Frontiers in Pharmacology | Pharmacogenetics and Pharmacogenomics

Original Research

Published on 30 Apr 2025

The impact of CYP2C9, VKORC1, and CYP4F2 polymorphisms on warfarin dose requirement in Saudi patients

in Pharmacogenetics and Pharmacogenomics

Salha Jokhab
Maha M. AlRasheed
Dana Bakheet
Abdulkareem AlMomen
Nouf AlAboud
Farhad Kamali

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1547142

3,282 views
4 citations

Review

Published on 28 Apr 2025

Research progress on m6A and drug resistance in gastrointestinal tumors

in Pharmacogenetics and Pharmacogenomics

Ziyi Xu
Bo Sun
Weizheng Wang
Yitao Fan
Jingxiang Su
Jiachun Sun
Xinyu Gu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1565738

2,838 views
4 citations

Original Research

Published on 28 Apr 2025

Genetic polymorphisms in SLC5A2 are associated with clinical outcomes and dapagliflozin response in heart failure patients

in Pharmacogenetics and Pharmacogenomics

Ahmed Essam Abou Warda
Rylie M. Flohr
Rania M. Sarhan
Mohamed Nabil Salem
Heba F. Salem
Ayman N. Moharram
Abdullah S. Alanazi
Christelle Lteif
Brian E. Gawronski
Leanne Dumeny

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1539870

4,268 views
3 citations

Original Research

Published on 14 Apr 2025

Global analysis of actionable genomic alterations in thyroid cancer and precision-based pharmacogenomic strategies

in Pharmacogenetics and Pharmacogenomics

Samantha Espinoza-Ferrao
Gabriela Echeverría-Garcés
Sebastián Rivera-Orellana
José Bueno-Miño
Emilia Castellanos-Molina
Melanie Benítez-Núñez
Andrés López-Cortés

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1524623

3,848 views

Methods

Published on 11 Apr 2025

Bioinformatic challenges for pharmacogenomic study: tools for genomic data analysis

in Pharmacogenetics and Pharmacogenomics

Mariamena Arbitrio
Marianna Milano
Maria Lucibello
Emanuela Altomare
Nicoletta Staropoli
Pierfrancesco Tassone
Pierosandro Tagliaferri
Mario Cannataro
Giuseppe Agapito

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1548991

4,411 views
1 citation

Original Research

Published on 07 Apr 2025

Evaluating the role of astragalus polysaccharide in modulating immune infiltration and enhancing prognostic biomarkers in pediatric acute myeloid leukemia

in Pharmacogenetics and Pharmacogenomics

Min-Hui He
Xian-Hui Zhang
Ji-Hong Zhang
Jie Pan
Chao Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1538888

2,320 views
2 citations

Original Research

Published on 01 Apr 2025

Pharmacogenetics polygenic response score predicts outcomes in aspirin-treated stroke patients

in Pharmacogenetics and Pharmacogenomics

Rui-Nan Ma
Dong Zhang
Zhi-Zhang Li
Ying Ding
Xiao-Guang Zhang
Jie Xue
Dan-Zhuoma Ci
Yue-Ying Bai
Liang Hu
Dai-Zhan Zhou

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1519383

2,447 views

Correction

Published on 31 Mar 2025

Corrigendum: A pharmacogenetically-guided acenocoumarol dosing algorithm for Chilean patients: a discovery cohort study

in Pharmacogenetics and Pharmacogenomics

Angela Roco
Elena Nieto
Marcelo Suárez
Mario Rojo
Maria Paz Bertoglia
Gabriel Verón
Francisca Tamayo
Annabella Arredondo
Daniela Cruz
Jessica Muñoz

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1588440

1,038 views
1 citation

Brief Research Report

Published on 28 Mar 2025

Balance of care activity after EMA recommendation for DPYD gene testing in Galicia

in Pharmacogenetics and Pharmacogenomics

Almudena Gil-Rodríguez
Sheila Recarey-Rama
Ana Rodríguez-Viyuela
Francisco Barros
Angel Carracedo
Olalla Maroñas

