Frontiers in Pharmacology | Pharmacogenetics and Pharmacogenomics

Original Research

Published on 03 Feb 2017

Endogenous Protein Interactome of Human UDP-Glucuronosyltransferases Exposed by Untargeted Proteomics

in Pharmacogenetics and Pharmacogenomics

Michèle Rouleau
Yannick Audet-Delage
Sylvie Desjardins
Mélanie Rouleau
Camille Girard-Bock
Chantal Guillemette

Frontiers in Pharmacology

doi 10.3389/fphar.2017.00023

5,360 views
13 citations

Review

Published on 30 Jan 2017

Physical Studies of P450–P450 Interactions: Predicting Quaternary Structures of P450 Complexes in Membranes from Their X-ray Crystal Structures

in Pharmacogenetics and Pharmacogenomics

James R. Reed
Wayne L. Backes

Frontiers in Pharmacology

doi 10.3389/fphar.2017.00028

6,800 views
30 citations

Original Research

Published on 04 Jan 2017

Genetic Variation in the Histamine Production, Response, and Degradation Pathway Is Associated with Histamine Pharmacodynamic Response in Children with Asthma

in Pharmacogenetics and Pharmacogenomics

Bridgette L. Jones
Catherine M. T. Sherwin
Xiaoxi Liu
Hongying Dai
Carrie A. Vyhlidal

Frontiers in Pharmacology

doi 10.3389/fphar.2016.00524

5,812 views
3 citations

Original Research

Published on 23 Dec 2016

A Novel Sensitive Method to Measure Catechol-O-Methyltransferase Activity Unravels the Presence of This Activity in Extracellular Vesicles Released by Rat Hepatocytes

in Pharmacogenetics and Pharmacogenomics

Enriqueta Casal
Laura Palomo
Diana Cabrera
Juan M. Falcon-Perez

Frontiers in Pharmacology

doi 10.3389/fphar.2016.00501

5,859 views
8 citations

Case Report

Published on 19 Dec 2016

Rivaroxaban-Induced Hemorrhage Associated with ABCB1 Genetic Defect

in Pharmacogenetics and Pharmacogenomics

Kuntheavy Ing Lorenzini
Youssef Daali
Pierre Fontana
Jules Desmeules
Caroline Samer

Frontiers in Pharmacology

doi 10.3389/fphar.2016.00494

7,707 views
54 citations

Original Research

Published on 02 Dec 2016

Pharmacogenomic Study Reveals New Variants of Drug Metabolizing Enzyme and Transporter Genes Associated with Steady-State Plasma Concentrations of Risperidone and 9-Hydroxyrisperidone in Thai Autism Spectrum Disorder Patients

in Pharmacogenetics and Pharmacogenomics

Sadeep Medhasi
Darawan Pinthong
Ekawat Pasomsub
Natchaya Vanwong
Nattawat Ngamsamut
Apichaya Puangpetch
Monpat Chamnanphon
Yaowaluck Hongkaew
Jirawat Pratoomwun
Penkhae Limsila

Frontiers in Pharmacology

doi 10.3389/fphar.2016.00475

5,219 views
18 citations

Review

Published on 01 Dec 2016

Cysteinyl Leukotrienes Pathway Genes, Atopic Asthma and Drug Response: From Population Isolates to Large Genome-Wide Association Studies

in Pharmacogenetics and Pharmacogenomics

Miles D. Thompson
Valerie Capra
Mark T. Clunes
G. E. Rovati
Jana Stankova
Mary C. Maj
David L. Duffy

Frontiers in Pharmacology

doi 10.3389/fphar.2016.00299

9,732 views
32 citations

Review

Published on 25 Nov 2016

Pregnane X Receptor (PXR)-Mediated Gene Repression and Cross-Talk of PXR with Other Nuclear Receptors via Coactivator Interactions

in Pharmacogenetics and Pharmacogenomics

Petr Pavek

Frontiers in Pharmacology

doi 10.3389/fphar.2016.00456

35,810 views
127 citations

Original Research

Published on 24 Nov 2016

Impact of CYP2C19 Variants on Clinical Efficacy of Clopidogrel and 1-Year Clinical Outcomes in Coronary Heart Patients Undergoing Percutaneous Coronary Intervention

in Pharmacogenetics and Pharmacogenomics

Hong Sun
Qiang Qu
Zhen-Fan Chen
Sheng-Lan Tan
Hai-Jun Zhou
Jian Qu
Hui Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2016.00453

4,756 views
17 citations

Original Research

Published on 16 Nov 2016

Age-Dependent Hepatic UDP-Glucuronosyltransferase Gene Expression and Activity in Children

in Pharmacogenetics and Pharmacogenomics

Elizabeth Neumann
Huma Mehboob
Jacqueline Ramírez
Snezana Mirkov
Min Zhang
Wanqing Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2016.00437

