Frontiers in Pharmacology | Pharmacogenetics and Pharmacogenomics

Original Research

Published on 11 Dec 2024

Paromomycin targets HDAC1-mediated SUMOylation and IGF1R translocation in glioblastoma

in Pharmacogenetics and Pharmacogenomics

Zhong Min
Yuejie Guo
Luo Ning

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1490878

529 views

Brief Research Report

Published on 05 Dec 2024

Clinical implications of a gain-of-function genetic polymorphism in DPYD (rs4294451) in colorectal cancer patients treated with fluoropyrimidines

in Pharmacogenetics and Pharmacogenomics

Elena De Mattia
Jerry Polesel
Lucia Scarabel
Erika Cecchin

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1516375

816 views

Original Research

Published on 04 Dec 2024

AH-6809 mediated regulation of lung adenocarcinoma metastasis through NLRP7 and prognostic analysis of key metastasis-related genes

in Pharmacogenetics and Pharmacogenomics

Xu Feng
Wei Wu
Feifei Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1486265

896 views

Original Research

Published on 03 Dec 2024

Pharmacogenomic profiling of the South Korean population: Insights and implications for personalized medicine

in Pharmacogenetics and Pharmacogenomics

Mi Seon Youn
Se Hwan Ahn
Ju Han Kim

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1476765

1,085 views

Review

Published on 28 Nov 2024

Advancements in precision medicine: multi-omics approach for tailored metformin treatment in type 2 diabetes

in Pharmacogenetics and Pharmacogenomics

Najeha Rizwana Anwardeen
Khaled Naja
Mohamed A. Elrayess

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1506767

1,173 views

Original Research

Published on 25 Nov 2024

Comparing commercial pharmacogenetic testing results and recommendations for antidepressants with established CPIC guidelines

in Pharmacogenetics and Pharmacogenomics

Tiffany T. Nguyen
Emili J. W. Leary
Joshua T. Lee
Sanjay K. Shukla
Sara A. Griesbach

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1500235

872 views

Original Research

Published on 20 Nov 2024

Metabolic pathways, genomic alterations, and post-translational modifications in pulmonary hypertension and cancer as therapeutic targets and biomarkers

in Pharmacogenetics and Pharmacogenomics

Xiujin Zhang
Zhiqing Fu
Haijun Wang
Li Sheng

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1490892

1,234 views

Original Research

Published on 18 Nov 2024

Investigation on regulation of N-acetyltransferase 2 expression by nuclear receptors in human hepatocytes

in Pharmacogenetics and Pharmacogenomics

Kyung U. Hong
Anthony P. Aureliano
Kennedy M. Walls
David W. Hein

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1488367

765 views

Original Research

Published on 15 Nov 2024

Population pharmacokinetic study of the effect of polymorphisms in the ABCB1 and CES1 genes on the pharmacokinetics of dabigatran

in Pharmacogenetics and Pharmacogenomics

Zhuan Yang
Wen Rui Tan
Qin Li
Ying Wang
Shijing Liu
Lu Chen
Yan Zhou
Chen Zeng
Yan Zeng
Yun Xiong

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1454612

511 views

Original Research

Published on 14 Nov 2024

Novel genomic variants influencing methotrexate delayed clearance in pediatric patients with acute lymphoblastic leukemia

in Pharmacogenetics and Pharmacogenomics

Jung Yoon Choi
Hoshik Kwon
Hyery Kim
Kyung Taek Hong
Youngeun Ma
Kyung-Nam Koh
Sunmin Yun
Keon Hee Yoo
Sang Hoon Song
Ho Joon Im

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1480657

891 views

Review

Published on 12 Nov 2024

Tumor microenvironment and cancer metastasis: molecular mechanisms and therapeutic implications

in Pharmacogenetics and Pharmacogenomics

Cigir Biray Avci
Bakiye Goker Bagca
Masoud Nikanfar
Leila Sabour Takanlou
Maryam Sabour Takanlou
Alireza Nourazarian

