Frontiers in Pharmacology | Pharmacogenetics and Pharmacogenomics

Original Research

Published on 13 Jun 2025

Hsa_circ_0002238 promotes the malignant behavior of colorectal cancer

in Pharmacogenetics and Pharmacogenomics

Lin-Ting Zhang
Yuejia Zhou
Tiantian Wang
Boran Chen
Zhigao Cai
Shubin Wang
Gangling Tong

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1541820

1,747 views
1 citation

Original Research

Published on 04 Jun 2025

Genetic polymorphisms as predictors of the response of hepatocellular carcinoma patients to doxorubicin chemotherapy: a genome-wide association study

in Pharmacogenetics and Pharmacogenomics

Sireen Abdul Rahim Shilbayeh
Naglaa F. Khedr
Mohammad A. Alshabeeb
Abdulmonem Ali Alsaleh
Abdalrhman Hamdan Alanizi
Omnia A. Abd El-Baset
Rehab H. Werida

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1604473

2,949 views
1 citation

Original Research

Published on 03 Jun 2025

Exosomal miR-24-3p mediates myoblast-macrophage crosstalk to promote abdominal muscle repair

in Pharmacogenetics and Pharmacogenomics

Yuchen Liu
Zhenyu Zou
Jinxin Cao
Tong Zhu
Yilin Zhu
Yingmo Shen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1604776

1,878 views

Brief Research Report

Published on 23 May 2025

Dynamic star allele definitions in Pharmacogenomics: impact on diplotype calls, Phenotype predictions and statin therapy recommendations

in Pharmacogenetics and Pharmacogenomics

Sven van der Maas
Simon Denil
Brigitte Maes
Gökhan Ertaylan
Pieter-Jan Volders

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1584658

2,449 views
2 citations

Brief Research Report

Published on 22 May 2025

Implementation and integration of a multidisciplinary pharmacogenomics service in an underserved integrated behavioral health clinic

in Pharmacogenetics and Pharmacogenomics

Bader M. Alghamdi
Sara Rogers
Susan Roberman
Meredith Williamson
Ladan Panahi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1594032

2,350 views
1 citation

Original Research

Published on 22 May 2025

Biological and prognostic insights into the prostaglandin D2 signaling axis in lung adenocarcinoma

in Pharmacogenetics and Pharmacogenomics

Qiang Liu
Huiguo Chen
Dongfang Tang
Huibiao Zhang
Shaogeng Chen
Yiran Meng
Boying Zheng
Fei Liu
Jing Zhou
Wen Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1562261

5,049 views
1 citation

Case Report

Published on 21 May 2025

The role of endoplasmic reticulum aminopeptidase ERAP2 pathogenic mutation rs1363907 in amoxicillin clavulanate-induced liver injury: a special case report

in Pharmacogenetics and Pharmacogenomics

Yan Zhan
Jin-Mao Liao
Ling Ye
Long Zhang
Zheng Zhang
Ji-Ye Yin

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1564124

1,917 views
2 citations

Original Research

Published on 20 May 2025

ARID1A deficiency attenuates the response to EGFR-TKI treatment in lung adenocarcinoma

in Pharmacogenetics and Pharmacogenomics

Fangfang Yang
Helei Hou
Guanqun Wang
Guangming Fu
Xingfa Huo
Xueqin Duan
Na Zhou
Xiaochun Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1582005

2,414 views
1 citation

Original Research

Published on 13 May 2025

Impact of CYP3A5 1* and 3* single nucleotide variants on tacrolimus pharmacokinetics and graft rejection risk in pediatric kidney transplant patients

in Pharmacogenetics and Pharmacogenomics

Lesly Yanira Xajil-Ramos
Jesús Alonso Gándara-Mireles
Rodrigo José Vargas Rosales
Oscar Kevin Sánchez García
Andrea Mariela Ruano Toledo
Amy Kateleen Aldana de la Cruz
Ismael Lares-Asseff
Leslie Patrón-Romero
Horacio Almanza-Reyes
Randall Lou-Meda

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1592134

3,768 views
4 citations

Case Report

Published on 13 May 2025

Primary hyperoxaluria type I diagnosed after a kidney transplant presenting with subcutaneous calcification: a case report of sodium thiosulfate treatment

in Pharmacogenetics and Pharmacogenomics

Min Wu
Jing Lu
Yu-Jia Wang
Yong-Qi Li
Qing Wei
Yu-Xiang Gong
Ri-Ning Tang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1485024