8,349 views
39 citations

Original Research

Published on 14 Nov 2016

Introduction of an N-Glycosylation Site into UDP-Glucuronosyltransferase 2B3 Alters Its Sensitivity to Cytochrome P450 3A1-Dependent Modulation

in Pharmacogenetics and Pharmacogenomics

Tatsuro Nakamura
Naho Yamaguchi
Yuu Miyauchi
Tomoki Takeda
Yasushi Yamazoe
Kiyoshi Nagata
Peter I. Mackenzie
Hideyuki Yamada
Yuji Ishii

Frontiers in Pharmacology

doi 10.3389/fphar.2016.00427

3,868 views
12 citations

Perspective

Published on 27 Oct 2016

Pharmacometabolomics Informs Viromics toward Precision Medicine

in Pharmacogenetics and Pharmacogenomics

Angeliki Balasopoulou
George P. Patrinos
Theodora Katsila

Frontiers in Pharmacology

doi 10.3389/fphar.2016.00411

3,921 views
15 citations

Review

Published on 24 Oct 2016

Structure and Protein–Protein Interactions of Human UDP-Glucuronosyltransferases

in Pharmacogenetics and Pharmacogenomics

Ryoichi Fujiwara
Tsuyoshi Yokoi
Miki Nakajima

Frontiers in Pharmacology

doi 10.3389/fphar.2016.00388

13,034 views
57 citations

Review

Published on 21 Oct 2016

Pharmacogenetics and Predictive Testing of Drug Hypersensitivity Reactions

in Pharmacogenetics and Pharmacogenomics

Ruwen Böhm
Ingolf Cascorbi

Frontiers in Pharmacology

doi 10.3389/fphar.2016.00396

12,703 views
31 citations

Original Research

Published on 29 Sep 2016

FCERI and Histamine Metabolism Gene Variability in Selective Responders to NSAIDS

in Pharmacogenetics and Pharmacogenomics

Gemma Amo
José A. Cornejo-García
Jesus M. García-Menaya
Concepcion Cordobes
M. J. Torres
Gara Esguevillas
Cristobalina Mayorga
Carmen Martinez
Natalia Blanca-Lopez
Gabriela Canto

Frontiers in Pharmacology

doi 10.3389/fphar.2016.00353

7,400 views
24 citations

Mini Review

Published on 21 Sep 2016

Pharmacogenomics of Prostaglandin and Leukotriene Receptors

in Pharmacogenetics and Pharmacogenomics

José A. Cornejo-García
James R. Perkins
Raquel Jurado-Escobar
Elena García-Martín
José A. Agúndez
Enrique Viguera
Natalia Pérez-Sánchez
Natalia Blanca-López

Frontiers in Pharmacology

doi 10.3389/fphar.2016.00316

9,909 views
39 citations

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Articles

Endogenous Protein Interactome of Human UDP-Glucuronosyltransferases Exposed by Untargeted Proteomics

Physical Studies of P450–P450 Interactions: Predicting Quaternary Structures of P450 Complexes in Membranes from Their X-ray Crystal Structures

Genetic Variation in the Histamine Production, Response, and Degradation Pathway Is Associated with Histamine Pharmacodynamic Response in Children with Asthma

A Novel Sensitive Method to Measure Catechol-O-Methyltransferase Activity Unravels the Presence of This Activity in Extracellular Vesicles Released by Rat Hepatocytes

Rivaroxaban-Induced Hemorrhage Associated with ABCB1 Genetic Defect

Pharmacogenomic Study Reveals New Variants of Drug Metabolizing Enzyme and Transporter Genes Associated with Steady-State Plasma Concentrations of Risperidone and 9-Hydroxyrisperidone in Thai Autism Spectrum Disorder Patients

Cysteinyl Leukotrienes Pathway Genes, Atopic Asthma and Drug Response: From Population Isolates to Large Genome-Wide Association Studies

Pregnane X Receptor (PXR)-Mediated Gene Repression and Cross-Talk of PXR with Other Nuclear Receptors via Coactivator Interactions

Impact of CYP2C19 Variants on Clinical Efficacy of Clopidogrel and 1-Year Clinical Outcomes in Coronary Heart Patients Undergoing Percutaneous Coronary Intervention

Age-Dependent Hepatic UDP-Glucuronosyltransferase Gene Expression and Activity in Children

Introduction of an N-Glycosylation Site into UDP-Glucuronosyltransferase 2B3 Alters Its Sensitivity to Cytochrome P450 3A1-Dependent Modulation

Pharmacometabolomics Informs Viromics toward Precision Medicine

Structure and Protein–Protein Interactions of Human UDP-Glucuronosyltransferases

Pharmacogenetics and Predictive Testing of Drug Hypersensitivity Reactions

FCERI and Histamine Metabolism Gene Variability in Selective Responders to NSAIDS

Pharmacogenomics of Prostaglandin and Leukotriene Receptors