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1442888

2,192 views

Original Research

Published on 01 Nov 2024

Multi-omics association study integrating GWAS and pQTL data revealed MIP-1α as a potential drug target for erectile dysfunction

in Pharmacogenetics and Pharmacogenomics

Jingwen Liu
Renbing Pan

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1495970

1,178 views

Original Research

Published on 01 Nov 2024

Allele frequencies and genotype distribution of three metformin transporter polymorphisms in Mexican population and their application in pharmacogenomics of type 2 diabetes

in Pharmacogenetics and Pharmacogenomics

Oscar I. Chávez-Arreola
Brissia Lazalde
Marisol López-López
Alberto Ortega-Vázquez
Quitzia L. Torres-Salazar

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1466394

811 views

Original Research

Published on 30 Oct 2024

The role of candidate pharmacogenetic variants in determining valproic acid efficacy, toxicity and concentrations in patients with epilepsy

in Pharmacogenetics and Pharmacogenomics

Hady Yazbeck
Joe Youssef
Wassim Nasreddine
Abdullah El Kurdi
Nathalie Zgheib
Ahmad Beydoun

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1483723

833 views

Original Research

Published on 25 Oct 2024

A mathematical model of glomerular fibrosis in diabetic kidney disease to predict therapeutic efficacy

in Pharmacogenetics and Pharmacogenomics

Haryana Y. Thomas
Ashlee N. Ford Versypt

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1481768

819 views

Original Research

Published on 24 Oct 2024

Impact of single-nucleotide variants and individual characteristics on adverse events of L-asparaginase in children with acute lymphoblastic leukemia

in Pharmacogenetics and Pharmacogenomics

Jesús Alonso Gándara-Mireles
Ismael Lares-Asseff
Elio Aarón Reyes Espinoza
Verónica Loera Castañeda
Lourdes Patricia Córdova Hurtado
Flor de María Reyes Gutiérrez
Antonio Sandoval-Cabrera
Ignacio Villanueva Fierro
Julio Cesar Grijalva Ávila
Claudia Castro Arreola

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1423049

681 views

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Articles

Paromomycin targets HDAC1-mediated SUMOylation and IGF1R translocation in glioblastoma

Clinical implications of a gain-of-function genetic polymorphism in DPYD (rs4294451) in colorectal cancer patients treated with fluoropyrimidines

AH-6809 mediated regulation of lung adenocarcinoma metastasis through NLRP7 and prognostic analysis of key metastasis-related genes

Pharmacogenomic profiling of the South Korean population: Insights and implications for personalized medicine

Advancements in precision medicine: multi-omics approach for tailored metformin treatment in type 2 diabetes

Comparing commercial pharmacogenetic testing results and recommendations for antidepressants with established CPIC guidelines

Metabolic pathways, genomic alterations, and post-translational modifications in pulmonary hypertension and cancer as therapeutic targets and biomarkers

Investigation on regulation of N-acetyltransferase 2 expression by nuclear receptors in human hepatocytes

Population pharmacokinetic study of the effect of polymorphisms in the ABCB1 and CES1 genes on the pharmacokinetics of dabigatran

Novel genomic variants influencing methotrexate delayed clearance in pediatric patients with acute lymphoblastic leukemia

Tumor microenvironment and cancer metastasis: molecular mechanisms and therapeutic implications

Multi-omics association study integrating GWAS and pQTL data revealed MIP-1α as a potential drug target for erectile dysfunction

Allele frequencies and genotype distribution of three metformin transporter polymorphisms in Mexican population and their application in pharmacogenomics of type 2 diabetes

The role of candidate pharmacogenetic variants in determining valproic acid efficacy, toxicity and concentrations in patients with epilepsy

A mathematical model of glomerular fibrosis in diabetic kidney disease to predict therapeutic efficacy

Impact of single-nucleotide variants and individual characteristics on adverse events of L-asparaginase in children with acute lymphoblastic leukemia