1,943 views

Original Research

Published on 01 May 2025

Unveiling the heritability of selected unexplored pharmacogenetic markers in the Saudi population

in Pharmacogenetics and Pharmacogenomics

Mohammad A. Alshabeeb
Deemah Alwadaani
Sireen A. R. Shilbayeh
Fatemah A. Alherz
Ali Alghubayshi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1559399

3,462 views

Original Research

Published on 30 Apr 2025

The impact of CYP2C9, VKORC1, and CYP4F2 polymorphisms on warfarin dose requirement in Saudi patients

in Pharmacogenetics and Pharmacogenomics

Salha Jokhab
Maha M. AlRasheed
Dana Bakheet
Abdulkareem AlMomen
Nouf AlAboud
Farhad Kamali

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1547142

2,709 views
2 citations

Review

Published on 28 Apr 2025

Research progress on m6A and drug resistance in gastrointestinal tumors

in Pharmacogenetics and Pharmacogenomics

Ziyi Xu
Bo Sun
Weizheng Wang
Yitao Fan
Jingxiang Su
Jiachun Sun
Xinyu Gu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1565738

2,563 views
3 citations

Original Research

Published on 28 Apr 2025

Genetic polymorphisms in SLC5A2 are associated with clinical outcomes and dapagliflozin response in heart failure patients

in Pharmacogenetics and Pharmacogenomics

Ahmed Essam Abou Warda
Rylie M. Flohr
Rania M. Sarhan
Mohamed Nabil Salem
Heba F. Salem
Ayman N. Moharram
Abdullah S. Alanazi
Christelle Lteif
Brian E. Gawronski
Leanne Dumeny

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1539870

3,845 views
2 citations

Original Research

Published on 14 Apr 2025

Global analysis of actionable genomic alterations in thyroid cancer and precision-based pharmacogenomic strategies

in Pharmacogenetics and Pharmacogenomics

Samantha Espinoza-Ferrao
Gabriela Echeverría-Garcés
Sebastián Rivera-Orellana
José Bueno-Miño
Emilia Castellanos-Molina
Melanie Benítez-Núñez
Andrés López-Cortés

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1524623

3,552 views

Methods

Published on 11 Apr 2025

Bioinformatic challenges for pharmacogenomic study: tools for genomic data analysis

in Pharmacogenetics and Pharmacogenomics

Mariamena Arbitrio
Marianna Milano
Maria Lucibello
Emanuela Altomare
Nicoletta Staropoli
Pierfrancesco Tassone
Pierosandro Tagliaferri
Mario Cannataro
Giuseppe Agapito

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1548991

4,037 views
1 citation

Original Research

Published on 07 Apr 2025

Evaluating the role of astragalus polysaccharide in modulating immune infiltration and enhancing prognostic biomarkers in pediatric acute myeloid leukemia

in Pharmacogenetics and Pharmacogenomics

Min-Hui He
Xian-Hui Zhang
Ji-Hong Zhang
Jie Pan
Chao Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1538888

2,088 views
2 citations

Original Research

Published on 01 Apr 2025

Pharmacogenetics polygenic response score predicts outcomes in aspirin-treated stroke patients

in Pharmacogenetics and Pharmacogenomics

Rui-Nan Ma
Dong Zhang
Zhi-Zhang Li
Ying Ding
Xiao-Guang Zhang
Jie Xue
Dan-Zhuoma Ci
Yue-Ying Bai
Liang Hu
Dai-Zhan Zhou

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1519383

2,137 views

Correction

Published on 31 Mar 2025

Corrigendum: A pharmacogenetically-guided acenocoumarol dosing algorithm for Chilean patients: a discovery cohort study

in Pharmacogenetics and Pharmacogenomics

Angela Roco
Elena Nieto
Marcelo Suárez
Mario Rojo
Maria Paz Bertoglia
Gabriel Verón
Francisca Tamayo
Annabella Arredondo
Daniela Cruz
Jessica Muñoz

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1588440

937 views
1 citation

Brief Research Report

Published on 28 Mar 2025

Balance of care activity after EMA recommendation for DPYD gene testing in Galicia

in Pharmacogenetics and Pharmacogenomics

Almudena Gil-Rodríguez
Sheila Recarey-Rama
Ana Rodríguez-Viyuela
Francisco Barros
Angel Carracedo
Olalla Maroñas

