Frontiers in Pharmacology | Pharmacogenetics and Pharmacogenomics

Review

Published on 28 Nov 2024

Advancements in precision medicine: multi-omics approach for tailored metformin treatment in type 2 diabetes

in Pharmacogenetics and Pharmacogenomics

Najeha Rizwana Anwardeen
Khaled Naja
Mohamed A. Elrayess

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1506767

4,923 views
6 citations

Original Research

Published on 25 Nov 2024

Comparing commercial pharmacogenetic testing results and recommendations for antidepressants with established CPIC guidelines

in Pharmacogenetics and Pharmacogenomics

Tiffany T. Nguyen
Emili J. W. Leary
Joshua T. Lee
Sanjay K. Shukla
Sara A. Griesbach

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1500235

3,374 views
2 citations

Original Research

Published on 20 Nov 2024

Metabolic pathways, genomic alterations, and post-translational modifications in pulmonary hypertension and cancer as therapeutic targets and biomarkers

in Pharmacogenetics and Pharmacogenomics

Xiujin Zhang
Zhiqing Fu
Haijun Wang
Li Sheng

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1490892

2,866 views
1 citation

Original Research

Published on 18 Nov 2024

Investigation on regulation of N-acetyltransferase 2 expression by nuclear receptors in human hepatocytes

in Pharmacogenetics and Pharmacogenomics

Kyung U. Hong
Anthony P. Aureliano
Kennedy M. Walls
David W. Hein

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1488367

2,154 views
1 citation

Original Research

Published on 15 Nov 2024

Population pharmacokinetic study of the effect of polymorphisms in the ABCB1 and CES1 genes on the pharmacokinetics of dabigatran

in Pharmacogenetics and Pharmacogenomics

Zhuan Yang
Wen Rui Tan
Qin Li
Ying Wang
Shijing Liu
Lu Chen
Yan Zhou
Chen Zeng
Yan Zeng
Yun Xiong

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1454612

2,117 views
1 citation

Original Research

Published on 14 Nov 2024

Novel genomic variants influencing methotrexate delayed clearance in pediatric patients with acute lymphoblastic leukemia

in Pharmacogenetics and Pharmacogenomics

Jung Yoon Choi
Hoshik Kwon
Hyery Kim
Kyung Taek Hong
Youngeun Ma
Kyung-Nam Koh
Sunmin Yun
Keon Hee Yoo
Sang Hoon Song
Ho Joon Im

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1480657

2,794 views
3 citations

Review

Published on 12 Nov 2024

Tumor microenvironment and cancer metastasis: molecular mechanisms and therapeutic implications

in Pharmacogenetics and Pharmacogenomics

Cigir Biray Avci
Bakiye Goker Bagca
Masoud Nikanfar
Leila Sabour Takanlou
Maryam Sabour Takanlou
Alireza Nourazarian

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1442888

10,639 views
44 citations

Original Research

Published on 01 Nov 2024

Multi-omics association study integrating GWAS and pQTL data revealed MIP-1α as a potential drug target for erectile dysfunction

in Pharmacogenetics and Pharmacogenomics

Jingwen Liu
Renbing Pan

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1495970

3,302 views
1 citation

Original Research

Published on 01 Nov 2024

Allele frequencies and genotype distribution of three metformin transporter polymorphisms in Mexican population and their application in pharmacogenomics of type 2 diabetes

in Pharmacogenetics and Pharmacogenomics

Oscar I. Chávez-Arreola
Brissia Lazalde
Marisol López-López
Alberto Ortega-Vázquez
Quitzia L. Torres-Salazar

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1466394

2,128 views

Original Research

Published on 30 Oct 2024

The role of candidate pharmacogenetic variants in determining valproic acid efficacy, toxicity and concentrations in patients with epilepsy

in Pharmacogenetics and Pharmacogenomics

Hady Yazbeck
Joe Youssef
Wassim Nasreddine
Abdullah El Kurdi
Nathalie Zgheib
Ahmad Beydoun

