Frontiers in Pharmacology | Pharmacogenetics and Pharmacogenomics

Original Research

Published on 21 May 2021

Effects of Genetic Polymorphism in CYP2D6, CYP2C19, and the Organic Cation Transporter OCT1 on Amitriptyline Pharmacokinetics in Healthy Volunteers and Depressive Disorder Patients

in Pharmacogenetics and Pharmacogenomics

Johannes Matthaei
Jürgen Brockmöller
Werner Steimer
Konstanze Pischa
Stefan Leucht
Maria Kullmann
Ole Jensen
Typhaine Ouethy
Mladen Vassilev Tzvetkov
Muhammad Rafehi

Frontiers in Pharmacology

doi 10.3389/fphar.2021.688950

9,427 views
21 citations

Original Research

Published on 21 May 2021

MicroRNA-33b is a Potential Non-Invasive Biomarker for Response to Atorvastatin Treatment in Chilean Subjects With Hypercholesterolemia: A Pilot Study

in Pharmacogenetics and Pharmacogenomics

Carmen Gloria Ubilla
Yalena Prado
Jeremy Angulo
Ignacio Obreque
Isis Paez
Nicolás Saavedra
Kathleen Saavedra
Tomás Zambrano
Luis A. Salazar

Frontiers in Pharmacology

doi 10.3389/fphar.2021.674252

2,882 views
8 citations

Original Research

Published on 19 May 2021

Pharmacogenetic Associations Between Atazanavir/UGT1A1*28 and Efavirenz/rs3745274 (CYP2B6) Account for Specific Adverse Reactions in Chilean Patients Undergoing Antiretroviral Therapy

in Pharmacogenetics and Pharmacogenomics

Daniela Poblete
Fernando Bernal
Gabriel Llull
Sebastian Archiles
Patricia Vasquez
Leonardo Chanqueo
Nicole Soto
María A. Lavanderos
Luis A. Quiñones
Nelson M. Varela

Frontiers in Pharmacology

doi 10.3389/fphar.2021.660965

5,097 views
6 citations

Original Research

Published on 18 May 2021

Association Between Genetic Polymorphisms of Metabolic Enzymes and Azathioprine-Induced Myelosuppression in 1,419 Chinese Patients: A Retrospective Study

in Pharmacogenetics and Pharmacogenomics

Zhao-Yang Chen
Yang-Hui Zhu
Ling-Yan Zhou
Wei-Qiao Shi
Zhou Qin
Bin Wu
Yu Yan
Yu-Wen Pei
Ning-Ning Chao
Rui Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2021.672769

5,137 views
17 citations

Original Research

Published on 07 May 2021

CYP2D6 in the Brain: Potential Impact on Adverse Drug Reactions in the Central Nervous System—Results From the ADRED Study

in Pharmacogenetics and Pharmacogenomics

Katja S. Just
Harald Dormann
Mathias Freitag
Marlen Schurig
Miriam Böhme
Michael Steffens
Catharina Scholl
Thomas Seufferlein
Ingo Graeff
Matthias Schwab

Frontiers in Pharmacology

doi 10.3389/fphar.2021.624104

17,075 views
17 citations

Original Research

Published on 07 May 2021

Effects of a Common Eight Base Pairs Duplication at the Exon 7-Intron 7 Junction on Splicing, Expression, and Function of OCT1

in Pharmacogenetics and Pharmacogenomics

Sarah Römer
Marleen J. Meyer
Kathrin Klein
Lennart V. Schneider
Johannes Matthaei
Ana Tzvetkova
Joanna Łapczuk-Romańska
Jochen Gaedcke
Marek Droździk
Jürgen Brockmöller

Frontiers in Pharmacology

doi 10.3389/fphar.2021.661480

3,215 views
2 citations

Review

Published on 30 Apr 2021

Extracellular Vesicles: A Novel Tool Facilitating Personalized Medicine and Pharmacogenomics in Oncology

in Pharmacogenetics and Pharmacogenomics

Katja Goričar
Vita Dolžan
Metka Lenassi

Frontiers in Pharmacology

doi 10.3389/fphar.2021.671298

6,629 views
25 citations

Original Research

Published on 30 Apr 2021

Genetic Variants in Cytosolic Phospholipase A2 Associated With Nonsteroidal Anti-Inflammatory Drug–Induced Acute Urticaria/Angioedema

in Pharmacogenetics and Pharmacogenomics

Raquel Jurado-Escobar
Inmaculada Doña
José Triano-Cornejo
James R. Perkins
Natalia Pérez-Sánchez
Almudena Testera-Montes
Marina Labella
Joan Bartra
José J. Laguna
Miguel Estravís