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1523536

2,581 views
3 citations

Editorial

Published on 26 Mar 2025

Editorial: State‐of‐the‐art hypothesis-driven systems pharmacology and artificial intelligence approaches to decipher disease complexity

in Pharmacogenetics and Pharmacogenomics

Cristina Correia
Choong-Yong Ung
Hu Li
James C. Costello

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1593164

1,844 views

Correction

Published on 26 Mar 2025

Corrigendum: Exploring perceived barriers and attitudes in young adults towards antidepressant pharmacotherapy, including the implementation of pharmacogenetic testing to optimize prescription practices

in Pharmacogenetics and Pharmacogenomics

Bradley Roberts
Zahra Cooper
Georgia Landery
Susanne Stanley
Bernadette T. Majda
Khan R. L. Collins
P. Anthony Akkari
Sean D. Hood
Jennifer Rodger

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1590955

1,110 views

Original Research

Published on 25 Mar 2025

Multigenetic pharmacogenomics–guided treatment shows greater improvements on motor symptoms compared to usual therapy in Parkinson’s disease: a small real-word prospective cohort study

in Pharmacogenetics and Pharmacogenomics

Yifan Li
Mao Li
Miao Wang
Jiarui Yao
Fengzhu Li
Siyu Chen
Xi Yin
Zhongbao Gao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1502379

2,211 views
1 citation

Review

Published on 20 Mar 2025

Deciphering gene mutations in the efficacy and toxicity of antineoplastic drugs: an oncology pharmacist’s perspective

in Pharmacogenetics and Pharmacogenomics

Yucai Jiang
Guolin Alexander Wen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1574010

2,753 views

Original Research

Published on 19 Mar 2025

Impact of CYP3A4 and ABCB1 genetic variants on tacrolimus dosing in Greek kidney transplant recipients

in Pharmacogenetics and Pharmacogenomics

Anna Tsironi
Konstantinos Lazaros
Effrosyni Mendrinou
Marios Papasotiriou
Stavroula Siamoglou
Kyriaki Kydonopoulou
Anne John
Alexandra Gerou
Spyridon Gerou
Bassam R. Ali

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1538432

2,886 views
2 citations

Editorial

Published on 17 Mar 2025

Editorial: Multi-omics technology: revealing the pathogenesis of diseases and the mechanism of drug efficacy of major diseases such as nutritional metabolism disorders and mental disorders

in Pharmacogenetics and Pharmacogenomics

Wenzhi Hao
Tianhao Liu
Xiliang Du
Gabriel Tao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1586223

1,272 views

Original Research

Published on 17 Mar 2025

Comprehensive pharmacogenomics profiling of the Serbian population

in Pharmacogenetics and Pharmacogenomics

Marina Jelovac
Djordje Pavlovic
Biljana Stankovic
Nikola Kotur
Bojan Ristivojevic
Sonja Pavlovic
Branka Zukic

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1553536

2,459 views
1 citation

Brief Research Report

Published on 11 Mar 2025

Effect of CYP3A5 genotypes on pharmacokinetic of tacrolimus in colombian liver transplant patients

in Pharmacogenetics and Pharmacogenomics

Erica Fernanda Lindarte
Gonzalo De Jesus Vasquez
Luis Guillermo Toro Rendón
Andrés Felipe Zuluaga Salazar
Jefferson Antonio Buendia

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1505490

1,753 views

Original Research

Published on 05 Mar 2025

Allele and genotype frequencies of variants in P450 cytochromes, transports, and DNA repair enzymes in the Dominican Republic population

in Pharmacogenetics and Pharmacogenomics

Elizabeth Pérez-Duval
Berniza Calderón
Marlen Izquierdo
José A. Herrera-Isidrón
Elizabeth Reyes-Reyes
Alejandro Herrera
Manuel Soto
Alba Beltré
Idania Rodeiro-Guerra

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1494482

2,677 views
1 citation

Review

Published on 03 Mar 2025

Genome-wide functional annotation of variants: a systematic review of state-of-the-art tools, techniques and resources

in Pharmacogenetics and Pharmacogenomics

Eleftherios Pilalis
Dimitrios Zisis
Christina Andrinopoulou
Theodora Karamanidou
Maria Antonara
Thanos G. Stavropoulos
Aristotelis Chatziioannou

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1474026

8,593 views
7 citations

Mini Review

Published on 27 Feb 2025

Precision medicine in colorectal cancer: genomics profiling and targeted treatment

in Pharmacogenetics and Pharmacogenomics

Adi Muradi Muhar
Adrian Joshua Velaro
Arya Tjipta Prananda
Sony Eka Nugraha
Princella Halim
Rony Abdi Syahputra