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1483723

2,466 views
2 citations

Original Research

Published on 25 Oct 2024

A mathematical model of glomerular fibrosis in diabetic kidney disease to predict therapeutic efficacy

in Pharmacogenetics and Pharmacogenomics

Haryana Y. Thomas
Ashlee N. Ford Versypt

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1481768

2,682 views
3 citations

Original Research

Published on 24 Oct 2024

Impact of single-nucleotide variants and individual characteristics on adverse events of L-asparaginase in children with acute lymphoblastic leukemia

in Pharmacogenetics and Pharmacogenomics

Jesús Alonso Gándara-Mireles
Ismael Lares-Asseff
Elio Aarón Reyes Espinoza
Verónica Loera Castañeda
Lourdes Patricia Córdova Hurtado
Flor de María Reyes Gutiérrez
Antonio Sandoval-Cabrera
Ignacio Villanueva Fierro
Julio Cesar Grijalva Ávila
Claudia Castro Arreola

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1423049

2,004 views
2 citations

Case Report

Published on 23 Oct 2024

Case report: Acute liver failure during deferasirox therapy and the potential role of pharmacogenetics

in Pharmacogenetics and Pharmacogenomics

Belén García-Fariña
Lydia Rink
Virginia Santarini
Marco Westkemper
Christian Dohna-Schwake
Birte Möhlendick

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1477755

3,752 views
6 citations

Original Research

Published on 18 Oct 2024

The role of NOP58 in prostate cancer progression through SUMOylation regulation and drug response

in Pharmacogenetics and Pharmacogenomics

Wei Guo
Shi Zong
Tao Liu
Yi Chao
Kaichen Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1476025

4,108 views
6 citations

Original Research

Published on 17 Oct 2024

Evaluation of the role of metabolizing enzymes and transporter variants in ezetimibe pharmacokinetics

in Pharmacogenetics and Pharmacogenomics

Eva González-Iglesias
Dolores Ochoa
Marcos Navares-Gómez
Pablo Zubiaur
Marina Aldama
Tamara de la Torre
Marta de los Ríos-Rodríguez
Paula Soria-Chacartegui
Andrea Rodríguez-Lopez
Francisco Abad-Santos

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1414059

2,353 views
4 citations

Original Research

Published on 11 Oct 2024

HLA-B allele frequencies and implications for pharmacogenetics in the Kuwaiti population

in Pharmacogenetics and Pharmacogenomics

Mohammed Dashti
Md Zubbair Malik
Abdullah Al-Matrouk
Saeeda Bhatti
Rasheeba Nizam
Sindhu Jacob
Fahd Al-Mulla
Thangavel Alphonse Thanaraj

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1423636

2,800 views

Original Research

Published on 09 Oct 2024

Pharmacogenetics testing for poor response to antidepressants: a transnosographic case series

in Pharmacogenetics and Pharmacogenomics

Marie-Agnès Lorvellec
Gilles Sipahimalani
Bertrand Lahutte
Hervé Delacour
Antoine Baldacci
Emeric Saguin

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1440523

4,990 views
5 citations

Case Report

Published on 08 Oct 2024

Pharmacogenomics assists in controlling blood pressure in cardiovascular and cerebrovascular patients during Rehabilitation: a case report

in Pharmacogenetics and Pharmacogenomics

Tian Hou
Luhai Yu
Xiaoliang Shi
Yueran Zhen
Longyu Ji
Zhenbang Wei
Yipeng Xu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1424683

4,243 views
3 citations

Original Research

Published on 04 Oct 2024

Targeting exercise-related genes and placental growth factor for therapeutic development in head and neck squamous cell carcinoma

in Pharmacogenetics and Pharmacogenomics

Qingyuan Shi
Haiyue Ying
Weibin Weng

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1476076

2,863 views
1 citation

Original Research

Published on 30 Sep 2024

SNPs in cytochromes P450 catalyzing cholesterol degradation in brain are associated with Parkinson’s disease

in Pharmacogenetics and Pharmacogenomics

Polina Petkova-Kirova
Anastasia Kolchina
Stephan Baas
Gudrun Wagenpfeil
Marcus Michael Unger
Julia Maria Schulze-Hentrich
Rita Bernhardt

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1477009

3,247 views
4 citations

Original Research

Published on 30 Sep 2024

Longitudinal assessment of SNPs rs72552763 and rs622342 in SLC22A1 over HbA1c control among Mexican-Mestizo diabetic type 2 patients

in Pharmacogenetics and Pharmacogenomics

Adiel Ortega-Ayala
Fernando De Andrés
Adrián Llerena
Carlos Miguel Bartolo-Montiel
Gustavo Acosta-Altamirano
Juan Arcadio Molina-Guarneros

