variant drug annotations of PharmGKB

Epigenetic regulation of bladder cancer in the context of aging

Analysis of six CYP450 genetic variants regarding the response to cannabidiol combined with anticonvulsant medication in mexican patients with drug-resistant epilepsy

Population-specific genetic differences of acute coronary syndrome in Han and Uyghur Chinese

Role of pharmacogenomics for prevention of hypersensitivity reactions induced by aromatic antiseizure medications

Correction: Overexpression of Nrf2 in bone marrow mesenchymal stem cells promotes B-cell acute lymphoblastic leukemia cells invasion and extramedullary organ infiltration through stimulation of the SDF-1/CXCR4 axis

Global variation in antibiotic prescribing guidelines and the implications for decreasing AMR in the future

The role and challenges of intratumoral microbiota in colorectal cancer immunotherapy

Clinicians’ experience on the effectiveness of pharmacotherapy in patients with first-episode depression: a randomized controlled trial based on pharmacogenomics

Clinical significance and gene prediction of a novel classification system based on tacrolimus concentration-to-dose ratio in the early post-liver transplant period

Statins and their impact on epigenetic regulation: insights into disease

Polymorphisms in CYP3A5, CYP3A4, and ABCB1 genes: implications for calcineurin inhibitors therapy in hematopoietic cell transplantation recipients—a systematic review

Epigenetic modifications of gut microbiota and their potential role in atherosclerosis

Clinical and cost-effectiveness of pharmacogenomic testing for anthracycline-induced cardiotoxicity in childhood cancer: a systematic review and meta-analysis

Editorial: Editor’s feature: negative findings in pharmacogenetics and pharmacogenomics volume II

Editorial: Post-translational modifications in human cancer: pharmacological insights and therapeutic opportunities

Exploring biomarkers for noise-induced hearing loss through mitochondrial DNA methylation analysis

Editorial: Pharmacogenomics for improving drug safety and efficacy in cancer

CYP2C19 variability and clinical outcomes of clopidogrel, proton pump inhibitors, and voriconazole in Southeast Asia: a systematic review and meta-analysis