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1532971

4,505 views
6 citations

Original Research

Published on 21 Feb 2025

The CYP2D6 phenotyping performance of single-point saliva metabolic ratio in a healthy Chinese Han population

in Pharmacogenetics and Pharmacogenomics

Yongfa Huang
Zhangyuting He
Xiaoduo Guan
Pei Hu
Rui Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1438760

1,655 views

Mini Review

Published on 12 Feb 2025

Association between CYP2C19 polymorphism and proton pump inhibitors adverse drug reactions: a narrative review

in Pharmacogenetics and Pharmacogenomics

Asmaa Ibrahim
Kazeem Yusuff
Ahmed Awaisu
Hazem Elewa

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1523399

4,393 views
4 citations

Original Research

Published on 03 Feb 2025

Leveraging AI to automate detection and quantification of extrachromosomal DNA to decode drug responses

in Pharmacogenetics and Pharmacogenomics

Kohen Goble
Aarav Mehta
Damien Guilbaud
Jacob Fessler
Jingting Chen
William Nenad
Christina G. Ford
Oliver Cope
Darby Cheng
William Dennis

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1516621

3,766 views
5 citations

Original Research

Published on 30 Jan 2025

Deciphering the heterogeneity and plasticity of the tumor microenvironment in liver cancer provides insights for prognosis

in Pharmacogenetics and Pharmacogenomics

Yihao Sun
Guojuan Shi
Jian Yang
Chun-Zhong Zhou
Chuhan Peng
Yu-Hong Luo
Ying Pan
Rui-Qi Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1495280

2,859 views

656 articles

articles

The impact of CYP2C9, VKORC1, and CYP4F2 polymorphisms on warfarin dose requirement in Saudi patients

Research progress on m6A and drug resistance in gastrointestinal tumors

Genetic polymorphisms in SLC5A2 are associated with clinical outcomes and dapagliflozin response in heart failure patients

Global analysis of actionable genomic alterations in thyroid cancer and precision-based pharmacogenomic strategies

Bioinformatic challenges for pharmacogenomic study: tools for genomic data analysis

Evaluating the role of astragalus polysaccharide in modulating immune infiltration and enhancing prognostic biomarkers in pediatric acute myeloid leukemia

Pharmacogenetics polygenic response score predicts outcomes in aspirin-treated stroke patients

Corrigendum: A pharmacogenetically-guided acenocoumarol dosing algorithm for Chilean patients: a discovery cohort study

Balance of care activity after EMA recommendation for DPYD gene testing in Galicia

Editorial: State‐of‐the‐art hypothesis-driven systems pharmacology and artificial intelligence approaches to decipher disease complexity

Corrigendum: Exploring perceived barriers and attitudes in young adults towards antidepressant pharmacotherapy, including the implementation of pharmacogenetic testing to optimize prescription practices

Multigenetic pharmacogenomics–guided treatment shows greater improvements on motor symptoms compared to usual therapy in Parkinson’s disease: a small real-word prospective cohort study

Deciphering gene mutations in the efficacy and toxicity of antineoplastic drugs: an oncology pharmacist’s perspective

Impact of CYP3A4 and ABCB1 genetic variants on tacrolimus dosing in Greek kidney transplant recipients

Editorial: Multi-omics technology: revealing the pathogenesis of diseases and the mechanism of drug efficacy of major diseases such as nutritional metabolism disorders and mental disorders

Comprehensive pharmacogenomics profiling of the Serbian population

Effect of CYP3A5 genotypes on pharmacokinetic of tacrolimus in colombian liver transplant patients

Allele and genotype frequencies of variants in P450 cytochromes, transports, and DNA repair enzymes in the Dominican Republic population

Genome-wide functional annotation of variants: a systematic review of state-of-the-art tools, techniques and resources

Precision medicine in colorectal cancer: genomics profiling and targeted treatment

The CYP2D6 phenotyping performance of single-point saliva metabolic ratio in a healthy Chinese Han population

Association between CYP2C19 polymorphism and proton pump inhibitors adverse drug reactions: a narrative review

Leveraging AI to automate detection and quantification of extrachromosomal DNA to decode drug responses

Deciphering the heterogeneity and plasticity of the tumor microenvironment in liver cancer provides insights for prognosis