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1523536

2,306 views
3 citations

Editorial

Published on 26 Mar 2025

Editorial: State‐of‐the‐art hypothesis-driven systems pharmacology and artificial intelligence approaches to decipher disease complexity

in Pharmacogenetics and Pharmacogenomics

Cristina Correia
Choong-Yong Ung
Hu Li
James C. Costello

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1593164

1,651 views

Correction

Published on 26 Mar 2025

Corrigendum: Exploring perceived barriers and attitudes in young adults towards antidepressant pharmacotherapy, including the implementation of pharmacogenetic testing to optimize prescription practices

in Pharmacogenetics and Pharmacogenomics

Bradley Roberts
Zahra Cooper
Georgia Landery
Susanne Stanley
Bernadette T. Majda
Khan R. L. Collins
P. Anthony Akkari
Sean D. Hood
Jennifer Rodger

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1590955

1,015 views

Original Research

Published on 25 Mar 2025

Multigenetic pharmacogenomics–guided treatment shows greater improvements on motor symptoms compared to usual therapy in Parkinson’s disease: a small real-word prospective cohort study

in Pharmacogenetics and Pharmacogenomics

Yifan Li
Mao Li
Miao Wang
Jiarui Yao
Fengzhu Li
Siyu Chen
Xi Yin
Zhongbao Gao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1502379

1,996 views
1 citation

Review

Published on 20 Mar 2025

Deciphering gene mutations in the efficacy and toxicity of antineoplastic drugs: an oncology pharmacist’s perspective

in Pharmacogenetics and Pharmacogenomics

Yucai Jiang
Guolin Alexander Wen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1574010

2,413 views

643 articles

articles

Hsa_circ_0002238 promotes the malignant behavior of colorectal cancer

Genetic polymorphisms as predictors of the response of hepatocellular carcinoma patients to doxorubicin chemotherapy: a genome-wide association study

Exosomal miR-24-3p mediates myoblast-macrophage crosstalk to promote abdominal muscle repair

Dynamic star allele definitions in Pharmacogenomics: impact on diplotype calls, Phenotype predictions and statin therapy recommendations

Implementation and integration of a multidisciplinary pharmacogenomics service in an underserved integrated behavioral health clinic

Biological and prognostic insights into the prostaglandin D2 signaling axis in lung adenocarcinoma

The role of endoplasmic reticulum aminopeptidase ERAP2 pathogenic mutation rs1363907 in amoxicillin clavulanate-induced liver injury: a special case report

ARID1A deficiency attenuates the response to EGFR-TKI treatment in lung adenocarcinoma

Impact of CYP3A5 1* and 3* single nucleotide variants on tacrolimus pharmacokinetics and graft rejection risk in pediatric kidney transplant patients

Primary hyperoxaluria type I diagnosed after a kidney transplant presenting with subcutaneous calcification: a case report of sodium thiosulfate treatment

Unveiling the heritability of selected unexplored pharmacogenetic markers in the Saudi population

The impact of CYP2C9, VKORC1, and CYP4F2 polymorphisms on warfarin dose requirement in Saudi patients

Research progress on m6A and drug resistance in gastrointestinal tumors

Genetic polymorphisms in SLC5A2 are associated with clinical outcomes and dapagliflozin response in heart failure patients

Global analysis of actionable genomic alterations in thyroid cancer and precision-based pharmacogenomic strategies

Bioinformatic challenges for pharmacogenomic study: tools for genomic data analysis

Evaluating the role of astragalus polysaccharide in modulating immune infiltration and enhancing prognostic biomarkers in pediatric acute myeloid leukemia

Pharmacogenetics polygenic response score predicts outcomes in aspirin-treated stroke patients

Corrigendum: A pharmacogenetically-guided acenocoumarol dosing algorithm for Chilean patients: a discovery cohort study

Balance of care activity after EMA recommendation for DPYD gene testing in Galicia

Editorial: State‐of‐the‐art hypothesis-driven systems pharmacology and artificial intelligence approaches to decipher disease complexity

Corrigendum: Exploring perceived barriers and attitudes in young adults towards antidepressant pharmacotherapy, including the implementation of pharmacogenetic testing to optimize prescription practices

Multigenetic pharmacogenomics–guided treatment shows greater improvements on motor symptoms compared to usual therapy in Parkinson’s disease: a small real-word prospective cohort study

Deciphering gene mutations in the efficacy and toxicity of antineoplastic drugs: an oncology pharmacist’s perspective