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1433519

3,234 views
5 citations

Original Research

Published on 27 Sep 2024

Prevalence of single-nucleotide variants in twenty-five pharmacogenes from a Cuban sample cohort

in Pharmacogenetics and Pharmacogenomics

Elizabeth Reyes-Reyes
José Alfredo Herrera-Isidrón
Elizabeth Cuétara-Lugo
Zhiv Shkedy
Dirk Valkenborg
Claudina Angela Pérez-Novo
Gisselle Fernández-Peña
Idania González-Pérez
Miguel David Fernández-Pérez
Wim Vanden-Berghe

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1467036

2,607 views
2 citations

Original Research

Published on 24 Sep 2024

Advancing pharmacogenomic research in US Hmong populations: prevalence of key single nucleotide variations in California Hmong

in Pharmacogenetics and Pharmacogenomics

Boguang Sun
Tou Thao
Kathleen Culhane-Pera
Eric Yang
Mai Yang Thor
Pao Yang
Metta Xiong
Zoua Vang
Robert J. Straka

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1432906

1,540 views

Case Report

Published on 23 Sep 2024

Case report: A case of severe capecitabine toxicity due to confirmed in trans compound heterozygosity of a common and rare DPYD variant

in Pharmacogenetics and Pharmacogenomics

Amy de Haar-Holleman
Pieter-Jan Cortoos
Jelle Vlaeminck
Paulien Van Landuyt
Stephane Steurbaut
Freya Vaeyens
Vincent Haufroid

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1459565

2,963 views
2 citations

643 articles

articles

Advancements in precision medicine: multi-omics approach for tailored metformin treatment in type 2 diabetes

Comparing commercial pharmacogenetic testing results and recommendations for antidepressants with established CPIC guidelines

Metabolic pathways, genomic alterations, and post-translational modifications in pulmonary hypertension and cancer as therapeutic targets and biomarkers

Investigation on regulation of N-acetyltransferase 2 expression by nuclear receptors in human hepatocytes

Population pharmacokinetic study of the effect of polymorphisms in the ABCB1 and CES1 genes on the pharmacokinetics of dabigatran

Novel genomic variants influencing methotrexate delayed clearance in pediatric patients with acute lymphoblastic leukemia

Tumor microenvironment and cancer metastasis: molecular mechanisms and therapeutic implications

Multi-omics association study integrating GWAS and pQTL data revealed MIP-1α as a potential drug target for erectile dysfunction

Allele frequencies and genotype distribution of three metformin transporter polymorphisms in Mexican population and their application in pharmacogenomics of type 2 diabetes

The role of candidate pharmacogenetic variants in determining valproic acid efficacy, toxicity and concentrations in patients with epilepsy

A mathematical model of glomerular fibrosis in diabetic kidney disease to predict therapeutic efficacy

Impact of single-nucleotide variants and individual characteristics on adverse events of L-asparaginase in children with acute lymphoblastic leukemia

Case report: Acute liver failure during deferasirox therapy and the potential role of pharmacogenetics

The role of NOP58 in prostate cancer progression through SUMOylation regulation and drug response

Evaluation of the role of metabolizing enzymes and transporter variants in ezetimibe pharmacokinetics

HLA-B allele frequencies and implications for pharmacogenetics in the Kuwaiti population

Pharmacogenetics testing for poor response to antidepressants: a transnosographic case series

Pharmacogenomics assists in controlling blood pressure in cardiovascular and cerebrovascular patients during Rehabilitation: a case report

Targeting exercise-related genes and placental growth factor for therapeutic development in head and neck squamous cell carcinoma

SNPs in cytochromes P450 catalyzing cholesterol degradation in brain are associated with Parkinson’s disease

Longitudinal assessment of SNPs rs72552763 and rs622342 in SLC22A1 over HbA1c control among Mexican-Mestizo diabetic type 2 patients

Prevalence of single-nucleotide variants in twenty-five pharmacogenes from a Cuban sample cohort

Advancing pharmacogenomic research in US Hmong populations: prevalence of key single nucleotide variations in California Hmong

Case report: A case of severe capecitabine toxicity due to confirmed in trans compound heterozygosity of a common and rare DPYD variant