Frontiers in Pharmacology

doi 10.3389/fphar.2021.667824

3,738 views
10 citations

Review

Published on 30 Apr 2021

Role of Pharmacogenetics in Adverse Drug Reactions: An Update towards Personalized Medicine

in Pharmacogenetics and Pharmacogenomics

Emanuele Micaglio
Emanuela T. Locati
Michelle M. Monasky
Federico Romani
Francesca Heilbron
Carlo Pappone

Frontiers in Pharmacology

doi 10.3389/fphar.2021.651720

28,441 views
41 citations

Original Research

Published on 29 Apr 2021

Analysis of Genetic and Non-genetic Predictors of Levodopa Induced Dyskinesia in Parkinson’s Disease

in Pharmacogenetics and Pharmacogenomics

Alfonsina Tirozzi
Nicola Modugno
Nicole Piera Palomba
Rosangela Ferese
Alessia Lombardi
Enrica Olivola
Alessandro Gialluisi
Teresa Esposito

Frontiers in Pharmacology

doi 10.3389/fphar.2021.640603

4,070 views
14 citations

Original Research

Published on 29 Apr 2021

Dexketoprofen Pharmacokinetics is not Significantly Altered by Genetic Polymorphism

in Pharmacogenetics and Pharmacogenomics

Gina Mejía-Abril
Pablo Zubiaur
Marcos Navares-Gómez
Gonzalo Villapalos-García
Manuel Román
Dolores Ochoa
Francisco Abad-Santos

Frontiers in Pharmacology

doi 10.3389/fphar.2021.660639

5,104 views
4 citations

Original Research

Published on 28 Apr 2021

The Extent and Impact of Variation in ADME Genes in Sub-Saharan African Populations

in Pharmacogenetics and Pharmacogenomics

Jorge E. B. da Rocha
Houcemeddine Othman
Gerrit Botha
Laura Cottino
David Twesigomwe
Samah Ahmed
Britt I. Drögemöller
Faisal M. Fadlelmola
Philip Machanick
Mamana Mbiyavanga

Frontiers in Pharmacology

doi 10.3389/fphar.2021.634016

13,797 views
23 citations

Review

Published on 26 Apr 2021

Current Pharmacogenetic Perspective on Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis

in Pharmacogenetics and Pharmacogenomics

Lin Cheng

Frontiers in Pharmacology

doi 10.3389/fphar.2021.588063

26,604 views
29 citations

Original Research

Published on 22 Apr 2021

Robust Performance of Potentially Functional SNPs in Machine Learning Models for the Prediction of Atorvastatin-Induced Myalgia

in Pharmacogenetics and Pharmacogenomics

Brandon N. S. Ooi
Raechell
Ariel F. Ying
Yong Zher Koh
Yu Jin
Sherman W. L. Yee
Justin H. S. Lee
Samuel S. Chong
Jack W. C. Tan
Jianjun Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2021.605764

4,207 views
9 citations

Original Research

Published on 22 Apr 2021

CYP3A5 and UGT1A9 Polymorphisms Influence Immunosuppressive Therapy in Pediatric Kidney Transplant Recipients

in Pharmacogenetics and Pharmacogenomics

Paola Krall
Dominique Yañez
Angélica Rojo
Ángela Delucchi
Miguel Córdova
Jorge Morales
Pía Boza
Alonso de la Rivera
Natalie Espinoza
Natalia Armijo

Frontiers in Pharmacology

doi 10.3389/fphar.2021.653525

5,920 views
12 citations

Perspective

Published on 22 Apr 2021

CYP2D6 Reduced Function Variants and Genotype/Phenotype Translations of CYP2D6 Intermediate Metabolizers: Implications for Personalized Drug Dosing in Psychiatry

in Pharmacogenetics and Pharmacogenomics

Espen Molden
Marin M. Jukić

Frontiers in Pharmacology

doi 10.3389/fphar.2021.650750

18,684 views
25 citations