Frontiers in Pharmacology | Pharmacology of Anti-Cancer Drugs

Original Research

Published on 24 Jun 2025

CircASH1L inhibits ferroptosis and enhances cisplatin resistance by sponging miR-515-5p to regulate cell cycle-related CDCA7/RRM2 in ovarian cancer cells

in Pharmacology of Anti-Cancer Drugs

Lu Feng
Xinru Zou
Longyu Tang
Yijun Yuan
Tianwen He
Bin Su
Ying Tang
Jiang Wang
Kang Liu
Jun Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1563869

347 views

Original Research

Accepted on 23 Jun 2025

Independent Risk and Protective Factors for Oxaliplatin-Induced Hypersensitivity Reactions: A Retrospective Study

in Pharmacology of Anti-Cancer Drugs

Jing Xue
Zhihao Lian
Xiaoyan Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1624322

130 views

Original Research

Accepted on 23 Jun 2025

EGCG and DOX dual-drug-loaded enzyme-responsive nanovesicles boost mitochondrial-mediated ICD for improved immunotherapy

in Pharmacology of Anti-Cancer Drugs

Mengxue Zhou
Ying Wang
Hongchun Cui
Huan Geng
Lifu Ruan
Yanni Zhao
Chuang Zhou
Weidong Dai
Jun Chen
Jizhong Yu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1624109

180 views

Original Research

Accepted on 23 Jun 2025

Aloe-emodin mediates the inhibitory effect of LncRNA D63785 on the PI3K/Akt/mTOR pathway in nasopharyngeal carcinoma

in Pharmacology of Anti-Cancer Drugs

Min He
Lei Xie
Jiayi Huang
Han Su
Jiahua Hu
Liuping Xie
Mengqin Li
Xin Zeng
Jianhong Tang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1573408

100 views

Review

Accepted on 23 Jun 2025

CXCR3 inhibitors for Therapeutic Interventions: Current status and perspectives

in Pharmacology of Anti-Cancer Drugs

Dan Zhou
Rongrong Huo
Yu Jiang
Li Zhang
Shufang Du

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1556196

122 views

Original Research

Accepted on 23 Jun 2025

Spatial deciphering the transcriptomic heterogeneity of tumor spread through air space in lung cancer

in Pharmacology of Anti-Cancer Drugs

Wenhao Wang
Wenhao Zhou
Jingli Fan
Tao Jiang
Guang Yang
Congcong Song
Siwei Xu
Haitao Luo
Huining Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1567527

107 views

Original Research

Accepted on 19 Jun 2025

Synergistic effect of regorafenib with aminoglycosides ferroptosis mediated liver injury

in Pharmacology of Anti-Cancer Drugs

Maha Raja
Shaojun Zhou
HAIHONG HU
Jinxiu Lei
Kui Zeng
Lushan Yu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1586578

163 views

Original Research

Published on 19 Jun 2025

Efficacy and safety of darolutamide versus abiraterone acetate plus prednisone in combination with ADT for mHSPC: a real-world clinical retrospective study

in Pharmacology of Anti-Cancer Drugs

Ting Hu
Fang Zhou
Yang Zheng
Bohan Luo
Yongliang Zhang
Chengpeng Gu
Guopeng Wang
Jinze Zhang
Jingzhi Tian
Yu Nie

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1608339

455 views

Brief Research Report

Published on 18 Jun 2025

An in silico evaluation of lorlatinib as a potential therapy for novel amino acid substitutions in the tyrosine kinase domain of the ALK protein associated with cancer

in Pharmacology of Anti-Cancer Drugs

Richard Junior Zapata Dongo
Julio A. Poterico
Diletta Fontana
Luca Mologni
Carla Alvarez-Chacon
Juan Rojas-Armas
Jaeson Calla

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1605314

1,501 views

Systematic Review

Published on 18 Jun 2025

Efficacy and safety of serplulimab in solid tumors: a meta-analysis

in Pharmacology of Anti-Cancer Drugs

Peimeng Shen
Tao Zhang
Lina Hao
Ming Jing
Yanxin Wu
Shuwen Yu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1604874

419 views

Review

Published on 18 Jun 2025

Targeting super-enhancers in liver cancer: from pathogenic mechanisms to clinical applications

in Pharmacology of Anti-Cancer Drugs

Chang-Lei Li
Zhi-Yuan Yao
Ao Sun
Jing-Yu Cao
Zu-Sen Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1589455

435 views

Review

Published on 17 Jun 2025

Targeting tumor-associated macrophages in gastric cancer progression and therapy: insights from molecular mechanisms to therapeutic applications

in Pharmacology of Anti-Cancer Drugs

ChengTao Wan
Jie Deng
Yu Zhu
Li Wan
Linyue Xu
Qiuyan Chen
Can Zou
Ju Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1549694

733 views

Review

Published on 17 Jun 2025

Multiple myeloma inhibitory effects of natural compounds: enhancement through nanoparticle carriers

in Pharmacology of Anti-Cancer Drugs

Erica Wong
Anna Staskiewicz
Joshua Pruner
Jean Lee
Michael Tucker
Barkley Smith
Lanerica Rogers
Ganiat Asuni
Xinyu Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1589090

773 views

Original Research

Published on 17 Jun 2025

Tricin selectively combats KRAS-mutant non-small cell lung cancer by inhibiting the PDGF-BB-induced SRC/MAPK/AP-1/PD-L1 signaling pathway and potentiating the antitumor effect of an anti-PD-1 antibody

in Pharmacology of Anti-Cancer Drugs

Jia-Xin Li
Shi-Yu Tan
Li-Qi Li
Yu-Hong Zheng
Lin Zhao
Hui-Rong Zhu
Hai-Lang He
Yan-Yu Zhang
Run-Ze Li
Tian-Yu Bao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1594213

854 views

Original Research

Accepted on 16 Jun 2025

Prevention of chemotherapy drug-mediated human hair follicle damage: combined use of cooling with antioxidant suppresses oxidative stress and prevents matrix keratinocyte cytotoxicity

in Pharmacology of Anti-Cancer Drugs

Khalidah Ibraheem
Adrian Smith
Andrew Collett
Nikolaos T. Georgopoulos

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1558593

301 views

Original Research

Accepted on 13 Jun 2025

Revealing Key Regulatory Factors in Lung adenocarcinoma: The Role of Epigenetic regulation of autophagy-related genes from Transcriptomics, scRNA-seq, and Machine Learning

in Pharmacology of Anti-Cancer Drugs

Zeng Xianchang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1542338

254 views